reactions list

Linoleic acid + CoA + ATP

(9Z,12Z-octadecadienoic acid) (lipid link)
category: Fatty Acyls [FA]
main_class: Fatty Acids and Conjugates [FA01]
sub_class: Unsaturated fatty acids [FA0103]
formula: C18H32O2
synonyms: cis-9, cis-12-octadecadienoic acid; cis,cis-Linoleic acid; cis,cis-9,12-octadecadienoic acid; Linoleate; 9Z,12Z-Linoleic acid; T
kegg id: C01595
status:
exact mass: 280.24
lipidmaps
pubchem substance url
localization: Unknown
notes:
first reaction there..
ok test

6.2.1.3 Long-chain-fatty-acid--CoA ligase.

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. (kegg)
proteins
Q96GR2 ACBG1_HUMAN
Q5FVE4 ACBG2_HUMAN
P33121 ACSL1_HUMAN
O95573 ACSL3_HUMAN
O60488 ACSL4_HUMAN
Q9ULC5 ACSL5_HUMAN
Q9UKU0 ACSL6_HUMAN
O14975 S27A2_HUMAN

details
["Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.", "The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24)."]


map 1: n-6 Polyunsaturated fatty acid biosynthesis

proteins:
  • acyl-CoA synthetase bubblegum family member 2 [ACSBG2] ncbi lipid_maps
  • acyl-CoA synthetase long-chain family member 1 [ACSL1] ncbi lipid_maps
    regulators:
    MIR205 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
    PPARA ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
  • acyl-CoA synthetase long-chain family member 3 [ACSL3] ncbi lipid_maps
    regulators:
    POU1F1 ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
    AR ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
  • acyl-CoA synthetase long-chain family member 4 [ACSL4] ncbi lipid_maps
    regulators:
    MIR205 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
  • acyl-CoA synthetase long-chain family member 5 [ACSL5] ncbi lipid_maps
  • acyl-CoA synthetase long-chain family member 6 [ACSL6] ncbi lipid_maps

Linoleoyl-CoA + Biotin + ADP

(3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-({3-[(2-{[(9Z,12Z)-octadeca-9,12-dienoyl]sulfanyl}ethyl)amino]-3-oxopro) (lipid link)
category: Fatty Acyls [FA]
main_class: Fatty esters [FA07]
sub_class: Fatty acyl CoAs [FA0705]
formula: C39H66N7O17P3S
kegg id: C02050
exact mass: 1029.34
status:
lipidmaps

Linoleoyl-CoA + O2

(3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-({3-[(2-{[(9Z,12Z)-octadeca-9,12-dienoyl]sulfanyl}ethyl)amino]-3-oxopro) (lipid link)
category: Fatty Acyls [FA]
main_class: Fatty esters [FA07]
sub_class: Fatty acyl CoAs [FA0705]
formula: C39H66N7O17P3S
kegg id: C02050
status:
exact mass: 1029.34
lipidmaps
localization: mitochondrial membrane

1.14.19.3 Acyl-CoA 6-desaturase.

(1) Linoleoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = gamma- linolenoyl-CoA + 2 ferricytochrome b5+ 2 H(2)O. (2) Alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = stearidonoyl-CoA + 2 ferricytochrome b5+ 2 H(2)O. (kegg)
proteins
O95864 FADS2_HUMAN

details
["The enzyme introduces a cis double bond at carbon 6 of acyl-CoAs.", "It is a front-end desaturase, introducing the new double bond between a pre-existing double bond and the carboxyl-end of the fatty acid.", "The human enzyme has a broad substrate range; it also acts on palmitoyl-CoA, generating sapienoyl-CoA, and on (9Z,12Z,15Z,18Z,21Z)- tetracosa-9,12,15,18,21-pentaenoyl-CoA, converting it to (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexaenoyl-CoA as part of a pathway that produces docosahexaenoate.", "The enzyme contains a cytochrome b5 domain that is assumed to act in vivo as the electron donor to the active site of the desaturase."]


map 1: n-6 Polyunsaturated fatty acid biosynthesis

proteins:

gamma-linolenoyl-CoA

(3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-({3-[(2-{[(6Z,12Z,15Z)-octadeca-6,12,15-trienoyl]sulfanyl}ethyl)amino]-) (lipid link)
category: Fatty Acyls [FA]
main_class: Fatty esters [FA07]
sub_class: Fatty acyl CoAs [FA0705]
formula: C39H64N7O17P3S
synonyms: (6Z,9Z,12Z)-6,9,12-octadecatrienoyl-CoA;(Z,Z,Z)-6,9,12-octadecatrienoyl-CoA;(Z,Z,Z)-6,9,12-octadecatrienoyl-coenzyme A;6-cis,9-c
exact mass: 1027.33
status:
lipidmaps

gamma-linolenoyl-CoA

(3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-({3-[(2-{[(6Z,12Z,15Z)-octadeca-6,12,15-trienoyl]sulfanyl}ethyl)amino]-) (lipid link)
category: Fatty Acyls [FA]
main_class: Fatty esters [FA07]
sub_class: Fatty acyl CoAs [FA0705]
formula: C39H64N7O17P3S
synonyms: (6Z,9Z,12Z)-6,9,12-octadecatrienoyl-CoA;(Z,Z,Z)-6,9,12-octadecatrienoyl-CoA;(Z,Z,Z)-6,9,12-octadecatrienoyl-coenzyme A;6-cis,9-c
status:
exact mass: 1027.33
lipidmaps
localization: Mitochondria

2.3.1.- Transferring groups other than amino-acyl groups.

(kegg)
proteins


map 1: n-6 Polyunsaturated fatty acid biosynthesis

proteins:

(8Z,11Z,14Z)-3-oxoicosa-8,11,14-trienoyl-CoA

(3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-4-({3-[(2-{[(8Z,11Z,14Z)-3-oxoicosa-8,11,14-trienoyl]sulfanyl}ethyl)amino]-3-oxopropyl) (lipid link)
category: Fatty Acyls [FA]
main_class: Fatty esters [FA07]
sub_class: Fatty acyl CoAs [FA0705]
formula: C41H66N7O18P3S
synonyms: (8Z,11Z,14Z)-3-oxoeicosa-8,11,14-trienoyl-CoA;(8Z,11Z,14Z)-3-oxoeicosa-8,11,14-trienoyl-coenzyme A;(8Z,11Z,14Z)-3-oxoicosa-8,11,
exact mass: 1069.34
status:
lipidmaps

(-)-Maackiain 3-O-glucoside

no systematic name (lipid link)
category: Polyketides [PK]
main_class: Flavonoids [PK12]
sub_class: Pterocarpans [PK1207]
formula: C22H22O10
synonyms: Trifolirhizin
status:
exact mass: 446.121
lipidmaps
pubchem substance url
localization: mitochondrial membrane

1.4.4.2 Glycine dehydrogenase (aminomethyl-transferring).

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L- lysine + CO(2). (kegg)
proteins
P23378 GCSP_HUMAN

details
["A component of the glycine cleavage system, which is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein.", "Previously known as glycine synthase."]


proteins:

    11-Hydroxyiridodial glucoside pentaacetate

    no systematic name (lipid link)
    category: Prenol Lipids [PR]
    main_class: Isoprenoids [PR01]
    sub_class: C10 isoprenoids (monoterpenes) [PR0102]
    formula: C26H36O13
    kegg id: C11666
    exact mass: 556.216
    status:
    lipidmaps
    pubchem substance url

    (8Z,11Z,14Z)-3-oxoicosa-8,11,14-trienoyl-CoA + NADPH

    (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-4-({3-[(2-{[(8Z,11Z,14Z)-3-oxoicosa-8,11,14-trienoyl]sulfanyl}ethyl)amino]-3-oxopropyl) (lipid link)
    category: Fatty Acyls [FA]
    main_class: Fatty esters [FA07]
    sub_class: Fatty acyl CoAs [FA0705]
    formula: C41H66N7O18P3S
    synonyms: (8Z,11Z,14Z)-3-oxoeicosa-8,11,14-trienoyl-CoA;(8Z,11Z,14Z)-3-oxoeicosa-8,11,14-trienoyl-coenzyme A;(8Z,11Z,14Z)-3-oxoicosa-8,11,
    status:
    exact mass: 1069.34
    lipidmaps
    localization: reticulum

    1.1.1.62 17-beta-estradiol 17-dehydrogenase.

    17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H. (kegg)
    proteins
    C9JRZ8 AK1BF_HUMAN
    Q8NBQ5 DHB11_HUMAN
    Q53GQ0 DHB12_HUMAN
    P14061 DHB1_HUMAN
    P37059 DHB2_HUMAN
    P56937 DHB7_HUMAN
    Q92506 DHB8_HUMAN
    O14756 H17B6_HUMAN

    details
    ["The enzyme oxidizes or reduces the hydroxy/keto group on C(17) of estrogens and androgens in mammals and regulates the biological potency of these steroids.", "The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.270.", "The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, it is Si-specific with respect to NAD(P)(+)."]


    map 1: n-6 Polyunsaturated fatty acid biosynthesis

    proteins:

    (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + NADP(+)

    (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-({3-[(2-{[(11Z,14Z)-3-oxoicosa-11,14-dienoyl]sulfanyl}ethyl)amino]-3-ox) (lipid link)
    category: Fatty Acyls [FA]
    main_class: Fatty esters [FA07]
    sub_class: Fatty acyl CoAs [FA0705]
    formula: C41H68N7O18P3S
    synonyms: (11Z,14Z)-3-ketoeicosa-11,14-dienoyl-CoA;(11Z,14Z)-3-ketoeicosa-11,14-dienoyl-coenzyme A;(11Z,14Z)-3-ketoicosa-11,14-dienoyl-CoA
    exact mass: 1071.36
    status:
    lipidmaps

    (8Z,11Z,14Z)-3-oxoicosa-8,11,14-trienoyl-CoA + NADPH

    (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-4-({3-[(2-{[(8Z,11Z,14Z)-3-oxoicosa-8,11,14-trienoyl]sulfanyl}ethyl)amino]-3-oxopropyl) (lipid link)
    category: Fatty Acyls [FA]
    main_class: Fatty esters [FA07]
    sub_class: Fatty acyl CoAs [FA0705]
    formula: C41H66N7O18P3S
    synonyms: (8Z,11Z,14Z)-3-oxoeicosa-8,11,14-trienoyl-CoA;(8Z,11Z,14Z)-3-oxoeicosa-8,11,14-trienoyl-coenzyme A;(8Z,11Z,14Z)-3-oxoicosa-8,11,
    status:
    exact mass: 1069.34
    lipidmaps
    localization: Unknown

    1.1.1.62 17-beta-estradiol 17-dehydrogenase.

    17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H. (kegg)
    proteins
    C9JRZ8 AK1BF_HUMAN
    Q8NBQ5 DHB11_HUMAN
    Q53GQ0 DHB12_HUMAN
    P14061 DHB1_HUMAN
    P37059 DHB2_HUMAN
    P56937 DHB7_HUMAN
    Q92506 DHB8_HUMAN
    O14756 H17B6_HUMAN

    details
    ["The enzyme oxidizes or reduces the hydroxy/keto group on C(17) of estrogens and androgens in mammals and regulates the biological potency of these steroids.", "The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.270.", "The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, it is Si-specific with respect to NAD(P)(+)."]


    map 1: n-6 Polyunsaturated fatty acid biosynthesis

    proteins:

    (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + NADP(+)

    (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-({3-[(2-{[(11Z,14Z)-3-oxoicosa-11,14-dienoyl]sulfanyl}ethyl)amino]-3-ox) (lipid link)
    category: Fatty Acyls [FA]
    main_class: Fatty esters [FA07]
    sub_class: Fatty acyl CoAs [FA0705]
    formula: C41H68N7O18P3S
    synonyms: (11Z,14Z)-3-ketoeicosa-11,14-dienoyl-CoA;(11Z,14Z)-3-ketoeicosa-11,14-dienoyl-coenzyme A;(11Z,14Z)-3-ketoicosa-11,14-dienoyl-CoA
    exact mass: 1071.36
    status:
    lipidmaps

    (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA

    (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-({3-[(2-{[(11Z,14Z)-3-oxoicosa-11,14-dienoyl]sulfanyl}ethyl)amino]-3-ox) (lipid link)
    category: Fatty Acyls [FA]
    main_class: Fatty esters [FA07]
    sub_class: Fatty acyl CoAs [FA0705]
    formula: C41H68N7O18P3S
    synonyms: (11Z,14Z)-3-ketoeicosa-11,14-dienoyl-CoA;(11Z,14Z)-3-ketoeicosa-11,14-dienoyl-coenzyme A;(11Z,14Z)-3-ketoicosa-11,14-dienoyl-CoA
    status:
    exact mass: 1071.36
    lipidmaps
    localization: reticulum

    4.2.1.n1 Transferred entry: 4.2.1.126.

    (kegg)
    proteins


    proteins:

      Arachidonyl-CoA + H2O

      (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-4-({3-[(2-{[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]sulfanyl}ethyl)amino]-3-oxoprop) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Fatty esters [FA07]
      sub_class: Fatty acyl CoAs [FA0705]
      formula: C41H66N7O17P3S
      synonyms: (5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraenoyl-CoA;(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraenoyl-coenzyme A;(5Z,8Z,11Z,14Z)-5,8,11,14-i
      kegg id: C02249
      exact mass: 1053.34
      status:
      lipidmaps

      Arachidonyl-CoA + malonyl-CoA

      (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-4-({3-[(2-{[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]sulfanyl}ethyl)amino]-3-oxoprop) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Fatty esters [FA07]
      sub_class: Fatty acyl CoAs [FA0705]
      formula: C41H66N7O17P3S
      synonyms: (5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraenoyl-CoA;(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraenoyl-coenzyme A;(5Z,8Z,11Z,14Z)-5,8,11,14-i
      kegg id: C02249
      status:
      exact mass: 1053.34
      lipidmaps
      localization: reticulum

      2.3.1.- Transferring groups other than amino-acyl groups.

      (kegg)
      proteins


      map 1: n-6 Polyunsaturated fatty acid biosynthesis

      proteins:

      (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + H2O + CoA + CO2

      (3'-phosphoadenosine 5'-{3-[(3R)-4-({3-[(2-{[(7Z,10Z,13Z,16Z)-3-oxodocosa-7,10,13,16,19-tetraenoyl]sulfanyl}ethyl)amino]-3-oxopro) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Fatty esters [FA07]
      sub_class: Fatty acyl CoAs [FA0705]
      formula: C43H68N7O18P3S
      synonyms: 3-oxo-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA;all-cis-7,10,13,16-3-oxodocosatetraenoyl-CoA
      exact mass: 1095.36
      status:
      lipidmaps

      3-oxo adrenoyl-CoA + NADPH + H+

      no systematic name (lipid link)
      formula: C43H64N7O18P3S-4
      synonyms: 3-oxo-(7Z,10Z,13Z,16Z)-docosa-7,10,13,16-tetraenoyl-CoA 3-oxo-(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA
      status:
      exact mass: 1091.99
      localization: reticulum

      1.1.1.330 Very-long-chain 3-oxoacyl-CoA reductase.

      A very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH. (kegg)
      proteins
      Q53GQ0 DHB12_HUMAN

      details
      ["The second component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs.", "The enzyme is active with substrates with chain length of C(16) to C(34), depending on the species.", "Cf. EC 2.3.1.199, EC 4.2.1.134 and EC 1.3.1.93.", "Formerly EC 1.1.1.n13 and EC 2.3.1.119."]


      proteins:

      (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + NADP(+)

      no systematic name (lipid link)
      category: Fatty Acyls [FA]
      main_class: Fatty esters [FA07]
      sub_class: Fatty acyl CoAs [FA0705]
      formula: C43H66N7O18P3S
      synonyms: (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-coenzyme A;all-cis-3-oxodocosa-7,10,13,16,19-pentaenoyl-CoA;all-cis-3-oxodocosa-7,10,
      exact mass: 1093.34
      status:
      lipidmaps

      Palmitic acid + ATP + CoA

      (hexadecanoic acid) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Fatty Acids and Conjugates [FA01]
      sub_class: Straight chain fatty acids [FA0101]
      formula: C16H32O2
      synonyms: Cetylic acid; Palmitate; n-Hexadecanoic acid; C16:0
      kegg id: C00249
      status:
      exact mass: 256.24
      lipidmaps
      pubchem substance url
      localization: reticulum
      proteins

      details
      ["The second component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs.", "The enzyme is active with substrates with chain length of C(16) to C(34), depending on the species.", "Cf. EC 2.3.1.199, EC 4.2.1.134 and EC 1.3.1.93.", "Formerly EC 1.1.1.n13 and EC 2.3.1.119."]


      proteins:
      • acyl-CoA synthetase bubblegum family member 1 [ACSBG1] ncbi lipid_maps
      • acyl-CoA synthetase long-chain family member 1 [ACSL1] ncbi lipid_maps
        regulators:
        MIR205 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
        PPARA ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
      • acyl-CoA synthetase long-chain family member 3 [ACSL3] ncbi lipid_maps
        regulators:
        POU1F1 ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
        AR ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
      • acyl-CoA synthetase long-chain family member 4 [ACSL4] ncbi lipid_maps
        regulators:
        MIR205 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
      • acyl-CoA synthetase long-chain family member 5 [ACSL5] ncbi lipid_maps
      • acyl-CoA synthetase long-chain family member 6 [ACSL6] ncbi lipid_maps
      • solute carrier family 27 (fatty acid transporter), member 2 [SLC27A2] ncbi lipid_maps
      • acyl-CoA synthetase bubblegum family member 2 [ACSBG2] ncbi lipid_maps

      Palmityl-CoA

      (3'-phosphoadenosine 5'-(3-{(3R)-4-[(3-{[2-(hexadecanoylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobuty) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Fatty esters [FA07]
      sub_class: Fatty acyl CoAs [FA0705]
      formula: C37H66N7O17P3S
      synonyms: Coenzyme A, S-hexadecanoate;Palmitoyl coenzyme A;S-Palmitoylcoenzyme A
      kegg id: C00154
      exact mass: 1005.34
      status:
      lipidmaps

      Palmitic acid + ATP + CoA

      (hexadecanoic acid) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Fatty Acids and Conjugates [FA01]
      sub_class: Straight chain fatty acids [FA0101]
      formula: C16H32O2
      synonyms: Cetylic acid; Palmitate; n-Hexadecanoic acid; C16:0
      kegg id: C00249
      status:
      exact mass: 256.24
      lipidmaps
      pubchem substance url
      localization: reticulum

      6.2.1.3 Long-chain-fatty-acid--CoA ligase.

      ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. (kegg)
      proteins
      Q96GR2 ACBG1_HUMAN
      Q5FVE4 ACBG2_HUMAN
      P33121 ACSL1_HUMAN
      O95573 ACSL3_HUMAN
      O60488 ACSL4_HUMAN
      Q9ULC5 ACSL5_HUMAN
      Q9UKU0 ACSL6_HUMAN
      O14975 S27A2_HUMAN

      details
      ["Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity.", "The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24)."]


      map 1: Unsaturated fatty acid biosynthesis

      proteins:
      • acyl-CoA synthetase long-chain family member 1 [ACSL1] ncbi lipid_maps
        regulators:
        MIR205 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
        PPARA ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
      • acyl-CoA synthetase long-chain family member 3 [ACSL3] ncbi lipid_maps
        regulators:
        POU1F1 ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
        AR ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
      • acyl-CoA synthetase long-chain family member 4 [ACSL4] ncbi lipid_maps
        regulators:
        MIR205 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
      • acyl-CoA synthetase long-chain family member 5 [ACSL5] ncbi lipid_maps
      • acyl-CoA synthetase long-chain family member 6 [ACSL6] ncbi lipid_maps
      • solute carrier family 27 (fatty acid transporter), member 2 [SLC27A2] ncbi lipid_maps
      • acyl-CoA synthetase bubblegum family member 1 [ACSBG1] ncbi lipid_maps
      • acyl-CoA synthetase bubblegum family member 2 [ACSBG2] ncbi lipid_maps

      Palmityl-CoA + AMP + PPi

      (3'-phosphoadenosine 5'-(3-{(3R)-4-[(3-{[2-(hexadecanoylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobuty) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Fatty esters [FA07]
      sub_class: Fatty acyl CoAs [FA0705]
      formula: C37H66N7O17P3S
      synonyms: Coenzyme A, S-hexadecanoate;Palmitoyl coenzyme A;S-Palmitoylcoenzyme A
      kegg id: C00154
      exact mass: 1005.34
      status:
      lipidmaps

      Arachidonic acid + O2

      (5Z,8Z,11Z,14Z-eicosatetraenoic acid) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Fatty Acids and Conjugates [FA01]
      sub_class: Unsaturated fatty acids [FA0103]
      formula: C20H32O2
      synonyms: 5Z,8Z,11Z,14Z-icosatetraenoic acid; AA; Arachidonate; cis-5,8,11,14-Eicosatetraenoic acid; (all-Z)-5,8,11,14-Eicosatetraenoic ac
      kegg id: C00219
      status:
      exact mass: 304.24
      lipidmaps
      pubchem substance url
      localization: Cytoplasm

      1.13.11.34 Arachidonate 5-lipoxygenase.

      Arachidonate + O(2) = leukotriene A(4) + H(2)O. (kegg)
      proteins
      P09917 LOX5_HUMAN


      map 1: Leukotriene biosynthesis and metabolism

      proteins:
      • arachidonate 5-lipoxygenase [ALOX5] ncbi lipid_maps
        regulators:
        MIR216A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

      5S-HpETE

      (5S-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Eicosanoids [FA03]
      sub_class: Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]
      formula: C20H32O4
      synonyms: 5-HpETE
      kegg id: C05356
      exact mass: 336.23
      status:
      lipidmaps
      pubchem substance url

      Palmityl-CoA + malonyl-CoA + H+

      (3'-phosphoadenosine 5'-(3-{(3R)-4-[(3-{[2-(hexadecanoylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobuty) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Fatty esters [FA07]
      sub_class: Fatty acyl CoAs [FA0705]
      formula: C37H66N7O17P3S
      synonyms: Coenzyme A, S-hexadecanoate;Palmitoyl coenzyme A;S-Palmitoylcoenzyme A
      kegg id: C00154
      status:
      exact mass: 1005.34
      lipidmaps
      localization: reticulum

      2.3.1.199 Very-long-chain 3-oxoacyl-CoA synthase.

      A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2). (kegg)
      proteins
      Q9BW60 ELOV1_HUMAN
      Q9NXB9 ELOV2_HUMAN
      Q9HB03 ELOV3_HUMAN
      Q9GZR5 ELOV4_HUMAN
      Q9NYP7 ELOV5_HUMAN
      Q9H5J4 ELOV6_HUMAN
      A1L3X0 ELOV7_HUMAN

      details
      ["This is the first component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs.", "Multiple forms exist with differing preferences for the substrate, and thus the specific form expressed determines the local composition of very-long-chain fatty acids.", "For example, the FAE1 form from the plant Arabidopsis thaliana accepts only 16 and 18 carbon substrates, with oleoyl-CoA (18:1) being the preferred substrate, while CER6 from the same plant prefers substrates with chain length of C(22) to C(32).", "Cf. EC 1.1.1.330, EC 4.2.1.134 and EC 1.3.1.93.", "Formerly EC 2.3.1.119 and EC 2.3.1.n8."]


      map 1: Unsaturated fatty acid biosynthesis

      proteins:

      3-oxooctadecanoyl-CoA + CoA + CO2

      (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(3-oxooctadecanoyl)sulfanyl]ethyl}amino)propyl]ami) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Fatty esters [FA07]
      sub_class: Fatty acyl CoAs [FA0705]
      formula: C39H68N7O18P3S
      synonyms: 3-Ketostearoyl-CoA;3-oxooctadecanoyl-coenzyme A;3-oxostearoyl-CoA;3-oxostearoyl-coenzyme A;beta-Ketostearoyl-CoA;beta-ketostearo
      kegg id: C16216
      exact mass: 1047.36
      status:
      lipidmaps

      5S-HpETE

      (5S-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Eicosanoids [FA03]
      sub_class: Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]
      formula: C20H32O4
      synonyms: 5-HpETE
      kegg id: C05356
      status:
      exact mass: 336.23
      lipidmaps
      pubchem substance url
      localization: Cytoplasm
      proteins

      details
      ["This is the first component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs.", "Multiple forms exist with differing preferences for the substrate, and thus the specific form expressed determines the local composition of very-long-chain fatty acids.", "For example, the FAE1 form from the plant Arabidopsis thaliana accepts only 16 and 18 carbon substrates, with oleoyl-CoA (18:1) being the preferred substrate, while CER6 from the same plant prefers substrates with chain length of C(22) to C(32).", "Cf. EC 1.1.1.330, EC 4.2.1.134 and EC 1.3.1.93.", "Formerly EC 2.3.1.119 and EC 2.3.1.n8."]


      map 1: Leukotriene biosynthesis and metabolism

      proteins:
      • arachidonate 5-lipoxygenase [ALOX5] ncbi lipid_maps
        regulators:
        MIR216A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

      LTA4 + H2O

      (5S,6S-epoxy-7E,9E,11Z,14Z-eicosatetraenoic acid) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Eicosanoids [FA03]
      sub_class: Leukotrienes [FA0302]
      formula: C20H30O3
      synonyms: Leukotriene A4
      kegg id: C00909
      exact mass: 318.219
      status:
      lipidmaps
      pubchem substance url

      3-oxooctadecanoyl-CoA + NADPH + H+

      (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(3-oxooctadecanoyl)sulfanyl]ethyl}amino)propyl]ami) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Fatty esters [FA07]
      sub_class: Fatty acyl CoAs [FA0705]
      formula: C39H68N7O18P3S
      synonyms: 3-Ketostearoyl-CoA;3-oxooctadecanoyl-coenzyme A;3-oxostearoyl-CoA;3-oxostearoyl-coenzyme A;beta-Ketostearoyl-CoA;beta-ketostearo
      kegg id: C16216
      status:
      exact mass: 1047.36
      lipidmaps
      localization: reticulum

      1.1.1.- With NAD(+) or NADP(+) as acceptor.

      (kegg)
      proteins


      map 1: Unsaturated fatty acid biosynthesis

      proteins:

      3-hydroxyoctadecanoyl-CoA + NADP(+)

      (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-4-{[3-({2-[(3-hydroxyoctadecanoyl)sulfanyl]ethyl}amino)-3-oxopropyl]amino}-2,2-dimethy) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Fatty esters [FA07]
      sub_class: Fatty acyl CoAs [FA0705]
      formula: C39H70N7O18P3S
      synonyms: 3-Hydroxyoctadecanoyl-coenzyme A;3-Hydroxystearoyl-CoA;3-hydroxystearoyl-coenzyme A;beta-Hydroxystearoyl-CoA;beta-Hydroxystearyl
      exact mass: 1049.37
      status:
      lipidmaps

      3-hydroxyoctadecanoyl-CoA

      (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-4-{[3-({2-[(3-hydroxyoctadecanoyl)sulfanyl]ethyl}amino)-3-oxopropyl]amino}-2,2-dimethy) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Fatty esters [FA07]
      sub_class: Fatty acyl CoAs [FA0705]
      formula: C39H70N7O18P3S
      synonyms: 3-Hydroxyoctadecanoyl-coenzyme A;3-Hydroxystearoyl-CoA;3-hydroxystearoyl-coenzyme A;beta-Hydroxystearoyl-CoA;beta-Hydroxystearyl
      status:
      exact mass: 1049.37
      lipidmaps
      localization: reticulum

      4.2.1.119 Enoyl-CoA hydratase 2.

      (3R)-3-hydroxyacyl-CoA = (2E)-2-enoyl-CoA + H(2)O. (kegg)
      proteins
      P51659 DHB4_HUMAN

      details
      ["This enzyme catalyzes a hydration step in peroxisomal beta-oxidation.", "The human multifunctional enzyme type 2 (MFE-2) is a 79000 Da enzyme composed of three functional units: (3R)-hydroxyacyl-CoA dehydrogenase, 2-enoyl-CoA hydratase 2 and sterol carrier protein 2-like units.", "The enzymes from Aeromonas caviae and Arabidopsis thaliana are monofunctional enzymes.", "2-enoyl-CoA hydratase 3 from Candida tropicalis is a part from multifunctional enzyme type 2."]


      map 1: Unsaturated fatty acid biosynthesis

      proteins:

      trans-2-octadecenoyl-CoA + H2O

      (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-({3-[(2-{[(2E)-octadec-2-enoyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Fatty esters [FA07]
      sub_class: Fatty acyl CoAs [FA0705]
      formula: C39H68N7O17P3S
      synonyms: (2E)-Octadecenoyl-CoA;(E)-2-octadecenoyl-CoA;(E)-2-octadecenoyl-coenzyme A;(E)-octadec-2-enoyl-CoA;(E)-octadec-2-enoyl-coenzyme
      exact mass: 1031.36
      status:
      lipidmaps

      5S-HpETE

      (5S-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Eicosanoids [FA03]
      sub_class: Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]
      formula: C20H32O4
      synonyms: 5-HpETE
      kegg id: C05356
      status:
      exact mass: 336.23
      lipidmaps
      pubchem substance url
      localization: Cytoplasm
      proteins

      details
      ["This enzyme catalyzes a hydration step in peroxisomal beta-oxidation.", "The human multifunctional enzyme type 2 (MFE-2) is a 79000 Da enzyme composed of three functional units: (3R)-hydroxyacyl-CoA dehydrogenase, 2-enoyl-CoA hydratase 2 and sterol carrier protein 2-like units.", "The enzymes from Aeromonas caviae and Arabidopsis thaliana are monofunctional enzymes.", "2-enoyl-CoA hydratase 3 from Candida tropicalis is a part from multifunctional enzyme type 2."]


      map 1: Leukotriene biosynthesis and metabolism

      proteins:
      • arachidonate 5-lipoxygenase [ALOX5] ncbi lipid_maps
        regulators:
        MIR216A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

      LTA4 + H2O

      (5S,6S-epoxy-7E,9E,11Z,14Z-eicosatetraenoic acid) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Eicosanoids [FA03]
      sub_class: Leukotrienes [FA0302]
      formula: C20H30O3
      synonyms: Leukotriene A4
      kegg id: C00909
      exact mass: 318.219
      status:
      lipidmaps
      pubchem substance url

      5S-HpETE

      (5S-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Eicosanoids [FA03]
      sub_class: Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]
      formula: C20H32O4
      synonyms: 5-HpETE
      kegg id: C05356
      status:
      exact mass: 336.23
      lipidmaps
      pubchem substance url
      localization: Cytoplasm

      1.13.11.34 Arachidonate 5-lipoxygenase.

      Arachidonate + O(2) = leukotriene A(4) + H(2)O. (kegg)
      proteins
      P09917 LOX5_HUMAN


      map 1: Leukotriene biosynthesis and metabolism

      proteins:
      • arachidonate 5-lipoxygenase [ALOX5] ncbi lipid_maps
        regulators:
        MIR216A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

      LTA4 + H2O

      (5S,6S-epoxy-7E,9E,11Z,14Z-eicosatetraenoic acid) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Eicosanoids [FA03]
      sub_class: Leukotrienes [FA0302]
      formula: C20H30O3
      synonyms: Leukotriene A4
      kegg id: C00909
      exact mass: 318.219
      status:
      lipidmaps
      pubchem substance url

      LTA4 + Glutathione

      (5S,6S-epoxy-7E,9E,11Z,14Z-eicosatetraenoic acid) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Eicosanoids [FA03]
      sub_class: Leukotrienes [FA0302]
      formula: C20H30O3
      synonyms: Leukotriene A4
      kegg id: C00909
      status:
      exact mass: 318.219
      lipidmaps
      pubchem substance url
      localization: Cytoplasm
      notes:
      (add enzyme MGST2)

      4.4.1.20 Leukotriene-C(4) synthase.

      Leukotriene C(4) = leukotriene A(4) + glutathione. (kegg)
      proteins
      Q16873 LTC4S_HUMAN

      details
      ["The reaction proceeds in the direction of addition.", "Not identical with EC 2.5.1.18.", "Formerly EC 2.5.1.37."]


      map 1: Leukotriene biosynthesis and metabolism

      proteins:

      LTC4

      (5S-hydroxy,6R-(S-glutathionyl),7E,9E,11Z,14Z-eicosatetraenoic acid) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Eicosanoids [FA03]
      sub_class: Leukotrienes [FA0302]
      formula: C30H47N3O9S
      synonyms: Leukotriene C4
      kegg id: C02166
      exact mass: 625.303
      status:
      lipidmaps
      pubchem substance url

      Arachidonic acid + O2

      (5Z,8Z,11Z,14Z-eicosatetraenoic acid) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Fatty Acids and Conjugates [FA01]
      sub_class: Unsaturated fatty acids [FA0103]
      formula: C20H32O2
      synonyms: 5Z,8Z,11Z,14Z-icosatetraenoic acid; AA; Arachidonate; cis-5,8,11,14-Eicosatetraenoic acid; (all-Z)-5,8,11,14-Eicosatetraenoic ac
      kegg id: C00219
      status:
      exact mass: 304.24
      lipidmaps
      pubchem substance url
      localization: lysosome

      1.14.99.1 Prostaglandin-endoperoxide synthase.

      Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O. (kegg)
      proteins
      P23219 PGH1_HUMAN
      P35354 PGH2_HUMAN

      details
      ["Acts both as a dioxygenase and as a peroxidase."]


      map 1: Arachidonic acid => PG2 group pathway

      proteins:
      • prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) [PTGS1] ncbi lipid_maps
      • prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [PTGS2] ncbi lipid_maps
        regulators:
        MIR143 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
        IGF2BP1 ( binding ) /1 (0, 0, 1)/ rzmd
        AR ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
        MIR146A ( microRNA binding ) /1 (0, 1, 0)/ rzmd
        MIR26B ( microRNA binding ) /1 (0, 1, 0)/ rzmd
        ITGAV ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd
        MIR101-1 ( microRNA binding ) /4 (0, 4, 0)/ rzmd
        MIR16-1 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
        MIR137 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
        MIR143 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
        NR2F2 ( transcriptional regulation ) /1 (0, 1, 0)/ rzmd
        Revlimid (Lenalidomide) [drugbank] rzmd
        Pomalyst (Pomalidomide) [drugbank] rzmd
        Synovir (Thalidomide) [drugbank] rzmd
        MIR1297 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
        MIR26A1 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
        SP1 ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
        SQSTM1 ( binding ) /1 (1, 0, 0)/ rzmd
        MIR216A ( microRNA binding ) /1 (0, 1, 0)/ rzmd
        MIR144 ( microRNA binding ) /1 (0, 1, 0)/ rzmd

      PGG2

      (9S,11R-epidioxy-15S-hydroperoxy-5Z,13E-prostadienoic acid) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Eicosanoids [FA03]
      sub_class: Prostaglandins [FA0301]
      formula: C20H32O6
      synonyms: Prostaglandin G2
      kegg id: C05956
      exact mass: 368.22
      status:
      lipidmaps
      pubchem substance url

      trans-2-octadecenoyl-CoA + NADPH + H+

      (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-({3-[(2-{[(2E)-octadec-2-enoyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Fatty esters [FA07]
      sub_class: Fatty acyl CoAs [FA0705]
      formula: C39H68N7O17P3S
      synonyms: (2E)-Octadecenoyl-CoA;(E)-2-octadecenoyl-CoA;(E)-2-octadecenoyl-coenzyme A;(E)-octadec-2-enoyl-CoA;(E)-octadec-2-enoyl-coenzyme
      status:
      exact mass: 1031.36
      lipidmaps
      localization: reticulum
      notes:
      Pathway: stearate biosynthesis I (animals and fungi)

      1.3.1.- With NAD(+) or NADP(+) as acceptor.

      (kegg)
      proteins


      map 1: Unsaturated fatty acid biosynthesis

      proteins:

      Stearoyl-CoA + NADP(+)

      (3'-phosphoadenosine 5'-(3-{(3R)-3-hydroxy-2,2-dimethyl-4-[(3-{[2-(octadecanoylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-4-oxobuty) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Fatty esters [FA07]
      sub_class: Fatty acyl CoAs [FA0705]
      formula: C39H70N7O17P3S
      synonyms: C18:0-CoA;C18:0-coenzyme A;S-stearoyl-CoA;S-stearoylcoenzyme A;octadecanoyl-CoA;octadecanoyl-coenzyme A;stearoyl-coenzyme A
      kegg id: C00412
      exact mass: 1033.38
      status:
      lipidmaps

      Stearoyl-CoA + H2O

      (3'-phosphoadenosine 5'-(3-{(3R)-3-hydroxy-2,2-dimethyl-4-[(3-{[2-(octadecanoylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-4-oxobuty) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Fatty esters [FA07]
      sub_class: Fatty acyl CoAs [FA0705]
      formula: C39H70N7O17P3S
      synonyms: C18:0-CoA;C18:0-coenzyme A;S-stearoyl-CoA;S-stearoylcoenzyme A;octadecanoyl-CoA;octadecanoyl-coenzyme A;stearoyl-coenzyme A
      kegg id: C00412
      status:
      exact mass: 1033.38
      lipidmaps
      localization: reticulum
      notes:
      Pathway: stearate biosynthesis I (animals and fungi)

      3.1.2.2 Palmitoyl-CoA hydrolase.

      Palmitoyl-CoA + H(2)O = CoA + palmitate. (kegg)
      proteins
      Q8N1Q8 ACO15_HUMAN
      Q86TX2 ACOT1_HUMAN
      P49753 ACOT2_HUMAN
      Q8N9L9 ACOT4_HUMAN
      Q14032 BAAT_HUMAN
      Q6ZUV0 BACHL_HUMAN
      O00154 BACH_HUMAN
      Q5T1C6 THEM4_HUMAN

      details
      ["Also hydrolyzes CoA thioesters of other long-chain fatty acids."]


      map 1: Unsaturated fatty acid biosynthesis

      proteins:

      Stearic acid + CoA + H+

      (octadecanoic acid) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Fatty Acids and Conjugates [FA01]
      sub_class: Straight chain fatty acids [FA0101]
      formula: C18H36O2
      synonyms: Cetylacetic acid; Stearate; n-Octadecanoic acid; Octadecanoate; C18:0
      kegg id: C01530
      exact mass: 284.272
      status:
      lipidmaps
      pubchem substance url

      (5Z,8Z,11Z,14Z,17Z)-icosapentaenoyl-CoA + malonyl-CoA + H+

      (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-[(2-{[(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl]sulfa) (lipid link)
      category: Fatty Acyls [FA]
      main_class: Fatty esters [FA07]
      sub_class: Fatty acyl CoAs [FA0705]
      formula: C41H64N7O17P3S
      synonyms: (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA;(5Z,8Z,11Z,14Z,17Z)-icosapentaenoyl-CoA;20:5(n-3);5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl-Co
      status:
      exact mass: 1051.33
      lipidmaps
      localization: reticulum
      notes:
      Pathway: stearate biosynthesis I (animals and fungi)
      The structure does not match to metacyc META&id=CPD-14423!!!

      2.3.1.- Transferring groups other than amino-acyl groups.

      (kegg)
      proteins


      map 1: n-3 Polyunsaturated fatty acid biosynthesis

      proteins:

      (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + CO2 + CoA

      no systematic name (lipid link)
      category: Fatty Acyls [FA]
      main_class: Fatty esters [FA07]
      sub_class: Fatty acyl CoAs [FA0705]
      formula: C43H66N7O18P3S
      synonyms: (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-coenzyme A;all-cis-3-oxodocosa-7,10,13,16,19-pentaenoyl-CoA;all-cis-3-oxodocosa-7,10,
      exact mass: 1093.34
      status:
      lipidmaps

      (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-CoA + NADPH + H+

      no systematic name (lipid link)
      category: Fatty Acyls [FA]
      main_class: Fatty esters [FA07]
      sub_class: Fatty acyl CoAs [FA0705]
      formula: C43H66N7O18P3S
      synonyms: (7Z,10Z,13Z,16Z,19Z)-3-oxodocosapentaenoyl-coenzyme A;all-cis-3-oxodocosa-7,10,13,16,19-pentaenoyl-CoA;all-cis-3-oxodocosa-7,10,
      status:
      exact mass: 1093.34
      lipidmaps
      localization: reticulum
      notes:
      Pathway: docosahexaenoate biosynthesis IV (4-desaturase, mammals)

      1.1.1.330 Very-long-chain 3-oxoacyl-CoA reductase.

      A very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH. (kegg)
      proteins
      Q53GQ0 DHB12_HUMAN

      details
      ["The second component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs.", "The enzyme is active with substrates with chain length of C(16) to C(34), depending on the species.", "Cf. EC 2.3.1.199, EC 4.2.1.134 and EC 1.3.1.93.", "Formerly EC 1.1.1.n13 and EC 2.3.1.119."]


      proteins:

        PGG2 + reduced acceptor

        (9S,11R-epidioxy-15S-hydroperoxy-5Z,13E-prostadienoic acid) (lipid link)
        category: Fatty Acyls [FA]
        main_class: Eicosanoids [FA03]
        sub_class: Prostaglandins [FA0301]
        formula: C20H32O6
        synonyms: Prostaglandin G2
        kegg id: C05956
        status:
        exact mass: 368.22
        lipidmaps
        pubchem substance url
        localization: peroxisome
        notes:
        This enzyme acts both as a dioxygenase and as a peroxidase. o/

        1.14.99.1 Prostaglandin-endoperoxide synthase.

        Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O. (kegg)
        proteins
        P23219 PGH1_HUMAN
        P35354 PGH2_HUMAN

        details
        ["Acts both as a dioxygenase and as a peroxidase."]


        map 1: Prostaglandin 2 biosynthesis and metabolism FM

        proteins:
        • prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) [PTGS1] ncbi lipid_maps
        • prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [PTGS2] ncbi lipid_maps
          regulators:
          MIR143 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
          IGF2BP1 ( binding ) /1 (0, 0, 1)/ rzmd
          AR ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
          MIR146A ( microRNA binding ) /1 (0, 1, 0)/ rzmd
          MIR26B ( microRNA binding ) /1 (0, 1, 0)/ rzmd
          ITGAV ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd
          MIR101-1 ( microRNA binding ) /4 (0, 4, 0)/ rzmd
          MIR16-1 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
          MIR137 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
          MIR143 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
          NR2F2 ( transcriptional regulation ) /1 (0, 1, 0)/ rzmd
          Revlimid (Lenalidomide) [drugbank] rzmd
          Pomalyst (Pomalidomide) [drugbank] rzmd
          Synovir (Thalidomide) [drugbank] rzmd
          MIR1297 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
          MIR26A1 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
          SP1 ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
          SQSTM1 ( binding ) /1 (1, 0, 0)/ rzmd
          MIR216A ( microRNA binding ) /1 (0, 1, 0)/ rzmd
          MIR144 ( microRNA binding ) /1 (0, 1, 0)/ rzmd

        PGH2 + H2O + acceptor

        (9S,11R-epidioxy-15S-hydroxy-5Z,13E-prostadienoic acid) (lipid link)
        category: Fatty Acyls [FA]
        main_class: Eicosanoids [FA03]
        sub_class: Prostaglandins [FA0301]
        formula: C20H32O5
        synonyms: Prostaglandin H2
        kegg id: C00427
        exact mass: 352.225
        status:
        lipidmaps
        pubchem substance url

        PGH2

        (9S,11R-epidioxy-15S-hydroxy-5Z,13E-prostadienoic acid) (lipid link)
        category: Fatty Acyls [FA]
        main_class: Eicosanoids [FA03]
        sub_class: Prostaglandins [FA0301]
        formula: C20H32O5
        synonyms: Prostaglandin H2
        kegg id: C00427
        status:
        exact mass: 352.225
        lipidmaps
        pubchem substance url
        localization: Unknown
        notes:
        o/

        5.3.99.5 Thromboxane-A synthase.

        (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha-epoxy-15-hydroxythromboxa-5,13-dienoate. (kegg)
        proteins
        P24557 THAS_HUMAN

        details
        ["Converts prostaglandin H(2) into thromboxane A(2)."]


        map 1: Prostaglandin 2 biosynthesis and metabolism FM

        proteins:

        12-hydroxy-5,8,10-heptadecatrienoic acid

        (12-hydroxy-5,8,10-heptadecatrienoic acid) (lipid link)
        category: Fatty Acyls [FA]
        main_class: Fatty Acids and Conjugates [FA01]
        sub_class: Hydroxy fatty acids [FA0105]
        formula: C17H28O3
        exact mass: 280.204
        status:
        lipidmaps
        pubchem substance url

        PGH2

        (9S,11R-epidioxy-15S-hydroxy-5Z,13E-prostadienoic acid) (lipid link)
        category: Fatty Acyls [FA]
        main_class: Eicosanoids [FA03]
        sub_class: Prostaglandins [FA0301]
        formula: C20H32O5
        synonyms: Prostaglandin H2
        kegg id: C00427
        status:
        exact mass: 352.225
        lipidmaps
        pubchem substance url
        localization: Unknown
        notes:
        o/

        5.3.99.5 Thromboxane-A synthase.

        (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha-epoxy-15-hydroxythromboxa-5,13-dienoate. (kegg)
        proteins
        P24557 THAS_HUMAN

        details
        ["Converts prostaglandin H(2) into thromboxane A(2)."]


        map 1: Prostaglandin 2 biosynthesis and metabolism FM

        proteins:

        TXA2

        (9S,11S-epoxy,15S-hydroxy-thromboxa-5Z,13E-dien-1-oic acid) (lipid link)
        category: Fatty Acyls [FA]
        main_class: Eicosanoids [FA03]
        sub_class: Thromboxanes [FA0303]
        formula: C20H32O5
        synonyms: Thromboxane A2
        kegg id: C02198
        exact mass: 352.225
        status:
        lipidmaps
        pubchem substance url

        TXA2

        (9S,11S-epoxy,15S-hydroxy-thromboxa-5Z,13E-dien-1-oic acid) (lipid link)
        category: Fatty Acyls [FA]
        main_class: Eicosanoids [FA03]
        sub_class: Thromboxanes [FA0303]
        formula: C20H32O5
        synonyms: Thromboxane A2
        kegg id: C02198
        status:
        exact mass: 352.225
        lipidmaps
        pubchem substance url
        localization: Unknown
        notes:
        o/

        Spontaneous Spontaneous

        Spontaneous (kegg)
        proteins

        details
        ["Converts prostaglandin H(2) into thromboxane A(2)."]


        map 1: Prostaglandin 2 biosynthesis and metabolism FM

        proteins:

          TXB2

          (9S,11,15S-trihydroxy-thromboxa-5Z,13E-dien-1-oic acid) (lipid link)
          category: Fatty Acyls [FA]
          main_class: Eicosanoids [FA03]
          sub_class: Thromboxanes [FA0303]
          formula: C20H34O6
          synonyms: Thromboxane B2
          kegg id: C05963
          exact mass: 370.236
          status:
          lipidmaps
          pubchem substance url

          PGH2

          (9S,11R-epidioxy-15S-hydroxy-5Z,13E-prostadienoic acid) (lipid link)
          category: Fatty Acyls [FA]
          main_class: Eicosanoids [FA03]
          sub_class: Prostaglandins [FA0301]
          formula: C20H32O5
          synonyms: Prostaglandin H2
          kegg id: C00427
          status:
          exact mass: 352.225
          lipidmaps
          pubchem substance url
          localization: Unknown
          notes:
          o/

          5.3.99.5 Thromboxane-A synthase.

          (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha-epoxy-15-hydroxythromboxa-5,13-dienoate. (kegg)
          proteins
          P24557 THAS_HUMAN

          details
          ["Converts prostaglandin H(2) into thromboxane A(2)."]


          map 1: Prostaglandin 2 biosynthesis and metabolism FM

          proteins:

          TXB2

          (9S,11,15S-trihydroxy-thromboxa-5Z,13E-dien-1-oic acid) (lipid link)
          category: Fatty Acyls [FA]
          main_class: Eicosanoids [FA03]
          sub_class: Thromboxanes [FA0303]
          formula: C20H34O6
          synonyms: Thromboxane B2
          kegg id: C05963
          exact mass: 370.236
          status:
          lipidmaps
          pubchem substance url

          PGG2

          (9S,11R-epidioxy-15S-hydroperoxy-5Z,13E-prostadienoic acid) (lipid link)
          category: Fatty Acyls [FA]
          main_class: Eicosanoids [FA03]
          sub_class: Prostaglandins [FA0301]
          formula: C20H32O6
          synonyms: Prostaglandin G2
          kegg id: C05956
          status:
          exact mass: 368.22
          lipidmaps
          pubchem substance url
          localization: Unknown
          notes:
          o/
          PTGES, PTGES2 (instead PGES, PGES2)

          5.3.99.3 Prostaglandin-E synthase.

          (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate. (kegg)
          proteins
          Q9H7Z7 PGES2_HUMAN
          O14684 PTGES_HUMAN
          Q15185 TEBP_HUMAN

          details
          ["Brings about the opening of the epidioxy bridge."]


          map 1: Prostaglandin 2 biosynthesis and metabolism FM

          proteins:

          15S-hydroperoxy-PGE2

          (9-oxo-11R-hydroxy-15S-hydroperoxy-5Z,13E-prostadienoic acid) (lipid link)
          category: Fatty Acyls [FA]
          main_class: Eicosanoids [FA03]
          sub_class: Prostaglandins [FA0301]
          formula: C20H32O6
          synonyms: 15S-Hp-PGE2
          exact mass: 368.22
          status:
          lipidmaps
          pubchem substance url

          PGH2 + O2

          (9S,11R-epidioxy-15S-hydroxy-5Z,13E-prostadienoic acid) (lipid link)
          category: Fatty Acyls [FA]
          main_class: Eicosanoids [FA03]
          sub_class: Prostaglandins [FA0301]
          formula: C20H32O5
          synonyms: Prostaglandin H2
          kegg id: C00427
          status:
          exact mass: 352.225
          lipidmaps
          pubchem substance url
          localization: Unknown
          notes:
          o/
          PTGES, PTGES2 (instead PGES, PGES2)

          1.14.99.1 Prostaglandin-endoperoxide synthase.

          Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O. (kegg)
          proteins
          P23219 PGH1_HUMAN
          P35354 PGH2_HUMAN

          details
          ["Acts both as a dioxygenase and as a peroxidase."]


          map 1: Prostaglandin 2 biosynthesis and metabolism FM

          proteins:
          • prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) [PTGS1] ncbi lipid_maps
          • prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [PTGS2] ncbi lipid_maps
            regulators:
            MIR143 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
            IGF2BP1 ( binding ) /1 (0, 0, 1)/ rzmd
            AR ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
            MIR146A ( microRNA binding ) /1 (0, 1, 0)/ rzmd
            MIR26B ( microRNA binding ) /1 (0, 1, 0)/ rzmd
            ITGAV ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd
            MIR101-1 ( microRNA binding ) /4 (0, 4, 0)/ rzmd
            MIR16-1 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
            MIR137 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
            MIR143 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
            NR2F2 ( transcriptional regulation ) /1 (0, 1, 0)/ rzmd
            Revlimid (Lenalidomide) [drugbank] rzmd
            Pomalyst (Pomalidomide) [drugbank] rzmd
            Synovir (Thalidomide) [drugbank] rzmd
            MIR1297 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
            MIR26A1 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
            SP1 ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
            SQSTM1 ( binding ) /1 (1, 0, 0)/ rzmd
            MIR216A ( microRNA binding ) /1 (0, 1, 0)/ rzmd
            MIR144 ( microRNA binding ) /1 (0, 1, 0)/ rzmd

          PGG2 + H2O

          (9S,11R-epidioxy-15S-hydroperoxy-5Z,13E-prostadienoic acid) (lipid link)
          category: Fatty Acyls [FA]
          main_class: Eicosanoids [FA03]
          sub_class: Prostaglandins [FA0301]
          formula: C20H32O6
          synonyms: Prostaglandin G2
          kegg id: C05956
          exact mass: 368.22
          status:
          lipidmaps
          pubchem substance url

          Arachidonic acid

          (5Z,8Z,11Z,14Z-eicosatetraenoic acid) (lipid link)
          category: Fatty Acyls [FA]
          main_class: Fatty Acids and Conjugates [FA01]
          sub_class: Unsaturated fatty acids [FA0103]
          formula: C20H32O2
          synonyms: 5Z,8Z,11Z,14Z-icosatetraenoic acid; AA; Arachidonate; cis-5,8,11,14-Eicosatetraenoic acid; (all-Z)-5,8,11,14-Eicosatetraenoic ac
          kegg id: C00219
          status:
          exact mass: 304.24
          lipidmaps
          pubchem substance url
          localization: Unknown
          notes:
          o/
          ALOXE3 instead LOXE3

          1.13.11.- With incorporation of two atoms of oxygen.

          (kegg)
          proteins


          map 1: Prostaglandin 2 biosynthesis and metabolism FM

          proteins:
          • arachidonate 12-lipoxygenase, 12R type [ALOX12B] ncbi lipid_maps
            regulators:
            MIR185 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
            TP63 ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
          • arachidonate lipoxygenase 3 [ALOXE3] ncbi lipid_maps

          PGG2

          (9S,11R-epidioxy-15S-hydroperoxy-5Z,13E-prostadienoic acid) (lipid link)
          category: Fatty Acyls [FA]
          main_class: Eicosanoids [FA03]
          sub_class: Prostaglandins [FA0301]
          formula: C20H32O6
          synonyms: Prostaglandin G2
          kegg id: C05956
          exact mass: 368.22
          status:
          lipidmaps
          pubchem substance url

          Arachidonic acid + O2

          (5Z,8Z,11Z,14Z-eicosatetraenoic acid) (lipid link)
          category: Fatty Acyls [FA]
          main_class: Fatty Acids and Conjugates [FA01]
          sub_class: Unsaturated fatty acids [FA0103]
          formula: C20H32O2
          synonyms: 5Z,8Z,11Z,14Z-icosatetraenoic acid; AA; Arachidonate; cis-5,8,11,14-Eicosatetraenoic acid; (all-Z)-5,8,11,14-Eicosatetraenoic ac
          kegg id: C00219
          status:
          exact mass: 304.24
          lipidmaps
          pubchem substance url
          localization: Unknown
          notes:
          o/
          ALOXE3 instead LOXE3

          1.14.99.1 Prostaglandin-endoperoxide synthase.

          Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O. (kegg)
          proteins
          P23219 PGH1_HUMAN
          P35354 PGH2_HUMAN

          details
          ["Acts both as a dioxygenase and as a peroxidase."]


          map 1: Prostaglandin 2 biosynthesis and metabolism FM

          proteins:
          • prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) [PTGS1] ncbi lipid_maps
          • prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [PTGS2] ncbi lipid_maps
            regulators:
            MIR143 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
            IGF2BP1 ( binding ) /1 (0, 0, 1)/ rzmd
            AR ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
            MIR146A ( microRNA binding ) /1 (0, 1, 0)/ rzmd
            MIR26B ( microRNA binding ) /1 (0, 1, 0)/ rzmd
            ITGAV ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd
            MIR101-1 ( microRNA binding ) /4 (0, 4, 0)/ rzmd
            MIR16-1 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
            MIR137 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
            MIR143 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
            NR2F2 ( transcriptional regulation ) /1 (0, 1, 0)/ rzmd
            Revlimid (Lenalidomide) [drugbank] rzmd
            Pomalyst (Pomalidomide) [drugbank] rzmd
            Synovir (Thalidomide) [drugbank] rzmd
            MIR1297 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
            MIR26A1 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
            SP1 ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
            SQSTM1 ( binding ) /1 (1, 0, 0)/ rzmd
            MIR216A ( microRNA binding ) /1 (0, 1, 0)/ rzmd
            MIR144 ( microRNA binding ) /1 (0, 1, 0)/ rzmd

          PGG2 + H2O

          (9S,11R-epidioxy-15S-hydroperoxy-5Z,13E-prostadienoic acid) (lipid link)
          category: Fatty Acyls [FA]
          main_class: Eicosanoids [FA03]
          sub_class: Prostaglandins [FA0301]
          formula: C20H32O6
          synonyms: Prostaglandin G2
          kegg id: C05956
          exact mass: 368.22
          status:
          lipidmaps
          pubchem substance url

          PGH2

          (9S,11R-epidioxy-15S-hydroxy-5Z,13E-prostadienoic acid) (lipid link)
          category: Fatty Acyls [FA]
          main_class: Eicosanoids [FA03]
          sub_class: Prostaglandins [FA0301]
          formula: C20H32O5
          synonyms: Prostaglandin H2
          kegg id: C00427
          status:
          exact mass: 352.225
          lipidmaps
          pubchem substance url
          localization: Unknown
          notes:
          o/
          PTGES, PTGES2 (instead PGES, PGES2)

          5.3.99.3 Prostaglandin-E synthase.

          (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate. (kegg)
          proteins
          Q9H7Z7 PGES2_HUMAN
          O14684 PTGES_HUMAN
          Q15185 TEBP_HUMAN

          details
          ["Brings about the opening of the epidioxy bridge."]


          map 1: Prostaglandin 2 biosynthesis and metabolism FM

          proteins:

          PGE2

          (9-oxo-11R,15S-dihydroxy-5Z,13E-prostadienoic acid) (lipid link)
          category: Fatty Acyls [FA]
          main_class: Eicosanoids [FA03]
          sub_class: Prostaglandins [FA0301]
          formula: C20H32O5
          synonyms: Prostaglandin E2; Dinoprostone; Prostin E2
          kegg id: C00584
          exact mass: 352.225
          status:
          lipidmaps
          pubchem substance url

          PGH2 + NADP(+)

          (9S,11R-epidioxy-15S-hydroxy-5Z,13E-prostadienoic acid) (lipid link)
          category: Fatty Acyls [FA]
          main_class: Eicosanoids [FA03]
          sub_class: Prostaglandins [FA0301]
          formula: C20H32O5
          synonyms: Prostaglandin H2
          kegg id: C00427
          status:
          exact mass: 352.225
          lipidmaps
          pubchem substance url
          localization: Unknown
          notes:
          o/
          AKR1A1 instead ALDX

          1.1.1.2 Alcohol dehydrogenase (NADP(+)).

          An alcohol + NADP(+) = an aldehyde + NADPH. (kegg)
          proteins
          P14550 AK1A1_HUMAN

          details
          ["Some members of this group oxidize only primary alcohols; others act also on secondary alcohols.", "May be identical with EC 1.1.1.19, EC 1.1.1.33 and EC 1.1.1.55.", "Re-specific with respect to NADPH."]


          map 1: Prostaglandin 2 biosynthesis and metabolism FM

          proteins:
          • aldo-keto reductase family 1, member A1 (aldehyde reductase) [AKR1A1] ncbi lipid_maps

          PGD2 + NADPH + H+

          (9S,15S-dihydroxy-11-oxo-5Z,13E-prostadienoic acid) (lipid link)
          category: Fatty Acyls [FA]
          main_class: Eicosanoids [FA03]
          sub_class: Prostaglandins [FA0301]
          formula: C20H32O5
          synonyms: Prostaglandin D2; 11-Dehydroprostaglandin F2-alpha; 11-Dehydroprostaglandin F2alpha; (5Z,13E,15S)-9alpha,15-Dihydroxy-11-oxopros
          kegg id: C00696
          exact mass: 352.225
          status:
          lipidmaps
          pubchem substance url

          PGE2

          (9-oxo-11R,15S-dihydroxy-5Z,13E-prostadienoic acid) (lipid link)
          category: Fatty Acyls [FA]
          main_class: Eicosanoids [FA03]
          sub_class: Prostaglandins [FA0301]
          formula: C20H32O5
          synonyms: Prostaglandin E2; Dinoprostone; Prostin E2
          kegg id: C00584
          status:
          exact mass: 352.225
          lipidmaps
          pubchem substance url
          localization: Unknown
          notes:
          o/

          unknown unknown

          unknown (kegg)
          proteins

          details
          ["Some members of this group oxidize only primary alcohols; others act also on secondary alcohols.", "May be identical with EC 1.1.1.19, EC 1.1.1.33 and EC 1.1.1.55.", "Re-specific with respect to NADPH."]


          map 1: Prostaglandin 2 biosynthesis and metabolism FM

          proteins:

            PGA2

            (9-oxo-15S-hydroxy-5Z,10Z,13E-prostatrienoic acid) (lipid link)
            category: Fatty Acyls [FA]
            main_class: Eicosanoids [FA03]
            sub_class: Prostaglandins [FA0301]
            formula: C20H30O4
            synonyms: Prostaglandin A2
            kegg id: C05953
            exact mass: 334.214
            status:
            lipidmaps
            pubchem substance url

            PGA2

            (9-oxo-15S-hydroxy-5Z,10Z,13E-prostatrienoic acid) (lipid link)
            category: Fatty Acyls [FA]
            main_class: Eicosanoids [FA03]
            sub_class: Prostaglandins [FA0301]
            formula: C20H30O4
            synonyms: Prostaglandin A2
            kegg id: C05953
            status:
            exact mass: 334.214
            lipidmaps
            pubchem substance url
            localization: Unknown
            notes:
            o/

            unknown unknown

            unknown (kegg)
            proteins

            details
            ["Some members of this group oxidize only primary alcohols; others act also on secondary alcohols.", "May be identical with EC 1.1.1.19, EC 1.1.1.33 and EC 1.1.1.55.", "Re-specific with respect to NADPH."]


            map 1: Prostaglandin 2 biosynthesis and metabolism FM

            proteins:

              PGC2

              (9-oxo-15S-hydroxy-5Z,11Z,13E-prostatrienoic acid) (lipid link)
              category: Fatty Acyls [FA]
              main_class: Eicosanoids [FA03]
              sub_class: Prostaglandins [FA0301]
              formula: C20H30O4
              synonyms: Prostaglandin C2
              kegg id: C05955
              exact mass: 334.214
              status:
              lipidmaps
              pubchem substance url

              PGC2

              (9-oxo-15S-hydroxy-5Z,11Z,13E-prostatrienoic acid) (lipid link)
              category: Fatty Acyls [FA]
              main_class: Eicosanoids [FA03]
              sub_class: Prostaglandins [FA0301]
              formula: C20H30O4
              synonyms: Prostaglandin C2
              kegg id: C05955
              status:
              exact mass: 334.214
              lipidmaps
              pubchem substance url
              localization: Unknown
              notes:
              o/

              5.3.3.- Transposing C=C bonds.

              (kegg)
              proteins


              map 1: Prostaglandin 2 biosynthesis and metabolism FM

              proteins:

                PGB2

                (15S-hydroxy-9-oxo-5Z,8(12),13E-prostatrienoic acid) (lipid link)
                category: Fatty Acyls [FA]
                main_class: Eicosanoids [FA03]
                sub_class: Prostaglandins [FA0301]
                formula: C20H30O4
                synonyms: Prostaglandin B2
                kegg id: C05954
                exact mass: 334.214
                status:
                lipidmaps
                pubchem substance url

                PGE2 + NADP(+)

                (9-oxo-11R,15S-dihydroxy-5Z,13E-prostadienoic acid) (lipid link)
                category: Fatty Acyls [FA]
                main_class: Eicosanoids [FA03]
                sub_class: Prostaglandins [FA0301]
                formula: C20H32O5
                synonyms: Prostaglandin E2; Dinoprostone; Prostin E2
                kegg id: C00584
                status:
                exact mass: 352.225
                lipidmaps
                pubchem substance url
                localization: Unknown
                notes:
                o/
                CBR2 gene not found

                1.1.1.189 Prostaglandin-E(2) 9-reductase.

                (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH. (kegg)
                proteins
                P16152 CBR1_HUMAN

                details
                ["Reduces prostaglandin E(2) to prostaglandin F(2)-alpha.", "A number of other 9-oxo- and 15-oxo-prostaglandin derivatives can also be reduced to the corresponding hydroxy compounds.", "May be identical with EC 1.1.1.197."]


                map 1: Prostaglandin 2 biosynthesis and metabolism FM

                proteins:

                PGF2alpha + NADPH + H+

                (9S,11R,15S-trihydroxy-5Z,13E-prostadienoic acid) (lipid link)
                category: Fatty Acyls [FA]
                main_class: Eicosanoids [FA03]
                sub_class: Prostaglandins [FA0301]
                formula: C20H34O5
                synonyms: Prostaglandin F2alpha; Prostaglandin F2a; Enzaprost; Dinoprost; Amoglandin; Cyclosin
                kegg id: C00639
                exact mass: 354.241
                status:
                lipidmaps
                pubchem substance url

                PGD2 + NADP(+)

                (9S,15S-dihydroxy-11-oxo-5Z,13E-prostadienoic acid) (lipid link)
                category: Fatty Acyls [FA]
                main_class: Eicosanoids [FA03]
                sub_class: Prostaglandins [FA0301]
                formula: C20H32O5
                synonyms: Prostaglandin D2; 11-Dehydroprostaglandin F2-alpha; 11-Dehydroprostaglandin F2alpha; (5Z,13E,15S)-9alpha,15-Dihydroxy-11-oxopros
                kegg id: C00696
                status:
                exact mass: 352.225
                lipidmaps
                pubchem substance url
                localization: Unknown
                notes:
                o/

                1.1.1.2 Alcohol dehydrogenase (NADP(+)).

                An alcohol + NADP(+) = an aldehyde + NADPH. (kegg)
                proteins
                P14550 AK1A1_HUMAN

                details
                ["Some members of this group oxidize only primary alcohols; others act also on secondary alcohols.", "May be identical with EC 1.1.1.19, EC 1.1.1.33 and EC 1.1.1.55.", "Re-specific with respect to NADPH."]


                map 1: Prostaglandin 2 biosynthesis and metabolism FM

                proteins:
                • aldo-keto reductase family 1, member A1 (aldehyde reductase) [AKR1A1] ncbi lipid_maps
                • aldo-keto reductase family 1, member C3 [AKR1C3] ncbi lipid_maps

                PGF2alpha + NADPH + H+

                (9S,11R,15S-trihydroxy-5Z,13E-prostadienoic acid) (lipid link)
                category: Fatty Acyls [FA]
                main_class: Eicosanoids [FA03]
                sub_class: Prostaglandins [FA0301]
                formula: C20H34O5
                synonyms: Prostaglandin F2alpha; Prostaglandin F2a; Enzaprost; Dinoprost; Amoglandin; Cyclosin
                kegg id: C00639
                exact mass: 354.241
                status:
                lipidmaps
                pubchem substance url

                PGF2alpha + NADP(+)

                (9S,11R,15S-trihydroxy-5Z,13E-prostadienoic acid) (lipid link)
                category: Fatty Acyls [FA]
                main_class: Eicosanoids [FA03]
                sub_class: Prostaglandins [FA0301]
                formula: C20H34O5
                synonyms: Prostaglandin F2alpha; Prostaglandin F2a; Enzaprost; Dinoprost; Amoglandin; Cyclosin
                kegg id: C00639
                status:
                exact mass: 354.241
                lipidmaps
                pubchem substance url
                localization: Unknown
                notes:
                o/

                1.1.1.188 Prostaglandin-F synthase.

                (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH. (kegg)
                proteins
                P42330 AK1C3_HUMAN

                details
                ["Reduces prostaglandin D(2) and prostaglandin H(2) to prostaglandin F(2); prostaglandin D(2) is not an intermediate in the reduction of prostaglandin H(2).", "Also catalyzes the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone."]


                map 1: Prostaglandin 2 biosynthesis and metabolism FM

                proteins:

                PGD2 + NADPH + H+

                (9S,15S-dihydroxy-11-oxo-5Z,13E-prostadienoic acid) (lipid link)
                category: Fatty Acyls [FA]
                main_class: Eicosanoids [FA03]
                sub_class: Prostaglandins [FA0301]
                formula: C20H32O5
                synonyms: Prostaglandin D2; 11-Dehydroprostaglandin F2-alpha; 11-Dehydroprostaglandin F2alpha; (5Z,13E,15S)-9alpha,15-Dihydroxy-11-oxopros
                kegg id: C00696
                exact mass: 352.225
                status:
                lipidmaps
                pubchem substance url

                PGG2

                (9S,11R-epidioxy-15S-hydroperoxy-5Z,13E-prostadienoic acid) (lipid link)
                category: Fatty Acyls [FA]
                main_class: Eicosanoids [FA03]
                sub_class: Prostaglandins [FA0301]
                formula: C20H32O6
                synonyms: Prostaglandin G2
                kegg id: C05956
                status:
                exact mass: 368.22
                lipidmaps
                pubchem substance url
                localization: Unknown
                notes:
                o/

                unknown unknown

                unknown (kegg)
                proteins

                details
                ["Reduces prostaglandin D(2) and prostaglandin H(2) to prostaglandin F(2); prostaglandin D(2) is not an intermediate in the reduction of prostaglandin H(2).", "Also catalyzes the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone."]


                map 1: Prostaglandin 2 biosynthesis and metabolism FM

                proteins:

                  delta-12-PGJ2

                  (11-oxo-15S-hydroxy-5Z,9Z,13E-prostatrienoic acid) (lipid link)
                  category: Fatty Acyls [FA]
                  main_class: Eicosanoids [FA03]
                  sub_class: Prostaglandins [FA0301]
                  formula: C20H30O4
                  synonyms: delta-12-Prostaglandin J2
                  kegg id: C05958
                  exact mass: 334.214
                  status:
                  lipidmaps
                  pubchem substance url

                  11beta-PGF2 + NADP(+)

                  (9S,11S,15S-trihydroxy-5Z,13E-prostadienoic acid) (lipid link)
                  category: Fatty Acyls [FA]
                  main_class: Eicosanoids [FA03]
                  sub_class: Prostaglandins [FA0301]
                  formula: C20H34O5
                  synonyms: 11beta-Prostaglandin F2; 9alpha,11beta-PGF2
                  kegg id: C05959
                  status:
                  exact mass: 354.241
                  lipidmaps
                  pubchem substance url
                  localization: Unknown
                  notes:
                  o/

                  1.1.1.188 Prostaglandin-F synthase.

                  (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH. (kegg)
                  proteins
                  P42330 AK1C3_HUMAN

                  details
                  ["Reduces prostaglandin D(2) and prostaglandin H(2) to prostaglandin F(2); prostaglandin D(2) is not an intermediate in the reduction of prostaglandin H(2).", "Also catalyzes the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone."]


                  map 1: Prostaglandin 2 biosynthesis and metabolism FM

                  proteins:

                  PGD2 + NADPH + H+

                  (9S,15S-dihydroxy-11-oxo-5Z,13E-prostadienoic acid) (lipid link)
                  category: Fatty Acyls [FA]
                  main_class: Eicosanoids [FA03]
                  sub_class: Prostaglandins [FA0301]
                  formula: C20H32O5
                  synonyms: Prostaglandin D2; 11-Dehydroprostaglandin F2-alpha; 11-Dehydroprostaglandin F2alpha; (5Z,13E,15S)-9alpha,15-Dihydroxy-11-oxopros
                  kegg id: C00696
                  exact mass: 352.225
                  status:
                  lipidmaps
                  pubchem substance url

                  PGG2

                  (9S,11R-epidioxy-15S-hydroperoxy-5Z,13E-prostadienoic acid) (lipid link)
                  category: Fatty Acyls [FA]
                  main_class: Eicosanoids [FA03]
                  sub_class: Prostaglandins [FA0301]
                  formula: C20H32O6
                  synonyms: Prostaglandin G2
                  kegg id: C05956
                  status:
                  exact mass: 368.22
                  lipidmaps
                  pubchem substance url
                  localization: Unknown
                  notes:
                  o/

                  1.11.1.15 Peroxiredoxin.

                  2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH. (kegg)
                  proteins
                  Q06830 PRDX1_HUMAN
                  P32119 PRDX2_HUMAN
                  P30048 PRDX3_HUMAN
                  Q13162 PRDX4_HUMAN
                  P30044 PRDX5_HUMAN
                  P30041 PRDX6_HUMAN
                  Q9Y6P5 SESN1_HUMAN
                  P58004 SESN2_HUMAN

                  details
                  ["Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins.", "They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins.", "The peroxidase reaction comprises two steps centered around a redox- active cysteine called the peroxidatic cysteine.", "All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid).", "The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes.", "For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants (R'-SH) (e.g. thioredoxin, AhpF, tryparedoxin or AhpD), completing the catalytic cycle.", "In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond.", "To recycle the disulfide, known atypical 2-Cys Prxs appear to use thioredoxin as an electron donor.", "The 1-Cys Prxs conserve only the peroxidatic cysteine, so that its oxidized form is directly reduced to cysteine by the reductant molecule."]


                  map 1: Prostaglandin 2 biosynthesis and metabolism FM

                  proteins:
                  • peroxiredoxin 1 [PRDX1] ncbi lipid_maps
                  • peroxiredoxin 2 [PRDX2] ncbi lipid_maps
                    regulators:
                    MIR200C ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                    MIR200B ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                  • peroxiredoxin 3 [PRDX3] ncbi lipid_maps
                    regulators:
                    MIR383 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                    MIR525 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                    MIR26A1 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                    MIR23B ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                  • peroxiredoxin 4 [PRDX4] ncbi lipid_maps
                  • peroxiredoxin 5 [PRDX5] ncbi lipid_maps

                  PGH2 + H2O

                  (9S,11R-epidioxy-15S-hydroxy-5Z,13E-prostadienoic acid) (lipid link)
                  category: Fatty Acyls [FA]
                  main_class: Eicosanoids [FA03]
                  sub_class: Prostaglandins [FA0301]
                  formula: C20H32O5
                  synonyms: Prostaglandin H2
                  kegg id: C00427
                  exact mass: 352.225
                  status:
                  lipidmaps
                  pubchem substance url

                  PGE2 + NAD(+)

                  (9-oxo-11R,15S-dihydroxy-5Z,13E-prostadienoic acid) (lipid link)
                  category: Fatty Acyls [FA]
                  main_class: Eicosanoids [FA03]
                  sub_class: Prostaglandins [FA0301]
                  formula: C20H32O5
                  synonyms: Prostaglandin E2; Dinoprostone; Prostin E2
                  kegg id: C00584
                  status:
                  exact mass: 352.225
                  lipidmaps
                  pubchem substance url
                  localization: Unknown
                  notes:
                  o/

                  1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD(+)).

                  (5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD(+) = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH. (kegg)
                  proteins
                  P15428 PGDH_HUMAN

                  details
                  ["Acts on prostaglandins E(2), F(2-alpha) and B(1), but not on prostaglandin D(2) (cf. EC 1.1.1.196 and EC 1.1.1.197)."]


                  map 1: Prostaglandin 2 biosynthesis and metabolism FM

                  proteins:
                  • hydroxyprostaglandin dehydrogenase 15-(NAD) [HPGD] ncbi lipid_maps
                    regulators:
                    MIR21 ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                  15-keto-PGE2 + NADH + H+

                  (9,15-dioxo-11R-hydroxy-5Z,13E-prostadienoic acid) (lipid link)
                  category: Fatty Acyls [FA]
                  main_class: Eicosanoids [FA03]
                  sub_class: Prostaglandins [FA0301]
                  formula: C20H30O5
                  synonyms: 15-keto-Prostaglandin E2
                  exact mass: 350.209
                  status:
                  lipidmaps
                  pubchem substance url

                  15-keto-PGE2 + NADP(+)

                  (9,15-dioxo-11R-hydroxy-5Z,13E-prostadienoic acid) (lipid link)
                  category: Fatty Acyls [FA]
                  main_class: Eicosanoids [FA03]
                  sub_class: Prostaglandins [FA0301]
                  formula: C20H30O5
                  synonyms: 15-keto-Prostaglandin E2
                  status:
                  exact mass: 350.209
                  lipidmaps
                  pubchem substance url
                  localization: Unknown
                  notes:
                  o/

                  1.1.1.189 Prostaglandin-E(2) 9-reductase.

                  (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH. (kegg)
                  proteins
                  P16152 CBR1_HUMAN

                  details
                  ["Reduces prostaglandin E(2) to prostaglandin F(2)-alpha.", "A number of other 9-oxo- and 15-oxo-prostaglandin derivatives can also be reduced to the corresponding hydroxy compounds.", "May be identical with EC 1.1.1.197."]


                  map 1: Prostaglandin 2 biosynthesis and metabolism FM

                  proteins:
                  • carbonyl reductase 1 [CBR1] ncbi lipid_maps
                    regulators:
                    HIF1A ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd

                  15-keto-PGF2alpha + NADPH + H+

                  (9S,11R-dihydroxy-15-oxo-5Z,13E-prostadienoic acid) (lipid link)
                  category: Fatty Acyls [FA]
                  main_class: Eicosanoids [FA03]
                  sub_class: Prostaglandins [FA0301]
                  formula: C20H32O5
                  synonyms: 15-keto-Prostaglandin F2alpha; 15k-PGF2a
                  kegg id: C05960
                  exact mass: 352.225
                  status:
                  lipidmaps
                  pubchem substance url

                  PGF2alpha + NADP(+)

                  (9S,11R,15S-trihydroxy-5Z,13E-prostadienoic acid) (lipid link)
                  category: Fatty Acyls [FA]
                  main_class: Eicosanoids [FA03]
                  sub_class: Prostaglandins [FA0301]
                  formula: C20H34O5
                  synonyms: Prostaglandin F2alpha; Prostaglandin F2a; Enzaprost; Dinoprost; Amoglandin; Cyclosin
                  kegg id: C00639
                  status:
                  exact mass: 354.241
                  lipidmaps
                  pubchem substance url
                  localization: Unknown
                  notes:
                  o/

                  1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP(+)).

                  (13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP(+) = (13E)- 11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH. (kegg)
                  proteins
                  P16152 CBR1_HUMAN

                  details
                  ["Acts on prostaglandins E(2), F(2)-alpha and B(1), but not on prostaglandin D(2) (cf. EC 1.1.1.141 and EC 1.1.1.196).", "May be identical with EC 1.1.1.189."]


                  map 1: Prostaglandin 2 biosynthesis and metabolism FM

                  proteins:
                  • carbonyl reductase 1 [CBR1] ncbi lipid_maps
                    regulators:
                    HIF1A ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd

                  15-keto-PGF2alpha + NADPH + H+

                  (9S,11R-dihydroxy-15-oxo-5Z,13E-prostadienoic acid) (lipid link)
                  category: Fatty Acyls [FA]
                  main_class: Eicosanoids [FA03]
                  sub_class: Prostaglandins [FA0301]
                  formula: C20H32O5
                  synonyms: 15-keto-Prostaglandin F2alpha; 15k-PGF2a
                  kegg id: C05960
                  exact mass: 352.225
                  status:
                  lipidmaps
                  pubchem substance url

                  PGF2alpha + NAD(+)

                  (9S,11R,15S-trihydroxy-5Z,13E-prostadienoic acid) (lipid link)
                  category: Fatty Acyls [FA]
                  main_class: Eicosanoids [FA03]
                  sub_class: Prostaglandins [FA0301]
                  formula: C20H34O5
                  synonyms: Prostaglandin F2alpha; Prostaglandin F2a; Enzaprost; Dinoprost; Amoglandin; Cyclosin
                  kegg id: C00639
                  status:
                  exact mass: 354.241
                  lipidmaps
                  pubchem substance url
                  localization: Unknown
                  notes:
                  o/

                  1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD(+)).

                  (5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD(+) = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH. (kegg)
                  proteins
                  P15428 PGDH_HUMAN

                  details
                  ["Acts on prostaglandins E(2), F(2-alpha) and B(1), but not on prostaglandin D(2) (cf. EC 1.1.1.196 and EC 1.1.1.197)."]


                  map 1: Prostaglandin 2 biosynthesis and metabolism FM

                  proteins:
                  • hydroxyprostaglandin dehydrogenase 15-(NAD) [HPGD] ncbi lipid_maps
                    regulators:
                    MIR21 ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                  15-keto-PGF2alpha + NADH + H+

                  (9S,11R-dihydroxy-15-oxo-5Z,13E-prostadienoic acid) (lipid link)
                  category: Fatty Acyls [FA]
                  main_class: Eicosanoids [FA03]
                  sub_class: Prostaglandins [FA0301]
                  formula: C20H32O5
                  synonyms: 15-keto-Prostaglandin F2alpha; 15k-PGF2a
                  kegg id: C05960
                  exact mass: 352.225
                  status:
                  lipidmaps
                  pubchem substance url

                  15-keto-PGF2alpha + NADP(+)

                  (9S,11R-dihydroxy-15-oxo-5Z,13E-prostadienoic acid) (lipid link)
                  category: Fatty Acyls [FA]
                  main_class: Eicosanoids [FA03]
                  sub_class: Prostaglandins [FA0301]
                  formula: C20H32O5
                  synonyms: 15-keto-Prostaglandin F2alpha; 15k-PGF2a
                  kegg id: C05960
                  status:
                  exact mass: 352.225
                  lipidmaps
                  pubchem substance url
                  localization: Unknown
                  notes:
                  o/

                  1.1.1.189 Prostaglandin-E(2) 9-reductase.

                  (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH. (kegg)
                  proteins
                  P16152 CBR1_HUMAN

                  details
                  ["Reduces prostaglandin E(2) to prostaglandin F(2)-alpha.", "A number of other 9-oxo- and 15-oxo-prostaglandin derivatives can also be reduced to the corresponding hydroxy compounds.", "May be identical with EC 1.1.1.197."]


                  map 1: Prostaglandin 2 biosynthesis and metabolism FM

                  proteins:
                  • carbonyl reductase 1 [CBR1] ncbi lipid_maps
                    regulators:
                    HIF1A ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd

                  PGF2alpha + NADPH + H+

                  (9S,11R,15S-trihydroxy-5Z,13E-prostadienoic acid) (lipid link)
                  category: Fatty Acyls [FA]
                  main_class: Eicosanoids [FA03]
                  sub_class: Prostaglandins [FA0301]
                  formula: C20H34O5
                  synonyms: Prostaglandin F2alpha; Prostaglandin F2a; Enzaprost; Dinoprost; Amoglandin; Cyclosin
                  kegg id: C00639
                  exact mass: 354.241
                  status:
                  lipidmaps
                  pubchem substance url

                  trans-2-tetracosenoyl-CoA(4?) + NADPH + H+

                  no systematic name (lipid link)
                  formula: C45H76N7O17P3S
                  synonyms: (2E)-tetracosenoyl-CoA, (E)-2-tetracosenoyl-CoA(4?), (E)-2-tetracosenoyl-coenzyme A(4?), trans-2-tetracosenoyl-coenzyme A(4?)
                  status:
                  exact mass: 1111.42
                  localization: peroxisome
                  notes:
                  In Pathway: very long chain fatty acid biosynthesis II

                  1.3.1.93 Very-long-chain enoyl-CoA reductase.

                  A very-long-chain acyl-CoA + NADP(+) = a very-long-chain trans-2,3- dehydroacyl-CoA + NADPH. (kegg)
                  proteins
                  Q9NZ01 TECR_HUMAN

                  details
                  ["This is the fourth component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs.", "Cf. EC 2.3.1.199, EC 1.1.1.330 and EC 4.2.1.134.", "Formerly EC 2.3.1.119."]


                  map 1: Unsaturated fatty acid biosynthesis

                  proteins:

                  CoA(24:0) + NADP(+)

                  (Tetracosanoyl-CoA) (lipid link)
                  category: Fatty Acyls [FA]
                  main_class: Fatty esters [FA07]
                  sub_class: Fatty acyl CoAs [FA0705]
                  formula: C45H82N7O17P3S
                  exact mass: 1117.47
                  status:
                  lipidmaps
                  pubchem substance url

                  CoA(24:0) + malonyl-CoA + H+

                  (Tetracosanoyl-CoA) (lipid link)
                  category: Fatty Acyls [FA]
                  main_class: Fatty esters [FA07]
                  sub_class: Fatty acyl CoAs [FA0705]
                  formula: C45H82N7O17P3S
                  status:
                  exact mass: 1117.47
                  lipidmaps
                  pubchem substance url
                  localization: peroxisome
                  notes:
                  In Pathway: very long chain fatty acid biosynthesis II

                  2.3.1.199 Very-long-chain 3-oxoacyl-CoA synthase.

                  A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2). (kegg)
                  proteins
                  Q9BW60 ELOV1_HUMAN
                  Q9NXB9 ELOV2_HUMAN
                  Q9HB03 ELOV3_HUMAN
                  Q9GZR5 ELOV4_HUMAN
                  Q9NYP7 ELOV5_HUMAN
                  Q9H5J4 ELOV6_HUMAN
                  A1L3X0 ELOV7_HUMAN

                  details
                  ["This is the first component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs.", "Multiple forms exist with differing preferences for the substrate, and thus the specific form expressed determines the local composition of very-long-chain fatty acids.", "For example, the FAE1 form from the plant Arabidopsis thaliana accepts only 16 and 18 carbon substrates, with oleoyl-CoA (18:1) being the preferred substrate, while CER6 from the same plant prefers substrates with chain length of C(22) to C(32).", "Cf. EC 1.1.1.330, EC 4.2.1.134 and EC 1.3.1.93.", "Formerly EC 2.3.1.119 and EC 2.3.1.n8."]


                  map 1: Unsaturated fatty acid biosynthesis

                  proteins:

                    3-oxodocosanoyl-CoA + CO2 + CoA

                    (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-({2-[(3-oxodocosanoyl)sulfanyl]ethyl}amino)-3-oxopropyl]amino) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C43H76N7O18P3S
                    synonyms: 3-keto-C22-CoA;3-ketobehenoyl-CoA;3-ketodocosanoyl-CoA;3-ketodocosanoyl-coenzyme A;3-oxobehenoyl-CoA;3-oxobehenoyl-coenzyme A;3-
                    exact mass: 1103.42
                    status:
                    lipidmaps

                    Phytanic acid + ATP + CoA

                    (3,7R,11R,15-tetramethyl-hexadecanoic acid) (lipid link)
                    category: Prenol Lipids [PR]
                    main_class: Isoprenoids [PR01]
                    sub_class: C20 isoprenoids (diterpenes) [PR0104]
                    formula: C20H40O2
                    synonyms: Hexadecanoic acid, 3,7,11,15-tetramethyl-; Phytanic acid; 3,7,11,15-Tetramethylhexadecanoic acid; Phytanoic acid
                    kegg id: C01607
                    status:
                    exact mass: 312.303
                    lipidmaps
                    pubchem substance url
                    localization: peroxisome
                    notes:
                    Peroxisomal branched chain fatty acid oxidation

                    6.2.1.24 Phytanate--CoA ligase.

                    ATP + phytanate + CoA = AMP + diphosphate + phytanoyl-CoA. (kegg)
                    proteins

                    details
                    ["Not identical with EC 6.2.1.20."]


                    map 1: Peroxisomal branched chain fatty acid oxidation

                    proteins:
                    • solute carrier family 27 (fatty acid transporter), member 2 [SLC27A2] ncbi lipid_maps

                    phytanoyl-CoA + AMP + PPi

                    ([(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[({hydroxy[hydroxy(3-hydroxy-2,2-dimethyl-3-({2-[(2-{[(3S,7R,11R)-3,7,11,15-tet) (lipid link)
                    category: Fatty Acyls
                    main_class: Fatty acyl thioesters
                    formula: C41H70N7O17P3S
                    synonyms: 3,7,11,15-Tetramethyl hexadecanoyl CoA; 3,7,11,15-Tetramethyl hexadecanoyl coenzyme A; Phytanoyl CoA; Phytanoyl coenzyme A; Phyt
                    kegg id: C02060
                    exact mass: 1061.41
                    status:
                    pubchem substance url

                    phytanoyl-CoA + 2-oxoglutarate + O2

                    ([(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[({hydroxy[hydroxy(3-hydroxy-2,2-dimethyl-3-({2-[(2-{[(3S,7R,11R)-3,7,11,15-tet) (lipid link)
                    category: Fatty Acyls
                    main_class: Fatty acyl thioesters
                    formula: C41H70N7O17P3S
                    synonyms: 3,7,11,15-Tetramethyl hexadecanoyl CoA; 3,7,11,15-Tetramethyl hexadecanoyl coenzyme A; Phytanoyl CoA; Phytanoyl coenzyme A; Phyt
                    kegg id: C02060
                    status:
                    exact mass: 1061.41
                    pubchem substance url
                    localization: peroxisome
                    notes:
                    Peroxisomal branched chain fatty acid oxidation

                    1.14.11.18 Phytanoyl-CoA dioxygenase.

                    Phytanoyl-CoA + 2-oxoglutarate + O(2) = 2-hydroxyphytanoyl-CoA + succinate + CO(2). (kegg)
                    proteins
                    O14832 PAHX_HUMAN

                    details
                    ["Part of the peroxisomal phytanic acid alpha-oxidation pathway."]


                    map 1: Peroxisomal branched chain fatty acid oxidation

                    proteins:

                    2-Hydroxyphytanoyl-CoA + succinate + CoA

                    ({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[3-hydroxy-3-({2-[(2-{[(3S,7R,11R)-2-hydroxy-3,7,11,15-) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C41H74N7O18P3S
                    kegg id: C07343
                    exact mass: 1077.4
                    status:
                    lipidmaps

                    2-Hydroxyphytanoyl-CoA

                    ({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({hydroxy[3-hydroxy-3-({2-[(2-{[(3S,7R,11R)-2-hydroxy-3,7,11,15-) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C41H74N7O18P3S
                    kegg id: C07343
                    status:
                    exact mass: 1077.4
                    lipidmaps
                    localization: peroxisome
                    notes:
                    Peroxisomal branched chain fatty acid oxidation

                    4.1.-.- Carbon-carbon lyases.

                    (kegg)
                    proteins


                    proteins:

                    pristanal + formyl-CoA

                    (2,6,10,14-tetramethylpentadecanal) (lipid link)
                    category: Prenol Lipids [PR]
                    main_class: Isoprenoids [PR01]
                    sub_class: C20 isoprenoids (diterpenes) [PR0104]
                    formula: C19H38O
                    exact mass: 282.292
                    status:
                    lipidmaps
                    pubchem substance url

                    pristanal + NAD(+)

                    (2,6,10,14-tetramethylpentadecanal) (lipid link)
                    category: Prenol Lipids [PR]
                    main_class: Isoprenoids [PR01]
                    sub_class: C20 isoprenoids (diterpenes) [PR0104]
                    formula: C19H38O
                    status:
                    exact mass: 282.292
                    lipidmaps
                    pubchem substance url
                    localization: peroxisome
                    notes:
                    Peroxisomal branched chain fatty acid oxidation

                    1.2.1.3 Aldehyde dehydrogenase (NAD(+)).

                    An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH. (kegg)
                    proteins
                    P30837 AL1B1_HUMAN
                    P51648 AL3A2_HUMAN
                    P49419 AL7A1_HUMAN
                    P49189 AL9A1_HUMAN
                    P05091 ALDH2_HUMAN

                    details
                    ["Wide specificity, including oxidation of D-glucuronolactone to D-glucarate.", "Formerly EC 1.1.1.70."]


                    map 1: Peroxisomal branched chain fatty acid oxidation

                    proteins:
                    • aldehyde dehydrogenase 3 family, member A2 [ALDH3A2] ncbi lipid_maps
                      regulators:
                      MIR495 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                      MIR192 ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                    Pristanic acid + NADH

                    (2,6,10,14-tetramethyl-pentadecanoic acid) (lipid link)
                    category: Prenol Lipids [PR]
                    main_class: Isoprenoids [PR01]
                    sub_class: C20 isoprenoids (diterpenes) [PR0104]
                    formula: C19H38O2
                    synonyms: Pentadecanoic acid, 2,6,10,14-tetramethyl-; 2,6,10,14-Tetramethylpentadecanoic acid; Pristanic acid
                    exact mass: 298.287
                    status:
                    lipidmaps
                    pubchem substance url

                    Pristanic acid + ATP + CoA

                    (2,6,10,14-tetramethyl-pentadecanoic acid) (lipid link)
                    category: Prenol Lipids [PR]
                    main_class: Isoprenoids [PR01]
                    sub_class: C20 isoprenoids (diterpenes) [PR0104]
                    formula: C19H38O2
                    synonyms: Pentadecanoic acid, 2,6,10,14-tetramethyl-; 2,6,10,14-Tetramethylpentadecanoic acid; Pristanic acid
                    status:
                    exact mass: 298.287
                    lipidmaps
                    pubchem substance url
                    localization: peroxisome
                    notes:
                    Peroxisomal branched chain fatty acid oxidation

                    6.2.1.- Acid--thiol ligases.

                    (kegg)
                    proteins


                    map 1: Peroxisomal branched chain fatty acid oxidation

                    proteins:
                    • solute carrier family 27 (fatty acid transporter), member 2 [SLC27A2] ncbi lipid_maps

                    2S-Pristanoyl-CoA + AMP + PPi

                    (2S,6R,10R,14-tetramethylpentadecanoyl-CoA) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C40H72N7O17P3S
                    exact mass: 1047.39
                    status:
                    lipidmaps
                    pubchem substance url

                    2S-Pristanoyl-CoA + O2

                    (2S,6R,10R,14-tetramethylpentadecanoyl-CoA) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C40H72N7O17P3S
                    status:
                    exact mass: 1047.39
                    lipidmaps
                    pubchem substance url
                    localization: peroxisome

                    1.3.3.6 Acyl-CoA oxidase.

                    Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2). (kegg)
                    proteins
                    Q15067 ACOX1_HUMAN
                    O15254 ACOX3_HUMAN

                    details
                    ["Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18)."]


                    map 1: Peroxisomal branched chain fatty acid oxidation

                    proteins:

                    (E)-2,3-didehydropristanoyl-CoA + H2O

                    (3'-phosphoadenosine 5'-(3-{(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-{[2-((2E)-2,6,10,14-tetramethylpentadec-2-enoylsulfanyl) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C40H70N7O17P3S
                    synonyms: (E)-2,3-didehydropristanoyl-CoA;trans-2,3-dehydropristanoyl-CoA;trans-2,3-didehydropristanoyl-CoA
                    exact mass: 1045.38
                    status:
                    lipidmaps

                    (E)-2,3-didehydropristanoyl-CoA + H2O

                    (3'-phosphoadenosine 5'-(3-{(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-{[2-((2E)-2,6,10,14-tetramethylpentadec-2-enoylsulfanyl) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C40H70N7O17P3S
                    synonyms: (E)-2,3-didehydropristanoyl-CoA;trans-2,3-dehydropristanoyl-CoA;trans-2,3-didehydropristanoyl-CoA
                    status:
                    exact mass: 1045.38
                    lipidmaps
                    localization: peroxisome

                    4.2.1.107 hydratase.

                    (24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestanoyl- CoA = (24E)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl- CoA + H(2)O. (kegg)
                    proteins
                    P51659 DHB4_HUMAN

                    details
                    ["Forms part of the rat peroxisomal multifunctional enzyme perMFE-2, which also exhibits a dehydrogenase activity.", "Involved in the beta-oxidation of the cholesterol side chain in the cholic-acid biosynthesis pathway."]


                    map 1: Peroxisomal branched chain fatty acid oxidation

                    proteins:

                    3-hydroxypristanoyl-CoA

                    (3'-phosphoadenosine 5'-(3-{(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-{[2-(3-hydroxy-2,6,10,14-tetramethylpentadecanoylsulfan) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C40H72N7O18P3S
                    synonyms: 3-hydroxy-2,6,10,14-tetramethylpentadecanoyl-CoA;3-hydroxy-2,6,10,14-tetramethylpentadecanoyl-coenzyme A;3-hydroxypristanoyl-coe
                    exact mass: 1063.39
                    status:
                    lipidmaps

                    3-hydroxypristanoyl-CoA + NAD(+)

                    (3'-phosphoadenosine 5'-(3-{(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-{[2-(3-hydroxy-2,6,10,14-tetramethylpentadecanoylsulfan) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C40H72N7O18P3S
                    synonyms: 3-hydroxy-2,6,10,14-tetramethylpentadecanoyl-CoA;3-hydroxy-2,6,10,14-tetramethylpentadecanoyl-coenzyme A;3-hydroxypristanoyl-coe
                    status:
                    exact mass: 1063.39
                    lipidmaps
                    localization: peroxisome

                    1.1.1.35 3-hydroxyacyl-CoA dehydrogenase.

                    (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. (kegg)
                    proteins
                    Q08426 ECHP_HUMAN
                    Q99714 HCD2_HUMAN
                    Q16836 HCDH_HUMAN

                    details
                    ["Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate.", "Some enzymes act, more slowly, with NADP(+).", "Broad specificity to acyl chain-length (cf. EC 1.1.1.211)."]


                    map 1: Peroxisomal branched chain fatty acid oxidation

                    proteins:

                    3-oxopristanoyl-CoA + NADH + H+

                    (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(2,6,10,14-tetramethyl-3-oxopentadecanoyl)sulfanyl) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C40H70N7O18P3S
                    synonyms: 2,6,10,14-3-oxotetramethylpentadecanoyl-CoA;2,6,10,14-3-oxotetramethylpentadecanoyl-coenzyme A;3-ketopristanoyl-CoA;3-ketoprista
                    exact mass: 1061.37
                    status:
                    lipidmaps

                    3-oxopristanoyl-CoA + CoA

                    (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(2,6,10,14-tetramethyl-3-oxopentadecanoyl)sulfanyl) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C40H70N7O18P3S
                    synonyms: 2,6,10,14-3-oxotetramethylpentadecanoyl-CoA;2,6,10,14-3-oxotetramethylpentadecanoyl-coenzyme A;3-ketopristanoyl-CoA;3-ketoprista
                    status:
                    exact mass: 1061.37
                    lipidmaps
                    localization: peroxisome

                    2.3.1.16 Acetyl-CoA C-acyltransferase.

                    Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. (kegg)
                    proteins
                    P55084 ECHB_HUMAN
                    P09110 THIK_HUMAN
                    P42765 THIM_HUMAN


                    map 1: Peroxisomal branched chain fatty acid oxidation

                    proteins:

                    4,8,12-trimethyltridecanoyl-CoA

                    (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(4,8,12-trimethyltridecanoyl)sulfanyl]ethyl}amino)) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C37H66N7O17P3S
                    synonyms: 4,8,12-TMTD-CoA;4,8,12-trimethyltridecanoyl-coenzyme A;4,8,12-trimethyltridecylyl-CoA;4,8,12-trimethyltridecylyl-coenzyme A
                    exact mass: 1005.34
                    status:
                    lipidmaps

                    4,8,12-trimethyltridecanoyl-CoA + O2 + H2O + CoA + NAD(+)

                    (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(4,8,12-trimethyltridecanoyl)sulfanyl]ethyl}amino)) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C37H66N7O17P3S
                    synonyms: 4,8,12-TMTD-CoA;4,8,12-trimethyltridecanoyl-coenzyme A;4,8,12-trimethyltridecylyl-CoA;4,8,12-trimethyltridecylyl-coenzyme A
                    status:
                    exact mass: 1005.34
                    lipidmaps
                    localization: peroxisome

                    1.3.3.6 Acyl-CoA oxidase.

                    Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2). (kegg)
                    proteins
                    Q15067 ACOX1_HUMAN
                    O15254 ACOX3_HUMAN

                    details
                    ["Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18)."]


                    map 1: Peroxisomal branched chain fatty acid oxidation

                    proteins:

                    4,8-dimethylnonanoyl-CoA + propionyl CoA + acetyl-CoA + NADH

                    no systematic name (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C32H56N7O17P3S
                    synonyms: 4,8-dimethylnonanoyl-Coenzyme A
                    exact mass: 935.267
                    status:
                    lipidmaps

                    4,8-dimethylnonanoyl-CoA + carnitine

                    no systematic name (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C32H56N7O17P3S
                    synonyms: 4,8-dimethylnonanoyl-Coenzyme A
                    status:
                    exact mass: 935.267
                    lipidmaps
                    localization: peroxisome

                    2.3.1.21 Carnitine O-palmitoyltransferase.

                    Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine. (kegg)
                    proteins
                    P50416 CPT1A_HUMAN
                    Q92523 CPT1B_HUMAN
                    Q8TCG5 CPT1C_HUMAN
                    P23786 CPT2_HUMAN

                    details
                    ["Broad specificity to acyl group, over the range C(8) to C(18); optimal activity with palmitoyl-CoA (cf. EC 2.3.1.7 and EC 2.3.1.137)."]


                    map 1: Peroxisomal branched chain fatty acid oxidation

                    proteins:
                    • carnitine O-octanoyltransferase [CROT] ncbi lipid_maps
                      regulators:
                      MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                    4,8 dimethylnonanoyl carnitine + CoA

                    (3-[(4,8-dimethylnonanoyl)oxy]-4-(trimethylazaniumyl)butanoate) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl carnitines [FA0707]
                    formula: C18H35NO4
                    exact mass: 329.257
                    status:
                    lipidmaps

                    4,8 dimethylnonanoyl carnitine + CoA

                    (3-[(4,8-dimethylnonanoyl)oxy]-4-(trimethylazaniumyl)butanoate) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl carnitines [FA0707]
                    formula: C18H35NO4
                    status:
                    exact mass: 329.257
                    lipidmaps
                    localization: Cytoplasm
                    notes:
                    Peroxisomal branched chain fatty acid oxidation

                    2.3.1.21 Carnitine O-palmitoyltransferase.

                    Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine. (kegg)
                    proteins
                    P50416 CPT1A_HUMAN
                    Q92523 CPT1B_HUMAN
                    Q8TCG5 CPT1C_HUMAN
                    P23786 CPT2_HUMAN

                    details
                    ["Broad specificity to acyl group, over the range C(8) to C(18); optimal activity with palmitoyl-CoA (cf. EC 2.3.1.7 and EC 2.3.1.137)."]


                    map 1: Peroxisomal branched chain fatty acid oxidation

                    proteins:
                    • carnitine palmitoyltransferase 1A (liver) [CPT1A] ncbi lipid_maps
                      regulators:
                      MIR370 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                      MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                    • carnitine palmitoyltransferase 1B (muscle) [CPT1B] ncbi lipid_maps
                      regulators:
                      ESRRA ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd
                      ESRRG ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd
                      MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                      PPARA ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                      PPARD ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd
                      PPARG ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                      RXRA ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                      STAT1 ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd
                    • carnitine palmitoyltransferase 2 [CPT2] ncbi lipid_maps
                      regulators:
                      ESRRA ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd
                      ESRRG ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd

                    4,8-dimethylnonanoyl-CoA + carnitine

                    no systematic name (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C32H56N7O17P3S
                    synonyms: 4,8-dimethylnonanoyl-Coenzyme A
                    exact mass: 935.267
                    status:
                    lipidmaps

                    Palmitoyl CoA / CoA(16:0) + carnitine

                    (Hexadecanoyl-CoA) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C37H66N7O17P3S
                    synonyms: Palmitoyl CoA
                    kegg id: C00154
                    status:
                    exact mass: 1005.34
                    lipidmaps
                    pubchem substance url
                    localization: Cytoplasm
                    notes:
                    Peroxisomal branched chain fatty acid oxidation

                    2.3.1.21 Carnitine O-palmitoyltransferase.

                    Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine. (kegg)
                    proteins
                    P50416 CPT1A_HUMAN
                    Q92523 CPT1B_HUMAN
                    Q8TCG5 CPT1C_HUMAN
                    P23786 CPT2_HUMAN

                    details
                    ["Broad specificity to acyl group, over the range C(8) to C(18); optimal activity with palmitoyl-CoA (cf. EC 2.3.1.7 and EC 2.3.1.137)."]


                    map 1: Peroxisomal branched chain fatty acid oxidation

                    proteins:
                    • carnitine palmitoyltransferase 1A (liver) [CPT1A] ncbi lipid_maps
                      regulators:
                      MIR370 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                      MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                    • carnitine palmitoyltransferase 1B (muscle) [CPT1B] ncbi lipid_maps
                      regulators:
                      ESRRA ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd
                      ESRRG ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd
                      MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                      PPARA ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                      PPARD ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd
                      PPARG ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                      RXRA ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                      STAT1 ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd

                    L-palmitoylcarnitine + CoA

                    ((3S)-3-hexadecanoyloxy-4-(trimethylammonio)butanoate) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl carnitines [FA0707]
                    formula: C23H45NO4
                    synonyms: (3S)-3-palmitoyloxy-4-(trimethylammonio)butanoate;(S)-palmitoylcarnitine
                    exact mass: 399.335
                    status:
                    lipidmaps

                    L-palmitoylcarnitine + CoA

                    ((3S)-3-hexadecanoyloxy-4-(trimethylammonio)butanoate) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl carnitines [FA0707]
                    formula: C23H45NO4
                    synonyms: (3S)-3-palmitoyloxy-4-(trimethylammonio)butanoate;(S)-palmitoylcarnitine
                    status:
                    exact mass: 399.335
                    lipidmaps
                    localization: Cytoplasm
                    notes:
                    Peroxisomal branched chain fatty acid oxidation

                    2.3.1.21 Carnitine O-palmitoyltransferase.

                    Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine. (kegg)
                    proteins
                    P50416 CPT1A_HUMAN
                    Q92523 CPT1B_HUMAN
                    Q8TCG5 CPT1C_HUMAN
                    P23786 CPT2_HUMAN

                    details
                    ["Broad specificity to acyl group, over the range C(8) to C(18); optimal activity with palmitoyl-CoA (cf. EC 2.3.1.7 and EC 2.3.1.137)."]


                    proteins:
                    • carnitine palmitoyltransferase 2 [CPT2] ncbi lipid_maps
                      regulators:
                      ESRRA ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd
                      ESRRG ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd

                    Palmitoyl CoA / CoA(16:0) + carnitine

                    (Hexadecanoyl-CoA) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C37H66N7O17P3S
                    synonyms: Palmitoyl CoA
                    kegg id: C00154
                    exact mass: 1005.34
                    status:
                    lipidmaps
                    pubchem substance url

                    Palmitoyl CoA / CoA(16:0) + FAD

                    (Hexadecanoyl-CoA) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C37H66N7O17P3S
                    synonyms: Palmitoyl CoA
                    kegg id: C00154
                    status:
                    exact mass: 1005.34
                    lipidmaps
                    pubchem substance url
                    localization: Mitochondria

                    1.3.3.6 Acyl-CoA oxidase.

                    Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2). (kegg)
                    proteins
                    Q15067 ACOX1_HUMAN
                    O15254 ACOX3_HUMAN

                    details
                    ["Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18)."]


                    map 1: Mitochondrial long chain fatty acid beta-oxidation

                    proteins:

                    2E-hexadecenoyl-CoA + FADH(2

                    (2E-hexadecenoyl-CoA) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C37H64N7O17P3S
                    synonyms: (2E)-Hexadecenoyl-CoA; (E)-hexadec-2-enoyl-CoA; Trans-hexadec-2-enoyl-CoA
                    kegg id: C05272
                    exact mass: 1003.33
                    status:
                    lipidmaps
                    pubchem substance url

                    2E-hexadecenoyl-CoA + H2O

                    (2E-hexadecenoyl-CoA) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C37H64N7O17P3S
                    synonyms: (2E)-Hexadecenoyl-CoA; (E)-hexadec-2-enoyl-CoA; Trans-hexadec-2-enoyl-CoA
                    kegg id: C05272
                    status:
                    exact mass: 1003.33
                    lipidmaps
                    pubchem substance url
                    localization: Mitochondria

                    4.2.1.17 Enoyl-CoA hydratase.

                    (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O. (kegg)
                    proteins
                    P40939 ECHA_HUMAN
                    P30084 ECHM_HUMAN
                    Q08426 ECHP_HUMAN

                    details
                    ["Acts in the reverse direction.", "With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74)."]


                    map 1: Mitochondrial long chain fatty acid beta-oxidation

                    proteins:
                    • enoyl CoA hydratase, short chain, 1, mitochondrial [ECHS1] ncbi lipid_maps
                    • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [HADHA] ncbi lipid_maps
                    • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [HADHB] ncbi lipid_maps
                      regulators:
                      MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                    3-hydroxypalmitoyl-CoA

                    (3S-hydroxyhexadecanoyl-CoA) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C37H66N7O18P3S
                    synonyms: (S)-3-hydroxypalmitoyl-CoA; (S)-3-hydroxypalmitoyl-Coenzyme A
                    exact mass: 1021.34
                    status:
                    lipidmaps
                    pubchem substance url

                    3-hydroxypalmitoyl-CoA + NAD(+)

                    (3S-hydroxyhexadecanoyl-CoA) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C37H66N7O18P3S
                    synonyms: (S)-3-hydroxypalmitoyl-CoA; (S)-3-hydroxypalmitoyl-Coenzyme A
                    status:
                    exact mass: 1021.34
                    lipidmaps
                    pubchem substance url
                    localization: Mitochondria

                    1.1.1.35 3-hydroxyacyl-CoA dehydrogenase.

                    (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. (kegg)
                    proteins
                    Q08426 ECHP_HUMAN
                    Q99714 HCD2_HUMAN
                    Q16836 HCDH_HUMAN

                    details
                    ["Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate.", "Some enzymes act, more slowly, with NADP(+).", "Broad specificity to acyl chain-length (cf. EC 1.1.1.211)."]


                    map 1: Mitochondrial long chain fatty acid beta-oxidation

                    proteins:
                    • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [HADHA] ncbi lipid_maps
                    • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [HADHB] ncbi lipid_maps
                      regulators:
                      MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                    3-oxopalmitoyl-CoA + NADH + H+

                    (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(3-oxohexadecanoyl)sulfanyl]ethyl}amino)propyl]ami) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C37H64N7O18P3S
                    exact mass: 1019.32
                    status:
                    lipidmaps

                    3-oxopalmitoyl-CoA + CoA

                    (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(3-oxohexadecanoyl)sulfanyl]ethyl}amino)propyl]ami) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C37H64N7O18P3S
                    status:
                    exact mass: 1019.32
                    lipidmaps
                    localization: Mitochondria

                    2.3.1.16 Acetyl-CoA C-acyltransferase.

                    Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. (kegg)
                    proteins
                    P55084 ECHB_HUMAN
                    P09110 THIK_HUMAN
                    P42765 THIM_HUMAN


                    map 1: Mitochondrial long chain fatty acid beta-oxidation

                    proteins:
                    • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [HADHA] ncbi lipid_maps
                    • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [HADHB] ncbi lipid_maps
                      regulators:
                      MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                    • acetyl-CoA acyltransferase 2 [ACAA2] ncbi lipid_maps

                    myristoyl-CoA + acetyl-CoA

                    (3'-phosphoadenosine 5'-(3-{(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-{[2-(tetradecanoylsulfanyl)ethyl]amino}propyl)amino]but) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C35H62N7O17P3S
                    synonyms: S-tetradecanoyl-coenzyme A;n-C14:0-CoA;n-C14:0-coenzyme A
                    exact mass: 977.314
                    status:
                    lipidmaps

                    myristoyl-CoA + FAD

                    (3'-phosphoadenosine 5'-(3-{(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-{[2-(tetradecanoylsulfanyl)ethyl]amino}propyl)amino]but) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C35H62N7O17P3S
                    synonyms: S-tetradecanoyl-coenzyme A;n-C14:0-CoA;n-C14:0-coenzyme A
                    status:
                    exact mass: 977.314
                    lipidmaps
                    localization: Mitochondria

                    1.3.3.6 Acyl-CoA oxidase.

                    Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2). (kegg)
                    proteins
                    Q15067 ACOX1_HUMAN
                    O15254 ACOX3_HUMAN

                    details
                    ["Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18)."]


                    map 1: Mitochondrial long chain fatty acid beta-oxidation

                    proteins:

                    trans-tetradec-2-enoyl-CoA + FADH(2

                    (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-{[(2E)-tetradec-2-enoyl]sulfanyl}ethyl)amino]propyl) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C35H60N7O17P3S
                    synonyms: trans-tetradec-2-enoyl-coenzyme A
                    exact mass: 975.298
                    status:
                    lipidmaps

                    trans-tetradec-2-enoyl-CoA + H2O

                    (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-{[(2E)-tetradec-2-enoyl]sulfanyl}ethyl)amino]propyl) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C35H60N7O17P3S
                    synonyms: trans-tetradec-2-enoyl-coenzyme A
                    status:
                    exact mass: 975.298
                    lipidmaps
                    localization: Mitochondria

                    4.2.1.17 Enoyl-CoA hydratase.

                    (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O. (kegg)
                    proteins
                    P40939 ECHA_HUMAN
                    P30084 ECHM_HUMAN
                    Q08426 ECHP_HUMAN

                    details
                    ["Acts in the reverse direction.", "With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74)."]


                    map 1: Mitochondrial long chain fatty acid beta-oxidation

                    proteins:
                    • enoyl CoA hydratase, short chain, 1, mitochondrial [ECHS1] ncbi lipid_maps
                    • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [HADHA] ncbi lipid_maps
                    • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [HADHB] ncbi lipid_maps
                      regulators:
                      MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                    3S-Hydroxytetradecanoyl-CoA

                    (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-4-({3-[(2-{[(3S)-3-hydroxytetradecanoyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-2,2-d) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C35H62N7O18P3S
                    kegg id: C05260
                    exact mass: 993.308
                    status:
                    lipidmaps

                    3S-Hydroxytetradecanoyl-CoA + NAD(+)

                    (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-4-({3-[(2-{[(3S)-3-hydroxytetradecanoyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-2,2-d) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C35H62N7O18P3S
                    kegg id: C05260
                    status:
                    exact mass: 993.308
                    lipidmaps
                    localization: Mitochondria

                    1.1.1.35 3-hydroxyacyl-CoA dehydrogenase.

                    (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. (kegg)
                    proteins
                    Q08426 ECHP_HUMAN
                    Q99714 HCD2_HUMAN
                    Q16836 HCDH_HUMAN

                    details
                    ["Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate.", "Some enzymes act, more slowly, with NADP(+).", "Broad specificity to acyl chain-length (cf. EC 1.1.1.211)."]


                    map 1: Mitochondrial long chain fatty acid beta-oxidation

                    proteins:
                    • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [HADHA] ncbi lipid_maps
                    • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [HADHB] ncbi lipid_maps
                      regulators:
                      MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                    3-oxotetradecanoyl-CoA + NADH + H+

                    (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(3-oxotetradecanoyl)sulfanyl]ethyl}amino)propyl]am) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C35H60N7O18P3S
                    synonyms: 3-oxomyristoyl-CoA
                    kegg id: C05261
                    exact mass: 991.293
                    status:
                    lipidmaps

                    3-oxotetradecanoyl-CoA + CoA

                    (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(3-oxotetradecanoyl)sulfanyl]ethyl}amino)propyl]am) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C35H60N7O18P3S
                    synonyms: 3-oxomyristoyl-CoA
                    kegg id: C05261
                    status:
                    exact mass: 991.293
                    lipidmaps
                    localization: Mitochondria

                    2.3.1.16 Acetyl-CoA C-acyltransferase.

                    Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. (kegg)
                    proteins
                    P55084 ECHB_HUMAN
                    P09110 THIK_HUMAN
                    P42765 THIM_HUMAN


                    map 1: Mitochondrial long chain fatty acid beta-oxidation

                    proteins:
                    • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [HADHA] ncbi lipid_maps
                    • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [HADHB] ncbi lipid_maps
                      regulators:
                      MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                    Lauroyl-CoA + acetyl-CoA

                    ({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-({[({[(3R)-3-[(2-{[2-(dodecanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C33H58N7O17P3S
                    kegg id: C01832
                    exact mass: 949.282
                    status:
                    lipidmaps

                    Lauroyl-CoA + FAD

                    ({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-({[({[(3R)-3-[(2-{[2-(dodecanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C33H58N7O17P3S
                    kegg id: C01832
                    status:
                    exact mass: 949.282
                    lipidmaps
                    localization: Mitochondria

                    1.3.3.6 Acyl-CoA oxidase.

                    Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2). (kegg)
                    proteins
                    Q15067 ACOX1_HUMAN
                    O15254 ACOX3_HUMAN

                    details
                    ["Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18)."]


                    map 1: Mitochondrial long chain fatty acid beta-oxidation

                    proteins:
                    • acyl-CoA dehydrogenase, C-4 to C-12 straight chain [ACADM] ncbi lipid_maps
                      regulators:
                      ESRRA ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd
                      ESRRG ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd

                    2E-dodecenoyl-CoA + FADH(2

                    (2E-dodecenoyl-CoA) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C33H56N7O17P3S
                    synonyms: (2E)-Dodecenoyl-CoA
                    kegg id: C03221
                    exact mass: 947.267
                    status:
                    lipidmaps
                    pubchem substance url

                    2E-dodecenoyl-CoA + H2O

                    (2E-dodecenoyl-CoA) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C33H56N7O17P3S
                    synonyms: (2E)-Dodecenoyl-CoA
                    kegg id: C03221
                    status:
                    exact mass: 947.267
                    lipidmaps
                    pubchem substance url
                    localization: Mitochondria

                    4.2.1.17 Enoyl-CoA hydratase.

                    (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O. (kegg)
                    proteins
                    P40939 ECHA_HUMAN
                    P30084 ECHM_HUMAN
                    Q08426 ECHP_HUMAN

                    details
                    ["Acts in the reverse direction.", "With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74)."]


                    map 1: Mitochondrial long chain fatty acid beta-oxidation

                    proteins:
                    • enoyl CoA hydratase, short chain, 1, mitochondrial [ECHS1] ncbi lipid_maps
                    • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [HADHA] ncbi lipid_maps
                    • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [HADHB] ncbi lipid_maps
                      regulators:
                      MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                    3S-hydroxylauroyl-CoA

                    (3S-hydroxydodecanoyl-CoA) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C33H58N7O18P3S
                    synonyms: (S)-3-Hydroxydodecanoyl-CoA; (S)-3-hydroxylauroyl-CoA
                    kegg id: C05262
                    exact mass: 965.277
                    status:
                    lipidmaps
                    pubchem substance url

                    3S-hydroxylauroyl-CoA + CoA

                    (3S-hydroxydodecanoyl-CoA) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C33H58N7O18P3S
                    synonyms: (S)-3-Hydroxydodecanoyl-CoA; (S)-3-hydroxylauroyl-CoA
                    kegg id: C05262
                    status:
                    exact mass: 965.277
                    lipidmaps
                    pubchem substance url
                    localization: Mitochondria

                    2.3.1.16 Acetyl-CoA C-acyltransferase.

                    Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. (kegg)
                    proteins
                    P55084 ECHB_HUMAN
                    P09110 THIK_HUMAN
                    P42765 THIM_HUMAN


                    map 1: Mitochondrial long chain fatty acid beta-oxidation

                    proteins:
                    • acetyl-CoA acyltransferase 2 [ACAA2] ncbi lipid_maps
                    • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [HADHA] ncbi lipid_maps
                    • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [HADHB] ncbi lipid_maps
                      regulators:
                      MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                    3-oxo-dodecanoyl-CoA + acetyl-CoA

                    (3-oxo-dodecanoyl-CoA) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C33H56N7O18P3S
                    synonyms: 3-Oxododecanoyl-CoA
                    kegg id: C05263
                    exact mass: 963.262
                    status:
                    lipidmaps
                    pubchem substance url

                    3-oxo-dodecanoyl-CoA + FAD

                    (3-oxo-dodecanoyl-CoA) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C33H56N7O18P3S
                    synonyms: 3-Oxododecanoyl-CoA
                    kegg id: C05263
                    status:
                    exact mass: 963.262
                    lipidmaps
                    pubchem substance url
                    localization: Mitochondria

                    1.3.3.6 Acyl-CoA oxidase.

                    Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2). (kegg)
                    proteins
                    Q15067 ACOX1_HUMAN
                    O15254 ACOX3_HUMAN

                    details
                    ["Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18)."]


                    map 1: Mitochondrial long chain fatty acid beta-oxidation

                    proteins:
                    • acyl-CoA dehydrogenase, C-4 to C-12 straight chain [ACADM] ncbi lipid_maps
                      regulators:
                      ESRRA ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd
                      ESRRG ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd

                    decanoyl-CoA + FADH(2

                    (3'-phosphoadenosine 5'-(3-{(3R)-4-[(3-{[2-(decanoylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl} d) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C31H54N7O17P3S
                    synonyms: 10:0-CoA;C10:0-CoA;Coenzyme A, S-decanoate;Decanoyl-coenzyme A;capryl-CoA;capryl-coenzyme A
                    kegg id: C05274
                    exact mass: 921.251
                    status:
                    lipidmaps

                    decanoyl-CoA + H2O

                    (3'-phosphoadenosine 5'-(3-{(3R)-4-[(3-{[2-(decanoylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl} d) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C31H54N7O17P3S
                    synonyms: 10:0-CoA;C10:0-CoA;Coenzyme A, S-decanoate;Decanoyl-coenzyme A;capryl-CoA;capryl-coenzyme A
                    kegg id: C05274
                    status:
                    exact mass: 921.251
                    lipidmaps
                    localization: Mitochondria

                    4.2.1.17 Enoyl-CoA hydratase.

                    (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O. (kegg)
                    proteins
                    P40939 ECHA_HUMAN
                    P30084 ECHM_HUMAN
                    Q08426 ECHP_HUMAN

                    details
                    ["Acts in the reverse direction.", "With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74)."]


                    map 1: Mitochondrial long chain fatty acid beta-oxidation

                    proteins:
                    • enoyl CoA hydratase, short chain, 1, mitochondrial [ECHS1] ncbi lipid_maps
                    • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [HADHA] ncbi lipid_maps
                    • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [HADHB] ncbi lipid_maps
                      regulators:
                      MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                    3S-hydroxy-decanoyl-CoA

                    (3S-hydroxy-decanoyl-CoA) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Fatty esters [FA07]
                    sub_class: Fatty acyl CoAs [FA0705]
                    formula: C31H54N7O18P3S
                    synonyms: (S)-3-Hydroxydecanoyl-CoA
                    kegg id: C05264
                    exact mass: 937.246
                    status:
                    lipidmaps
                    pubchem substance url

                    TXA2 + H2O

                    (9S,11S-epoxy,15S-hydroxy-thromboxa-5Z,13E-dien-1-oic acid) (lipid link)
                    category: Fatty Acyls [FA]
                    main_class: Eicosanoids [FA03]
                    sub_class: Thromboxanes [FA0303]
                    formula: C20H32O5
                    synonyms: Thromboxane A2
                    kegg id: C02198
                    status:
                    exact mass: 352.225
                    lipidmaps
                    pubchem substance url
                    localization: Unknown
                    proteins

                    details
                    ["Acts in the reverse direction.", "With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74)."]


                    proteins:

                      3S-hydroxy-decanoyl-CoA + NAD(+)

                      (3S-hydroxy-decanoyl-CoA) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C31H54N7O18P3S
                      synonyms: (S)-3-Hydroxydecanoyl-CoA
                      kegg id: C05264
                      status:
                      exact mass: 937.246
                      lipidmaps
                      pubchem substance url
                      localization: Mitochondria

                      1.1.1.35 3-hydroxyacyl-CoA dehydrogenase.

                      (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. (kegg)
                      proteins
                      Q08426 ECHP_HUMAN
                      Q99714 HCD2_HUMAN
                      Q16836 HCDH_HUMAN

                      details
                      ["Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate.", "Some enzymes act, more slowly, with NADP(+).", "Broad specificity to acyl chain-length (cf. EC 1.1.1.211)."]


                      map 1: Mitochondrial long chain fatty acid beta-oxidation

                      proteins:
                      • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [HADHA] ncbi lipid_maps
                      • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [HADHB] ncbi lipid_maps
                        regulators:
                        MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                      3-oxodecanoyl-CoA + NADH + H+

                      (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(3-oxodecanoyl)sulfanyl]ethyl}amino)propyl]amino}b) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C31H52N7O18P3S
                      synonyms: 3-ketodecanoyl-CoA;3-ketodecanoyl-coenzyme A;3-oxodecanoyl-coenzyme A
                      kegg id: C05265
                      exact mass: 935.23
                      status:
                      lipidmaps

                      3-oxodecanoyl-CoA + CoA

                      (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(3-oxodecanoyl)sulfanyl]ethyl}amino)propyl]amino}b) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C31H52N7O18P3S
                      synonyms: 3-ketodecanoyl-CoA;3-ketodecanoyl-coenzyme A;3-oxodecanoyl-coenzyme A
                      kegg id: C05265
                      status:
                      exact mass: 935.23
                      lipidmaps
                      localization: Mitochondria

                      2.3.1.16 Acetyl-CoA C-acyltransferase.

                      Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. (kegg)
                      proteins
                      P55084 ECHB_HUMAN
                      P09110 THIK_HUMAN
                      P42765 THIM_HUMAN


                      map 1: Mitochondrial long chain fatty acid beta-oxidation

                      proteins:
                      • acetyl-CoA acyltransferase 2 [ACAA2] ncbi lipid_maps
                      • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [HADHA] ncbi lipid_maps
                      • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [HADHB] ncbi lipid_maps
                        regulators:
                        MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                      Octanoyl-CoA + acetyl-CoA

                      ({[5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({[hydroxy({3-hydroxy-2,2-dimethyl-3-[(2-{[2-(octanoylsulfanyl)ethyl]carbamoyl) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C29H50N7O17P3S
                      kegg id: C01944
                      exact mass: 893.22
                      status:
                      lipidmaps

                      Octanoyl-CoA + FAD

                      ({[5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[hydroxy({[hydroxy({3-hydroxy-2,2-dimethyl-3-[(2-{[2-(octanoylsulfanyl)ethyl]carbamoyl) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C29H50N7O17P3S
                      kegg id: C01944
                      status:
                      exact mass: 893.22
                      lipidmaps
                      localization: Unknown

                      1.3.3.6 Acyl-CoA oxidase.

                      Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2). (kegg)
                      proteins
                      Q15067 ACOX1_HUMAN
                      O15254 ACOX3_HUMAN

                      details
                      ["Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18)."]


                      map 1: Mitochondrial long chain fatty acid beta-oxidation

                      proteins:
                      • acyl-CoA dehydrogenase, C-4 to C-12 straight chain [ACADM] ncbi lipid_maps
                        regulators:
                        ESRRA ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd
                        ESRRG ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd

                      trans-oct-2-enoyl-CoA + FADH(2

                      (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-({3-[(2-{[(2E)-oct-2-enoyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-4-o) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C29H48N7O17P3S
                      synonyms: (2E)-octenoyl-coenzyme A;2,3-trans-octenoyl coenzyme A;2E-octenoyl-CoA;2E-octenoyl-coenzyme A;oct-2-trans-enoyl-CoA;oct-trans-2-
                      exact mass: 891.204
                      status:
                      lipidmaps

                      trans-oct-2-enoyl-CoA + H2O

                      (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-({3-[(2-{[(2E)-oct-2-enoyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-4-o) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C29H48N7O17P3S
                      synonyms: (2E)-octenoyl-coenzyme A;2,3-trans-octenoyl coenzyme A;2E-octenoyl-CoA;2E-octenoyl-coenzyme A;oct-2-trans-enoyl-CoA;oct-trans-2-
                      status:
                      exact mass: 891.204
                      lipidmaps
                      localization: Mitochondria

                      4.2.1.17 Enoyl-CoA hydratase.

                      (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O. (kegg)
                      proteins
                      P40939 ECHA_HUMAN
                      P30084 ECHM_HUMAN
                      Q08426 ECHP_HUMAN

                      details
                      ["Acts in the reverse direction.", "With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74)."]


                      map 1: Mitochondrial long chain fatty acid beta-oxidation

                      proteins:
                      • enoyl CoA hydratase, short chain, 1, mitochondrial [ECHS1] ncbi lipid_maps
                      • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [HADHA] ncbi lipid_maps
                      • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [HADHB] ncbi lipid_maps
                        regulators:
                        MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                      3S-hydroxy-octanoyl-CoA

                      (3S-hydroxy-octanoyl-CoA) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C29H50N7O18P3S
                      synonyms: (S)-3-Hydroxyoctanoyl-CoA
                      kegg id: C05266
                      exact mass: 909.215
                      status:
                      lipidmaps
                      pubchem substance url

                      trans-oct-2-enoyl-CoA + NAD(+)

                      (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-({3-[(2-{[(2E)-oct-2-enoyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-4-o) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C29H48N7O17P3S
                      synonyms: (2E)-octenoyl-coenzyme A;2,3-trans-octenoyl coenzyme A;2E-octenoyl-CoA;2E-octenoyl-coenzyme A;oct-2-trans-enoyl-CoA;oct-trans-2-
                      status:
                      exact mass: 891.204
                      lipidmaps
                      localization: Mitochondria

                      1.1.1.35 3-hydroxyacyl-CoA dehydrogenase.

                      (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. (kegg)
                      proteins
                      Q08426 ECHP_HUMAN
                      Q99714 HCD2_HUMAN
                      Q16836 HCDH_HUMAN

                      details
                      ["Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate.", "Some enzymes act, more slowly, with NADP(+).", "Broad specificity to acyl chain-length (cf. EC 1.1.1.211)."]


                      map 1: Mitochondrial long chain fatty acid beta-oxidation

                      proteins:
                      • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [HADHA] ncbi lipid_maps
                      • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [HADHB] ncbi lipid_maps
                        regulators:
                        MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                      3-Oxooctanoyl-CoA + NADH + H+

                      (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(3-oxooctanoyl)sulfanyl]ethyl}amino)propyl]amino}b) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C29H48N7O18P3S
                      synonyms: 3-ketooctanoyl-CoA;3-ketooctanoyl-coenzyme A;3-oxooctanoyl-coenzyme A
                      kegg id: C05267
                      exact mass: 907.199
                      status:
                      lipidmaps

                      3-Oxooctanoyl-CoA + CoA

                      (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(3-oxooctanoyl)sulfanyl]ethyl}amino)propyl]amino}b) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C29H48N7O18P3S
                      synonyms: 3-ketooctanoyl-CoA;3-ketooctanoyl-coenzyme A;3-oxooctanoyl-coenzyme A
                      kegg id: C05267
                      status:
                      exact mass: 907.199
                      lipidmaps
                      localization: Mitochondria

                      2.3.1.16 Acetyl-CoA C-acyltransferase.

                      Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. (kegg)
                      proteins
                      P55084 ECHB_HUMAN
                      P09110 THIK_HUMAN
                      P42765 THIM_HUMAN


                      map 1: Mitochondrial long chain fatty acid beta-oxidation

                      proteins:
                      • acetyl-CoA acyltransferase 2 [ACAA2] ncbi lipid_maps
                      • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [HADHA] ncbi lipid_maps
                      • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [HADHB] ncbi lipid_maps
                        regulators:
                        MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                      Hexanoyl-CoA + acetyl-CoA

                      (3'-phosphoadenosine 5'-(3-{(3R)-3-hydroxy-4-[(3-{[2-(hexanoylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-2,2-dimethyl-4-oxobutyl} d) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C27H46N7O17P3S
                      synonyms: Coenzyme A, S-hexanoate;Hexanoyl-coenzyme A;S-Hexanoyl-coenzym-A;S-hexanoyl-CoA;S-hexanoyl-coenzyme-A;caproyl-CoA;caproyl-coenzy
                      kegg id: C05270
                      exact mass: 865.188
                      status:
                      lipidmaps

                      Hexanoyl-CoA + FAD

                      (3'-phosphoadenosine 5'-(3-{(3R)-3-hydroxy-4-[(3-{[2-(hexanoylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-2,2-dimethyl-4-oxobutyl} d) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C27H46N7O17P3S
                      synonyms: Coenzyme A, S-hexanoate;Hexanoyl-coenzyme A;S-Hexanoyl-coenzym-A;S-hexanoyl-CoA;S-hexanoyl-coenzyme-A;caproyl-CoA;caproyl-coenzy
                      kegg id: C05270
                      status:
                      exact mass: 865.188
                      lipidmaps
                      localization: Mitochondria

                      1.3.3.6 Acyl-CoA oxidase.

                      Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2). (kegg)
                      proteins
                      Q15067 ACOX1_HUMAN
                      O15254 ACOX3_HUMAN

                      details
                      ["Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18)."]


                      map 1: Mitochondrial long chain fatty acid beta-oxidation

                      proteins:
                      • acyl-CoA dehydrogenase, C-4 to C-12 straight chain [ACADM] ncbi lipid_maps
                        regulators:
                        ESRRA ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd
                        ESRRG ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd

                      trans-hex-2-enoyl-CoA + FADH(2

                      (3'-phosphoadenosine 5'-{3-[(3R)-4-({3-[(2-{[(2E)-hex-2-enoyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-3-hydroxy-2,2-dimethyl-4-o) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C27H44N7O17P3S
                      synonyms: (2E)-hexenoyl-coenzyme A;2E-hexenoyl-CoA;2E-hexenoyl-coenzyme A;trans-2,3-dehydrohexanoyl-CoA;trans-2,3-dehydrohexanoyl-coenzyme
                      exact mass: 863.173
                      status:
                      lipidmaps

                      trans-hex-2-enoyl-CoA + H2O

                      (3'-phosphoadenosine 5'-{3-[(3R)-4-({3-[(2-{[(2E)-hex-2-enoyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-3-hydroxy-2,2-dimethyl-4-o) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C27H44N7O17P3S
                      synonyms: (2E)-hexenoyl-coenzyme A;2E-hexenoyl-CoA;2E-hexenoyl-coenzyme A;trans-2,3-dehydrohexanoyl-CoA;trans-2,3-dehydrohexanoyl-coenzyme
                      status:
                      exact mass: 863.173
                      lipidmaps
                      localization: Mitochondria

                      4.2.1.17 Enoyl-CoA hydratase.

                      (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O. (kegg)
                      proteins
                      P40939 ECHA_HUMAN
                      P30084 ECHM_HUMAN
                      Q08426 ECHP_HUMAN

                      details
                      ["Acts in the reverse direction.", "With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74)."]


                      map 1: Mitochondrial long chain fatty acid beta-oxidation

                      proteins:
                      • enoyl CoA hydratase, short chain, 1, mitochondrial [ECHS1] ncbi lipid_maps
                      • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [HADHA] ncbi lipid_maps
                      • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [HADHB] ncbi lipid_maps
                        regulators:
                        MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                      3S-hydroxy-hexanoyl-CoA

                      (3S-hydroxy-hexanoyl-CoA) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C27H46N7O18P3S
                      synonyms: (S)-3-Hydroxyhexanoyl-CoA
                      kegg id: C05268
                      exact mass: 881.183
                      status:
                      lipidmaps
                      pubchem substance url

                      3S-hydroxy-hexanoyl-CoA + NAD(+)

                      (3S-hydroxy-hexanoyl-CoA) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C27H46N7O18P3S
                      synonyms: (S)-3-Hydroxyhexanoyl-CoA
                      kegg id: C05268
                      status:
                      exact mass: 881.183
                      lipidmaps
                      pubchem substance url
                      localization: Mitochondria

                      1.1.1.35 3-hydroxyacyl-CoA dehydrogenase.

                      (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. (kegg)
                      proteins
                      Q08426 ECHP_HUMAN
                      Q99714 HCD2_HUMAN
                      Q16836 HCDH_HUMAN

                      details
                      ["Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate.", "Some enzymes act, more slowly, with NADP(+).", "Broad specificity to acyl chain-length (cf. EC 1.1.1.211)."]


                      map 1: Mitochondrial long chain fatty acid beta-oxidation

                      proteins:
                      • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [HADHA] ncbi lipid_maps
                      • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [HADHB] ncbi lipid_maps
                        regulators:
                        MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                      3-Oxohexanoyl-CoA + NADH + H+

                      (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(3-oxohexanoyl)sulfanyl]ethyl}amino)propyl]amino}b) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C27H44N7O18P3S
                      synonyms: 3-Ketohexanoyl-coenzyme A;3-oxohexanoyl-coenzyme A;Coenzyme A, S-(3-oxohexanoate);adenosine 3'-phosphoric acid 5'-[diphosphoric
                      kegg id: C05269
                      exact mass: 879.168
                      status:
                      lipidmaps

                      3-Oxohexanoyl-CoA + CoA

                      (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(3-oxohexanoyl)sulfanyl]ethyl}amino)propyl]amino}b) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C27H44N7O18P3S
                      synonyms: 3-Ketohexanoyl-coenzyme A;3-oxohexanoyl-coenzyme A;Coenzyme A, S-(3-oxohexanoate);adenosine 3'-phosphoric acid 5'-[diphosphoric
                      kegg id: C05269
                      status:
                      exact mass: 879.168
                      lipidmaps
                      localization: Mitochondria

                      2.3.1.16 Acetyl-CoA C-acyltransferase.

                      Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. (kegg)
                      proteins
                      P55084 ECHB_HUMAN
                      P09110 THIK_HUMAN
                      P42765 THIM_HUMAN


                      map 1: Mitochondrial long chain fatty acid beta-oxidation

                      proteins:
                      • acetyl-CoA acyltransferase 2 [ACAA2] ncbi lipid_maps
                      • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [HADHA] ncbi lipid_maps
                      • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [HADHB] ncbi lipid_maps
                        regulators:
                        MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                      Butyryl-CoA + acetyl-CoA

                      (3'-phosphoadenosine 5'-(3-{(3R)-4-[(3-{[2-(butanoylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl} d) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C25H42N7O17P3S
                      synonyms: 4:0-CoA;Butyryl-CoA;Butyryl-coa;Butyryl-coenzyme A;C4:0-CoA;Coenzyme A, S-butanoate;S-Butyryl-coenzym-A;S-butanoyl-CoA;S-butanoy
                      kegg id: C00136
                      exact mass: 837.157
                      status:
                      lipidmaps

                      Butyryl-CoA + FAD

                      (3'-phosphoadenosine 5'-(3-{(3R)-4-[(3-{[2-(butanoylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl} d) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C25H42N7O17P3S
                      synonyms: 4:0-CoA;Butyryl-CoA;Butyryl-coa;Butyryl-coenzyme A;C4:0-CoA;Coenzyme A, S-butanoate;S-Butyryl-coenzym-A;S-butanoyl-CoA;S-butanoy
                      kegg id: C00136
                      status:
                      exact mass: 837.157
                      lipidmaps
                      localization: Mitochondria
                      notes:
                      In GG pathway ACADM instead ACADMS!

                      1.3.3.6 Acyl-CoA oxidase.

                      Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2). (kegg)
                      proteins
                      Q15067 ACOX1_HUMAN
                      O15254 ACOX3_HUMAN

                      details
                      ["Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18)."]


                      map 1: Mitochondrial long chain fatty acid beta-oxidation

                      proteins:
                      • acyl-CoA dehydrogenase, C-2 to C-3 short chain [ACADS] ncbi lipid_maps

                      Crotonoyl-CoA + FADH(2

                      (3'-phosphoadenosine 5'-{3-[(3R)-4-({3-[(2-{[(2E)-but-2-enoyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-3-hydroxy-2,2-dimethyl-4-o) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C25H40N7O17P3S
                      synonyms: (E)-but-2-enoyl-CoA;trans-butyr-2-enoyl-CoA
                      kegg id: C00877
                      exact mass: 835.141
                      status:
                      lipidmaps

                      Crotonoyl-CoA + H2O

                      (3'-phosphoadenosine 5'-{3-[(3R)-4-({3-[(2-{[(2E)-but-2-enoyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-3-hydroxy-2,2-dimethyl-4-o) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C25H40N7O17P3S
                      synonyms: (E)-but-2-enoyl-CoA;trans-butyr-2-enoyl-CoA
                      kegg id: C00877
                      status:
                      exact mass: 835.141
                      lipidmaps
                      localization: Mitochondria
                      notes:
                      In GG pathway ACADM instead ACADMS!

                      4.2.1.74 Long-chain-enoyl-CoA hydratase.

                      (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H(2)O. (kegg)
                      proteins

                      details
                      ["Acts in the reverse direction.", "The best substrate is oct-3-enoyl-CoA.", "Unlike EC 4.2.1.17 does not act on crotonoyl-CoA."]


                      map 1: Mitochondrial long chain fatty acid beta-oxidation

                      proteins:
                      • enoyl CoA hydratase, short chain, 1, mitochondrial [ECHS1] ncbi lipid_maps
                      • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [HADHA] ncbi lipid_maps
                      • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [HADHB] ncbi lipid_maps
                        regulators:
                        MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                      (S)-3-hydroxybutanoyl-CoA

                      (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-4-({3-[(2-{[(3S)-3-hydroxybutanoyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-2,2-dimeth) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C25H42N7O18P3S
                      synonyms: (3S)-3-hydroxybutanoyl-CoA;(S)-3-hydroxybutyroyl-CoA;L(+)-3-hydroxybutyroyl-CoA;L(+)-beta-hydroxybutyroyl-CoA;L-3-hydroxybutanoy
                      exact mass: 853.152
                      status:
                      lipidmaps

                      (S)-3-hydroxybutanoyl-CoA + NAD(+)

                      (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-4-({3-[(2-{[(3S)-3-hydroxybutanoyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-2,2-dimeth) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C25H42N7O18P3S
                      synonyms: (3S)-3-hydroxybutanoyl-CoA;(S)-3-hydroxybutyroyl-CoA;L(+)-3-hydroxybutyroyl-CoA;L(+)-beta-hydroxybutyroyl-CoA;L-3-hydroxybutanoy
                      status:
                      exact mass: 853.152
                      lipidmaps
                      localization: Mitochondria
                      notes:
                      In GG pathway ACADM instead ACADMS!

                      1.1.1.35 3-hydroxyacyl-CoA dehydrogenase.

                      (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. (kegg)
                      proteins
                      Q08426 ECHP_HUMAN
                      Q99714 HCD2_HUMAN
                      Q16836 HCDH_HUMAN

                      details
                      ["Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate.", "Some enzymes act, more slowly, with NADP(+).", "Broad specificity to acyl chain-length (cf. EC 1.1.1.211)."]


                      map 1: Mitochondrial long chain fatty acid beta-oxidation

                      proteins:
                      • hydroxyacyl-CoA dehydrogenase [HADH] ncbi lipid_maps
                        regulators:
                        STAT6 ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                      • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [HADHA] ncbi lipid_maps
                      • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [HADHB] ncbi lipid_maps
                        regulators:
                        MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                      Acetoacetyl-CoA + NADH + H+

                      (Acetoacetyl-CoA) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C25H40N7O18P3S
                      kegg id: C00332
                      exact mass: 851.136
                      status:
                      lipidmaps
                      pubchem substance url

                      Acetoacetyl-CoA + CoA

                      (Acetoacetyl-CoA) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C25H40N7O18P3S
                      kegg id: C00332
                      status:
                      exact mass: 851.136
                      lipidmaps
                      pubchem substance url
                      localization: Mitochondria
                      notes:
                      In GG pathway ACADM instead ACADMS!

                      2.3.1.16 Acetyl-CoA C-acyltransferase.

                      Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. (kegg)
                      proteins
                      P55084 ECHB_HUMAN
                      P09110 THIK_HUMAN
                      P42765 THIM_HUMAN


                      map 1: Mitochondrial long chain fatty acid beta-oxidation

                      proteins:
                      • acetyl-CoA acyltransferase 2 [ACAA2] ncbi lipid_maps
                      • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit [HADHA] ncbi lipid_maps
                      • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit [HADHB] ncbi lipid_maps
                        regulators:
                        MIR33A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                      Acetyl-CoA

                      (3'-phosphoadenosine 5'-(3-{(3R)-4-[(3-{[2-(acetylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl} dih) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C23H38N7O17P3S
                      synonyms: AcCoA;S-acetyl-CoA;S-acetyl-coenzyme A
                      kegg id: C00024
                      exact mass: 809.126
                      status:
                      lipidmaps

                      Acetoacetyl-CoA + H2O + acetyl-CoA

                      (Acetoacetyl-CoA) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C25H40N7O18P3S
                      kegg id: C00332
                      status:
                      exact mass: 851.136
                      lipidmaps
                      pubchem substance url
                      localization: Mitochondria

                      2.3.3.10 Hydroxymethylglutaryl-CoA synthase.

                      Acetyl-CoA + H(2)O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. (kegg)
                      proteins
                      Q01581 HMCS1_HUMAN
                      P54868 HMCS2_HUMAN

                      details
                      ["Formerly EC 4.1.3.5."]


                      map 1: Mitochondrial long chain fatty acid beta-oxidation

                      proteins:
                      • 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) [HMGCS2] ncbi lipid_maps

                      HMG-CoA + CoA

                      (3S-Hydroxy-3-methyl-glutaryl CoA) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty esters [FA07]
                      sub_class: Fatty acyl CoAs [FA0705]
                      formula: C27H44N7O20P3S
                      synonyms: 3-Hydroxy-3-methyl-glutaryl CoA
                      exact mass: 911.157
                      status:
                      lipidmaps
                      pubchem substance url

                      Arachidonic acid + O2

                      (5Z,8Z,11Z,14Z-eicosatetraenoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty Acids and Conjugates [FA01]
                      sub_class: Unsaturated fatty acids [FA0103]
                      formula: C20H32O2
                      synonyms: 5Z,8Z,11Z,14Z-icosatetraenoic acid; AA; Arachidonate; cis-5,8,11,14-Eicosatetraenoic acid; (all-Z)-5,8,11,14-Eicosatetraenoic ac
                      kegg id: C00219
                      status:
                      exact mass: 304.24
                      lipidmaps
                      pubchem substance url
                      localization: Cytoplasm

                      1.13.11.31 Arachidonate 12-lipoxygenase.

                      Arachidonate + O(2) = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa- 5,8,10,14-tetraenoate. (kegg)
                      proteins
                      P18054 LOX12_HUMAN
                      P16050 LOX15_HUMAN

                      details
                      ["The product is rapidly reduced to the corresponding 12S-hydroxy compound."]


                      map 1: HETE and HPETE biosynthesis and metabolism

                      proteins:

                      12S-HpETE

                      (12S-hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Eicosanoids [FA03]
                      sub_class: Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]
                      formula: C20H32O4
                      kegg id: C05965
                      exact mass: 336.23
                      status:
                      lipidmaps
                      pubchem substance url

                      LTC4 + H2O

                      (5S-hydroxy,6R-(S-glutathionyl),7E,9E,11Z,14Z-eicosatetraenoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Eicosanoids [FA03]
                      sub_class: Leukotrienes [FA0302]
                      formula: C30H47N3O9S
                      synonyms: Leukotriene C4
                      kegg id: C02166
                      status:
                      exact mass: 625.303
                      lipidmaps
                      pubchem substance url
                      localization: extracellular

                      2.3.2.2 Gamma-glutamyltransferase.

                      A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid. (kegg)
                      proteins
                      P19440 GGT1_HUMAN
                      A6NGU5 GGT3_HUMAN
                      P36269 GGT5_HUMAN
                      Q6P531 GGT6_HUMAN
                      Q9UJ14 GGT7_HUMAN

                      details
                      ["The mammlian enzyme is part of the cell antioxidant defense mechanism.", "It initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH levels.", "The protein also has EC 3.4.19.13 activity.", "The enzyme consists of two chains that are created by the proteolytic cleavage of a single precursor polypeptide.", "The N-terminal L-threonine of the C-terminal subunit functions as the active site for both the cleavage and the hydrolysis reactions."]


                      map 1: Leukotriene biosynthesis and metabolism

                      proteins:

                      LTD4 + L-Glutamic acid

                      (5S-hydroxy-6R-(S-cysteinylglycinyl)-7E,9E,11E,14Z-eicosatetraenoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Eicosanoids [FA03]
                      sub_class: Leukotrienes [FA0302]
                      formula: C25H40N2O6S
                      synonyms: Leukotriene D4
                      kegg id: C05951
                      exact mass: 496.261
                      status:
                      lipidmaps
                      pubchem substance url

                      2-methoxy-12-methyloctadec-17-en-5-ynoyl anhydride + Glutathione

                      (2-methoxy-12-methyloctadec-17-en-5-ynoyl anhydride) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Other Fatty Acyls [FA00]
                      formula: C40H66O5
                      synonyms: Acetylenic acids
                      status:
                      exact mass: 626.491
                      lipidmaps
                      pubchem substance url
                      localization: Cytoplasm

                      1.11.1.9 Glutathione peroxidase.

                      2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O. (kegg)
                      proteins
                      P07203 GPX1_HUMAN
                      P18283 GPX2_HUMAN
                      P22352 GPX3_HUMAN
                      O75715 GPX5_HUMAN
                      P59796 GPX6_HUMAN
                      Q96SL4 GPX7_HUMAN
                      Q8TED1 GPX8_HUMAN
                      P30041 PRDX6_HUMAN

                      details
                      ["Steroid and lipid hydroperoxides, but not the product of reaction of EC 1.13.11.12 on phospholipids, can act as acceptor, but more slowly than H(2)O(2) (cf. EC 1.11.1.12)."]


                      proteins:
                      • glutathione peroxidase 1 [GPX1] ncbi lipid_maps
                        regulators:
                        TP53 ( transcriptional regulation ) /2 (2, 0, 0)/ rzmd

                      12S-HETE

                      (12S-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Eicosanoids [FA03]
                      sub_class: Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]
                      formula: C20H32O3
                      kegg id: C14777
                      exact mass: 320.235
                      status:
                      lipidmaps
                      pubchem substance url

                      12S-HpETE + O2

                      (12S-hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Eicosanoids [FA03]
                      sub_class: Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]
                      formula: C20H32O4
                      kegg id: C05965
                      status:
                      exact mass: 336.23
                      lipidmaps
                      pubchem substance url
                      localization: Cytoplasm

                      1.13.11.34 Arachidonate 5-lipoxygenase.

                      Arachidonate + O(2) = leukotriene A(4) + H(2)O. (kegg)
                      proteins
                      P09917 LOX5_HUMAN


                      map 1: HETE and HPETE biosynthesis and metabolism

                      proteins:
                      • arachidonate 5-lipoxygenase [ALOX5] ncbi lipid_maps
                        regulators:
                        MIR216A ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                      5,12-diHPETE

                      (5,12-dihydroperoxy-6,8,10,14-eicosatetraenoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Eicosanoids [FA03]
                      sub_class: Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]
                      formula: C20H32O6
                      exact mass: 368.22
                      status:
                      lipidmaps
                      pubchem substance url

                      5,12-diHPETE

                      (5,12-dihydroperoxy-6,8,10,14-eicosatetraenoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Eicosanoids [FA03]
                      sub_class: Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]
                      formula: C20H32O6
                      exact mass: 368.22
                      status:
                      lipidmaps
                      pubchem substance url

                      5S-HpETE + O2

                      (5S-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Eicosanoids [FA03]
                      sub_class: Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]
                      formula: C20H32O4
                      synonyms: 5-HpETE
                      kegg id: C05356
                      status:
                      exact mass: 336.23
                      lipidmaps
                      pubchem substance url
                      localization: Cytoplasm

                      1.13.11.33 Arachidonate 15-lipoxygenase.

                      Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa- 5,8,11,13-tetraenoate. (kegg)
                      proteins
                      P16050 LOX15_HUMAN
                      O15296 LX15B_HUMAN

                      details
                      ["The product is rapidly converted to the corresponding 15S-hydroxy compound."]


                      map 1: HETE and HPETE biosynthesis and metabolism

                      proteins:

                      5,15-diHPETE

                      (5,15-dihydroperoxy-6,8,11,13-eicosatetraenoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Eicosanoids [FA03]
                      sub_class: Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]
                      formula: C20H32O6
                      exact mass: 368.22
                      status:
                      lipidmaps
                      pubchem substance url

                      Arachidonic acid + NADPH + H+

                      (5Z,8Z,11Z,14Z-eicosatetraenoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty Acids and Conjugates [FA01]
                      sub_class: Unsaturated fatty acids [FA0103]
                      formula: C20H32O2
                      synonyms: 5Z,8Z,11Z,14Z-icosatetraenoic acid; AA; Arachidonate; cis-5,8,11,14-Eicosatetraenoic acid; (all-Z)-5,8,11,14-Eicosatetraenoic ac
                      kegg id: C00219
                      status:
                      exact mass: 304.24
                      lipidmaps
                      pubchem substance url
                      localization: reticulum

                      1.14.14.1 Unspecific monooxygenase.

                      RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O. (kegg)
                      proteins
                      P04798 CP1A1_HUMAN
                      P05177 CP1A2_HUMAN
                      Q16678 CP1B1_HUMAN
                      P20853 CP2A7_HUMAN
                      Q16696 CP2AD_HUMAN
                      P10632 CP2C8_HUMAN
                      P33260 CP2CI_HUMAN
                      P10635 CP2D6_HUMAN
                      A0A087X1C5 CP2D7_HUMAN
                      P24903 CP2F1_HUMAN
                      P51589 CP2J2_HUMAN
                      Q96SQ9 CP2S1_HUMAN
                      Q7Z449 CP2U1_HUMAN
                      Q9HB55 CP343_HUMAN
                      P08684 CP3A4_HUMAN
                      P20815 CP3A5_HUMAN
                      P24462 CP3A7_HUMAN
                      P13584 CP4B1_HUMAN
                      P98187 CP4F8_HUMAN
                      Q9HCS2 CP4FC_HUMAN
                      Q8N118 CP4X1_HUMAN
                      Q86W10 CP4Z1_HUMAN

                      details
                      ["Acts on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups.", "Together with EC 1.6.2.4, it forms a system in which two reducing equivalents are supplied by NADPH.", "Some of the reactions attributed to EC 1.14.15.3 belong here.", "Formerly EC 1.14.1.1, EC 1.14.14.2, EC 1.14.99.8 and EC 1.99.1.1."]


                      map 1: HETE and HPETE biosynthesis and metabolism

                      proteins:
                      • cytochrome P450, family 2, subfamily J, polypeptide 2 [CYP2J2] ncbi lipid_maps
                        regulators:
                        JUN ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd

                      (+/-)8,9-EpETrE + NADP(+) + H2O

                      (8,9-epoxy-5Z,11Z,14Z-eicosatrienoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Eicosanoids [FA03]
                      sub_class: Epoxyeicosatrienoic acids [FA0308]
                      formula: C20H32O3
                      synonyms: 8,9-EET
                      kegg id: C14769
                      exact mass: 320.235
                      status:
                      lipidmaps
                      pubchem substance url

                      (+/-)8,9-EpETrE + H2O

                      (8,9-epoxy-5Z,11Z,14Z-eicosatrienoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Eicosanoids [FA03]
                      sub_class: Epoxyeicosatrienoic acids [FA0308]
                      formula: C20H32O3
                      synonyms: 8,9-EET
                      kegg id: C14769
                      status:
                      exact mass: 320.235
                      lipidmaps
                      pubchem substance url
                      localization: reticulum

                      3.3.2.- Ether hydrolases.

                      (kegg)
                      proteins


                      map 1: HETE and HPETE biosynthesis and metabolism

                      proteins:

                      (+/-)8,9-DiHETrE

                      (8,9-dihydroxy-5Z,11Z,14Z-eicosatrienoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Eicosanoids [FA03]
                      sub_class: Hydroxy/hydroperoxyeicosatrienoic acids [FA0305]
                      formula: C20H34O4
                      kegg id: C14773
                      exact mass: 338.246
                      status:
                      lipidmaps
                      pubchem substance url

                      Arachidonic acid + NADPH + H+

                      (5Z,8Z,11Z,14Z-eicosatetraenoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty Acids and Conjugates [FA01]
                      sub_class: Unsaturated fatty acids [FA0103]
                      formula: C20H32O2
                      synonyms: 5Z,8Z,11Z,14Z-icosatetraenoic acid; AA; Arachidonate; cis-5,8,11,14-Eicosatetraenoic acid; (all-Z)-5,8,11,14-Eicosatetraenoic ac
                      kegg id: C00219
                      status:
                      exact mass: 304.24
                      lipidmaps
                      pubchem substance url
                      localization: reticulum

                      1.14.14.1 Unspecific monooxygenase.

                      RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O. (kegg)
                      proteins
                      P04798 CP1A1_HUMAN
                      P05177 CP1A2_HUMAN
                      Q16678 CP1B1_HUMAN
                      P20853 CP2A7_HUMAN
                      Q16696 CP2AD_HUMAN
                      P10632 CP2C8_HUMAN
                      P33260 CP2CI_HUMAN
                      P10635 CP2D6_HUMAN
                      A0A087X1C5 CP2D7_HUMAN
                      P24903 CP2F1_HUMAN
                      P51589 CP2J2_HUMAN
                      Q96SQ9 CP2S1_HUMAN
                      Q7Z449 CP2U1_HUMAN
                      Q9HB55 CP343_HUMAN
                      P08684 CP3A4_HUMAN
                      P20815 CP3A5_HUMAN
                      P24462 CP3A7_HUMAN
                      P13584 CP4B1_HUMAN
                      P98187 CP4F8_HUMAN
                      Q9HCS2 CP4FC_HUMAN
                      Q8N118 CP4X1_HUMAN
                      Q86W10 CP4Z1_HUMAN

                      details
                      ["Acts on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups.", "Together with EC 1.6.2.4, it forms a system in which two reducing equivalents are supplied by NADPH.", "Some of the reactions attributed to EC 1.14.15.3 belong here.", "Formerly EC 1.14.1.1, EC 1.14.14.2, EC 1.14.99.8 and EC 1.99.1.1."]


                      map 1: HETE and HPETE biosynthesis and metabolism

                      proteins:
                      • cytochrome P450, family 2, subfamily E, polypeptide 1 [CYP2E1] ncbi lipid_maps
                      • cytochrome P450, family 2, subfamily J, polypeptide 2 [CYP2J2] ncbi lipid_maps
                        regulators:
                        JUN ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd

                      19-HETE + NADP(+) + H2O

                      ((5Z,8Z,11Z,14Z)-19-hydroxy-5,8,11,14-icosatetraenoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Eicosanoids [FA03]
                      sub_class: Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]
                      formula: C20H32O3
                      synonyms: (5Z,8Z,11Z,14Z)-19-hydroxy-5,8,11,14-eicosatetraenoic acid;(all-cis)-19-hydroxy-5,8,11,14-eicosatetraenoic acid;(all-cis)-19-hyd
                      exact mass: 320.235
                      status:
                      lipidmaps

                      Arachidonic acid + NADPH + H+ + O2

                      (5Z,8Z,11Z,14Z-eicosatetraenoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty Acids and Conjugates [FA01]
                      sub_class: Unsaturated fatty acids [FA0103]
                      formula: C20H32O2
                      synonyms: 5Z,8Z,11Z,14Z-icosatetraenoic acid; AA; Arachidonate; cis-5,8,11,14-Eicosatetraenoic acid; (all-Z)-5,8,11,14-Eicosatetraenoic ac
                      kegg id: C00219
                      status:
                      exact mass: 304.24
                      lipidmaps
                      pubchem substance url
                      localization: reticulum

                      1.14.13.30 Leukotriene-B(4) 20-monooxygenase.

                      (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + O(2) = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa- 6,8,10,14-tetraenoate + NADP(+) + H(2)O. (kegg)
                      proteins
                      P78329 CP4F2_HUMAN
                      Q08477 CP4F3_HUMAN

                      details
                      ["Not identical with EC 1.14.13.34."]


                      map 1: HETE and HPETE biosynthesis and metabolism

                      proteins:
                      • cytochrome P450, family 4, subfamily F, polypeptide 2 [CYP4F2] ncbi lipid_maps
                      • cytochrome P450, family 4, subfamily F, polypeptide 3 [CYP4F3] ncbi lipid_maps
                      • cytochrome P450, family 4, subfamily A, polypeptide 11 [CYP4A11] ncbi lipid_maps

                      20-HETE + H2O + NADP(+)

                      (20-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Eicosanoids [FA03]
                      sub_class: Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]
                      formula: C20H32O3
                      synonyms: 20-hydroxy Arachidonic Acid
                      kegg id: C14748
                      exact mass: 320.235
                      status:
                      lipidmaps
                      pubchem substance url

                      Arachidonic acid + O2

                      (5Z,8Z,11Z,14Z-eicosatetraenoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Fatty Acids and Conjugates [FA01]
                      sub_class: Unsaturated fatty acids [FA0103]
                      formula: C20H32O2
                      synonyms: 5Z,8Z,11Z,14Z-icosatetraenoic acid; AA; Arachidonate; cis-5,8,11,14-Eicosatetraenoic acid; (all-Z)-5,8,11,14-Eicosatetraenoic ac
                      kegg id: C00219
                      status:
                      exact mass: 304.24
                      lipidmaps
                      pubchem substance url
                      localization: Cytoplasm

                      1.13.11.- With incorporation of two atoms of oxygen.

                      (kegg)
                      proteins


                      map 1: HETE and HPETE biosynthesis and metabolism

                      proteins:
                      • arachidonate 12-lipoxygenase, 12R type [ALOX12B] ncbi lipid_maps
                        regulators:
                        MIR185 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                        TP63 ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd

                      12R-HpETE

                      (12R-hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Eicosanoids [FA03]
                      sub_class: Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]
                      formula: C20H32O4
                      kegg id: C14812
                      exact mass: 336.23
                      status:
                      lipidmaps
                      pubchem substance url

                      12R-HpETE + Glutathione

                      (12R-hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Eicosanoids [FA03]
                      sub_class: Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]
                      formula: C20H32O4
                      kegg id: C14812
                      status:
                      exact mass: 336.23
                      lipidmaps
                      pubchem substance url
                      localization: Cytoplasm

                      1.11.1.9 Glutathione peroxidase.

                      2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O. (kegg)
                      proteins
                      P07203 GPX1_HUMAN
                      P18283 GPX2_HUMAN
                      P22352 GPX3_HUMAN
                      O75715 GPX5_HUMAN
                      P59796 GPX6_HUMAN
                      Q96SL4 GPX7_HUMAN
                      Q8TED1 GPX8_HUMAN
                      P30041 PRDX6_HUMAN

                      details
                      ["Steroid and lipid hydroperoxides, but not the product of reaction of EC 1.13.11.12 on phospholipids, can act as acceptor, but more slowly than H(2)O(2) (cf. EC 1.11.1.12)."]


                      map 1: HETE and HPETE biosynthesis and metabolism

                      proteins:
                      • glutathione peroxidase 1 [GPX1] ncbi lipid_maps
                        regulators:
                        TP53 ( transcriptional regulation ) /2 (2, 0, 0)/ rzmd

                      12R-HETE + H2O + Oxi-glutathione

                      (12R-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Eicosanoids [FA03]
                      sub_class: Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]
                      formula: C20H32O3
                      kegg id: C14822
                      exact mass: 320.235
                      status:
                      lipidmaps
                      pubchem substance url

                      5S-HpETE + O2

                      (5S-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Eicosanoids [FA03]
                      sub_class: Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]
                      formula: C20H32O4
                      synonyms: 5-HpETE
                      kegg id: C05356
                      status:
                      exact mass: 336.23
                      lipidmaps
                      pubchem substance url
                      localization: Cytoplasm

                      1.13.11.31 Arachidonate 12-lipoxygenase.

                      Arachidonate + O(2) = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa- 5,8,10,14-tetraenoate. (kegg)
                      proteins
                      P18054 LOX12_HUMAN
                      P16050 LOX15_HUMAN

                      details
                      ["The product is rapidly reduced to the corresponding 12S-hydroxy compound."]


                      map 1: HETE and HPETE biosynthesis and metabolism

                      proteins:

                      5,12-diHPETE

                      (5,12-dihydroperoxy-6,8,10,14-eicosatetraenoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Eicosanoids [FA03]
                      sub_class: Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]
                      formula: C20H32O6
                      exact mass: 368.22
                      status:
                      lipidmaps
                      pubchem substance url

                      5S-HpETE + Glutathione

                      (5S-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid) (lipid link)
                      category: Fatty Acyls [FA]
                      main_class: Eicosanoids [FA03]
                      sub_class: Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]
                      formula: C20H32O4
                      synonyms: 5-HpETE
                      kegg id: C05356
                      status:
                      exact mass: 336.23
                      lipidmaps
                      pubchem substance url
                      localization: Cytoplasm

                      2.5.1.18 Glutathione transferase.

                      RX + glutathione = HX + R-S-glutathione. (kegg)
                      proteins
                      P0CG29 GST2_HUMAN
                      P08263 GSTA1_HUMAN
                      P09210 GSTA2_HUMAN
                      Q16772 GSTA3_HUMAN
                      O15217 GSTA4_HUMAN
                      Q7RTV2 GSTA5_HUMAN
                      Q9Y2Q3 GSTK1_HUMAN
                      P09488 GSTM1_HUMAN
                      P28161 GSTM2_HUMAN
                      P21266 GSTM3_HUMAN
                      Q03013 GSTM4_HUMAN
                      P46439 GSTM5_HUMAN
                      P78417 GSTO1_HUMAN
                      Q9H4Y5 GSTO2_HUMAN
                      P09211 GSTP1_HUMAN
                      P30711 GSTT1_HUMAN
                      P0CG30 GSTT2_HUMAN
                      O60760 HPGDS_HUMAN
                      O43708 MAAI_HUMAN
                      P10620 MGST1_HUMAN
                      Q99735 MGST2_HUMAN
                      O14880 MGST3_HUMAN

                      details
                      ["A group of enzymes of broad specificity.", "R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.", "Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange.", "Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7."]


                      map 1: HETE and HPETE biosynthesis and metabolism

                      proteins:

                        5S-HETE + Oxi-glutathione + H2O

                        (5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid) (lipid link)
                        category: Fatty Acyls [FA]
                        main_class: Eicosanoids [FA03]
                        sub_class: Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]
                        formula: C20H32O3
                        kegg id: C04805
                        exact mass: 320.235
                        status:
                        lipidmaps
                        pubchem substance url

                        sn-Glycerol 3-phosphate + NAD(+)

                        () (lipid link)
                        category:
                        main_class:
                        sub_class:
                        formula: C3H9O6P
                        synonyms: Glycerophosphoric acid; D-Glycerol 1-phosphate
                        kegg id: C00093
                        status:
                        exact mass: 172.014
                        pubchem substance url
                        localization: Unknown

                        1.1.1.8 Glycerol-3-phosphate dehydrogenase (NAD(+)).

                        sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. (kegg)
                        proteins
                        Q8N335 GPD1L_HUMAN
                        P21695 GPDA_HUMAN

                        details
                        ["Also acts on propane-1,2-diol phosphate and glycerone sulfate (but with a much lower affinity)."]


                        map 1: Glycerophospholipid metabolism

                        proteins:
                        • glycerol-3-phosphate dehydrogenase 1-like [GPD1L] ncbi lipid_maps
                          regulators:
                          MIR210 ( microRNA binding ) /2 (0, 2, 0)/ rzmd
                        • glycerol-3-phosphate dehydrogenase 1 (soluble) [GPD1] ncbi lipid_maps
                          regulators:
                          MLXIPL ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                          PPARG ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                          PPARA ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd

                        Glycerone phosphate + NADH

                        (3-Hydroxy-2-oxopropyl phosphate) (lipid link)
                        category:
                        main_class:
                        sub_class:
                        formula: C3H7O6P
                        synonyms: Dihydroxyacetone phosphate; 3-Hydroxy-2-oxopropyl phosphate
                        kegg id: C00111
                        exact mass: 169.998
                        status:

                        sn-Glycerol 3-phosphate + Quinone

                        () (lipid link)
                        category:
                        main_class:
                        sub_class:
                        formula: C3H9O6P
                        synonyms: Glycerophosphoric acid; D-Glycerol 1-phosphate
                        kegg id: C00093
                        status:
                        exact mass: 172.014
                        pubchem substance url
                        localization: mitochondrial membrane

                        1.1.5.3 Glycerol-3-phosphate dehydrogenase.

                        sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol. (kegg)
                        proteins
                        P43304 GPDM_HUMAN

                        details
                        ["An essential membrane enzyme, functioning at the central junction of glycolysis, respiration and phospholipid biosynthesis.", "In bacteria, the enzyme is localized to the cytoplasmic membrane, while in eukaryotes it is tightly bound to the outer surface of the inner mitochondrial membrane.", "In eukaryotes, this enzyme, together with the cytosolic enzyme EC 1.1.1.8 forms the glycerol-3-phosphate shuttle by which NADH produced in the cytosol, primarily from glycolysis, can be reoxidized to NAD(+) by the mitochondrial electron-transport chain.", "This shuttle plays a critical role in transferring reducing equivalents from cytosolic NADH into the mitochondrial matrix.", "Insect flight muscle uses only CoQ(10) as the physiological quinone whereas hamster and rat mitochondria use mainly CoQ(9).", "The enzyme is activated by calcium.", "Formerly EC 1.1.2.1 and EC 1.1.99.5."]


                        map 1: Glycerophospholipid metabolism

                        proteins:
                        • glycerol-3-phosphate dehydrogenase 2 (mitochondrial) [GPD2] ncbi lipid_maps

                        Glycerone phosphate + Hydroquinone

                        (3-Hydroxy-2-oxopropyl phosphate) (lipid link)
                        category:
                        main_class:
                        sub_class:
                        formula: C3H7O6P
                        synonyms: Dihydroxyacetone phosphate; 3-Hydroxy-2-oxopropyl phosphate
                        kegg id: C00111
                        exact mass: 169.998
                        status:

                        sn-Glycerol 3-phosphate + Acyl-CoA

                        () (lipid link)
                        category:
                        main_class:
                        sub_class:
                        formula: C3H9O6P
                        synonyms: Glycerophosphoric acid; D-Glycerol 1-phosphate
                        kegg id: C00093
                        status:
                        exact mass: 172.014
                        pubchem substance url
                        localization: Mitochondria

                        2.3.1.15 Glycerol-3-phosphate 1-O-acyltransferase.

                        Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate. (kegg)
                        proteins
                        Q9HCL2 GPAT1_HUMAN
                        Q6NUI2 GPAT2_HUMAN
                        Q53EU6 GPAT3_HUMAN
                        Q86UL3 GPAT4_HUMAN

                        details
                        ["Acyl-[acyl-carrier-protein] can also act as acyl donor.", "Acts only with derivatives of fatty acids of chain length above C(10)."]


                        map 1: Glycerophospholipid metabolism
                        map 2: Glycerolipid metabolism

                        proteins:

                        1-Acyl-sn-glycerol 3-phosphate + CoA

                        () (lipid link)
                        category:
                        main_class:
                        sub_class:
                        formula: C4H8O7PR
                        synonyms: 2-Lysophosphatidate; Lysophosphatidate; Lysophosphatidic acid
                        kegg id: C00681
                        exact mass: 199.001
                        status:

                        1,2-Diacyl-sn-glycerol 3-phosphate + CoA

                        (1,2-Diacyl-sn-glycerol 3-phosphate) (lipid link)
                        category:
                        main_class:
                        sub_class:
                        formula: C5H7O8PR2
                        synonyms: Phosphatidate; Phosphatidic acid; 3-sn-Phosphatidate
                        kegg id: C00416
                        status:
                        exact mass: 225.988
                        lipidmaps
                        pubchem substance url
                        localization: Mitochondria

                        3.2.1.51 Alpha-L-fucosidase.

                        An alpha-L-fucoside + H(2)O = L-fucose + an alcohol. (kegg)
                        proteins
                        Q9BTY2 FUCO2_HUMAN
                        P04066 FUCO_HUMAN


                        map 1: Glycerophospholipid metabolism

                        proteins:
                        • 1-acylglycerol-3-phosphate O-acyltransferase 1 [AGPAT1] ncbi lipid_maps
                        • 1-acylglycerol-3-phosphate O-acyltransferase 2 [AGPAT2] ncbi lipid_maps
                        • membrane bound O-acyltransferase domain containing 2 [MBOAT2] ncbi lipid_maps
                        • membrane bound O-acyltransferase domain containing 2 [MBOAT2] ncbi lipid_maps
                        • lysocardiolipin acyltransferase 1 [LCLAT1] ncbi lipid_maps
                        • 1-acylglycerol-3-phosphate O-acyltransferase 5 [AGPAT5] ncbi lipid_maps
                        • 1-acylglycerol-3-phosphate O-acyltransferase 3 [AGPAT3] ncbi lipid_maps

                        1-Acyl-sn-glycerol 3-phosphate + Acyl-CoA

                        () (lipid link)
                        category:
                        main_class:
                        sub_class:
                        formula: C4H8O7PR
                        synonyms: 2-Lysophosphatidate; Lysophosphatidate; Lysophosphatidic acid
                        kegg id: C00681
                        exact mass: 199.001
                        status:

                        CDP-glycerol + H2O

                        () (lipid link)
                        category:
                        main_class:
                        sub_class:
                        formula: C12H21N3O13P2
                        synonyms:
                        kegg id: C00513
                        status:
                        exact mass: 477.055
                        pubchem substance url
                        localization: Unknown
                        notes:
                        добавить CMP и prot ADPRM (http://www.ncbi.nlm.nih.gov/gene/56985)

                        3.6.1.16 CDP-glycerol diphosphatase.

                        CDP-glycerol + H(2)O = CMP + sn-glycerol 3-phosphate. (kegg)
                        proteins
                        Q3LIE5 ADPRM_HUMAN


                        map 1: Glycerophospholipid metabolism

                        proteins:
                        • ADP-ribose/CDP-alcohol diphosphatase, manganese dependent [ADPRM ] ncbi lipid_maps

                        sn-Glycerol 3-phosphate

                        () (lipid link)
                        category:
                        main_class:
                        sub_class:
                        formula: C3H9O6P
                        synonyms: Glycerophosphoric acid; D-Glycerol 1-phosphate
                        kegg id: C00093
                        exact mass: 172.014
                        status:
                        pubchem substance url

                        1,2-Diacyl-sn-glycerol 3-phosphate + CTP (Cytidine 5'-triphosphate; Cytidine triphosphate)

                        (1,2-Diacyl-sn-glycerol 3-phosphate) (lipid link)
                        category:
                        main_class:
                        sub_class:
                        formula: C5H7O8PR2
                        synonyms: Phosphatidate; Phosphatidic acid; 3-sn-Phosphatidate
                        kegg id: C00416
                        status:
                        exact mass: 225.988
                        lipidmaps
                        pubchem substance url
                        localization: Mitochondria

                        2.7.7.41 Phosphatidate cytidylyltransferase.

                        CTP + phosphatidate = diphosphate + CDP-diacylglycerol. (kegg)
                        proteins
                        Q92903 CDS1_HUMAN
                        O95674 CDS2_HUMAN
                        Q96BW9 TAM41_HUMAN


                        map 1: Glycerophospholipid metabolism

                        proteins:
                        • CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 [CDS1] ncbi lipid_maps
                          regulators:
                          PPARGC1A ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                          ESRRA ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                          PPARD ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                        • CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 [CDS2] ncbi lipid_maps

                        CDP-diacyl glycerol + PPi

                        (1,2-diacyl-sn-glycero-3-cytidine-5'-diphosphate) (lipid link)
                        category: Glycerophospholipids [GP]
                        main_class: CDP-Glycerols [GP13]
                        sub_class: CDP-diacylglycerols [GP1301]
                        formula:
                        synonyms: CDP-DAG
                        kegg id: C00269
                        exact mass:
                        status:
                        lipidmaps
                        pubchem substance url

                        5,15-diHPETE + O2

                        (5,15-dihydroperoxy-6,8,11,13-eicosatetraenoic acid) (lipid link)
                        category: Fatty Acyls [FA]
                        main_class: Eicosanoids [FA03]
                        sub_class: Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]
                        formula: C20H32O6
                        status:
                        exact mass: 368.22
                        lipidmaps
                        pubchem substance url
                        localization: Cytoplasm

                        1.13.11.34 Arachidonate 5-lipoxygenase.

                        Arachidonate + O(2) = leukotriene A(4) + H(2)O. (kegg)
                        proteins
                        P09917 LOX5_HUMAN


                        map 1: HETE and HPETE biosynthesis and metabolism

                        proteins:

                          15S-HpETE

                          (15S-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoic acid) (lipid link)
                          category: Fatty Acyls [FA]
                          main_class: Eicosanoids [FA03]
                          sub_class: Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306]
                          formula: C20H32O4
                          synonyms: 15-HpETE
                          kegg id: C05966
                          exact mass: 336.23
                          status:
                          lipidmaps
                          pubchem substance url

                          CDP-diacyl glycerol

                          (1,2-diacyl-sn-glycero-3-cytidine-5'-diphosphate) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: CDP-Glycerols [GP13]
                          sub_class: CDP-diacylglycerols [GP1301]
                          formula:
                          synonyms: CDP-DAG
                          kegg id: C00269
                          status:
                          exact mass:
                          lipidmaps
                          pubchem substance url
                          localization: Cytoplasm
                          notes:
                          i

                          2.7.8.11 CDP-diacylglycerol--inositol 3-phosphatidyltransferase.

                          CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol. (kegg)
                          proteins
                          O14735 CDIPT_HUMAN


                          map 1: Glycerophospholipid metabolism

                          proteins:
                          • CDP-diacylglycerol--inositol 3-phosphatidyltransferase [CDIPT] ncbi lipid_maps

                          Phosphatidylinositol + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                          (1,2-diacyl-sn-glycero-3-phospho-(1-myo-inositol)) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphoinositols [GP06]
                          sub_class: Diacylglycerophosphoinositols [GP0601]
                          formula:
                          synonyms: 1-Phosphatidyl-D-myo-inositol; 1-Phosphatidyl-1D-myo-inositol; 1-Phosphatidyl-myo-inositol; Phosphatidyl-1D-myo-inositol; (3-Phosphatidyl)-1-D-inositol; Phosphatidylinositol; PI
                          kegg id: C01194
                          exact mass: 0
                          status:
                          lipidmaps
                          pubchem substance url

                          myo-Inositol

                          () (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C6H12O6
                          synonyms: D-myo-Inositol; 1D-myo-Inositol; L-myo-Inositol; 1L-myo-Inositol; meso-Inositol; Inositol
                          kegg id: C00137
                          status:
                          exact mass: 180.063
                          pubchem substance url
                          localization: Cytoplasm
                          notes:
                          i

                          2.7.8.11 CDP-diacylglycerol--inositol 3-phosphatidyltransferase.

                          CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol. (kegg)
                          proteins
                          O14735 CDIPT_HUMAN


                          map 1: Glycerophospholipid metabolism

                          proteins:
                          • CDP-diacylglycerol--inositol 3-phosphatidyltransferase [CDIPT] ncbi lipid_maps

                          Phosphatidylinositol + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                          (1,2-diacyl-sn-glycero-3-phospho-(1-myo-inositol)) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphoinositols [GP06]
                          sub_class: Diacylglycerophosphoinositols [GP0601]
                          formula:
                          synonyms: 1-Phosphatidyl-D-myo-inositol; 1-Phosphatidyl-1D-myo-inositol; 1-Phosphatidyl-myo-inositol; Phosphatidyl-1D-myo-inositol; (3-Phosphatidyl)-1-D-inositol; Phosphatidylinositol; PI
                          kegg id: C01194
                          exact mass: 0
                          status:
                          lipidmaps
                          pubchem substance url

                          L-serine

                          () (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C3H7NO3
                          synonyms: serine
                          kegg id:
                          status:
                          exact mass: 105.043
                          localization: Cytoplasm

                          2.3.1.50 Serine C-palmitoyltransferase.

                          Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO(2). (kegg)
                          proteins
                          O15269 SPTC1_HUMAN
                          O15270 SPTC2_HUMAN
                          Q9NUV7 SPTC3_HUMAN


                          map 1: Sphingolipid metabolism

                          proteins:
                          • serine palmitoyltransferase, long chain base subunit 1 [SPTLC1] ncbi lipid_maps
                          • serine palmitoyltransferase, long chain base subunit 2 [SPTLC2] ncbi lipid_maps
                          • serine palmitoyltransferase, long chain base subunit 3 [SPTLC3] ncbi lipid_maps

                          3-ketosphinganine + CoA + CO2 + H2O

                          (3-dehydrosphinganine) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Sphingoid bases [SP01]
                          sub_class: Sphinganines [SP0102]
                          formula: C18H37NO2
                          kegg id: C02934
                          exact mass: 299.282
                          status:
                          lipidmaps
                          pubchem substance url

                          3-ketosphinganine + NADPH

                          (3-dehydrosphinganine) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Sphingoid bases [SP01]
                          sub_class: Sphinganines [SP0102]
                          formula: C18H37NO2
                          kegg id: C02934
                          status:
                          exact mass: 299.282
                          lipidmaps
                          pubchem substance url
                          localization: Cytoplasm

                          1.1.1.102 3-dehydrosphinganine reductase.

                          Sphinganine + NADP(+) = 3-dehydrosphinganine + NADPH. (kegg)
                          proteins
                          Q06136 KDSR_HUMAN


                          map 1: Sphingolipid metabolism

                          proteins:

                          Sphinganine + NADP(+)

                          (Sphinganine) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Sphingoid bases [SP01]
                          sub_class: Sphinganines [SP0102]
                          formula: C18H39NO2
                          synonyms: Dihydrosphingosine; Octadecasphinganine; D-erythro-Sphinganine; D-erythro-2-Amino-1,3-octadecanediol
                          kegg id: C00836
                          exact mass: 301.298
                          status:
                          lipidmaps
                          pubchem substance url

                          Sphinganine + ATP

                          (Sphinganine) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Sphingoid bases [SP01]
                          sub_class: Sphinganines [SP0102]
                          formula: C18H39NO2
                          synonyms: Dihydrosphingosine; Octadecasphinganine; D-erythro-Sphinganine; D-erythro-2-Amino-1,3-octadecanediol
                          kegg id: C00836
                          status:
                          exact mass: 301.298
                          lipidmaps
                          pubchem substance url
                          localization: Cytoplasm

                          2.7.1.91 Sphinganine kinase.

                          ATP + sphinganine = ADP + sphinganine 1-phosphate. (kegg)
                          proteins
                          Q9NYA1 SPHK1_HUMAN
                          Q9NRA0 SPHK2_HUMAN


                          map 1: Sphingolipid metabolism

                          proteins:
                          • sphingosine kinase 1 [SPHK1] ncbi lipid_maps
                            regulators:
                            FLNA ( binding ) /1 (1, 0, 0)/ rzmd
                            MIR124-1 ( microRNA binding ) /3 (0, 3, 0)/ rzmd
                            MIR124-2 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                            MIR124-3 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                            PPARA ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                            MIR515-1 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                            MIR506 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                            E2F1 ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                            MIR613 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                          • sphingosine kinase 2 [SPHK2] ncbi lipid_maps
                            regulators:
                            SALL4 ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd
                            MIR613 ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                          Sphinganine-phosphate + ADP

                          (Sphinganine-1-phosphate) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Sphingoid bases [SP01]
                          sub_class: Sphingoid base 1-phosphates [SP0105]
                          formula: C18H40NO5P
                          synonyms: Dihydrosphingosine phosphate
                          kegg id: C01120
                          exact mass: 381.264
                          status:
                          lipidmaps
                          pubchem substance url

                          Sphinganine-phosphate

                          (Sphinganine-1-phosphate) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Sphingoid bases [SP01]
                          sub_class: Sphingoid base 1-phosphates [SP0105]
                          formula: C18H40NO5P
                          synonyms: Dihydrosphingosine phosphate
                          kegg id: C01120
                          status:
                          exact mass: 381.264
                          lipidmaps
                          pubchem substance url
                          localization: Cytoplasm

                          4.1.2.27 Sphinganine-1-phosphate aldolase.

                          Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde. (kegg)
                          proteins
                          O95470 SGPL1_HUMAN


                          map 1: Sphingolipid metabolism

                          proteins:
                          • sphingosine-1-phosphate lyase 1 [SGPL1] ncbi lipid_maps
                            regulators:
                            MIR125B1 ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                          Palmitaldehyde

                          (hexadecanal) (lipid link)
                          category: Fatty Acyls [FA]
                          main_class: Fatty aldehydes [FA06]
                          formula: C16H32O
                          synonyms: Palmitic aldehyde
                          kegg id: C00517
                          exact mass: 240.245
                          status:
                          lipidmaps
                          pubchem substance url

                          O-Phosphoethanolamine

                          () (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula:
                          synonyms: Phosphoethanolamine
                          kegg id:
                          exact mass: 0
                          status:

                          Sphinganine + acetyl-CoA

                          (Sphinganine) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Sphingoid bases [SP01]
                          sub_class: Sphinganines [SP0102]
                          formula: C18H39NO2
                          synonyms: Dihydrosphingosine; Octadecasphinganine; D-erythro-Sphinganine; D-erythro-2-Amino-1,3-octadecanediol
                          kegg id: C00836
                          status:
                          exact mass: 301.298
                          lipidmaps
                          pubchem substance url
                          localization: Unknown

                          2.3.1.24 Sphingosine N-acyltransferase.

                          Acyl-CoA + sphingosine = CoA + N-acylsphingosine. (kegg)
                          proteins
                          Q8IU89 CERS3_HUMAN
                          Q8N5B7 CERS5_HUMAN

                          details
                          ["Acts on sphingosine or its 2-epimer."]


                          map 1: Sphingolipid metabolism

                          proteins:

                          Dihydroceramide + CoA

                          (N-acyl-sphinganine) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Ceramides [SP02]
                          sub_class: N-acylsphinganines (dihydroceramides) [SP0202]
                          formula:
                          kegg id: C12126
                          exact mass:
                          status:
                          lipidmaps
                          pubchem substance url

                          Sphingosine + ATP

                          (Sphing-4-enine) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Sphingoid bases [SP01]
                          sub_class: Sphing-4-enines (Sphingosines) [SP0101]
                          formula: C18H37NO2
                          synonyms: Sphingosine; 4-Sphingenine; D-erythro-Sphingosine; (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol; 4-trans-Sphingenine; Sphingenine; 2
                          kegg id: C00319
                          status:
                          exact mass: 299.282
                          lipidmaps
                          pubchem substance url
                          localization: Unknown

                          2.7.1.91 Sphinganine kinase.

                          ATP + sphinganine = ADP + sphinganine 1-phosphate. (kegg)
                          proteins
                          Q9NYA1 SPHK1_HUMAN
                          Q9NRA0 SPHK2_HUMAN


                          map 1: Sphingolipid metabolism

                          proteins:
                          • sphingosine kinase 1 [SPHK1] ncbi lipid_maps
                            regulators:
                            FLNA ( binding ) /1 (1, 0, 0)/ rzmd
                            MIR124-1 ( microRNA binding ) /3 (0, 3, 0)/ rzmd
                            MIR124-2 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                            MIR124-3 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                            PPARA ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                            MIR515-1 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                            MIR506 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                            E2F1 ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                            MIR613 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                          • sphingosine kinase 2 [SPHK2] ncbi lipid_maps
                            regulators:
                            SALL4 ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd
                            MIR613 ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                          Sphingosine-1-phosphate + ADP

                          (Sphing-4-enine-1-phosphate) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Sphingoid bases [SP01]
                          sub_class: Sphingoid base 1-phosphates [SP0105]
                          formula: C18H38NO5P
                          kegg id: C06124
                          exact mass: 379.249
                          status:
                          lipidmaps
                          pubchem substance url

                          Dihydroceramide + O2 + H+

                          (N-acyl-sphinganine) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Ceramides [SP02]
                          sub_class: N-acylsphinganines (dihydroceramides) [SP0202]
                          formula:
                          kegg id: C12126
                          status:
                          exact mass:
                          lipidmaps
                          pubchem substance url
                          localization: reticulum

                          1.14.-.- Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O(2).

                          (kegg)
                          proteins


                          map 1: Sphingolipid metabolism

                          proteins:

                          Ceramide + H2O

                          (N-acyl-sphing-4-enine) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Ceramides [SP02]
                          sub_class: N-acylsphingosines (ceramides) [SP0201]
                          formula:
                          synonyms: N-acylsphingosine
                          kegg id: C00195
                          exact mass:
                          status:
                          lipidmaps
                          pubchem substance url

                          Ceramide + ATP

                          (N-acyl-sphing-4-enine) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Ceramides [SP02]
                          sub_class: N-acylsphingosines (ceramides) [SP0201]
                          formula:
                          synonyms: N-acylsphingosine
                          kegg id: C00195
                          status:
                          exact mass:
                          lipidmaps
                          pubchem substance url
                          localization: reticulum

                          2.7.1.138 Ceramide kinase.

                          ATP + ceramide = ADP + ceramide 1-phosphate. (kegg)
                          proteins
                          Q8TCT0 CERK1_HUMAN


                          map 1: Sphingolipid metabolism

                          proteins:

                          N-Acyl ceramide phosphate + ADP

                          (N-(acyl)-sphing-4-enine-1-phosphate) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Ceramides [SP02]
                          sub_class: Ceramide 1-phosphates [SP0205]
                          formula:
                          kegg id: C02960
                          exact mass:
                          status:
                          lipidmaps
                          pubchem substance url

                          PC

                          (1,2-diacyl-sn-glycero-3-phosphocholine) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphocholines [GP01]
                          sub_class: Diacylglycerophosphocholines [GP0101]
                          formula: C10H18NO8P
                          synonyms: Phosphatidylcholine; Diacylphosphatidylcholine
                          kegg id: C00157
                          status:
                          exact mass: 311.077
                          lipidmaps
                          pubchem substance url
                          localization: Cytoplasm

                          2.7.8.27 Sphingomyelin synthase.

                          A ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl- sn-glycerol. (kegg)
                          proteins
                          Q86VZ5 SMS1_HUMAN
                          Q8NHU3 SMS2_HUMAN

                          details
                          ["The reaction can occur in both directions.", "Occupies a central position in sphingolipid and glycerophospholipid metabolism.", "Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signaling in a variety of mammalian cell types.", "Unlike EC 2.7.8.3 CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin."]


                          map 1: Sphingolipid metabolism

                          proteins:

                          Sphingomyelin

                          (N-acyl-sphing-4-enine-1-phosphocholine) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Phosphosphingolipids [SP03]
                          sub_class: Ceramide phosphocholines (sphingomyelins) [SP0301]
                          formula:
                          kegg id: C00550
                          exact mass:
                          status:
                          lipidmaps
                          pubchem substance url

                          Ceramide

                          (N-acyl-sphing-4-enine) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Ceramides [SP02]
                          sub_class: N-acylsphingosines (ceramides) [SP0201]
                          formula:
                          synonyms: N-acylsphingosine
                          kegg id: C00195
                          status:
                          exact mass:
                          lipidmaps
                          pubchem substance url
                          localization: Cytoplasm

                          2.7.8.27 Sphingomyelin synthase.

                          A ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl- sn-glycerol. (kegg)
                          proteins
                          Q86VZ5 SMS1_HUMAN
                          Q8NHU3 SMS2_HUMAN

                          details
                          ["The reaction can occur in both directions.", "Occupies a central position in sphingolipid and glycerophospholipid metabolism.", "Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signaling in a variety of mammalian cell types.", "Unlike EC 2.7.8.3 CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin."]


                          map 1: Sphingolipid metabolism

                          proteins:

                          Sphingomyelin

                          (N-acyl-sphing-4-enine-1-phosphocholine) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Phosphosphingolipids [SP03]
                          sub_class: Ceramide phosphocholines (sphingomyelins) [SP0301]
                          formula:
                          kegg id: C00550
                          exact mass:
                          status:
                          lipidmaps
                          pubchem substance url

                          Ceramide + UDP-D-galactose

                          (N-acyl-sphing-4-enine) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Ceramides [SP02]
                          sub_class: N-acylsphingosines (ceramides) [SP0201]
                          formula:
                          synonyms: N-acylsphingosine
                          kegg id: C00195
                          status:
                          exact mass:
                          lipidmaps
                          pubchem substance url
                          localization: reticulum

                          2.4.1.45 2-hydroxyacylsphingosine 1-beta-galactosyltransferase.

                          UDP-alpha-D-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D- galactosyl)-2-(2-hydroxyacyl)sphingosine. (kegg)
                          proteins
                          Q16880 CGT_HUMAN

                          details
                          ["Highly specific."]


                          map 1: Sphingolipid metabolism

                          proteins:

                          galactosylceramide + UDP

                          () (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C10H17NO8R2
                          synonyms: D-Galactosyl-N-acylsphingosine, galactosylceramides
                          kegg id:
                          exact mass: 0
                          status:

                          galactosylceramide

                          () (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C10H17NO8R2
                          synonyms: D-Galactosyl-N-acylsphingosine, galactosylceramides
                          kegg id:
                          status:
                          exact mass: 0
                          localization: Golgi apparatus

                          2.8.2.11 Galactosylceramide sulfotransferase.

                          3'-phosphoadenylyl sulfate + a galactosylceramide = adenosine3',5'-bisphosphate + a galactosylceramidesulfate. (kegg)
                          proteins
                          Q99999 G3ST1_HUMAN

                          details
                          ["Also acts on lactosylceramide and monogalactosylalkylacylglycerol."]


                          map 1: Sphingolipid metabolism

                          proteins:

                          Galactosylceramide sulfate

                          ((3-sulfo)Galβ-N-(acyl)-sphing-4-enine ) (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula:
                          synonyms:
                          kegg id: C06125
                          exact mass: 0
                          status:
                          lipidmaps

                          Galactosylceramide sulfate + H2O

                          ((3-sulfo)Galβ-N-(acyl)-sphing-4-enine ) (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula:
                          synonyms:
                          kegg id: C06125
                          status:
                          exact mass: 0
                          lipidmaps
                          localization: Golgi apparatus

                          3.1.6.8 Cerebroside-sulfatase.

                          A cerebroside 3-sulfate + H(2)O = a cerebroside + sulfate. (kegg)
                          proteins
                          P15289 ARSA_HUMAN

                          details
                          ["Hydrolyzes galactose-3-sulfate residues in a number of lipids.", "Also hydrolyzes ascorbate 2-sulfate and many phenol sulfates."]


                          map 1: Sphingolipid metabolism

                          proteins:

                          galactosylceramide + SO(,4)('2-)

                          () (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C10H17NO8R2
                          synonyms: D-Galactosyl-N-acylsphingosine, galactosylceramides
                          kegg id:
                          exact mass: 0
                          status:

                          galactosylceramide

                          () (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C10H17NO8R2
                          synonyms: D-Galactosyl-N-acylsphingosine, galactosylceramides
                          kegg id:
                          status:
                          exact mass: 0
                          localization: Golgi apparatus

                          2.4.99.9 Lactosylceramide alpha-2,3-sialyltransferase.

                          CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D- galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide. (kegg)
                          proteins
                          Q9UNP4 SIAT9_HUMAN

                          details
                          ["Lactose cannot act as acceptor."]


                          map 1: Sphingolipid metabolism

                          proteins:
                          • ST3 beta-galactoside alpha-2,3-sialyltransferase 5 [ST3GAL5] ncbi lipid_maps

                          GM4

                          (NeuAcα2-3Galβ-Cer) (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula:
                          synonyms:
                          kegg id: C06128
                          exact mass: 0
                          status:
                          lipidmaps

                          Cytidine monophosphate N-acetylneuraminic acid

                          () (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C20H31N4O16P
                          synonyms: CMP-NeuNAc, CMP-beta-Neu5ac
                          kegg id: C00128
                          status:
                          exact mass: 0
                          localization: Golgi apparatus

                          2.4.99.9 Lactosylceramide alpha-2,3-sialyltransferase.

                          CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D- galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide. (kegg)
                          proteins
                          Q9UNP4 SIAT9_HUMAN

                          details
                          ["Lactose cannot act as acceptor."]


                          map 1: Sphingolipid metabolism

                          proteins:
                          • ST3 beta-galactoside alpha-2,3-sialyltransferase 5 [ST3GAL5] ncbi lipid_maps

                          GM4

                          (NeuAcα2-3Galβ-Cer) (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula:
                          synonyms:
                          kegg id: C06128
                          exact mass: 0
                          status:
                          lipidmaps

                          Ceramide + UDP-D-glucose

                          (N-acyl-sphing-4-enine) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Ceramides [SP02]
                          sub_class: N-acylsphingosines (ceramides) [SP0201]
                          formula:
                          synonyms: N-acylsphingosine
                          kegg id: C00195
                          status:
                          exact mass:
                          lipidmaps
                          pubchem substance url
                          localization: reticulum

                          2.4.1.80 Ceramide glucosyltransferase.

                          UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine. (kegg)
                          proteins
                          Q16739 CEGT_HUMAN

                          details
                          ["Sphingosine and dihydrosphingosine can also act as acceptors; CDP- glucose can act as donor."]


                          map 1: Sphingolipid metabolism

                          proteins:

                          GlcCer + UDP

                          (Glcbeta-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Neutral glycosphingolipids [SP05]
                          sub_class: Simple Glc series [SP0501]
                          formula:
                          synonyms: Glucosyl ceramide
                          kegg id: C01190
                          exact mass:
                          status:
                          lipidmaps
                          pubchem substance url

                          GlcCer + UDP-D-galactose

                          (Glcbeta-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Neutral glycosphingolipids [SP05]
                          sub_class: Simple Glc series [SP0501]
                          formula:
                          synonyms: Glucosyl ceramide
                          kegg id: C01190
                          status:
                          exact mass:
                          lipidmaps
                          pubchem substance url
                          localization: Cytoplasm

                          2.4.1.274 Glucosylceramide beta-1,4-galactosyltransferase.

                          UDP-alpha-D-galactose + beta-D-glucosyl-(1<->1)-ceramide = UDP + beta-D- galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide. (kegg)
                          proteins
                          Q9UBX8 B4GT6_HUMAN

                          details
                          ["Involved in the synthesis of several different major classes of glycosphingolipids."]


                          map 1: Sphingolipid metabolism

                          proteins:
                          • UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 [B4GALT6] ncbi lipid_maps

                          LacCer + UDP

                          (Galbeta1-4Glcbeta-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Neutral glycosphingolipids [SP05]
                          sub_class: Simple Glc series [SP0501]
                          formula:
                          kegg id: C01290
                          exact mass:
                          status:
                          lipidmaps
                          pubchem substance url

                          GlcCer + UDP-D-galactose

                          (Glcbeta-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Neutral glycosphingolipids [SP05]
                          sub_class: Simple Glc series [SP0501]
                          formula:
                          synonyms: Glucosyl ceramide
                          kegg id: C01190
                          status:
                          exact mass:
                          lipidmaps
                          pubchem substance url
                          localization: Cytoplasm

                          2.4.1.274 Glucosylceramide beta-1,4-galactosyltransferase.

                          UDP-alpha-D-galactose + beta-D-glucosyl-(1<->1)-ceramide = UDP + beta-D- galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide. (kegg)
                          proteins
                          Q9UBX8 B4GT6_HUMAN

                          details
                          ["Involved in the synthesis of several different major classes of glycosphingolipids."]


                          map 1: Sphingolipid metabolism

                          proteins:
                          • UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 [B4GALT6] ncbi lipid_maps

                          LacCer(d18:1/12:0) + UDP

                          (N-(dodecanoyl)-1-b-lactosyl-sphing-4-enine) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Neutral glycosphingolipids [SP05]
                          sub_class: Simple Glc series [SP0501]
                          formula: C42H79NO13
                          synonyms: C12 lactosyl ceramide
                          exact mass: 805.555
                          status:
                          lipidmaps
                          pubchem substance url

                          LacCer + UDP-N-acetyl-D-galactosamine

                          (Galbeta1-4Glcbeta-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Neutral glycosphingolipids [SP05]
                          sub_class: Simple Glc series [SP0501]
                          formula:
                          kegg id: C01290
                          status:
                          exact mass:
                          lipidmaps
                          pubchem substance url
                          localization: Unknown

                          2.4.1.92 N-acetylgalactosaminyltransferase.

                          UDP-N-acetyl-alpha-D-galactosamine + O-(N-acetyl-alpha-neuraminyl)- (2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl-(1<->1)- ceramide = UDP + O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl- (1->4)-O-(N-acetyl-alpha-neuraminyl-(2->3))-O-beta-D-galactopyranosyl- (1->4)-beta-D-glucopyranosyl-(1<->1)-ceramide. (kegg)
                          proteins
                          Q00973 B4GN1_HUMAN

                          details
                          ["Catalyzes the formation of the gangliosides (i.e. sialic-acid- containing glycosphingolipids) GM2, GD2 and SM2 from GM3, GD3 and SM3, respectively.", "Asialo-GM3 and lactosylceramide are also substrates, but glycoproteins and oligosaccharides are not substrates."]


                          map 1: Ganglioside Metabolism N1

                          proteins:
                          • beta-1,4-N-acetyl-galactosaminyl transferase 1 [B4GALNT1] ncbi lipid_maps

                          asialo-GM2, GA2, Tay-Sachs globoside + UDP

                          (GalNAcbeta1-4Galbeta1-4Glcbeta-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Neutral glycosphingolipids [SP05]
                          sub_class: GalNAcbeta1-4Galbeta1-4Glc- (Ganglio series) [SP0503]
                          formula:
                          exact mass:
                          status:
                          lipidmaps
                          pubchem substance url

                          asialo-GM2, GA2, Tay-Sachs globoside + UDP-D-galactose

                          (GalNAcbeta1-4Galbeta1-4Glcbeta-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Neutral glycosphingolipids [SP05]
                          sub_class: GalNAcbeta1-4Galbeta1-4Glc- (Ganglio series) [SP0503]
                          formula:
                          status:
                          exact mass:
                          lipidmaps
                          pubchem substance url
                          localization: Unknown

                          2.4.1.62 Ganglioside galactosyltransferase.

                          UDP-alpha-D-galactose + an N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha- N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide = UDP + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D- galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D- galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide. (kegg)
                          proteins
                          O96024 B3GT4_HUMAN

                          details
                          ["The substrate is also known as gangloside GM2, the product as gangloside GM1a."]


                          map 1: Ganglioside Metabolism N1

                          proteins:
                          • UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 [B3GALT4] ncbi lipid_maps

                          asialo-GM1 + UDP

                          (Galbeta1-3GalNAcbeta1-4Galbeta1-4Glcbeta-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Neutral glycosphingolipids [SP05]
                          sub_class: GalNAcbeta1-4Galbeta1-4Glc- (Ganglio series) [SP0503]
                          formula:
                          synonyms: AM1; GA1
                          exact mass:
                          status:
                          lipidmaps
                          pubchem substance url

                          GM2 + H2O

                          ( GalNAcβ1-4(NeuAcα2-3)Galβ1-4Glcβ-Cer) (lipid link)
                          category:
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          status:
                          exact mass: 0
                          lipidmaps
                          localization: Golgi apparatus

                          3.2.1.18 Exo-alpha-sialidase.

                          Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. (kegg)
                          proteins
                          Q99519 NEUR1_HUMAN
                          Q9Y3R4 NEUR2_HUMAN
                          Q9UQ49 NEUR3_HUMAN
                          Q8WWR8 NEUR4_HUMAN

                          details
                          ["The enzyme does not act on 4-O-acetylated sialic acids.", "An endo-alpha-sialidase activity is listed as EC 3.2.1.129.", "See also EC 4.2.2.15."]


                          map 1: Ganglioside Metabolism N1

                          proteins:

                          asialo-GM2, GA2, Tay-Sachs globoside

                          (GalNAcbeta1-4Galbeta1-4Glcbeta-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Neutral glycosphingolipids [SP05]
                          sub_class: GalNAcbeta1-4Galbeta1-4Glc- (Ganglio series) [SP0503]
                          formula:
                          exact mass:
                          status:
                          lipidmaps
                          pubchem substance url

                          N-Acetylneuraminic acid

                          ( (2S,4S,5R,6R)-5-acetamido-2,4-dihydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid) (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C11H19NO9
                          synonyms: Aceneuramic acid, Sialic acid
                          kegg id:
                          exact mass: 0
                          status:

                          GM2 + UDP-D-galactose

                          ( GalNAcβ1-4(NeuAcα2-3)Galβ1-4Glcβ-Cer) (lipid link)
                          category:
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          status:
                          exact mass: 0
                          lipidmaps
                          localization: Golgi apparatus

                          2.4.1.62 Ganglioside galactosyltransferase.

                          UDP-alpha-D-galactose + an N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha- N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide = UDP + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D- galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D- galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide. (kegg)
                          proteins
                          O96024 B3GT4_HUMAN

                          details
                          ["The substrate is also known as gangloside GM2, the product as gangloside GM1a."]


                          map 1: Ganglioside Metabolism N1

                          proteins:
                          • UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 [B3GALT4] ncbi lipid_maps

                          GM1a + UDP

                          ( ) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          exact mass: 0
                          status:
                          lipidmaps

                          GD3 + UDP-N-acetyl-D-galactosamine

                          ( NeuAcα2-8NeuAcα2-3Galβ1-4Glcβ-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          status:
                          exact mass: 0
                          lipidmaps
                          localization: Golgi apparatus

                          2.4.1.92 N-acetylgalactosaminyltransferase.

                          UDP-N-acetyl-alpha-D-galactosamine + O-(N-acetyl-alpha-neuraminyl)- (2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl-(1<->1)- ceramide = UDP + O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl- (1->4)-O-(N-acetyl-alpha-neuraminyl-(2->3))-O-beta-D-galactopyranosyl- (1->4)-beta-D-glucopyranosyl-(1<->1)-ceramide. (kegg)
                          proteins
                          Q00973 B4GN1_HUMAN

                          details
                          ["Catalyzes the formation of the gangliosides (i.e. sialic-acid- containing glycosphingolipids) GM2, GD2 and SM2 from GM3, GD3 and SM3, respectively.", "Asialo-GM3 and lactosylceramide are also substrates, but glycoproteins and oligosaccharides are not substrates."]


                          map 1: Ganglioside Metabolism N1

                          proteins:
                          • beta-1,4-N-acetyl-galactosaminyl transferase 1 [B4GALNT1] ncbi lipid_maps

                          GD2 + UDP

                          () (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          exact mass: 0
                          status:
                          lipidmaps

                          9-O-Acetyl-GD3 + acetyl-CoA

                          ((2S,3R,4E)-2-alkanamido-3-hydroxyoctadec-4-en-1-yl 5-acetamido-9-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranonosy) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula: C55H92N3O30R
                          synonyms: 9-O-Ac-GD3
                          kegg id:
                          status:
                          exact mass: 0
                          localization: Golgi apparatus

                          2.3.1.- Transferring groups other than amino-acyl groups.

                          (kegg)
                          proteins


                          map 1: Ganglioside Metabolism N1

                          proteins:
                          • solute carrier family 33 (acetyl-CoA transporter), member 1 [SLC33A1] ncbi lipid_maps

                          GD3 + CoA

                          ( NeuAcα2-8NeuAcα2-3Galβ1-4Glcβ-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          exact mass: 0
                          status:
                          lipidmaps

                          GD3 + H2O

                          ( NeuAcα2-8NeuAcα2-3Galβ1-4Glcβ-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          status:
                          exact mass: 0
                          lipidmaps
                          localization: Cytoplasm

                          3.2.1.18 Exo-alpha-sialidase.

                          Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. (kegg)
                          proteins
                          Q99519 NEUR1_HUMAN
                          Q9Y3R4 NEUR2_HUMAN
                          Q9UQ49 NEUR3_HUMAN
                          Q8WWR8 NEUR4_HUMAN

                          details
                          ["The enzyme does not act on 4-O-acetylated sialic acids.", "An endo-alpha-sialidase activity is listed as EC 3.2.1.129.", "See also EC 4.2.2.15."]


                          map 1: Ganglioside Metabolism N1

                          proteins:

                          N-Acetylneuraminic acid

                          ( (2S,4S,5R,6R)-5-acetamido-2,4-dihydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid) (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C11H19NO9
                          synonyms: Aceneuramic acid, Sialic acid
                          kegg id:
                          exact mass: 0
                          status:

                          GM3

                          (NeuAcα2-3Galβ1-4Glcβ-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          exact mass: 0
                          status:
                          lipidmaps

                          GM3 + UDP-N-acetyl-D-galactosamine

                          (NeuAcα2-3Galβ1-4Glcβ-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          status:
                          exact mass: 0
                          lipidmaps
                          localization: Cytoplasm

                          2.4.1.92 N-acetylgalactosaminyltransferase.

                          UDP-N-acetyl-alpha-D-galactosamine + O-(N-acetyl-alpha-neuraminyl)- (2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl-(1<->1)- ceramide = UDP + O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl- (1->4)-O-(N-acetyl-alpha-neuraminyl-(2->3))-O-beta-D-galactopyranosyl- (1->4)-beta-D-glucopyranosyl-(1<->1)-ceramide. (kegg)
                          proteins
                          Q00973 B4GN1_HUMAN

                          details
                          ["Catalyzes the formation of the gangliosides (i.e. sialic-acid- containing glycosphingolipids) GM2, GD2 and SM2 from GM3, GD3 and SM3, respectively.", "Asialo-GM3 and lactosylceramide are also substrates, but glycoproteins and oligosaccharides are not substrates."]


                          map 1: Ganglioside Metabolism N1

                          proteins:
                          • beta-1,4-N-acetyl-galactosaminyl transferase 1 [B4GALNT1] ncbi lipid_maps

                          GM2 + UDP

                          ( GalNAcβ1-4(NeuAcα2-3)Galβ1-4Glcβ-Cer) (lipid link)
                          category:
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          exact mass: 0
                          status:
                          lipidmaps

                          GD2 + UDP-D-galactose

                          () (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          status:
                          exact mass: 0
                          lipidmaps
                          localization: Golgi apparatus

                          2.4.1.62 Ganglioside galactosyltransferase.

                          UDP-alpha-D-galactose + an N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha- N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide = UDP + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D- galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D- galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide. (kegg)
                          proteins
                          O96024 B3GT4_HUMAN

                          details
                          ["The substrate is also known as gangloside GM2, the product as gangloside GM1a."]


                          map 1: Ganglioside Metabolism N1

                          proteins:
                          • UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 [B3GALT4] ncbi lipid_maps

                          GD1b + UDP

                          ( Galβ1-3GalNAcβ1-4(NeuAcα2-8NeuAcα2-3)Galβ1-4Glcβ-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          exact mass: 0
                          status:
                          lipidmaps

                          GM3

                          (NeuAcα2-3Galβ1-4Glcβ-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          status:
                          exact mass: 0
                          lipidmaps
                          localization: Golgi apparatus
                          notes:
                          In reaction as substrate also exists CMP-N-Acetylneuraminic acid

                          2.4.99.8 Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase.

                          CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D- galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N- acetylneuraminyl-(2->3)-beta-D-galactosyl-R. (kegg)
                          proteins
                          Q92185 SIA8A_HUMAN

                          details
                          ["Gangliosides act as acceptors."]


                          map 1: Ganglioside Metabolism N1

                          proteins:
                          • ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 [ST8SIA1] ncbi lipid_maps
                            regulators:
                            FOXC2 ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                            MIR33A ( microRNA binding ) /0 (0, 0, 0)/ rzmd
                            MIRLET7E ( microRNA binding ) /0 (0, 0, 0)/ rzmd

                          GT3 + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                          (NeuAcα2-8NeuAcα2-8NeuAcα2-3Galβ1-4Glcβ-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          exact mass: 0
                          status:
                          lipidmaps

                          GT3 + UDP-N-acetyl-D-galactosamine

                          (NeuAcα2-8NeuAcα2-8NeuAcα2-3Galβ1-4Glcβ-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          status:
                          exact mass: 0
                          lipidmaps
                          localization: Golgi apparatus
                          notes:
                          In reaction as substrate also exists CMP-N-Acetylneuraminic acid

                          2.4.1.92 N-acetylgalactosaminyltransferase.

                          UDP-N-acetyl-alpha-D-galactosamine + O-(N-acetyl-alpha-neuraminyl)- (2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl-(1<->1)- ceramide = UDP + O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl- (1->4)-O-(N-acetyl-alpha-neuraminyl-(2->3))-O-beta-D-galactopyranosyl- (1->4)-beta-D-glucopyranosyl-(1<->1)-ceramide. (kegg)
                          proteins
                          Q00973 B4GN1_HUMAN

                          details
                          ["Catalyzes the formation of the gangliosides (i.e. sialic-acid- containing glycosphingolipids) GM2, GD2 and SM2 from GM3, GD3 and SM3, respectively.", "Asialo-GM3 and lactosylceramide are also substrates, but glycoproteins and oligosaccharides are not substrates."]


                          map 1: Ganglioside Metabolism N2

                          proteins:
                          • beta-1,4-N-acetyl-galactosaminyl transferase 1 [B4GALNT1] ncbi lipid_maps

                          GT2 + UDP

                          ( GalNAcβ1-4(NeuAcα2-8NeuAcα2-8NeuAcα2-3)Galβ1-4Glcβ-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          exact mass: 0
                          status:
                          lipidmaps

                          GT2 + UDP-N-acetyl-D-galactosamine

                          ( GalNAcβ1-4(NeuAcα2-8NeuAcα2-8NeuAcα2-3)Galβ1-4Glcβ-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          status:
                          exact mass: 0
                          lipidmaps
                          localization: Golgi apparatus
                          notes:
                          In reaction as substrate also exists CMP-N-Acetylneuraminic acid

                          2.4.1.62 Ganglioside galactosyltransferase.

                          UDP-alpha-D-galactose + an N-acetyl-beta-D-galactosaminyl-(1->4)-(alpha- N-acetylneuraminyl-(2->3))-beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide = UDP + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D- galactosaminyl-(1->4)-(alpha-N-acetylneuraminyl-(2->3))-beta-D- galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide. (kegg)
                          proteins
                          O96024 B3GT4_HUMAN

                          details
                          ["The substrate is also known as gangloside GM2, the product as gangloside GM1a."]


                          map 1: Ganglioside Metabolism N1

                          proteins:
                          • UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 [B3GALT4] ncbi lipid_maps

                          GT1c + UDP

                          ( Galβ1-3GalNAcβ1-4(NeuAcα2-8NeuAcα2-8NeuAcα2-3)Galβ1-4Glcβ-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          exact mass: 0
                          status:
                          lipidmaps

                          GM1a + H2O

                          ( ) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          status:
                          exact mass: 0
                          lipidmaps
                          localization: Golgi apparatus

                          3.2.1.18 Exo-alpha-sialidase.

                          Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. (kegg)
                          proteins
                          Q99519 NEUR1_HUMAN
                          Q9Y3R4 NEUR2_HUMAN
                          Q9UQ49 NEUR3_HUMAN
                          Q8WWR8 NEUR4_HUMAN

                          details
                          ["The enzyme does not act on 4-O-acetylated sialic acids.", "An endo-alpha-sialidase activity is listed as EC 3.2.1.129.", "See also EC 4.2.2.15."]


                          map 1: Ganglioside Metabolism N2

                          proteins:

                          N-Acetylneuraminic acid

                          ( (2S,4S,5R,6R)-5-acetamido-2,4-dihydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid) (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C11H19NO9
                          synonyms: Aceneuramic acid, Sialic acid
                          kegg id:
                          exact mass: 0
                          status:

                          GD1a

                          (NeuAcα2-3Galβ1-3GalNAcβ1-4(NeuAcα2-3)Galβ1-4Glcβ-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          exact mass: 0
                          status:
                          lipidmaps

                          Phosphatidylinositol + H2O

                          (1,2-diacyl-sn-glycero-3-phospho-(1-myo-inositol)) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphoinositols [GP06]
                          sub_class: Diacylglycerophosphoinositols [GP0601]
                          formula:
                          synonyms: 1-Phosphatidyl-D-myo-inositol; 1-Phosphatidyl-1D-myo-inositol; 1-Phosphatidyl-myo-inositol; Phosphatidyl-1D-myo-inositol; (3-Phosphatidyl)-1-D-inositol; Phosphatidylinositol; PI
                          kegg id: C01194
                          status:
                          exact mass: 0
                          lipidmaps
                          pubchem substance url
                          localization: Unknown

                          2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferase.

                          Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. (kegg)
                          proteins
                          Q8WTS1 ABHD5_HUMAN
                          Q53EU6 GPAT3_HUMAN
                          Q6UWP7 LCLT1_HUMAN
                          Q6ZWT7 MBOA2_HUMAN
                          Q7L5N7 PCAT2_HUMAN
                          Q99943 PLCA_HUMAN
                          O15120 PLCB_HUMAN
                          Q9NRZ7 PLCC_HUMAN
                          Q9NRZ5 PLCD_HUMAN
                          Q9NUQ2 PLCE_HUMAN

                          details
                          ["Acyl-[acyl-carrier-protein] can also act as acyl donor.", "The animal enzyme is specific for the transfer of unsaturated fatty acyl groups."]


                          map 1: Glycerophospholipid metabolism

                          proteins:

                          1-Acylglycerophosphoinositol + Carboxylic acid

                          (1-Acyl-sn-glycero-3-phosphoinositol) (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C10H18O12PR
                          synonyms:
                          kegg id: C03819
                          exact mass: 0
                          status:
                          pubchem substance url

                          CDP-diacyl glycerol

                          (1,2-diacyl-sn-glycero-3-cytidine-5'-diphosphate) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: CDP-Glycerols [GP13]
                          sub_class: CDP-diacylglycerols [GP1301]
                          formula:
                          synonyms: CDP-DAG
                          kegg id: C00269
                          status:
                          exact mass:
                          lipidmaps
                          pubchem substance url
                          localization: Mitochondria

                          2.7.8.5 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase.

                          CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate. (kegg)
                          proteins
                          Q32NB8 PGPS1_HUMAN


                          map 1: Glycerophospholipid metabolism

                          proteins:

                          PGP + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                          (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate)) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphoglycerophosphates [GP05]
                          sub_class: Diacylglycerophosphoglycerophosphates [GP0501]
                          formula:
                          kegg id: C03892
                          exact mass:
                          status:
                          lipidmaps
                          pubchem substance url

                          sn-Glycerol 3-phosphate

                          () (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C3H9O6P
                          synonyms: Glycerophosphoric acid; D-Glycerol 1-phosphate
                          kegg id: C00093
                          status:
                          exact mass: 172.014
                          pubchem substance url
                          localization: Mitochondria

                          2.7.8.5 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase.

                          CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate. (kegg)
                          proteins
                          Q32NB8 PGPS1_HUMAN


                          map 1: Glycerophospholipid metabolism

                          proteins:

                          PGP + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                          (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate)) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphoglycerophosphates [GP05]
                          sub_class: Diacylglycerophosphoglycerophosphates [GP0501]
                          formula:
                          kegg id: C03892
                          exact mass:
                          status:
                          lipidmaps
                          pubchem substance url

                          CDP-diacyl glycerol

                          (1,2-diacyl-sn-glycero-3-cytidine-5'-diphosphate) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: CDP-Glycerols [GP13]
                          sub_class: CDP-diacylglycerols [GP1301]
                          formula:
                          synonyms: CDP-DAG
                          kegg id: C00269
                          status:
                          exact mass:
                          lipidmaps
                          pubchem substance url
                          localization: Unknown

                          2.7.8.41 Cardiolipin synthase (CMP-forming).

                          A CDP-diacylglycerol + a phosphatidylglycerol = a cardiolipin + CMP. (kegg)
                          proteins
                          Q9UJA2 CRLS1_HUMAN

                          details
                          ["The eukaryotic enzyme is involved in the biosynthesis of the mitochondrial phospholipid cardiolipin."]


                          map 1: Glycerophospholipid metabolism

                          proteins:

                          Cardiolipin (CL) + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                          (1',3'-Bis-(1,2-diacyl-sn-glycero-3-phospho)-sn-glycerol) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphoglycerophosphoglycerols [GP12]
                          sub_class: Diacylglycerophosphoglycerophosphodiradylglycerols [GP1201]
                          formula:
                          synonyms: 1,3-bis(sn-3'-phosphatidyl)-sn-glycerol; 1,3-bis(sn-3-phosphatidyl)-sn-glycerol
                          kegg id: C05980
                          exact mass:
                          status:
                          lipidmaps
                          pubchem substance url

                          Monolysocardiolipin + Acyl-CoA

                          () (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C12H19O16P2R3
                          synonyms: MLCL, 2-monolysocardiolipin
                          kegg id: C18129
                          status:
                          exact mass: 0
                          pubchem substance url
                          localization: Unknown
                          notes:
                          LCLAT1 lysocardiolipin acyltransferase 1 ( 1AGPAT8, AGPAT8, ALCAT1, HSRG1849, LYCAT, UNQ1849)

                          2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferase.

                          Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. (kegg)
                          proteins
                          Q8WTS1 ABHD5_HUMAN
                          Q53EU6 GPAT3_HUMAN
                          Q6UWP7 LCLT1_HUMAN
                          Q6ZWT7 MBOA2_HUMAN
                          Q7L5N7 PCAT2_HUMAN
                          Q99943 PLCA_HUMAN
                          O15120 PLCB_HUMAN
                          Q9NRZ7 PLCC_HUMAN
                          Q9NRZ5 PLCD_HUMAN
                          Q9NUQ2 PLCE_HUMAN

                          details
                          ["Acyl-[acyl-carrier-protein] can also act as acyl donor.", "The animal enzyme is specific for the transfer of unsaturated fatty acyl groups."]


                          map 1: Glycerophospholipid metabolism

                          proteins:

                          Cardiolipin (CL) + CoA

                          (1',3'-Bis-(1,2-diacyl-sn-glycero-3-phospho)-sn-glycerol) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphoglycerophosphoglycerols [GP12]
                          sub_class: Diacylglycerophosphoglycerophosphodiradylglycerols [GP1201]
                          formula:
                          synonyms: 1,3-bis(sn-3'-phosphatidyl)-sn-glycerol; 1,3-bis(sn-3-phosphatidyl)-sn-glycerol
                          kegg id: C05980
                          exact mass:
                          status:
                          lipidmaps
                          pubchem substance url

                          1-Acyl-sn-glycero-3-phosphoglycerol + Acyl-CoA

                          (1-Acyl-sn-glycero-3-phosphoglycerol) (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C7H14O9PR
                          synonyms:
                          kegg id:
                          status:
                          exact mass: 0
                          pubchem substance url
                          localization: Unknown

                          2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferase.

                          Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. (kegg)
                          proteins
                          Q8WTS1 ABHD5_HUMAN
                          Q53EU6 GPAT3_HUMAN
                          Q6UWP7 LCLT1_HUMAN
                          Q6ZWT7 MBOA2_HUMAN
                          Q7L5N7 PCAT2_HUMAN
                          Q99943 PLCA_HUMAN
                          O15120 PLCB_HUMAN
                          Q9NRZ7 PLCC_HUMAN
                          Q9NRZ5 PLCD_HUMAN
                          Q9NUQ2 PLCE_HUMAN

                          details
                          ["Acyl-[acyl-carrier-protein] can also act as acyl donor.", "The animal enzyme is specific for the transfer of unsaturated fatty acyl groups."]


                          map 1: Glycerophospholipid metabolism

                          proteins:

                          PG + CoA

                          (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphoglycerols [GP04]
                          sub_class: Diacylglycerophosphoglycerols [GP0401]
                          formula:
                          kegg id: C00344
                          exact mass:
                          status:
                          lipidmaps
                          pubchem substance url

                          PC + H2O

                          (1,2-diacyl-sn-glycero-3-phosphocholine) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphocholines [GP01]
                          sub_class: Diacylglycerophosphocholines [GP0101]
                          formula: C10H18NO8P
                          synonyms: Phosphatidylcholine; Diacylphosphatidylcholine
                          kegg id: C00157
                          status:
                          exact mass: 311.077
                          lipidmaps
                          pubchem substance url
                          localization: Golgi apparatus

                          3.1.4.4 Phospholipase D.

                          A phosphatidylcholine + H(2)O = choline + a phosphatidate. (kegg)
                          proteins
                          Q13393 PLD1_HUMAN
                          O14939 PLD2_HUMAN
                          Q8IV08 PLD3_HUMAN
                          Q96BZ4 PLD4_HUMAN

                          details
                          ["Also acts on other phosphatidyl esters."]


                          map 1: Glycerophospholipid metabolism

                          proteins:
                          • phospholipase D family, member 4 [PLD4] ncbi lipid_maps
                            regulators:
                            RALA ( binding ) /2 (0, 0, 2)/ rzmd
                            ARF1 ( binding ) /1 (1, 0, 0)/ rzmd
                          • phospholipase D family, member 3 [PLD3] ncbi lipid_maps
                            regulators:
                            RALA ( binding ) /2 (0, 0, 2)/ rzmd
                            ARF1 ( binding ) /1 (1, 0, 0)/ rzmd
                          • phospholipase D1, phosphatidylcholine-specific [PLD1] ncbi lipid_maps
                            regulators:
                            CFL1 ( binding ) /1 (1, 0, 0)/ rzmd
                            CFL2 ( binding ) /1 (1, 0, 0)/ rzmd
                            PEA15 ( binding ) /2 (2, 0, 0)/ rzmd
                            RALA ( binding ) /2 (0, 0, 2)/ rzmd
                            ARF1 ( binding ) /1 (1, 0, 0)/ rzmd
                            MIR638 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                            MIR103A1 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                            MIR107 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                          • phospholipase D2 [PLD2] ncbi lipid_maps
                            regulators:
                            MIR203A ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                            RALA ( binding ) /2 (0, 0, 2)/ rzmd
                            ARF1 ( binding ) /1 (1, 0, 0)/ rzmd
                            MIR103A1 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                            MIR107 ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                          PA

                          (1,2-diacyl-sn-glycero-3-phosphate) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphates [GP10]
                          sub_class: Diacylglycerophosphates [GP1001]
                          formula:
                          synonyms: Phosphatidic acid
                          kegg id: C00416
                          exact mass:
                          status:
                          lipidmaps
                          pubchem substance url

                          Choline

                          () (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C5H14NO
                          synonyms: Bilineurine, 2-Hydroxy-N,N,N-trimethylethanaminium, Bursine
                          kegg id: C00114
                          exact mass: 104.107
                          status:
                          pubchem substance url

                          GT1c + CMP-N-Acetylneuraminic acid

                          ( Galβ1-3GalNAcβ1-4(NeuAcα2-8NeuAcα2-8NeuAcα2-3)Galβ1-4Glcβ-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          status:
                          exact mass: 0
                          lipidmaps
                          localization: Golgi apparatus

                          2.4.99.4 Beta-galactoside alpha-2,3-sialyltransferase.

                          CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D- galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl- 1,3-N-acetyl-alpha-D-galactosaminyl-R. (kegg)
                          proteins
                          Q11201 SIA4A_HUMAN
                          Q16842 SIA4B_HUMAN

                          details
                          ["The acceptor is Gal-beta-1,3-GalNAc-R, where R is H, a threonine or serine residue in a glycoprotein, or a glycolipid.", "Lactose can also act as acceptor.", "May be identical with EC 2.4.99.2."]


                          map 1: Ganglioside Metabolism N2

                          proteins:
                          • ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [ST3GAL1] ncbi lipid_maps
                          • ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [ST3GAL2] ncbi lipid_maps
                          • ST3 beta-galactoside alpha-2,3-sialyltransferase 4 [ST3GAL4] ncbi lipid_maps
                            regulators:
                            MIR193A ( microRNA binding ) /0 (0, 0, 0)/ rzmd
                            MIR224 ( microRNA binding ) /0 (0, 0, 0)/ rzmd

                          GQ1c + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                          (NeuAcα2-3Galβ1-3GalNAcβ1-4(NeuAcα2-8NeuAcα2-8NeuAcα2-3)Galβ1-4Glcβ-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          exact mass: 0
                          status:
                          lipidmaps

                          GQ1c + CMP-N-Acetylneuraminic acid

                          (NeuAcα2-3Galβ1-3GalNAcβ1-4(NeuAcα2-8NeuAcα2-8NeuAcα2-3)Galβ1-4Glcβ-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          status:
                          exact mass: 0
                          lipidmaps
                          localization: Golgi apparatus

                          2.4.99.- Transferring other glycosyl groups.

                          (kegg)
                          proteins


                          map 1: Ganglioside Metabolism N2

                          proteins:
                          • ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 [ST6GALNAC5] ncbi lipid_maps
                          • ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 [ST6GALNAC6] ncbi lipid_maps

                          GP1c + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                          (NeuAcα2-8NeuAcα2-3Galβ1-3GalNAcβ1-4(NeuAcα2-8NeuAcα2-8NeuAcα2-3)Galβ1-4Glcβ-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          exact mass: 0
                          status:
                          lipidmaps

                          GT1b + CMP-N-Acetylneuraminic acid

                          (NeuAcα2-3Galβ1-3GalNAcβ1-4(NeuAcα2-8NeuAcα2-3)Galβ1-4Glcβ-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          status:
                          exact mass: 0
                          lipidmaps
                          localization: Golgi apparatus

                          2.4.99.8 Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase.

                          CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D- galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N- acetylneuraminyl-(2->3)-beta-D-galactosyl-R. (kegg)
                          proteins
                          Q92185 SIA8A_HUMAN

                          details
                          ["Gangliosides act as acceptors."]


                          map 1: Ganglioside Metabolism N2

                          proteins:
                          • ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 [ST8SIA1] ncbi lipid_maps
                            regulators:
                            FOXC2 ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                            MIR33A ( microRNA binding ) /0 (0, 0, 0)/ rzmd
                            MIRLET7E ( microRNA binding ) /0 (0, 0, 0)/ rzmd
                          • ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 [ST8SIA5] ncbi lipid_maps

                          GQ1b + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                          ( NeuAcα2-8NeuAcα2-3Galβ1-3GalNAcβ1-4(NeuAcα2-8NeuAcα2-3)Galβ1-4Glcβ-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          exact mass: 0
                          status:
                          lipidmaps

                          GT1b + CMP-N-Acetylneuraminic acid

                          (NeuAcα2-3Galβ1-3GalNAcβ1-4(NeuAcα2-8NeuAcα2-3)Galβ1-4Glcβ-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          status:
                          exact mass: 0
                          lipidmaps
                          localization: Golgi apparatus

                          2.4.99.- Transferring other glycosyl groups.

                          (kegg)
                          proteins


                          map 1: Ganglioside Metabolism N2

                          proteins:
                          • ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 [ST6GALNAC6] ncbi lipid_maps
                          • ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 [ST6GALNAC5] ncbi lipid_maps

                          GQ1ba + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                          (NeuAcα2-3Galβ1-3(NeuAcα2-6)GalNAcβ1-4(NeuAcα2-8NeuAcα2-3)Galβ1-4Glcβ-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          exact mass: 0
                          status:
                          lipidmaps

                          GD1a + CMP-N-Acetylneuraminic acid

                          (NeuAcα2-3Galβ1-3GalNAcβ1-4(NeuAcα2-3)Galβ1-4Glcβ-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          status:
                          exact mass: 0
                          lipidmaps
                          localization: Golgi apparatus

                          2.4.99.8 Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase.

                          CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D- galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N- acetylneuraminyl-(2->3)-beta-D-galactosyl-R. (kegg)
                          proteins
                          Q92185 SIA8A_HUMAN

                          details
                          ["Gangliosides act as acceptors."]


                          map 1: Ganglioside Metabolism N2

                          proteins:
                          • ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 [ST8SIA5] ncbi lipid_maps
                          • ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 [ST8SIA1] ncbi lipid_maps
                            regulators:
                            FOXC2 ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                            MIR33A ( microRNA binding ) /0 (0, 0, 0)/ rzmd
                            MIRLET7E ( microRNA binding ) /0 (0, 0, 0)/ rzmd

                          GT1a + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                          (NeuAcα2-8NeuAcα2-3Galβ1-3GalNAcβ1-4(NeuAcα2-3)Galβ1-4Glcβ-Cer) (lipid link)
                          category: Sphingolipids [SP]
                          main_class: Acidic glycosphingolipids [SP06]
                          sub_class: Gangliosides [SP0601]
                          formula:
                          synonyms:
                          kegg id:
                          exact mass: 0
                          status:
                          lipidmaps

                          1,2-DG + ATP

                          (1,2-diacyl-sn-glycerol) (lipid link)
                          category: Glycerolipids [GL]
                          main_class: Diradylglycerols [GL02]
                          sub_class: Diacylglycerols [GL0201]
                          formula:
                          synonyms: 1,2-diacylglycerol; 1,2-DAG
                          kegg id: C00641
                          status:
                          exact mass:
                          lipidmaps
                          pubchem substance url
                          localization: Unknown
                          notes:
                          DGKK DGKA,DGKB,DGKG, DGKH, DGKQ, DGKZ, DGKE, DGKD, DGKI

                          2.7.1.107 Diacylglycerol kinase (ATP).

                          ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate. (kegg)
                          proteins
                          Q53H12 AGK_HUMAN
                          P23743 DGKA_HUMAN
                          Q9Y6T7 DGKB_HUMAN
                          Q16760 DGKD_HUMAN
                          P52429 DGKE_HUMAN
                          P49619 DGKG_HUMAN
                          Q86XP1 DGKH_HUMAN
                          O75912 DGKI_HUMAN
                          Q5KSL6 DGKK_HUMAN
                          P52824 DGKQ_HUMAN
                          Q13574 DGKZ_HUMAN

                          details
                          ["Involved in synthesis of membrane phospholipids and the neutral lipid triacylglycerol.", "Activity is stimulated by certain phospholipids.", "In plants and animals the product 1,2-diacyl-sn-glycerol 3-phosphate is an important second messenger.", "cf. EC 2.7.1.174."]


                          map 1: Glycerophospholipid metabolism

                          proteins:

                          1,2-diacyl-sn-glycerol 3-phosphate + ADP

                          no systematic name (lipid link)
                          formula: C5H7O8PR2
                          synonyms: 1,2-diacyl-sn-glycerol 3-phosphates
                          exact mass: 225.988
                          status:

                          PE + H2O

                          (1,2-diacyl-sn-glycero-3-phosphoethanolamine) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphoethanolamines [GP02]
                          sub_class: Diacylglycerophosphoethanolamines [GP0201]
                          formula:
                          kegg id: C00350
                          status:
                          exact mass:
                          lipidmaps
                          pubchem substance url
                          localization: Golgi apparatus

                          3.1.4.4 Phospholipase D.

                          A phosphatidylcholine + H(2)O = choline + a phosphatidate. (kegg)
                          proteins
                          Q13393 PLD1_HUMAN
                          O14939 PLD2_HUMAN
                          Q8IV08 PLD3_HUMAN
                          Q96BZ4 PLD4_HUMAN

                          details
                          ["Also acts on other phosphatidyl esters."]


                          map 1: Glycerophospholipid metabolism

                          proteins:
                          • phospholipase D family, member 4 [PLD4] ncbi lipid_maps
                            regulators:
                            RALA ( binding ) /2 (0, 0, 2)/ rzmd
                            ARF1 ( binding ) /1 (1, 0, 0)/ rzmd
                          • phospholipase D family, member 3 [PLD3] ncbi lipid_maps
                            regulators:
                            RALA ( binding ) /2 (0, 0, 2)/ rzmd
                            ARF1 ( binding ) /1 (1, 0, 0)/ rzmd
                          • phospholipase D1, phosphatidylcholine-specific [PLD1] ncbi lipid_maps
                            regulators:
                            CFL1 ( binding ) /1 (1, 0, 0)/ rzmd
                            CFL2 ( binding ) /1 (1, 0, 0)/ rzmd
                            PEA15 ( binding ) /2 (2, 0, 0)/ rzmd
                            RALA ( binding ) /2 (0, 0, 2)/ rzmd
                            ARF1 ( binding ) /1 (1, 0, 0)/ rzmd
                            MIR638 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                            MIR103A1 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                            MIR107 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                          • phospholipase D2 [PLD2] ncbi lipid_maps
                            regulators:
                            MIR203A ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                            RALA ( binding ) /2 (0, 0, 2)/ rzmd
                            ARF1 ( binding ) /1 (1, 0, 0)/ rzmd
                            MIR103A1 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                            MIR107 ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                          1,2-diacyl-sn-glycerol 3-phosphate

                          no systematic name (lipid link)
                          formula: C5H7O8PR2
                          synonyms: 1,2-diacyl-sn-glycerol 3-phosphates
                          exact mass: 225.988
                          status:

                          Ethanolamine

                          () (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C2H7NO
                          synonyms: Aminoethanol; 2-Hydroxyethylamine
                          kegg id:
                          exact mass: 61.0528
                          status:
                          pubchem substance url

                          Acetyl-CoA + H2O + CO2 + ATP

                          (3'-phosphoadenosine 5'-(3-{(3R)-4-[(3-{[2-(acetylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl} dih) (lipid link)
                          category: Fatty Acyls [FA]
                          main_class: Fatty esters [FA07]
                          sub_class: Fatty acyl CoAs [FA0705]
                          formula: C23H38N7O17P3S
                          synonyms: AcCoA;S-acetyl-CoA;S-acetyl-coenzyme A
                          kegg id: C00024
                          status:
                          exact mass: 809.126
                          lipidmaps
                          localization: Golgi apparatus

                          6.4.1.2 Acetyl-CoA carboxylase.

                          ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA. (kegg)
                          proteins
                          Q13085 ACACA_HUMAN
                          O00763 ACACB_HUMAN

                          details
                          ["Also catalyzes transcarboxylation; the plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA."]


                          map 1: Saturated fatty acid biosynthesis

                          proteins:

                          Malonyl-CoA + ADP

                          (3'-phosphoadenosine 5'-{3-[(3R)-4-{[3-({2-[(3-carboxyacetyl)sulfanyl]ethyl}amino)-3-oxopropyl]amino}-3-hydroxy-2,2-dimethyl-4-ox) (lipid link)
                          category: Fatty Acyls [FA]
                          main_class: Fatty esters [FA07]
                          sub_class: Fatty acyl CoAs [FA0705]
                          formula: C24H38N7O19P3S
                          synonyms: Coenzyme A, S-(hydrogen propanedioate);S-(Hydrogen malonyl)coenzyme A
                          kegg id: C00083
                          exact mass: 853.116
                          status:
                          lipidmaps

                          PC

                          (1,2-diacyl-sn-glycero-3-phosphocholine) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphocholines [GP01]
                          sub_class: Diacylglycerophosphocholines [GP0101]
                          formula: C10H18NO8P
                          synonyms: Phosphatidylcholine; Diacylphosphatidylcholine
                          kegg id: C00157
                          status:
                          exact mass: 311.077
                          lipidmaps
                          pubchem substance url
                          localization: Unknown
                          notes:
                          LMHD, PSS1, PSSA Phosphatidylserine synthase 1

                          2.7.8.29 L-serine-phosphatidylethanolamine phosphatidyltransferase.

                          L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine. (kegg)
                          proteins
                          P48651 PTSS1_HUMAN
                          Q9BVG9 PTSS2_HUMAN

                          details
                          ["This mammalian enzyme catalyzes an exchange reaction in which the polar head group of phosphatidylethanolamine is replaced by L-serine."]


                          map 1: Glycerophospholipid metabolism

                          proteins:
                          • phosphatidylserine synthase 1 [PTDSS1] ncbi lipid_maps
                            regulators:
                            MIR495 ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                          Choline

                          () (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C5H14NO
                          synonyms: Bilineurine, 2-Hydroxy-N,N,N-trimethylethanaminium, Bursine
                          kegg id: C00114
                          exact mass: 104.107
                          status:
                          pubchem substance url

                          Phosphatidyl-L-serine

                          (1,2-Diacyl-sn-glycerol 3-phospho-L-serine) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphoserines [GP03]
                          sub_class: Diacylglycerophosphoserines [GP0301]
                          formula: C8H12NO10PR2
                          synonyms: 1,2-Diacyl-sn-glycerol 3-phospho-L-serine; 3-O-sn-Phosphatidyl-L-serine; O3-Phosphatidyl-L-serine; L-1-Phosphatidylserine, Phosphatidylserine
                          kegg id: C02737
                          exact mass: 0
                          status:
                          lipidmaps
                          pubchem substance url

                          L-Serine

                          (L-2-Amino-3-hydroxypropionic acid, L-3-Hydroxy-alanine) (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C3H7NO3
                          synonyms: L-3-Hydroxy-alanine; Serine
                          kegg id: C00065
                          status:
                          exact mass: 105.043
                          pubchem substance url
                          localization: Unknown
                          notes:
                          LMHD, PSS1, PSSA Phosphatidylserine synthase 1

                          2.7.8.29 L-serine-phosphatidylethanolamine phosphatidyltransferase.

                          L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine. (kegg)
                          proteins
                          P48651 PTSS1_HUMAN
                          Q9BVG9 PTSS2_HUMAN

                          details
                          ["This mammalian enzyme catalyzes an exchange reaction in which the polar head group of phosphatidylethanolamine is replaced by L-serine."]


                          map 1: Glycerophospholipid metabolism

                          proteins:
                          • phosphatidylserine synthase 1 [PTDSS1] ncbi lipid_maps
                            regulators:
                            MIR495 ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                          Choline

                          () (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C5H14NO
                          synonyms: Bilineurine, 2-Hydroxy-N,N,N-trimethylethanaminium, Bursine
                          kegg id: C00114
                          exact mass: 104.107
                          status:
                          pubchem substance url

                          Phosphatidyl-L-serine

                          (1,2-Diacyl-sn-glycerol 3-phospho-L-serine) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphoserines [GP03]
                          sub_class: Diacylglycerophosphoserines [GP0301]
                          formula: C8H12NO10PR2
                          synonyms: 1,2-Diacyl-sn-glycerol 3-phospho-L-serine; 3-O-sn-Phosphatidyl-L-serine; O3-Phosphatidyl-L-serine; L-1-Phosphatidylserine, Phosphatidylserine
                          kegg id: C02737
                          exact mass: 0
                          status:
                          lipidmaps
                          pubchem substance url

                          Phosphatidyl-L-serine

                          (1,2-Diacyl-sn-glycerol 3-phospho-L-serine) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphoserines [GP03]
                          sub_class: Diacylglycerophosphoserines [GP0301]
                          formula: C8H12NO10PR2
                          synonyms: 1,2-Diacyl-sn-glycerol 3-phospho-L-serine; 3-O-sn-Phosphatidyl-L-serine; O3-Phosphatidyl-L-serine; L-1-Phosphatidylserine, Phosphatidylserine
                          kegg id: C02737
                          status:
                          exact mass: 0
                          lipidmaps
                          pubchem substance url
                          localization: cell membrane

                          4.1.1.65 Phosphatidylserine decarboxylase.

                          Phosphatidyl-L-serine = phosphatidylethanolamine + CO(2). (kegg)
                          proteins
                          Q9UG56 PISD_HUMAN


                          map 1: Glycerophospholipid metabolism

                          proteins:

                          PE + CO2

                          (1,2-diacyl-sn-glycero-3-phosphoethanolamine) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphoethanolamines [GP02]
                          sub_class: Diacylglycerophosphoethanolamines [GP0201]
                          formula:
                          kegg id: C00350
                          exact mass:
                          status:
                          lipidmaps
                          pubchem substance url

                          PE

                          (1,2-diacyl-sn-glycero-3-phosphoethanolamine) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphoethanolamines [GP02]
                          sub_class: Diacylglycerophosphoethanolamines [GP0201]
                          formula:
                          kegg id: C00350
                          status:
                          exact mass:
                          lipidmaps
                          pubchem substance url
                          localization: reticulum

                          2.7.8.29 L-serine-phosphatidylethanolamine phosphatidyltransferase.

                          L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine. (kegg)
                          proteins
                          P48651 PTSS1_HUMAN
                          Q9BVG9 PTSS2_HUMAN

                          details
                          ["This mammalian enzyme catalyzes an exchange reaction in which the polar head group of phosphatidylethanolamine is replaced by L-serine."]


                          map 1: Glycerophospholipid metabolism

                          proteins:

                          Ethanolamine

                          () (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C2H7NO
                          synonyms: Aminoethanol; 2-Hydroxyethylamine
                          kegg id:
                          exact mass: 61.0528
                          status:
                          pubchem substance url

                          Phosphatidyl-L-serine

                          (1,2-Diacyl-sn-glycerol 3-phospho-L-serine) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphoserines [GP03]
                          sub_class: Diacylglycerophosphoserines [GP0301]
                          formula: C8H12NO10PR2
                          synonyms: 1,2-Diacyl-sn-glycerol 3-phospho-L-serine; 3-O-sn-Phosphatidyl-L-serine; O3-Phosphatidyl-L-serine; L-1-Phosphatidylserine, Phosphatidylserine
                          kegg id: C02737
                          exact mass: 0
                          status:
                          lipidmaps
                          pubchem substance url

                          Phosphatidyl-L-serine + H2O

                          (1,2-Diacyl-sn-glycerol 3-phospho-L-serine) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphoserines [GP03]
                          sub_class: Diacylglycerophosphoserines [GP0301]
                          formula: C8H12NO10PR2
                          synonyms: 1,2-Diacyl-sn-glycerol 3-phospho-L-serine; 3-O-sn-Phosphatidyl-L-serine; O3-Phosphatidyl-L-serine; L-1-Phosphatidylserine, Phosphatidylserine
                          kegg id: C02737
                          status:
                          exact mass: 0
                          lipidmaps
                          pubchem substance url
                          localization: lysosome

                          3.1.1.32 Phospholipase A(1).

                          Phosphatidylcholine + H(2)O = 2-acylglycerophosphocholine + a carboxylate. (kegg)
                          proteins
                          Q8WU67 ABHD3_HUMAN
                          P53816 HRSL3_HUMAN

                          details
                          ["Has a much broader specificity than EC 3.1.1.4."]


                          map 1: Glycerophospholipid metabolism

                          proteins:

                          2-Acyl-sn-glycero-3-phosphoserine

                          (2-acyl-sn-glycero-3-phosphoserine) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphoserines [GP03]
                          sub_class: Monoacylglycerophosphoserines [GP0305]
                          formula: C7H13NO9PR
                          synonyms:
                          kegg id: C05974
                          exact mass: 0
                          status:
                          lipidmaps

                          Fatty acid

                          (fatty acid) (lipid link)
                          category: Fatty Acyls [FA]
                          main_class: Fatty Acids and Conjugates [FA01]
                          sub_class: Straight chain fatty acids [FA0101]
                          formula: CHO2R
                          synonyms:
                          kegg id: C00162
                          exact mass: 0
                          status:
                          lipidmaps
                          pubchem substance url

                          1-Acyl-sn-glycero-3-phosphoserine + Acyl-CoA

                          () (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C7H13NO9PR
                          synonyms: 1-Acyl-sn-glycero-3-phosphoserine
                          kegg id: C18125
                          status:
                          exact mass: 286.033
                          pubchem substance url
                          localization: Unknown

                          2.3.1.23 1-acylglycerophosphocholine O-acyltransferase.

                          Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl- sn-glycero-3-phosphocholine. (kegg)
                          proteins
                          Q643R3 LPCT4_HUMAN
                          Q6P1A2 MBOA5_HUMAN
                          Q8NF37 PCAT1_HUMAN
                          Q7L5N7 PCAT2_HUMAN

                          details
                          ["Acts preferentially with unsaturated acyl-CoA derivatives.", "1-acyl-sn-glycero-3-phosphoinositol can also act as acceptor."]


                          map 1: Glycerophospholipid metabolism

                          proteins:

                          Phosphatidyl-L-serine + CoA

                          (1,2-Diacyl-sn-glycerol 3-phospho-L-serine) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphoserines [GP03]
                          sub_class: Diacylglycerophosphoserines [GP0301]
                          formula: C8H12NO10PR2
                          synonyms: 1,2-Diacyl-sn-glycerol 3-phospho-L-serine; 3-O-sn-Phosphatidyl-L-serine; O3-Phosphatidyl-L-serine; L-1-Phosphatidylserine, Phosphatidylserine
                          kegg id: C02737
                          exact mass: 0
                          status:
                          lipidmaps
                          pubchem substance url

                          LTD4 + H2O

                          (5S-hydroxy-6R-(S-cysteinylglycinyl)-7E,9E,11E,14Z-eicosatetraenoic acid) (lipid link)
                          category: Fatty Acyls [FA]
                          main_class: Eicosanoids [FA03]
                          sub_class: Leukotrienes [FA0302]
                          formula: C25H40N2O6S
                          synonyms: Leukotriene D4
                          kegg id: C05951
                          status:
                          exact mass: 496.261
                          lipidmaps
                          pubchem substance url
                          localization: extracellular

                          3.4.13.19 Membrane dipeptidase.

                          Hydrolysis of dipeptides. (kegg)
                          proteins
                          P16444 DPEP1_HUMAN
                          Q9H4A9 DPEP2_HUMAN
                          Q9H4B8 DPEP3_HUMAN

                          details
                          ["Membrane bound, with broad specificity.", "Abundant in the kidney cortex.", "Inhibited by bestatin and cilastatin.", "Belongs to peptidase family M19.", "Formerly EC 3.4.3.1, EC 3.4.3.2, EC 3.4.3.6, EC 3.4.13.1, EC 3.4.13.2, EC 3.4.13.8, EC 3.4.13.11 and EC 3.4.13.15."]


                          map 1: Leukotriene biosynthesis and metabolism

                          proteins:

                          LTE4 + glycine

                          (5S-hydroxy,6R-(S-cysteinyl),7E,9E,11Z,14Z-eicosatetraenoic acid) (lipid link)
                          category: Fatty Acyls [FA]
                          main_class: Eicosanoids [FA03]
                          sub_class: Leukotrienes [FA0302]
                          formula: C23H37NO5S
                          synonyms: Leukotriene E4
                          kegg id: C05952
                          exact mass: 439.239
                          status:
                          lipidmaps
                          pubchem substance url

                          Phosphatidyl-N-methylethanolamine

                          () (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula:
                          synonyms:
                          kegg id: C01241
                          status:
                          exact mass: 0
                          localization: Unknown

                          2.1.1.71 Phosphatidyl-N-methylethanolamine N-methyltransferase.

                          S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl- L-homocysteine + phosphatidyl-N-dimethylethanolamine. (kegg)
                          proteins
                          Q9UBM1 PEMT_HUMAN

                          details
                          ["Also catalyzes the transfer of a further methylgroup, producing phosphatidylcholine."]


                          map 1: Glycerophospholipid metabolism

                          proteins:

                          PE-NMe2

                          (1,2-diacyl-sn-glycero-3-phospho-(N-dimethyl)-ethanolamine) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphoethanolamines [GP02]
                          sub_class: Diacylglycerophosphoethanolamines [GP0201]
                          formula:
                          kegg id: C04308
                          exact mass:
                          status:
                          lipidmaps
                          pubchem substance url

                          S-Adenosyl-L-homocysteine

                          () (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C14H20N6O5S
                          synonyms: S-Adenosylhomocysteine
                          kegg id: C00021
                          exact mass: 384.122
                          status:
                          pubchem substance url

                          S-Adenosyl-L-methionine

                          () (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C15H22N6O5S
                          synonyms: S-Adenosylmethionine; AdoMet; SAM
                          kegg id: C00019
                          status:
                          exact mass: 398.137
                          pubchem substance url
                          localization: Unknown

                          2.1.1.71 Phosphatidyl-N-methylethanolamine N-methyltransferase.

                          S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl- L-homocysteine + phosphatidyl-N-dimethylethanolamine. (kegg)
                          proteins
                          Q9UBM1 PEMT_HUMAN

                          details
                          ["Also catalyzes the transfer of a further methylgroup, producing phosphatidylcholine."]


                          map 1: Glycerophospholipid metabolism

                          proteins:

                          PE-NMe2

                          (1,2-diacyl-sn-glycero-3-phospho-(N-dimethyl)-ethanolamine) (lipid link)
                          category: Glycerophospholipids [GP]
                          main_class: Glycerophosphoethanolamines [GP02]
                          sub_class: Diacylglycerophosphoethanolamines [GP0201]
                          formula:
                          kegg id: C04308
                          exact mass:
                          status:
                          lipidmaps
                          pubchem substance url

                          S-Adenosyl-L-homocysteine

                          () (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C14H20N6O5S
                          synonyms: S-Adenosylhomocysteine
                          kegg id: C00021
                          exact mass: 384.122
                          status:
                          pubchem substance url

                          1,2-Diacyl-sn-glycerol 3-phosphate + H2O

                          (1,2-Diacyl-sn-glycerol 3-phosphate) (lipid link)
                          category:
                          main_class:
                          sub_class:
                          formula: C5H7O8PR2
                          synonyms: Phosphatidate; Phosphatidic acid; 3-sn-Phosphatidate
                          kegg id: C00416
                          status:
                          exact mass: 225.988
                          lipidmaps
                          pubchem substance url
                          localization: Unknown
                          notes:

                          phosphatidate phosphatase LPIN LPIN1, LPIN3, PLPP1, PLPP2, PLPP3, LPIN2

                          3.1.3.4 Phosphatidate phosphatase.

                          A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate. (kegg)
                          proteins
                          Q14693 LPIN1_HUMAN
                          Q92539 LPIN2_HUMAN
                          Q9BQK8 LPIN3_HUMAN
                          O14494 PLPP1_HUMAN
                          O43688 PLPP2_HUMAN
                          O14495 PLPP3_HUMAN
                          Q5VZY2 PLPP4_HUMAN
                          Q8NEB5 PLPP5_HUMAN
                          Q96GM1 PLPR2_HUMAN
                          Q6T4P5 PLPR3_HUMAN
                          Q7Z2D5 PLPR4_HUMAN

                          details
                          ["This enzyme catalyzes the Mg(2+)-dependent dephosphorylation of a 1,2-diacylglycerol-3-phosphate, yielding a 1,2-diacyl-sn-glycerol (DAG), the substrate for de novo lipid synthesis via the Kennedy pathway and for the synthesis of triacylglycerol.", "In lipid signaling, the enzyme generates a pool of DAG to be used for protein kinase C activation.", "The mammalian enzymes are known as lipins."]


                          map 1: Glycerophospholipid metabolism
                          map 2: Glycerolipid metabolism

                          proteins:

                            1,2-DG + Phosphate

                            (1,2-diacyl-sn-glycerol) (lipid link)
                            category: Glycerolipids [GL]
                            main_class: Diradylglycerols [GL02]
                            sub_class: Diacylglycerols [GL0201]
                            formula:
                            synonyms: 1,2-diacylglycerol; 1,2-DAG
                            kegg id: C00641
                            exact mass:
                            status:
                            lipidmaps
                            pubchem substance url

                            GD1a + CMP-N-Acetylneuraminic acid

                            (NeuAcα2-3Galβ1-3GalNAcβ1-4(NeuAcα2-3)Galβ1-4Glcβ-Cer) (lipid link)
                            category: Sphingolipids [SP]
                            main_class: Acidic glycosphingolipids [SP06]
                            sub_class: Gangliosides [SP0601]
                            formula:
                            synonyms:
                            kegg id:
                            status:
                            exact mass: 0
                            lipidmaps
                            localization: Golgi apparatus

                            2.4.99.- Transferring other glycosyl groups.

                            (kegg)
                            proteins


                            map 1: Ganglioside Metabolism N2

                            proteins:
                            • ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 [ST6GALNAC6] ncbi lipid_maps
                            • ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 [ST6GALNAC5] ncbi lipid_maps

                            GT1aa + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                            ( NeuAcα2-3Galβ1-3(NeuAcα2-6)GalNAcβ1-4(NeuAcα2-3)Galβ1-4Glcβ-Cer) (lipid link)
                            category: Sphingolipids [SP]
                            main_class: Acidic glycosphingolipids [SP06]
                            sub_class: Gangliosides [SP0601]
                            formula:
                            synonyms:
                            kegg id:
                            exact mass: 0
                            status:
                            lipidmaps

                            PC + H2O

                            (1,2-diacyl-sn-glycero-3-phosphocholine) (lipid link)
                            category: Glycerophospholipids [GP]
                            main_class: Glycerophosphocholines [GP01]
                            sub_class: Diacylglycerophosphocholines [GP0101]
                            formula: C10H18NO8P
                            synonyms: Phosphatidylcholine; Diacylphosphatidylcholine
                            kegg id: C00157
                            status:
                            exact mass: 311.077
                            lipidmaps
                            pubchem substance url
                            localization: Cytoplasm
                            proteins


                            map 1: Glycerophospholipid metabolism

                            proteins:
                            • phospholipase A2, group IVB (cytosolic) [PLA2G4B] ncbi lipid_maps
                            • phospholipase A2, group XVI [PLA2G16] ncbi lipid_maps
                            • phospholipase A2, group IVE [PLA2G4E] ncbi lipid_maps
                            • phospholipase B1 [PLB1] ncbi lipid_maps
                            • phospholipase A2, group IVF [PLA2G4F] ncbi lipid_maps
                            • phospholipase A2, group IID [PLA2G2D] ncbi lipid_maps
                            • phospholipase A2, group IVD (cytosolic) [PLA2G4D] ncbi lipid_maps
                            • phospholipase A2, group IIE [PLA2G2E] ncbi lipid_maps
                            • phospholipase A2, group IIC [PLA2G2C] ncbi lipid_maps
                            • phospholipase A2, group III [PLA2G3] ncbi lipid_maps
                              regulators:
                              MAPK1 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                              MAPK3 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                            • phospholipase A2, group IB (pancreas) [PLA2G1B] ncbi lipid_maps
                              regulators:
                              MAPK1 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                              MAPK3 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                            • phospholipase A2, group IIA (platelets, synovial fluid) [PLA2G2A] ncbi lipid_maps
                              regulators:
                              MAPK1 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                              MAPK3 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                            • phospholipase A2, group IVA (cytosolic, calcium-dependent) [PLA2G4A] ncbi lipid_maps
                              regulators:
                              PRKCA ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                              MAPK1 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                              MAPK3 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                            • phospholipase A2, group V [PLA2G5] ncbi lipid_maps
                              regulators:
                              MAPK1 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                              MAPK3 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                            • phospholipase A2, group IIF [PLA2G2F] ncbi lipid_maps
                            • phospholipase A2, group XIIA [PLA2G12A] ncbi lipid_maps
                            • phospholipase A2, group VI (cytosolic, calcium-independent) [PLA2G6] ncbi lipid_maps
                              regulators:
                              MAPK1 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                              MAPK3 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                              STAT1 ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd
                            • phospholipase A2, group X [PLA2G10] ncbi lipid_maps
                              regulators:
                              MAPK1 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                              MAPK3 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                            • phospholipase A2, group XIIB [PLA2G12B] ncbi lipid_maps
                            • phospholipase A2, group IVC (cytosolic, calcium-independent) [PLA2G4C] ncbi lipid_maps
                            • phospholipase A2, group IVB (cytosolic) [PLA2G4B] ncbi lipid_maps

                            LPC

                            (1-acyl-sn-glycero-3-phosphocholine) (lipid link)
                            category: Glycerophospholipids [GP]
                            main_class: Glycerophosphocholines [GP01]
                            sub_class: Monoacylglycerophosphocholines [GP0105]
                            formula:
                            kegg id: C04230
                            exact mass:
                            status:
                            lipidmaps
                            pubchem substance url

                            Fatty acid

                            (fatty acid) (lipid link)
                            category: Fatty Acyls [FA]
                            main_class: Fatty Acids and Conjugates [FA01]
                            sub_class: Straight chain fatty acids [FA0101]
                            formula: CHO2R
                            synonyms:
                            kegg id: C00162
                            exact mass: 0
                            status:
                            lipidmaps
                            pubchem substance url

                            LPC + Acyl-CoA

                            (1-acyl-sn-glycero-3-phosphocholine) (lipid link)
                            category: Glycerophospholipids [GP]
                            main_class: Glycerophosphocholines [GP01]
                            sub_class: Monoacylglycerophosphocholines [GP0105]
                            formula:
                            kegg id: C04230
                            status:
                            exact mass:
                            lipidmaps
                            pubchem substance url
                            localization: Cytoplasm

                            2.3.1.23 1-acylglycerophosphocholine O-acyltransferase.

                            Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl- sn-glycero-3-phosphocholine. (kegg)
                            proteins
                            Q643R3 LPCT4_HUMAN
                            Q6P1A2 MBOA5_HUMAN
                            Q8NF37 PCAT1_HUMAN
                            Q7L5N7 PCAT2_HUMAN

                            details
                            ["Acts preferentially with unsaturated acyl-CoA derivatives.", "1-acyl-sn-glycero-3-phosphoinositol can also act as acceptor."]


                            map 1: Glycerophospholipid metabolism

                            proteins:

                            PC + CoA

                            (1,2-diacyl-sn-glycero-3-phosphocholine) (lipid link)
                            category: Glycerophospholipids [GP]
                            main_class: Glycerophosphocholines [GP01]
                            sub_class: Diacylglycerophosphocholines [GP0101]
                            formula: C10H18NO8P
                            synonyms: Phosphatidylcholine; Diacylphosphatidylcholine
                            kegg id: C00157
                            exact mass: 311.077
                            status:
                            lipidmaps
                            pubchem substance url

                            PC + H2O

                            (1,2-diacyl-sn-glycero-3-phosphocholine) (lipid link)
                            category: Glycerophospholipids [GP]
                            main_class: Glycerophosphocholines [GP01]
                            sub_class: Diacylglycerophosphocholines [GP0101]
                            formula: C10H18NO8P
                            synonyms: Phosphatidylcholine; Diacylphosphatidylcholine
                            kegg id: C00157
                            status:
                            exact mass: 311.077
                            lipidmaps
                            pubchem substance url
                            localization: Unknown

                            3.1.1.32 Phospholipase A(1).

                            Phosphatidylcholine + H(2)O = 2-acylglycerophosphocholine + a carboxylate. (kegg)
                            proteins
                            Q8WU67 ABHD3_HUMAN
                            P53816 HRSL3_HUMAN

                            details
                            ["Has a much broader specificity than EC 3.1.1.4."]


                            map 1: Glycerophospholipid metabolism

                            proteins:

                            2-acyl-sn-glycero-3-phosphocholine

                            (2-acyl-sn-glycero-3-phosphocholine) (lipid link)
                            category: Glycerophospholipids [GP]
                            main_class: Glycerophosphocholines [GP01]
                            sub_class: Monoacylglycerophosphocholines [GP0105]
                            formula:
                            kegg id: C04233
                            exact mass:
                            status:
                            lipidmaps
                            pubchem substance url

                            Carboxylate

                            () (lipid link)
                            category:
                            main_class:
                            sub_class:
                            formula: CO2R
                            synonyms: R-COOH; Monocarboxylate; Carboxylic acid
                            kegg id: C00060
                            exact mass: 0
                            status:
                            pubchem substance url

                            LPC + H2O

                            (1-acyl-sn-glycero-3-phosphocholine) (lipid link)
                            category: Glycerophospholipids [GP]
                            main_class: Glycerophosphocholines [GP01]
                            sub_class: Monoacylglycerophosphocholines [GP0105]
                            formula:
                            kegg id: C04230
                            status:
                            exact mass:
                            lipidmaps
                            pubchem substance url
                            localization: Unknown
                            notes:
                            add 1178(CLC), 374569(ASPG)

                            3.1.1.5 Lysophospholipase.

                            2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate. (kegg)
                            proteins
                            Q86U10 LPP60_HUMAN
                            P47712 PA24A_HUMAN
                            Q6P1J6 PLB1_HUMAN
                            Q8IY17 PLPL6_HUMAN
                            Q9NP80 PLPL8_HUMAN


                            map 1: Glycerophospholipid metabolism

                            proteins:

                            Fatty acid

                            (fatty acid) (lipid link)
                            category: Fatty Acyls [FA]
                            main_class: Fatty Acids and Conjugates [FA01]
                            sub_class: Straight chain fatty acids [FA0101]
                            formula: CHO2R
                            synonyms:
                            kegg id: C00162
                            exact mass: 0
                            status:
                            lipidmaps
                            pubchem substance url

                            sn-Glycero-3-phosphocholine

                            () (lipid link)
                            category:
                            main_class:
                            sub_class:
                            formula: C8H21NO6P
                            synonyms: Glycerophosphocholine
                            kegg id: C00670
                            exact mass: 258.111
                            status:
                            pubchem substance url

                            2-acyl-sn-glycero-3-phosphocholine + H2O

                            (2-acyl-sn-glycero-3-phosphocholine) (lipid link)
                            category: Glycerophospholipids [GP]
                            main_class: Glycerophosphocholines [GP01]
                            sub_class: Monoacylglycerophosphocholines [GP0105]
                            formula:
                            kegg id: C04233
                            status:
                            exact mass:
                            lipidmaps
                            pubchem substance url
                            localization: Unknown
                            notes:
                            add 1178(CLC), 374569(ASPG)

                            3.1.1.5 Lysophospholipase.

                            2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate. (kegg)
                            proteins
                            Q86U10 LPP60_HUMAN
                            P47712 PA24A_HUMAN
                            Q6P1J6 PLB1_HUMAN
                            Q8IY17 PLPL6_HUMAN
                            Q9NP80 PLPL8_HUMAN


                            map 1: Glycerophospholipid metabolism

                            proteins:

                            Fatty acid

                            (fatty acid) (lipid link)
                            category: Fatty Acyls [FA]
                            main_class: Fatty Acids and Conjugates [FA01]
                            sub_class: Straight chain fatty acids [FA0101]
                            formula: CHO2R
                            synonyms:
                            kegg id: C00162
                            exact mass: 0
                            status:
                            lipidmaps
                            pubchem substance url

                            sn-Glycero-3-phosphocholine

                            () (lipid link)
                            category:
                            main_class:
                            sub_class:
                            formula: C8H21NO6P
                            synonyms: Glycerophosphocholine
                            kegg id: C00670
                            exact mass: 258.111
                            status:
                            pubchem substance url

                            sn-Glycero-3-phosphocholine + H2O

                            () (lipid link)
                            category:
                            main_class:
                            sub_class:
                            formula: C8H21NO6P
                            synonyms: Glycerophosphocholine
                            kegg id: C00670
                            status:
                            exact mass: 258.111
                            pubchem substance url
                            localization: Unknown
                            notes:
                            add 56261 (GPCPD1)

                            3.1.4.2 Glycerophosphocholine phosphodiesterase.

                            sn-glycero-3-phosphocholine + H(2)O = choline + sn-glycerol 3-phosphate. (kegg)
                            proteins
                            Q9NPB8 GPCP1_HUMAN

                            details
                            ["Also acts on sn-glycero-3-phosphoethanolamine."]


                            map 1: Glycerophospholipid metabolism

                            proteins:

                              sn-Glycerol 3-phosphate

                              () (lipid link)
                              category:
                              main_class:
                              sub_class:
                              formula: C3H9O6P
                              synonyms: Glycerophosphoric acid; D-Glycerol 1-phosphate
                              kegg id: C00093
                              exact mass: 172.014
                              status:
                              pubchem substance url

                              Choline

                              () (lipid link)
                              category:
                              main_class:
                              sub_class:
                              formula: C5H14NO
                              synonyms: Bilineurine, 2-Hydroxy-N,N,N-trimethylethanaminium, Bursine
                              kegg id: C00114
                              exact mass: 104.107
                              status:
                              pubchem substance url

                              1,2-DG

                              (1,2-diacyl-sn-glycerol) (lipid link)
                              category: Glycerolipids [GL]
                              main_class: Diradylglycerols [GL02]
                              sub_class: Diacylglycerols [GL0201]
                              formula:
                              synonyms: 1,2-diacylglycerol; 1,2-DAG
                              kegg id: C00641
                              status:
                              exact mass:
                              lipidmaps
                              pubchem substance url
                              localization: Cytoplasm

                              2.7.8.2 Diacylglycerol cholinephosphotransferase.

                              CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine. (kegg)
                              proteins
                              Q9Y6K0 CEPT1_HUMAN
                              Q8WUD6 CHPT1_HUMAN

                              details
                              ["1-alkyl-2-acylglycerol can act as acceptor.", "Formerly EC 2.7.8.16."]


                              map 1: Glycerophospholipid metabolism

                              proteins:

                              PC + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                              (1,2-diacyl-sn-glycero-3-phosphocholine) (lipid link)
                              category: Glycerophospholipids [GP]
                              main_class: Glycerophosphocholines [GP01]
                              sub_class: Diacylglycerophosphocholines [GP0101]
                              formula: C10H18NO8P
                              synonyms: Phosphatidylcholine; Diacylphosphatidylcholine
                              kegg id: C00157
                              exact mass: 311.077
                              status:
                              lipidmaps
                              pubchem substance url

                              CDP-choline

                              (Cytidine 5-diphosphocholine) (lipid link)
                              category:
                              main_class:
                              sub_class:
                              formula: C14H26N4O11P2
                              synonyms: Citicoline
                              kegg id: C00307
                              status:
                              exact mass: 488.107
                              pubchem substance url
                              localization: Cytoplasm

                              2.7.8.2 Diacylglycerol cholinephosphotransferase.

                              CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine. (kegg)
                              proteins
                              Q9Y6K0 CEPT1_HUMAN
                              Q8WUD6 CHPT1_HUMAN

                              details
                              ["1-alkyl-2-acylglycerol can act as acceptor.", "Formerly EC 2.7.8.16."]


                              map 1: Glycerophospholipid metabolism

                              proteins:

                              PC + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                              (1,2-diacyl-sn-glycero-3-phosphocholine) (lipid link)
                              category: Glycerophospholipids [GP]
                              main_class: Glycerophosphocholines [GP01]
                              sub_class: Diacylglycerophosphocholines [GP0101]
                              formula: C10H18NO8P
                              synonyms: Phosphatidylcholine; Diacylphosphatidylcholine
                              kegg id: C00157
                              exact mass: 311.077
                              status:
                              lipidmaps
                              pubchem substance url

                              1,2-DG

                              (1,2-diacyl-sn-glycerol) (lipid link)
                              category: Glycerolipids [GL]
                              main_class: Diradylglycerols [GL02]
                              sub_class: Diacylglycerols [GL0201]
                              formula:
                              synonyms: 1,2-diacylglycerol; 1,2-DAG
                              kegg id: C00641
                              status:
                              exact mass:
                              lipidmaps
                              pubchem substance url
                              localization: Cytoplasm

                              2.7.8.1 Ethanolaminephosphotransferase.

                              CDP-ethanolamine + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylethanolamine. (kegg)
                              proteins
                              Q9Y6K0 CEPT1_HUMAN
                              Q9C0D9 EPT1_HUMAN


                              map 1: Glycerophospholipid metabolism

                              proteins:
                              • choline/ethanolamine phosphotransferase 1 [CEPT1] ncbi lipid_maps
                              • ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific) [EPT1] ncbi lipid_maps

                              PE + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                              (1,2-diacyl-sn-glycero-3-phosphoethanolamine) (lipid link)
                              category: Glycerophospholipids [GP]
                              main_class: Glycerophosphoethanolamines [GP02]
                              sub_class: Diacylglycerophosphoethanolamines [GP0201]
                              formula:
                              kegg id: C00350
                              exact mass:
                              status:
                              lipidmaps
                              pubchem substance url

                              CDP-ethanolamine

                              () (lipid link)
                              category:
                              main_class:
                              sub_class:
                              formula: C11H20N4O11P2
                              synonyms: Cytidine diphosphate ethanolamine
                              kegg id: C00570
                              status:
                              exact mass: 446.06
                              pubchem substance url
                              localization: Cytoplasm

                              2.7.8.1 Ethanolaminephosphotransferase.

                              CDP-ethanolamine + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylethanolamine. (kegg)
                              proteins
                              Q9Y6K0 CEPT1_HUMAN
                              Q9C0D9 EPT1_HUMAN


                              map 1: Glycerophospholipid metabolism

                              proteins:
                              • choline/ethanolamine phosphotransferase 1 [CEPT1] ncbi lipid_maps
                              • ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific) [EPT1] ncbi lipid_maps

                              PE + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                              (1,2-diacyl-sn-glycero-3-phosphoethanolamine) (lipid link)
                              category: Glycerophospholipids [GP]
                              main_class: Glycerophosphoethanolamines [GP02]
                              sub_class: Diacylglycerophosphoethanolamines [GP0201]
                              formula:
                              kegg id: C00350
                              exact mass:
                              status:
                              lipidmaps
                              pubchem substance url

                              PE + H2O

                              (1,2-diacyl-sn-glycero-3-phosphoethanolamine) (lipid link)
                              category: Glycerophospholipids [GP]
                              main_class: Glycerophosphoethanolamines [GP02]
                              sub_class: Diacylglycerophosphoethanolamines [GP0201]
                              formula:
                              kegg id: C00350
                              status:
                              exact mass:
                              lipidmaps
                              pubchem substance url
                              localization: Cytoplasm

                              3.1.1.4 Phospholipase A(2).

                              Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate. (kegg)
                              proteins
                              Q8WU67 ABHD3_HUMAN
                              P53816 HRSL3_HUMAN
                              P04054 PA21B_HUMAN
                              P47712 PA24A_HUMAN
                              P0C869 PA24B_HUMAN
                              Q9UP65 PA24C_HUMAN
                              Q86XP0 PA24D_HUMAN
                              Q3MJ16 PA24E_HUMAN
                              Q68DD2 PA24F_HUMAN
                              Q9NZ20 PA2G3_HUMAN
                              P39877 PA2G5_HUMAN
                              P14555 PA2GA_HUMAN
                              Q9UNK4 PA2GD_HUMAN
                              Q9NZK7 PA2GE_HUMAN
                              Q9BZM2 PA2GF_HUMAN
                              O15496 PA2GX_HUMAN
                              Q9BZM1 PG12A_HUMAN
                              Q6P1J6 PLB1_HUMAN
                              O60733 PLPL9_HUMAN

                              details
                              ["Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position."]


                              map 1: Glycerophospholipid metabolism
                              map 2: ETHER lipid metabolism

                              proteins:
                              • phospholipase A2, group IVB (cytosolic) [PLA2G4B] ncbi lipid_maps
                              • phospholipase A2, group XVI [PLA2G16] ncbi lipid_maps
                              • phospholipase A2, group IVE [PLA2G4E] ncbi lipid_maps
                              • phospholipase B1 [PLB1] ncbi lipid_maps
                              • phospholipase A2, group IVF [PLA2G4F] ncbi lipid_maps
                              • phospholipase A2, group IVD (cytosolic) [PLA2G4D] ncbi lipid_maps
                              • phospholipase A2, group IIE [PLA2G2E] ncbi lipid_maps
                              • phospholipase A2, group IIC [PLA2G2C] ncbi lipid_maps
                              • phospholipase A2, group III [PLA2G3] ncbi lipid_maps
                                regulators:
                                MAPK1 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                                MAPK3 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                              • phospholipase A2, group IB (pancreas) [PLA2G1B] ncbi lipid_maps
                                regulators:
                                MAPK1 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                                MAPK3 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                              • phospholipase A2, group IIA (platelets, synovial fluid) [PLA2G2A] ncbi lipid_maps
                                regulators:
                                MAPK1 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                                MAPK3 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                              • phospholipase A2, group IVA (cytosolic, calcium-dependent) [PLA2G4A] ncbi lipid_maps
                                regulators:
                                PRKCA ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                                MAPK1 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                                MAPK3 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                              • phospholipase A2, group V [PLA2G5] ncbi lipid_maps
                                regulators:
                                MAPK1 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                                MAPK3 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                              • phospholipase A2, group IIF [PLA2G2F] ncbi lipid_maps
                              • phospholipase A2, group XIIA [PLA2G12A] ncbi lipid_maps
                              • phospholipase A2, group VI (cytosolic, calcium-independent) [PLA2G6] ncbi lipid_maps
                                regulators:
                                MAPK1 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                                MAPK3 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                                STAT1 ( transcriptional regulation ) /1 (0, 0, 1)/ rzmd
                              • phospholipase A2, group X [PLA2G10] ncbi lipid_maps
                                regulators:
                                MAPK1 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                                MAPK3 ( phosphorylation ) /1 (1, 0, 0)/ rzmd
                              • phospholipase A2, group XIIB [PLA2G12B] ncbi lipid_maps
                              • phospholipase A2, group IVC (cytosolic, calcium-independent) [PLA2G4C] ncbi lipid_maps

                              LPE

                              (1-acyl-sn-glycero-3-phosphoethanolamine) (lipid link)
                              category: Glycerophospholipids [GP]
                              main_class: Glycerophosphoethanolamines [GP02]
                              sub_class: Monoacylglycerophosphoethanolamines [GP0205]
                              formula:
                              kegg id: C04438
                              exact mass:
                              status:
                              lipidmaps
                              pubchem substance url

                              Fatty acid

                              (fatty acid) (lipid link)
                              category: Fatty Acyls [FA]
                              main_class: Fatty Acids and Conjugates [FA01]
                              sub_class: Straight chain fatty acids [FA0101]
                              formula: CHO2R
                              synonyms:
                              kegg id: C00162
                              exact mass: 0
                              status:
                              lipidmaps
                              pubchem substance url

                              LPE + H2O

                              (1-acyl-sn-glycero-3-phosphoethanolamine) (lipid link)
                              category: Glycerophospholipids [GP]
                              main_class: Glycerophosphoethanolamines [GP02]
                              sub_class: Monoacylglycerophosphoethanolamines [GP0205]
                              formula:
                              kegg id: C04438
                              status:
                              exact mass:
                              lipidmaps
                              pubchem substance url
                              localization: Unknown
                              notes:
                              add CLC, ASPG

                              3.1.1.5 Lysophospholipase.

                              2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate. (kegg)
                              proteins
                              Q86U10 LPP60_HUMAN
                              P47712 PA24A_HUMAN
                              Q6P1J6 PLB1_HUMAN
                              Q8IY17 PLPL6_HUMAN
                              Q9NP80 PLPL8_HUMAN


                              map 1: Glycerophospholipid metabolism

                              proteins:

                              Fatty acid

                              (fatty acid) (lipid link)
                              category: Fatty Acyls [FA]
                              main_class: Fatty Acids and Conjugates [FA01]
                              sub_class: Straight chain fatty acids [FA0101]
                              formula: CHO2R
                              synonyms:
                              kegg id: C00162
                              exact mass: 0
                              status:
                              lipidmaps
                              pubchem substance url

                              sn-Glycero-3-phosphoethanolamine

                              (sn-Glycero-3-phosphoethanolamine) (lipid link)
                              category:
                              main_class:
                              sub_class:
                              formula: C5H14NO6P
                              synonyms: Glycerophosphoethanolamine
                              kegg id: C01233
                              exact mass: 215.056
                              status:
                              pubchem substance url

                              sn-Glycero-3-phosphoethanolamine + H2O

                              (sn-Glycero-3-phosphoethanolamine) (lipid link)
                              category:
                              main_class:
                              sub_class:
                              formula: C5H14NO6P
                              synonyms: Glycerophosphoethanolamine
                              kegg id: C01233
                              status:
                              exact mass: 215.056
                              pubchem substance url
                              localization: Unknown

                              3.1.4.2 Glycerophosphocholine phosphodiesterase.

                              sn-glycero-3-phosphocholine + H(2)O = choline + sn-glycerol 3-phosphate. (kegg)
                              proteins
                              Q9NPB8 GPCP1_HUMAN

                              details
                              ["Also acts on sn-glycero-3-phosphoethanolamine."]


                              map 1: Glycerophospholipid metabolism

                              proteins:

                                sn-Glycerol 3-phosphate

                                () (lipid link)
                                category:
                                main_class:
                                sub_class:
                                formula: C3H9O6P
                                synonyms: Glycerophosphoric acid; D-Glycerol 1-phosphate
                                kegg id: C00093
                                exact mass: 172.014
                                status:
                                pubchem substance url

                                Ethanolamine

                                () (lipid link)
                                category:
                                main_class:
                                sub_class:
                                formula: C2H7NO
                                synonyms: Aminoethanol; 2-Hydroxyethylamine
                                kegg id:
                                exact mass: 61.0528
                                status:
                                pubchem substance url

                                LPE + Acyl-CoA

                                (1-acyl-sn-glycero-3-phosphoethanolamine) (lipid link)
                                category: Glycerophospholipids [GP]
                                main_class: Glycerophosphoethanolamines [GP02]
                                sub_class: Monoacylglycerophosphoethanolamines [GP0205]
                                formula:
                                kegg id: C04438
                                status:
                                exact mass:
                                lipidmaps
                                pubchem substance url
                                localization: Unknown

                                2.3.1.23 1-acylglycerophosphocholine O-acyltransferase.

                                Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl- sn-glycero-3-phosphocholine. (kegg)
                                proteins
                                Q643R3 LPCT4_HUMAN
                                Q6P1A2 MBOA5_HUMAN
                                Q8NF37 PCAT1_HUMAN
                                Q7L5N7 PCAT2_HUMAN

                                details
                                ["Acts preferentially with unsaturated acyl-CoA derivatives.", "1-acyl-sn-glycero-3-phosphoinositol can also act as acceptor."]


                                map 1: Glycerophospholipid metabolism

                                proteins:
                                • membrane bound O-acyltransferase domain containing 2 [MBOAT2] ncbi lipid_maps

                                PE + CoA

                                (1,2-diacyl-sn-glycero-3-phosphoethanolamine) (lipid link)
                                category: Glycerophospholipids [GP]
                                main_class: Glycerophosphoethanolamines [GP02]
                                sub_class: Diacylglycerophosphoethanolamines [GP0201]
                                formula:
                                kegg id: C00350
                                exact mass:
                                status:
                                lipidmaps
                                pubchem substance url

                                PE + H2O

                                (1,2-diacyl-sn-glycero-3-phosphoethanolamine) (lipid link)
                                category: Glycerophospholipids [GP]
                                main_class: Glycerophosphoethanolamines [GP02]
                                sub_class: Diacylglycerophosphoethanolamines [GP0201]
                                formula:
                                kegg id: C00350
                                status:
                                exact mass:
                                lipidmaps
                                pubchem substance url
                                localization: Unknown

                                3.1.1.32 Phospholipase A(1).

                                Phosphatidylcholine + H(2)O = 2-acylglycerophosphocholine + a carboxylate. (kegg)
                                proteins
                                Q8WU67 ABHD3_HUMAN
                                P53816 HRSL3_HUMAN

                                details
                                ["Has a much broader specificity than EC 3.1.1.4."]


                                map 1: Glycerophospholipid metabolism

                                proteins:

                                Fatty acid

                                (fatty acid) (lipid link)
                                category: Fatty Acyls [FA]
                                main_class: Fatty Acids and Conjugates [FA01]
                                sub_class: Straight chain fatty acids [FA0101]
                                formula: CHO2R
                                synonyms:
                                kegg id: C00162
                                exact mass: 0
                                status:
                                lipidmaps
                                pubchem substance url

                                L-1-Lysophosphatidylethanolamine

                                (2-acyl-sn-glycero-3-phosphoethanolamine) (lipid link)
                                category: Glycerophospholipids [GP]
                                main_class: Glycerophosphoethanolamines [GP02]
                                sub_class: Monoacylglycerophosphoethanolamines [GP0205]
                                formula: C6H13NO7PR
                                synonyms: O-(2-Acyl-sn-glycero-3-phospho)-ethanolamine
                                kegg id: C05973
                                exact mass: 0
                                status:
                                lipidmaps
                                pubchem substance url

                                L-1-Lysophosphatidylethanolamine + H2O

                                (2-acyl-sn-glycero-3-phosphoethanolamine) (lipid link)
                                category: Glycerophospholipids [GP]
                                main_class: Glycerophosphoethanolamines [GP02]
                                sub_class: Monoacylglycerophosphoethanolamines [GP0205]
                                formula: C6H13NO7PR
                                synonyms: O-(2-Acyl-sn-glycero-3-phospho)-ethanolamine
                                kegg id: C05973
                                status:
                                exact mass: 0
                                lipidmaps
                                pubchem substance url
                                localization: Unknown
                                notes:
                                add CLC,

                                3.1.1.5 Lysophospholipase.

                                2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate. (kegg)
                                proteins
                                Q86U10 LPP60_HUMAN
                                P47712 PA24A_HUMAN
                                Q6P1J6 PLB1_HUMAN
                                Q8IY17 PLPL6_HUMAN
                                Q9NP80 PLPL8_HUMAN


                                proteins:

                                Fatty acid

                                (fatty acid) (lipid link)
                                category: Fatty Acyls [FA]
                                main_class: Fatty Acids and Conjugates [FA01]
                                sub_class: Straight chain fatty acids [FA0101]
                                formula: CHO2R
                                synonyms:
                                kegg id: C00162
                                exact mass: 0
                                status:
                                lipidmaps
                                pubchem substance url

                                sn-Glycero-3-phosphoethanolamine

                                (sn-Glycero-3-phosphoethanolamine) (lipid link)
                                category:
                                main_class:
                                sub_class:
                                formula: C5H14NO6P
                                synonyms: Glycerophosphoethanolamine
                                kegg id: C01233
                                exact mass: 215.056
                                status:
                                pubchem substance url

                                Phosphocholine + CTP (Cytidine 5'-triphosphate; Cytidine triphosphate)

                                () (lipid link)
                                category:
                                main_class:
                                sub_class:
                                formula: C5H15NO4P
                                synonyms: Choline phosphate, Phosphorylcholine, O-Phosphocholine
                                kegg id: C00588
                                status:
                                exact mass: 184.074
                                localization: Unknown
                                notes:
                                PCYT1B - ret. mem., PCYT1A - cyt

                                2.7.7.15 Choline-phosphate cytidylyltransferase.

                                CTP + phosphocholine = diphosphate + CDP-choline. (kegg)
                                proteins
                                P49585 PCY1A_HUMAN
                                Q9Y5K3 PCY1B_HUMAN


                                map 1: Glycerophospholipid metabolism

                                proteins:
                                • phosphate cytidylyltransferase 1, choline, alpha [PCYT1A] ncbi lipid_maps
                                • phosphate cytidylyltransferase 1, choline, beta [PCYT1B] ncbi lipid_maps

                                CDP-choline

                                (Cytidine 5-diphosphocholine) (lipid link)
                                category:
                                main_class:
                                sub_class:
                                formula: C14H26N4O11P2
                                synonyms: Citicoline
                                kegg id: C00307
                                exact mass: 488.107
                                status:
                                pubchem substance url

                                Diphosphate

                                () (lipid link)
                                category:
                                main_class:
                                sub_class:
                                formula: H4P2O7
                                synonyms: Diphosphoric acid, Pyrophosphate, Pyrophosphoric acid, PPi
                                kegg id: C00013
                                exact mass: 177.943
                                status:
                                pubchem substance url

                                Choline + ATP

                                () (lipid link)
                                category:
                                main_class:
                                sub_class:
                                formula: C5H14NO
                                synonyms: Bilineurine, 2-Hydroxy-N,N,N-trimethylethanaminium, Bursine
                                kegg id: C00114
                                status:
                                exact mass: 104.107
                                pubchem substance url
                                localization: Cytoplasm

                                2.7.1.32 Choline kinase.

                                ATP + choline = ADP + phosphocholine. (kegg)
                                proteins
                                P35790 CHKA_HUMAN
                                Q9Y259 CHKB_HUMAN

                                details
                                ["Ethanolamine and its methyl and ethyl derivatives can also act as acceptors."]


                                map 1: Glycerophospholipid metabolism

                                proteins:

                                Phosphocholine + ADP

                                () (lipid link)
                                category:
                                main_class:
                                sub_class:
                                formula: C5H15NO4P
                                synonyms: Choline phosphate, Phosphorylcholine, O-Phosphocholine
                                kegg id: C00588
                                exact mass: 184.074
                                status:

                                Phosphocholine + H2O

                                () (lipid link)
                                category:
                                main_class:
                                sub_class:
                                formula: C5H15NO4P
                                synonyms: Choline phosphate, Phosphorylcholine, O-Phosphocholine
                                kegg id: C00588
                                status:
                                exact mass: 184.074
                                localization: Unknown

                                3.1.3.75 Phosphoethanolamine/phosphocholine phosphatase.

                                (1) O-phosphoethanolamine + H(2)O = ethanolamine + phosphate. (2) Phosphocholine + H(2)O = choline + phosphate. (kegg)
                                proteins
                                Q8TCT1 PHOP1_HUMAN

                                details
                                ["The enzyme is highly specific for phosphoethanolamine and phosphocholine."]


                                map 1: Glycerophospholipid metabolism

                                proteins:

                                Choline + Phosphate

                                () (lipid link)
                                category:
                                main_class:
                                sub_class:
                                formula: C5H14NO
                                synonyms: Bilineurine, 2-Hydroxy-N,N,N-trimethylethanaminium, Bursine
                                kegg id: C00114
                                exact mass: 104.107
                                status:
                                pubchem substance url

                                O-Phosphoethanolamine + H2O

                                () (lipid link)
                                category:
                                main_class:
                                sub_class:
                                formula:
                                synonyms: Phosphoethanolamine
                                kegg id:
                                status:
                                exact mass: 0
                                localization: Unknown

                                3.1.3.75 Phosphoethanolamine/phosphocholine phosphatase.

                                (1) O-phosphoethanolamine + H(2)O = ethanolamine + phosphate. (2) Phosphocholine + H(2)O = choline + phosphate. (kegg)
                                proteins
                                Q8TCT1 PHOP1_HUMAN

                                details
                                ["The enzyme is highly specific for phosphoethanolamine and phosphocholine."]


                                map 1: Glycerophospholipid metabolism

                                proteins:

                                Ethanolamine + Phosphate

                                (2-Hydroxyethylamine) (lipid link)
                                category:
                                main_class:
                                sub_class:
                                formula: C2H7NO
                                synonyms: Aminoethanol; 2-Hydroxyethylamine
                                kegg id: c00189
                                exact mass: 61.0528
                                status:
                                pubchem substance url

                                Ethanolamine + ATP

                                (2-Hydroxyethylamine) (lipid link)
                                category:
                                main_class:
                                sub_class:
                                formula: C2H7NO
                                synonyms: Aminoethanol; 2-Hydroxyethylamine
                                kegg id: c00189
                                status:
                                exact mass: 61.0528
                                pubchem substance url
                                localization: Unknown

                                2.7.1.82 Ethanolamine kinase.

                                ATP + ethanolamine = ADP + O-phosphoethanolamine. (kegg)
                                proteins
                                P35790 CHKA_HUMAN
                                Q9Y259 CHKB_HUMAN
                                Q9HBU6 EKI1_HUMAN
                                Q9NVF9 EKI2_HUMAN


                                map 1: Glycerophospholipid metabolism

                                proteins:

                                O-Phosphoethanolamine + ADP

                                () (lipid link)
                                category:
                                main_class:
                                sub_class:
                                formula:
                                synonyms: Phosphoethanolamine
                                kegg id:
                                exact mass: 0
                                status:

                                O-Phosphoethanolamine + CTP (Cytidine 5'-triphosphate; Cytidine triphosphate)

                                () (lipid link)
                                category:
                                main_class:
                                sub_class:
                                formula:
                                synonyms: Phosphoethanolamine
                                kegg id:
                                status:
                                exact mass: 0
                                localization: Cytoplasm

                                2.7.7.14 Ethanolamine-phosphate cytidylyltransferase.

                                CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine. (kegg)
                                proteins
                                Q99447 PCY2_HUMAN


                                map 1: Glycerophospholipid metabolism

                                proteins:
                                • phosphate cytidylyltransferase 2, ethanolamine [PCYT2] ncbi lipid_maps

                                CDP-ethanolamine

                                () (lipid link)
                                category:
                                main_class:
                                sub_class:
                                formula: C11H20N4O11P2
                                synonyms: Cytidine diphosphate ethanolamine
                                kegg id: C00570
                                exact mass: 446.06
                                status:
                                pubchem substance url

                                Diphosphate

                                () (lipid link)
                                category:
                                main_class:
                                sub_class:
                                formula: H4P2O7
                                synonyms: Diphosphoric acid, Pyrophosphate, Pyrophosphoric acid, PPi
                                kegg id: C00013
                                exact mass: 177.943
                                status:
                                pubchem substance url

                                O-Phosphoethanolamine + H2O

                                () (lipid link)
                                category:
                                main_class:
                                sub_class:
                                formula:
                                synonyms: Phosphoethanolamine
                                kegg id:
                                status:
                                exact mass: 0
                                localization: Unknown

                                4.2.3.2 Ethanolamine-phosphate phospho-lyase.

                                Ethanolamine phosphate + H(2)O = acetaldehyde + NH(3) + phosphate. (kegg)
                                proteins
                                Q8TBG4 AT2L1_HUMAN

                                details
                                ["Also acts on D- (or L)-1-aminopropan-2-ol O-phosphate.", "Formerly EC 4.2.99.7."]


                                map 1: Glycerophospholipid metabolism

                                proteins:

                                Acetaldehyde + Phosphate + NH3

                                (Ethanal) (lipid link)
                                category:
                                main_class:
                                sub_class:
                                formula: C2H4O
                                synonyms: Ethanal
                                kegg id: C00084
                                exact mass: 44.0262
                                status:
                                pubchem substance url

                                Acetylcholine + H2O

                                (2-(acetyloxy)-N,N,N-trimethylethanaminium) (lipid link)
                                category:
                                main_class:
                                sub_class:
                                formula: C7H16NO2
                                synonyms: O-Acetylcholine
                                kegg id: C01996
                                status:
                                exact mass: 146.118
                                pubchem substance url
                                localization: Unknown

                                3.1.1.7 Acetylcholinesterase.

                                Acetylcholine + H(2)O = choline + acetate. (kegg)
                                proteins
                                P22303 ACES_HUMAN

                                details
                                ["Acts on a variety of acetic esters.", "Also catalyzes transacetylations."]


                                map 1: Glycerophospholipid metabolism

                                proteins:
                                • acetylcholinesterase (Yt blood group) [ACHE] ncbi lipid_maps
                                  regulators:
                                  MIR212 ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                                Acetic acid

                                (ethanoic acid) (lipid link)
                                category: Fatty Acyls [FA]
                                main_class: Fatty Acids and Conjugates [FA01]
                                sub_class: Straight chain fatty acids [FA0101]
                                formula: C2H4O2
                                synonyms: Vinegar acid; 10.Methanecarboxylic acid; acetate; C2:0
                                kegg id: C00033
                                exact mass: 60.0211
                                status:
                                lipidmaps
                                pubchem substance url

                                Choline

                                () (lipid link)
                                category:
                                main_class:
                                sub_class:
                                formula: C5H14NO
                                synonyms: Bilineurine, 2-Hydroxy-N,N,N-trimethylethanaminium, Bursine
                                kegg id: C00114
                                exact mass: 104.107
                                status:
                                pubchem substance url

                                Choline + acetyl-CoA

                                () (lipid link)
                                category:
                                main_class:
                                sub_class:
                                formula: C5H14NO
                                synonyms: Bilineurine, 2-Hydroxy-N,N,N-trimethylethanaminium, Bursine
                                kegg id: C00114
                                status:
                                exact mass: 104.107
                                pubchem substance url
                                localization: Cytoplasm

                                2.3.1.6 Choline O-acetyltransferase.

                                Acetyl-CoA + choline = CoA + O-acetylcholine. (kegg)
                                proteins
                                P28329 CLAT_HUMAN

                                details
                                ["Propanoyl-CoA can act, more slowly, in place of acetyl-CoA."]


                                map 1: Glycerophospholipid metabolism

                                proteins:

                                  Acetylcholine + CoA

                                  (2-(acetyloxy)-N,N,N-trimethylethanaminium) (lipid link)
                                  category:
                                  main_class:
                                  sub_class:
                                  formula: C7H16NO2
                                  synonyms: O-Acetylcholine
                                  kegg id: C01996
                                  exact mass: 146.118
                                  status:
                                  pubchem substance url

                                  1-Acyl-sn-glycerol 3-phosphate

                                  () (lipid link)
                                  category:
                                  main_class:
                                  sub_class:
                                  formula: C4H8O7PR
                                  synonyms: 2-Lysophosphatidate; Lysophosphatidate; Lysophosphatidic acid
                                  kegg id: C00681
                                  status:
                                  exact mass: 199.001
                                  localization: Unknown

                                  2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferase.

                                  Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. (kegg)
                                  proteins
                                  Q8WTS1 ABHD5_HUMAN
                                  Q53EU6 GPAT3_HUMAN
                                  Q6UWP7 LCLT1_HUMAN
                                  Q6ZWT7 MBOA2_HUMAN
                                  Q7L5N7 PCAT2_HUMAN
                                  Q99943 PLCA_HUMAN
                                  O15120 PLCB_HUMAN
                                  Q9NRZ7 PLCC_HUMAN
                                  Q9NRZ5 PLCD_HUMAN
                                  Q9NUQ2 PLCE_HUMAN

                                  details
                                  ["Acyl-[acyl-carrier-protein] can also act as acyl donor.", "The animal enzyme is specific for the transfer of unsaturated fatty acyl groups."]


                                  map 1: Glycerophospholipid metabolism

                                  proteins:

                                    1,2-Diacyl-sn-glycerol 3-phosphate + CoA

                                    (1,2-Diacyl-sn-glycerol 3-phosphate) (lipid link)
                                    category:
                                    main_class:
                                    sub_class:
                                    formula: C5H7O8PR2
                                    synonyms: Phosphatidate; Phosphatidic acid; 3-sn-Phosphatidate
                                    kegg id: C00416
                                    exact mass: 225.988
                                    status:
                                    lipidmaps
                                    pubchem substance url

                                    2,3-Dehydroacyl-CoA

                                    () (lipid link)
                                    category:
                                    main_class:
                                    sub_class:
                                    formula: C24H37N7O17P3SR
                                    synonyms: Dehydroacyl-CoA, 2-enoyl-CoA
                                    kegg id: C00605
                                    status:
                                    exact mass: 820.118
                                    pubchem substance url
                                    localization: Unknown

                                    2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferase.

                                    Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. (kegg)
                                    proteins
                                    Q8WTS1 ABHD5_HUMAN
                                    Q53EU6 GPAT3_HUMAN
                                    Q6UWP7 LCLT1_HUMAN
                                    Q6ZWT7 MBOA2_HUMAN
                                    Q7L5N7 PCAT2_HUMAN
                                    Q99943 PLCA_HUMAN
                                    O15120 PLCB_HUMAN
                                    Q9NRZ7 PLCC_HUMAN
                                    Q9NRZ5 PLCD_HUMAN
                                    Q9NUQ2 PLCE_HUMAN

                                    details
                                    ["Acyl-[acyl-carrier-protein] can also act as acyl donor.", "The animal enzyme is specific for the transfer of unsaturated fatty acyl groups."]


                                    map 1: Glycerophospholipid metabolism

                                    proteins:

                                      1,2-Diacyl-sn-glycerol 3-phosphate + CoA

                                      (1,2-Diacyl-sn-glycerol 3-phosphate) (lipid link)
                                      category:
                                      main_class:
                                      sub_class:
                                      formula: C5H7O8PR2
                                      synonyms: Phosphatidate; Phosphatidic acid; 3-sn-Phosphatidate
                                      kegg id: C00416
                                      exact mass: 225.988
                                      status:
                                      lipidmaps
                                      pubchem substance url

                                      PC + H2O

                                      (1,2-diacyl-sn-glycero-3-phosphocholine) (lipid link)
                                      category: Glycerophospholipids [GP]
                                      main_class: Glycerophosphocholines [GP01]
                                      sub_class: Diacylglycerophosphocholines [GP0101]
                                      formula: C10H18NO8P
                                      synonyms: Phosphatidylcholine; Diacylphosphatidylcholine
                                      kegg id: C00157
                                      status:
                                      exact mass: 311.077
                                      lipidmaps
                                      pubchem substance url
                                      localization: Unknown

                                      3.1.1.4 Phospholipase A(2).

                                      Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate. (kegg)
                                      proteins
                                      Q8WU67 ABHD3_HUMAN
                                      P53816 HRSL3_HUMAN
                                      P04054 PA21B_HUMAN
                                      P47712 PA24A_HUMAN
                                      P0C869 PA24B_HUMAN
                                      Q9UP65 PA24C_HUMAN
                                      Q86XP0 PA24D_HUMAN
                                      Q3MJ16 PA24E_HUMAN
                                      Q68DD2 PA24F_HUMAN
                                      Q9NZ20 PA2G3_HUMAN
                                      P39877 PA2G5_HUMAN
                                      P14555 PA2GA_HUMAN
                                      Q9UNK4 PA2GD_HUMAN
                                      Q9NZK7 PA2GE_HUMAN
                                      Q9BZM2 PA2GF_HUMAN
                                      O15496 PA2GX_HUMAN
                                      Q9BZM1 PG12A_HUMAN
                                      Q6P1J6 PLB1_HUMAN
                                      O60733 PLPL9_HUMAN

                                      details
                                      ["Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position."]


                                      map 1: Glycerophospholipid metabolism

                                      proteins:

                                        Arachidonic acid

                                        (5Z,8Z,11Z,14Z-eicosatetraenoic acid) (lipid link)
                                        category: Fatty Acyls [FA]
                                        main_class: Fatty Acids and Conjugates [FA01]
                                        sub_class: Unsaturated fatty acids [FA0103]
                                        formula: C20H32O2
                                        synonyms: 5Z,8Z,11Z,14Z-icosatetraenoic acid; AA; Arachidonate; cis-5,8,11,14-Eicosatetraenoic acid; (all-Z)-5,8,11,14-Eicosatetraenoic ac
                                        kegg id: C00219
                                        exact mass: 304.24
                                        status:
                                        lipidmaps
                                        pubchem substance url

                                        2-Lysolecithin

                                        (1-Acyl-sn-glycerol-3-phosphocholine) (lipid link)
                                        category:
                                        main_class:
                                        sub_class:
                                        formula: C9H20NO7PR
                                        synonyms: 1-Acyl-sn-glycero-3-phosphocholine, alpha-Acylglycerophosphocholine, 2-Lysophosphatidylcholine, 1-Acylglycerophosphocholine
                                        kegg id: C04230
                                        exact mass: 0
                                        status:
                                        lipidmaps
                                        pubchem substance url

                                        1-Lysolecithin

                                        (2-Acyl-sn-glycero-3-phosphocholine) (lipid link)
                                        category: Glycerophospholipids [GP]
                                        main_class: Glycerophosphocholines [GP01]
                                        sub_class: Monoacylglycerophosphocholines [GP0105]
                                        formula: C9H20NO7PR
                                        synonyms: 2-Acylglycero-3-phosphocholine; 1-Lysophosphatidylcholine; 1-Lysolecithin; 3-Lysolecithin
                                        kegg id: C04233
                                        status:
                                        exact mass: 0
                                        lipidmaps
                                        pubchem substance url
                                        localization: extracellular
                                        notes:
                                        Croset M, Brossard N, Polette A, Lagarde M. Characterization of plasma unsaturated lysophosphatidylcholines in human and rat. Biochem J. 2000 Jan 1;345 Pt 1:61-7. PMID:
                                        10600639
                                        The rate and extent of the acyl group shift from the sn-2 to sn-1 position of these lysoPtdCho were studied by the incubation of 1-lyso, 2-[(14)C]C(18:2)n-6-glycerophosphocholine (GPC) with plasma. The rapid isomerization of this lipid occurred at pH 7 (20% isomerization within 2 min) and was not prevented by its association with albumin.

                                        5.4.1.1 Lysolecithin acylmutase.

                                        2-lysolecithin = 3-lysolecithin. (kegg)
                                        proteins


                                        map 1: Glycerophospholipid metabolism

                                        proteins:

                                          2-Lysolecithin

                                          (1-Acyl-sn-glycerol-3-phosphocholine) (lipid link)
                                          category:
                                          main_class:
                                          sub_class:
                                          formula: C9H20NO7PR
                                          synonyms: 1-Acyl-sn-glycero-3-phosphocholine, alpha-Acylglycerophosphocholine, 2-Lysophosphatidylcholine, 1-Acylglycerophosphocholine
                                          kegg id: C04230
                                          exact mass: 0
                                          status:
                                          lipidmaps
                                          pubchem substance url

                                          PC

                                          (1,2-diacyl-sn-glycero-3-phosphocholine) (lipid link)
                                          category: Glycerophospholipids [GP]
                                          main_class: Glycerophosphocholines [GP01]
                                          sub_class: Diacylglycerophosphocholines [GP0101]
                                          formula: C10H18NO8P
                                          synonyms: Phosphatidylcholine; Diacylphosphatidylcholine
                                          kegg id: C00157
                                          status:
                                          exact mass: 311.077
                                          lipidmaps
                                          pubchem substance url
                                          localization: Unknown

                                          2.3.1.135 Phosphatidylcholine--retinol O-acyltransferase.

                                          Phosphatidylcholine + retinol--[cellular-retinol-binding-protein] = 2-acylglycerophosphocholine + retinyl-ester--[cellular-retinol-binding- protein]. (kegg)
                                          proteins
                                          O95237 LRAT_HUMAN

                                          details
                                          ["A key enzyme in retinoid metabolism, catalyzing the transfer of an acyl group from the sn-1 position of phosphatidylcholine to retinol, forming retinyl esters which are then stored.", "Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein, but has higher affinity for the bound form.", "Can also esterify 11-cis-retinol."]


                                          proteins:

                                            1-Lysolecithin

                                            (2-Acyl-sn-glycero-3-phosphocholine) (lipid link)
                                            category: Glycerophospholipids [GP]
                                            main_class: Glycerophosphocholines [GP01]
                                            sub_class: Monoacylglycerophosphocholines [GP0105]
                                            formula: C9H20NO7PR
                                            synonyms: 2-Acylglycero-3-phosphocholine; 1-Lysophosphatidylcholine; 1-Lysolecithin; 3-Lysolecithin
                                            kegg id: C04233
                                            exact mass: 0
                                            status:
                                            lipidmaps
                                            pubchem substance url

                                            Retinyl ester

                                            () (lipid link)
                                            category:
                                            main_class:
                                            sub_class:
                                            formula: C21H29O2R
                                            synonyms: all-trans-Retinyl ester
                                            kegg id: C02075
                                            exact mass: 302.225
                                            status:

                                            Retinol

                                            (Retinol) (lipid link)
                                            category: Prenol Lipids [PR]
                                            main_class: Isoprenoids [PR01]
                                            sub_class: Retinoids [PR0109]
                                            formula: C20H30O
                                            synonyms: Vitamin A
                                            kegg id: C00473
                                            status:
                                            exact mass: 286.23
                                            lipidmaps
                                            pubchem substance url
                                            localization: Unknown

                                            2.3.1.135 Phosphatidylcholine--retinol O-acyltransferase.

                                            Phosphatidylcholine + retinol--[cellular-retinol-binding-protein] = 2-acylglycerophosphocholine + retinyl-ester--[cellular-retinol-binding- protein]. (kegg)
                                            proteins
                                            O95237 LRAT_HUMAN

                                            details
                                            ["A key enzyme in retinoid metabolism, catalyzing the transfer of an acyl group from the sn-1 position of phosphatidylcholine to retinol, forming retinyl esters which are then stored.", "Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein, but has higher affinity for the bound form.", "Can also esterify 11-cis-retinol."]


                                            proteins:

                                              1-Lysolecithin

                                              (2-Acyl-sn-glycero-3-phosphocholine) (lipid link)
                                              category: Glycerophospholipids [GP]
                                              main_class: Glycerophosphocholines [GP01]
                                              sub_class: Monoacylglycerophosphocholines [GP0105]
                                              formula: C9H20NO7PR
                                              synonyms: 2-Acylglycero-3-phosphocholine; 1-Lysophosphatidylcholine; 1-Lysolecithin; 3-Lysolecithin
                                              kegg id: C04233
                                              exact mass: 0
                                              status:
                                              lipidmaps
                                              pubchem substance url

                                              Retinyl ester

                                              () (lipid link)
                                              category:
                                              main_class:
                                              sub_class:
                                              formula: C21H29O2R
                                              synonyms: all-trans-Retinyl ester
                                              kegg id: C02075
                                              exact mass: 302.225
                                              status:

                                              11-cis-Retinol

                                              (11Z-retinol) (lipid link)
                                              category: Prenol Lipids [PR]
                                              main_class: Isoprenoids [PR01]
                                              sub_class: Retinoids [PR0109]
                                              formula: C20H30O
                                              kegg id: C00899
                                              status:
                                              exact mass: 286.23
                                              lipidmaps
                                              pubchem substance url
                                              localization: Unknown

                                              2.3.1.135 Phosphatidylcholine--retinol O-acyltransferase.

                                              Phosphatidylcholine + retinol--[cellular-retinol-binding-protein] = 2-acylglycerophosphocholine + retinyl-ester--[cellular-retinol-binding- protein]. (kegg)
                                              proteins
                                              O95237 LRAT_HUMAN

                                              details
                                              ["A key enzyme in retinoid metabolism, catalyzing the transfer of an acyl group from the sn-1 position of phosphatidylcholine to retinol, forming retinyl esters which are then stored.", "Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein, but has higher affinity for the bound form.", "Can also esterify 11-cis-retinol."]


                                              proteins:

                                                11-cis-retinyl palmitate

                                                (3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2E,4Z,6E,8E-tetraen-1-yl hexadecanoate) (lipid link)
                                                category: Prenol Lipids [PR]
                                                main_class: Isoprenoids [PR01]
                                                sub_class: Retinoids [PR0109]
                                                formula: C36H60O2
                                                synonyms: 11-cis-Retinyl palmitate; 11-cis-retinyl palmitate
                                                kegg id: C03455
                                                exact mass: 524.459
                                                status:
                                                lipidmaps
                                                pubchem substance url

                                                1-Lysolecithin

                                                (2-Acyl-sn-glycero-3-phosphocholine) (lipid link)
                                                category: Glycerophospholipids [GP]
                                                main_class: Glycerophosphocholines [GP01]
                                                sub_class: Monoacylglycerophosphocholines [GP0105]
                                                formula: C9H20NO7PR
                                                synonyms: 2-Acylglycero-3-phosphocholine; 1-Lysophosphatidylcholine; 1-Lysolecithin; 3-Lysolecithin
                                                kegg id: C04233
                                                exact mass: 0
                                                status:
                                                lipidmaps
                                                pubchem substance url

                                                Palmitoylphosphatidylcholine

                                                (1-Palmitoyl-2-acyl-sn-glycero-3-phosphocholine) (lipid link)
                                                category:
                                                main_class:
                                                sub_class:
                                                formula: C25H49NO8PR
                                                synonyms:
                                                kegg id: C03889
                                                status:
                                                exact mass: 0
                                                pubchem substance url
                                                localization: Unknown

                                                2.3.1.135 Phosphatidylcholine--retinol O-acyltransferase.

                                                Phosphatidylcholine + retinol--[cellular-retinol-binding-protein] = 2-acylglycerophosphocholine + retinyl-ester--[cellular-retinol-binding- protein]. (kegg)
                                                proteins
                                                O95237 LRAT_HUMAN

                                                details
                                                ["A key enzyme in retinoid metabolism, catalyzing the transfer of an acyl group from the sn-1 position of phosphatidylcholine to retinol, forming retinyl esters which are then stored.", "Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein, but has higher affinity for the bound form.", "Can also esterify 11-cis-retinol."]


                                                proteins:

                                                  11-cis-retinyl palmitate

                                                  (3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2E,4Z,6E,8E-tetraen-1-yl hexadecanoate) (lipid link)
                                                  category: Prenol Lipids [PR]
                                                  main_class: Isoprenoids [PR01]
                                                  sub_class: Retinoids [PR0109]
                                                  formula: C36H60O2
                                                  synonyms: 11-cis-Retinyl palmitate; 11-cis-retinyl palmitate
                                                  kegg id: C03455
                                                  exact mass: 524.459
                                                  status:
                                                  lipidmaps
                                                  pubchem substance url

                                                  1-Lysolecithin

                                                  (2-Acyl-sn-glycero-3-phosphocholine) (lipid link)
                                                  category: Glycerophospholipids [GP]
                                                  main_class: Glycerophosphocholines [GP01]
                                                  sub_class: Monoacylglycerophosphocholines [GP0105]
                                                  formula: C9H20NO7PR
                                                  synonyms: 2-Acylglycero-3-phosphocholine; 1-Lysophosphatidylcholine; 1-Lysolecithin; 3-Lysolecithin
                                                  kegg id: C04233
                                                  exact mass: 0
                                                  status:
                                                  lipidmaps
                                                  pubchem substance url

                                                  Carboxylate

                                                  () (lipid link)
                                                  category:
                                                  main_class:
                                                  sub_class:
                                                  formula: CO2R
                                                  synonyms: R-COOH; Monocarboxylate; Carboxylic acid
                                                  kegg id: C00060
                                                  status:
                                                  exact mass: 0
                                                  pubchem substance url
                                                  localization: Unknown

                                                  3.1.1.5 Lysophospholipase.

                                                  2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate. (kegg)
                                                  proteins
                                                  Q86U10 LPP60_HUMAN
                                                  P47712 PA24A_HUMAN
                                                  Q6P1J6 PLB1_HUMAN
                                                  Q8IY17 PLPL6_HUMAN
                                                  Q9NP80 PLPL8_HUMAN


                                                  map 1: Glycerophospholipid metabolism

                                                  proteins:

                                                    1-Lysolecithin + H2O

                                                    (2-Acyl-sn-glycero-3-phosphocholine) (lipid link)
                                                    category: Glycerophospholipids [GP]
                                                    main_class: Glycerophosphocholines [GP01]
                                                    sub_class: Monoacylglycerophosphocholines [GP0105]
                                                    formula: C9H20NO7PR
                                                    synonyms: 2-Acylglycero-3-phosphocholine; 1-Lysophosphatidylcholine; 1-Lysolecithin; 3-Lysolecithin
                                                    kegg id: C04233
                                                    exact mass: 0
                                                    status:
                                                    lipidmaps
                                                    pubchem substance url

                                                    sn-Glycero-3-phosphocholine

                                                    () (lipid link)
                                                    category:
                                                    main_class:
                                                    sub_class:
                                                    formula: C8H21NO6P
                                                    synonyms: Glycerophosphocholine
                                                    kegg id: C00670
                                                    status:
                                                    exact mass: 258.111
                                                    pubchem substance url
                                                    localization: Unknown

                                                    3.1.1.5 Lysophospholipase.

                                                    2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate. (kegg)
                                                    proteins
                                                    Q86U10 LPP60_HUMAN
                                                    P47712 PA24A_HUMAN
                                                    Q6P1J6 PLB1_HUMAN
                                                    Q8IY17 PLPL6_HUMAN
                                                    Q9NP80 PLPL8_HUMAN


                                                    map 1: Glycerophospholipid metabolism

                                                    proteins:

                                                      1-Lysolecithin + H2O

                                                      (2-Acyl-sn-glycero-3-phosphocholine) (lipid link)
                                                      category: Glycerophospholipids [GP]
                                                      main_class: Glycerophosphocholines [GP01]
                                                      sub_class: Monoacylglycerophosphocholines [GP0105]
                                                      formula: C9H20NO7PR
                                                      synonyms: 2-Acylglycero-3-phosphocholine; 1-Lysophosphatidylcholine; 1-Lysolecithin; 3-Lysolecithin
                                                      kegg id: C04233
                                                      exact mass: 0
                                                      status:
                                                      lipidmaps
                                                      pubchem substance url

                                                      Long-chain alcohol

                                                      () (lipid link)
                                                      category:
                                                      main_class:
                                                      sub_class:
                                                      formula: CH3OR
                                                      synonyms: long-chain fatty alcohol
                                                      kegg id: C00339
                                                      status:
                                                      exact mass: 0
                                                      pubchem substance url
                                                      localization: Unknown

                                                      2.5.1.26 Alkylglycerone-phosphate synthase.

                                                      1-acyl-glycerone 3-phosphate + a long-chain alcohol = an alkyl-glycerone 3-phosphate + a long-chain acid anion. (kegg)
                                                      proteins
                                                      O00116 ADAS_HUMAN

                                                      details
                                                      ["The ester-linked fatty acid of the substrate is cleaved and replaced by a long-chain alcohol in an ether linkage."]


                                                      map 1: ETHER lipid metabolism

                                                      proteins:

                                                        1-Alkyl-glycerone 3-phosphate

                                                        () (lipid link)
                                                        category:
                                                        main_class:
                                                        sub_class:
                                                        formula: C3H6O6PR
                                                        synonyms: O-Alkylglycerone phosphate; Alkyl-glycerone 3-phosphate; Dihydroxyacetone phosphate alkyl ether
                                                        kegg id: C03715
                                                        exact mass: 0
                                                        status:
                                                        pubchem substance url

                                                        Long-chain acid anion

                                                        () (lipid link)
                                                        category:
                                                        main_class:
                                                        sub_class:
                                                        formula: C3H4O2R(C2H4)n
                                                        synonyms:
                                                        kegg id: C03129
                                                        exact mass: 0
                                                        status:
                                                        pubchem substance url

                                                        1-Acyl-glycerone 3-phosphate

                                                        () (lipid link)
                                                        category:
                                                        main_class:
                                                        sub_class:
                                                        formula: C4H6O7PR
                                                        synonyms: Acylglycerone phosphate; Dihydroxyacetone phosphate acyl ester
                                                        kegg id: C03372
                                                        status:
                                                        exact mass: 0
                                                        pubchem substance url
                                                        localization: Unknown

                                                        2.5.1.26 Alkylglycerone-phosphate synthase.

                                                        1-acyl-glycerone 3-phosphate + a long-chain alcohol = an alkyl-glycerone 3-phosphate + a long-chain acid anion. (kegg)
                                                        proteins
                                                        O00116 ADAS_HUMAN

                                                        details
                                                        ["The ester-linked fatty acid of the substrate is cleaved and replaced by a long-chain alcohol in an ether linkage."]


                                                        map 1: ETHER lipid metabolism

                                                        proteins:

                                                          1-Alkyl-glycerone 3-phosphate

                                                          () (lipid link)
                                                          category:
                                                          main_class:
                                                          sub_class:
                                                          formula: C3H6O6PR
                                                          synonyms: O-Alkylglycerone phosphate; Alkyl-glycerone 3-phosphate; Dihydroxyacetone phosphate alkyl ether
                                                          kegg id: C03715
                                                          exact mass: 0
                                                          status:
                                                          pubchem substance url

                                                          Long-chain acid anion

                                                          () (lipid link)
                                                          category:
                                                          main_class:
                                                          sub_class:
                                                          formula: C3H4O2R(C2H4)n
                                                          synonyms:
                                                          kegg id: C03129
                                                          exact mass: 0
                                                          status:
                                                          pubchem substance url

                                                          CDP-choline

                                                          (Cytidine 5-diphosphocholine) (lipid link)
                                                          category:
                                                          main_class:
                                                          sub_class:
                                                          formula: C14H26N4O11P2
                                                          synonyms: Citicoline
                                                          kegg id: C00307
                                                          status:
                                                          exact mass: 488.107
                                                          pubchem substance url
                                                          localization: Unknown

                                                          2.7.8.2 Diacylglycerol cholinephosphotransferase.

                                                          CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine. (kegg)
                                                          proteins
                                                          Q9Y6K0 CEPT1_HUMAN
                                                          Q8WUD6 CHPT1_HUMAN

                                                          details
                                                          ["1-alkyl-2-acylglycerol can act as acceptor.", "Formerly EC 2.7.8.16."]


                                                          map 1: ETHER lipid metabolism

                                                          proteins:

                                                            2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                                                            (2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine) (lipid link)
                                                            category:
                                                            main_class:
                                                            sub_class:
                                                            formula: C10H22NO7PR
                                                            synonyms: Platelet-activating factor; PAF
                                                            kegg id: C04598
                                                            exact mass: 0
                                                            status:
                                                            pubchem substance url

                                                            2-Acetyl-1-alkyl-sn-glycerol

                                                            (1-alkyl-2-acetyl-sn-glycerol) (lipid link)
                                                            category:
                                                            main_class:
                                                            sub_class:
                                                            formula: C5H9O4R
                                                            synonyms: 1-O-Alkyl-2-acetyl-sn-glycerol
                                                            kegg id: C03820
                                                            status:
                                                            exact mass: 0
                                                            pubchem substance url
                                                            localization: Unknown

                                                            2.7.8.2 Diacylglycerol cholinephosphotransferase.

                                                            CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine. (kegg)
                                                            proteins
                                                            Q9Y6K0 CEPT1_HUMAN
                                                            Q8WUD6 CHPT1_HUMAN

                                                            details
                                                            ["1-alkyl-2-acylglycerol can act as acceptor.", "Formerly EC 2.7.8.16."]


                                                            map 1: ETHER lipid metabolism

                                                            proteins:

                                                              2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                                                              (2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine) (lipid link)
                                                              category:
                                                              main_class:
                                                              sub_class:
                                                              formula: C10H22NO7PR
                                                              synonyms: Platelet-activating factor; PAF
                                                              kegg id: C04598
                                                              exact mass: 0
                                                              status:
                                                              pubchem substance url

                                                              2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O

                                                              (2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine) (lipid link)
                                                              category:
                                                              main_class:
                                                              sub_class:
                                                              formula: C10H22NO7PR
                                                              synonyms: Platelet-activating factor; PAF
                                                              kegg id: C04598
                                                              status:
                                                              exact mass: 0
                                                              pubchem substance url
                                                              localization: Unknown

                                                              3.1.1.47 1-alkyl-2-acetylglycerophosphocholine esterase.

                                                              1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl- sn-glycero-3-phosphocholine + acetate. (kegg)
                                                              proteins
                                                              Q86U10 LPP60_HUMAN
                                                              P68402 PA1B2_HUMAN
                                                              Q15102 PA1B3_HUMAN
                                                              Q99487 PAFA2_HUMAN
                                                              Q13093 PAFA_HUMAN


                                                              map 1: ETHER lipid metabolism

                                                              proteins:

                                                                Acetic acid

                                                                (ethanoic acid) (lipid link)
                                                                category: Fatty Acyls [FA]
                                                                main_class: Fatty Acids and Conjugates [FA01]
                                                                sub_class: Straight chain fatty acids [FA0101]
                                                                formula: C2H4O2
                                                                synonyms: Vinegar acid; 10.Methanecarboxylic acid; acetate; C2:0
                                                                kegg id: C00033
                                                                exact mass: 60.0211
                                                                status:
                                                                lipidmaps
                                                                pubchem substance url

                                                                PC(O-18:0/0:0)

                                                                (1-octadecyl-sn-glycero-3-phosphocholine) (lipid link)
                                                                category: Glycerophospholipids [GP]
                                                                main_class: Glycerophosphocholines [GP01]
                                                                sub_class: Monoalkylglycerophosphocholines [GP0106]
                                                                formula: C26H56NO6P
                                                                synonyms: 3,5,9-Trioxa-4-phosphaheptacosan-1-aminium, 4,7-dihydroxy-N,N,N-trimethyl-, inner salt, 4-oxide, (R)-; 1-O-Octadecyl-sn-glycero-
                                                                kegg id: C04317
                                                                exact mass: 509.385
                                                                status:
                                                                lipidmaps
                                                                pubchem substance url

                                                                1-Organyl-2-lyso-sn-glycero-3-phosphocholine + acetyl-CoA

                                                                (2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine) (lipid link)
                                                                category:
                                                                main_class:
                                                                sub_class:
                                                                formula: C8H20NO6PR
                                                                synonyms: 1-Alkyl-2-lyso-sn-glycero-3-phosphocholine, 1-Radyl-2-lyso-sn-glycero-3-phosphocholine, 1-Alkyl-sn-glycero-3-phosphocholine
                                                                kegg id: C04317
                                                                status:
                                                                exact mass: 0
                                                                pubchem substance url
                                                                localization: Unknown

                                                                2.3.1.67 1-alkylglycerophosphocholine O-acetyltransferase.

                                                                Acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine = CoA + 2-acetyl-1- alkyl-sn-glycero-3-phosphocholine. (kegg)
                                                                proteins
                                                                Q643R3 LPCT4_HUMAN
                                                                Q8NF37 PCAT1_HUMAN
                                                                Q7L5N7 PCAT2_HUMAN


                                                                map 1: ETHER lipid metabolism

                                                                proteins:

                                                                  2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine + CoA

                                                                  (2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine) (lipid link)
                                                                  category:
                                                                  main_class:
                                                                  sub_class:
                                                                  formula: C10H22NO7PR
                                                                  synonyms: Platelet-activating factor; PAF
                                                                  kegg id: C04598
                                                                  exact mass: 0
                                                                  status:
                                                                  pubchem substance url

                                                                  1-Organyl-2-lyso-sn-glycero-3-phosphocholine + Acyl-CoA

                                                                  (2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine) (lipid link)
                                                                  category:
                                                                  main_class:
                                                                  sub_class:
                                                                  formula: C8H20NO6PR
                                                                  synonyms: 1-Alkyl-2-lyso-sn-glycero-3-phosphocholine, 1-Radyl-2-lyso-sn-glycero-3-phosphocholine, 1-Alkyl-sn-glycero-3-phosphocholine
                                                                  kegg id: C04317
                                                                  status:
                                                                  exact mass: 0
                                                                  pubchem substance url
                                                                  localization: Unknown

                                                                  2.3.1.23 1-acylglycerophosphocholine O-acyltransferase.

                                                                  Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl- sn-glycero-3-phosphocholine. (kegg)
                                                                  proteins
                                                                  Q643R3 LPCT4_HUMAN
                                                                  Q6P1A2 MBOA5_HUMAN
                                                                  Q8NF37 PCAT1_HUMAN
                                                                  Q7L5N7 PCAT2_HUMAN

                                                                  details
                                                                  ["Acts preferentially with unsaturated acyl-CoA derivatives.", "1-acyl-sn-glycero-3-phosphoinositol can also act as acceptor."]


                                                                  map 1: ETHER lipid metabolism

                                                                  proteins:

                                                                    1-Organyl-2-acyl-sn-glycero-3-phosphocholine + CoA

                                                                    (2-Acyl-1-alkyl-sn-glycero-3-phosphocholine) (lipid link)
                                                                    category:
                                                                    main_class:
                                                                    sub_class:
                                                                    formula: C9H19NO7PR2
                                                                    synonyms: 1-Radyl-2-acyl-sn-glycero-3-phosphocholine
                                                                    kegg id: C05212
                                                                    exact mass: 0
                                                                    status:
                                                                    pubchem substance url

                                                                    1-Organyl-2-acyl-sn-glycero-3-phosphocholine + H2O

                                                                    (2-Acyl-1-alkyl-sn-glycero-3-phosphocholine) (lipid link)
                                                                    category:
                                                                    main_class:
                                                                    sub_class:
                                                                    formula: C9H19NO7PR2
                                                                    synonyms: 1-Radyl-2-acyl-sn-glycero-3-phosphocholine
                                                                    kegg id: C05212
                                                                    status:
                                                                    exact mass: 0
                                                                    pubchem substance url
                                                                    localization: Cytoplasm

                                                                    3.1.1.4 Phospholipase A(2).

                                                                    Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate. (kegg)
                                                                    proteins
                                                                    Q8WU67 ABHD3_HUMAN
                                                                    P53816 HRSL3_HUMAN
                                                                    P04054 PA21B_HUMAN
                                                                    P47712 PA24A_HUMAN
                                                                    P0C869 PA24B_HUMAN
                                                                    Q9UP65 PA24C_HUMAN
                                                                    Q86XP0 PA24D_HUMAN
                                                                    Q3MJ16 PA24E_HUMAN
                                                                    Q68DD2 PA24F_HUMAN
                                                                    Q9NZ20 PA2G3_HUMAN
                                                                    P39877 PA2G5_HUMAN
                                                                    P14555 PA2GA_HUMAN
                                                                    Q9UNK4 PA2GD_HUMAN
                                                                    Q9NZK7 PA2GE_HUMAN
                                                                    Q9BZM2 PA2GF_HUMAN
                                                                    O15496 PA2GX_HUMAN
                                                                    Q9BZM1 PG12A_HUMAN
                                                                    Q6P1J6 PLB1_HUMAN
                                                                    O60733 PLPL9_HUMAN

                                                                    details
                                                                    ["Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position."]


                                                                    map 1: ETHER lipid metabolism

                                                                    proteins:

                                                                      Carboxylate

                                                                      () (lipid link)
                                                                      category:
                                                                      main_class:
                                                                      sub_class:
                                                                      formula: CO2R
                                                                      synonyms: R-COOH; Monocarboxylate; Carboxylic acid
                                                                      kegg id: C00060
                                                                      exact mass: 0
                                                                      status:
                                                                      pubchem substance url

                                                                      1-Organyl-2-lyso-sn-glycero-3-phosphocholine

                                                                      (2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine) (lipid link)
                                                                      category:
                                                                      main_class:
                                                                      sub_class:
                                                                      formula: C8H20NO6PR
                                                                      synonyms: 1-Alkyl-2-lyso-sn-glycero-3-phosphocholine, 1-Radyl-2-lyso-sn-glycero-3-phosphocholine, 1-Alkyl-sn-glycero-3-phosphocholine
                                                                      kegg id: C04317
                                                                      exact mass: 0
                                                                      status:
                                                                      pubchem substance url

                                                                      CDP-choline

                                                                      (Cytidine 5-diphosphocholine) (lipid link)
                                                                      category:
                                                                      main_class:
                                                                      sub_class:
                                                                      formula: C14H26N4O11P2
                                                                      synonyms: Citicoline
                                                                      kegg id: C00307
                                                                      status:
                                                                      exact mass: 488.107
                                                                      pubchem substance url
                                                                      localization: Unknown

                                                                      2.7.8.2 Diacylglycerol cholinephosphotransferase.

                                                                      CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine. (kegg)
                                                                      proteins
                                                                      Q9Y6K0 CEPT1_HUMAN
                                                                      Q8WUD6 CHPT1_HUMAN

                                                                      details
                                                                      ["1-alkyl-2-acylglycerol can act as acceptor.", "Formerly EC 2.7.8.16."]


                                                                      map 1: ETHER lipid metabolism

                                                                      proteins:

                                                                        1-Organyl-2-acyl-sn-glycero-3-phosphocholine + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                                                                        (2-Acyl-1-alkyl-sn-glycero-3-phosphocholine) (lipid link)
                                                                        category:
                                                                        main_class:
                                                                        sub_class:
                                                                        formula: C9H19NO7PR2
                                                                        synonyms: 1-Radyl-2-acyl-sn-glycero-3-phosphocholine
                                                                        kegg id: C05212
                                                                        exact mass: 0
                                                                        status:
                                                                        pubchem substance url

                                                                        2-Acyl-1-alkyl-sn-glycerol

                                                                        (2-Acyl-1-alkyl-sn-glycerol) (lipid link)
                                                                        category:
                                                                        main_class:
                                                                        sub_class:
                                                                        formula: C4H6O4R2
                                                                        synonyms: 1-Alkyl-2-acylglycerol
                                                                        kegg id: C03201
                                                                        status:
                                                                        exact mass: 0
                                                                        pubchem substance url
                                                                        localization: Unknown

                                                                        2.7.8.2 Diacylglycerol cholinephosphotransferase.

                                                                        CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine. (kegg)
                                                                        proteins
                                                                        Q9Y6K0 CEPT1_HUMAN
                                                                        Q8WUD6 CHPT1_HUMAN

                                                                        details
                                                                        ["1-alkyl-2-acylglycerol can act as acceptor.", "Formerly EC 2.7.8.16."]


                                                                        map 1: ETHER lipid metabolism

                                                                        proteins:

                                                                          1-Organyl-2-acyl-sn-glycero-3-phosphocholine + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                                                                          (2-Acyl-1-alkyl-sn-glycero-3-phosphocholine) (lipid link)
                                                                          category:
                                                                          main_class:
                                                                          sub_class:
                                                                          formula: C9H19NO7PR2
                                                                          synonyms: 1-Radyl-2-acyl-sn-glycero-3-phosphocholine
                                                                          kegg id: C05212
                                                                          exact mass: 0
                                                                          status:
                                                                          pubchem substance url

                                                                          asialo-GM1 + CMP-N-Acetylneuraminic acid

                                                                          (Galbeta1-3GalNAcbeta1-4Galbeta1-4Glcbeta-Cer) (lipid link)
                                                                          category: Sphingolipids [SP]
                                                                          main_class: Neutral glycosphingolipids [SP05]
                                                                          sub_class: GalNAcbeta1-4Galbeta1-4Glc- (Ganglio series) [SP0503]
                                                                          formula:
                                                                          synonyms: AM1; GA1
                                                                          status:
                                                                          exact mass:
                                                                          lipidmaps
                                                                          pubchem substance url
                                                                          localization: Golgi apparatus

                                                                          2.4.99.4 Beta-galactoside alpha-2,3-sialyltransferase.

                                                                          CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D- galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl- 1,3-N-acetyl-alpha-D-galactosaminyl-R. (kegg)
                                                                          proteins
                                                                          Q11201 SIA4A_HUMAN
                                                                          Q16842 SIA4B_HUMAN

                                                                          details
                                                                          ["The acceptor is Gal-beta-1,3-GalNAc-R, where R is H, a threonine or serine residue in a glycoprotein, or a glycolipid.", "Lactose can also act as acceptor.", "May be identical with EC 2.4.99.2."]


                                                                          map 1: Ganglioside Metabolism N2

                                                                          proteins:
                                                                          • ST3 beta-galactoside alpha-2,3-sialyltransferase 4 [ST3GAL4] ncbi lipid_maps
                                                                            regulators:
                                                                            MIR193A ( microRNA binding ) /0 (0, 0, 0)/ rzmd
                                                                            MIR224 ( microRNA binding ) /0 (0, 0, 0)/ rzmd
                                                                          • ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [ST3GAL2] ncbi lipid_maps
                                                                          • ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [ST3GAL1] ncbi lipid_maps

                                                                          GM1b + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                                                                          ( NeuAcα2-3Galβ1-3GalNAcβ1-4Galβ1-4Glcβ-Cer) (lipid link)
                                                                          category:
                                                                          main_class:
                                                                          sub_class:
                                                                          formula:
                                                                          synonyms:
                                                                          kegg id:
                                                                          exact mass: 0
                                                                          status:
                                                                          lipidmaps

                                                                          GM1b + CMP-N-Acetylneuraminic acid

                                                                          ( NeuAcα2-3Galβ1-3GalNAcβ1-4Galβ1-4Glcβ-Cer) (lipid link)
                                                                          category:
                                                                          main_class:
                                                                          sub_class:
                                                                          formula:
                                                                          synonyms:
                                                                          kegg id:
                                                                          status:
                                                                          exact mass: 0
                                                                          lipidmaps
                                                                          localization: Golgi apparatus

                                                                          2.4.99.8 Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase.

                                                                          CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D- galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N- acetylneuraminyl-(2->3)-beta-D-galactosyl-R. (kegg)
                                                                          proteins
                                                                          Q92185 SIA8A_HUMAN

                                                                          details
                                                                          ["Gangliosides act as acceptors."]


                                                                          map 1: Ganglioside Metabolism N2

                                                                          proteins:
                                                                          • ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 [ST8SIA1] ncbi lipid_maps
                                                                            regulators:
                                                                            FOXC2 ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                                                                            MIR33A ( microRNA binding ) /0 (0, 0, 0)/ rzmd
                                                                            MIRLET7E ( microRNA binding ) /0 (0, 0, 0)/ rzmd
                                                                          • ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 [ST8SIA5] ncbi lipid_maps

                                                                          GM1c + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                                                                          ( NeuAcα2-8NeuAcα2-3Galβ1-3GalNAcβ1-4Galβ1-4Glcβ-Cer ) (lipid link)
                                                                          category: Sphingolipids [SP]
                                                                          main_class: Acidic glycosphingolipids [SP06]
                                                                          sub_class: Gangliosides [SP0601]
                                                                          formula:
                                                                          synonyms:
                                                                          kegg id:
                                                                          exact mass: 0
                                                                          status:
                                                                          lipidmaps

                                                                          GD1a + CMP-N-Acetylneuraminic acid

                                                                          (NeuAcα2-3Galβ1-3GalNAcβ1-4(NeuAcα2-3)Galβ1-4Glcβ-Cer) (lipid link)
                                                                          category: Sphingolipids [SP]
                                                                          main_class: Acidic glycosphingolipids [SP06]
                                                                          sub_class: Gangliosides [SP0601]
                                                                          formula:
                                                                          synonyms:
                                                                          kegg id:
                                                                          status:
                                                                          exact mass: 0
                                                                          lipidmaps
                                                                          localization: Golgi apparatus

                                                                          2.4.99.- Transferring other glycosyl groups.

                                                                          (kegg)
                                                                          proteins


                                                                          map 1: Ganglioside Metabolism N2

                                                                          proteins:
                                                                          • ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 [ST6GALNAC6] ncbi lipid_maps
                                                                          • ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 [ST6GALNAC5] ncbi lipid_maps

                                                                          GM1aa + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                                                                          ( Galβ1-3(NeuAcα2-6)GalNAcβ1-4(NeuAcα2-3)Galβ1-4Glcβ-Cer ) (lipid link)
                                                                          category: Sphingolipids [SP]
                                                                          main_class: Acidic glycosphingolipids [SP06]
                                                                          sub_class: Gangliosides [SP0601]
                                                                          formula:
                                                                          synonyms:
                                                                          kegg id:
                                                                          exact mass: 0
                                                                          status:
                                                                          lipidmaps

                                                                          LacCer + UDP-D-galactose

                                                                          (Galbeta1-4Glcbeta-Cer) (lipid link)
                                                                          category: Sphingolipids [SP]
                                                                          main_class: Neutral glycosphingolipids [SP05]
                                                                          sub_class: Simple Glc series [SP0501]
                                                                          formula:
                                                                          kegg id: C01290
                                                                          status:
                                                                          exact mass:
                                                                          lipidmaps
                                                                          pubchem substance url
                                                                          localization: Golgi apparatus

                                                                          2.4.1.- Hexosyltransferases.

                                                                          (kegg)
                                                                          proteins


                                                                          map 1: Neolacto-series GSL Metabolism N1

                                                                          proteins:
                                                                          • UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 [B4GALT1] ncbi lipid_maps
                                                                          • UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 [B4GALT2] ncbi lipid_maps
                                                                          • UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 [B4GALT3] ncbi lipid_maps
                                                                          • UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 [B4GALT4] ncbi lipid_maps

                                                                          paragloboside, nLc4Cer + UDP

                                                                          (Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glcbeta-Cer) (lipid link)
                                                                          category: Sphingolipids [SP]
                                                                          main_class: Neutral glycosphingolipids [SP05]
                                                                          sub_class: Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc- (Neolacto series) [SP0505]
                                                                          formula:
                                                                          exact mass:
                                                                          status:
                                                                          lipidmaps
                                                                          pubchem substance url

                                                                          paragloboside, nLc4Cer + GDP-L-fucose

                                                                          (Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glcbeta-Cer) (lipid link)
                                                                          category: Sphingolipids [SP]
                                                                          main_class: Neutral glycosphingolipids [SP05]
                                                                          sub_class: Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc- (Neolacto series) [SP0505]
                                                                          formula:
                                                                          status:
                                                                          exact mass:
                                                                          lipidmaps
                                                                          pubchem substance url
                                                                          localization: Golgi apparatus

                                                                          2.4.1.152 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase.

                                                                          GDP-beta-L-fucose + (1->4)-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R = GDP + (1->4)-beta-D-galactosyl-(alpha-(1->3)-L-fucosyl)-N-acetyl-D- glucosaminyl-R. (kegg)
                                                                          proteins

                                                                          details
                                                                          ["Normally acts on a glycoconjugate where R (see CA line) is a glycoprotein or glycolipid.", "This enzyme fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4, unlike EC 2.4.1.65, which fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3."]


                                                                          map 1: Neolacto-series GSL Metabolism N1

                                                                          proteins:
                                                                          • fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) [FUT4] ncbi lipid_maps
                                                                            regulators:
                                                                            MIR199B ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                                                                            MIR26A1 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                                                                            MIR26B ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                                                                            MIR493 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                                                                          • fucosyltransferase 7 (alpha (1,3) fucosyltransferase) [FUT7] ncbi lipid_maps
                                                                          • fucosyltransferase 3 [FUT3] ncbi lipid_maps
                                                                          • fucosyltransferase 5 [FUT5] ncbi lipid_maps
                                                                          • fucosyltransferase 6 [FUT6] ncbi lipid_maps

                                                                          X-hapten, SSEA-1, Lex-5

                                                                          (Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galbeta1-4Glcbeta-Cer) (lipid link)
                                                                          category: Sphingolipids [SP]
                                                                          main_class: Neutral glycosphingolipids [SP05]
                                                                          sub_class: Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc- (Neolacto series) [SP0505]
                                                                          formula:
                                                                          exact mass:
                                                                          status:
                                                                          lipidmaps
                                                                          pubchem substance url

                                                                          X-hapten, SSEA-1, Lex-5

                                                                          (Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galbeta1-4Glcbeta-Cer) (lipid link)
                                                                          category: Sphingolipids [SP]
                                                                          main_class: Neutral glycosphingolipids [SP05]
                                                                          sub_class: Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc- (Neolacto series) [SP0505]
                                                                          formula:
                                                                          status:
                                                                          exact mass:
                                                                          lipidmaps
                                                                          pubchem substance url
                                                                          localization: Golgi apparatus

                                                                          2.4.1.149 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase.

                                                                          UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-D- glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D- galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R. (kegg)
                                                                          proteins
                                                                          Q9NY97 B3GN2_HUMAN
                                                                          Q9Y2A9 B3GN3_HUMAN
                                                                          Q9C0J1 B3GN4_HUMAN

                                                                          details
                                                                          ["Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on asialo- alpha(1)-acid glycoprotein and other glycoproteins and oligosaccharides."]


                                                                          map 1: Neolacto-series GSL Metabolism N1

                                                                          proteins:
                                                                          • UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 [B3GNT6] ncbi lipid_maps

                                                                          ClcNAc-Lex-5 + UDP

                                                                          ( GlcNAcβ1-3Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ1-4Glcβ-Cer ) (lipid link)
                                                                          category: Sphingolipids [SP]
                                                                          main_class: Neutral glycosphingolipids [SP05]
                                                                          sub_class: Galβ1-4GlcNAcβ1-3Galβ1-4Glc- (Neolacto series) [SP0505]
                                                                          formula:
                                                                          synonyms:
                                                                          kegg id:
                                                                          exact mass: 0
                                                                          status:
                                                                          lipidmaps

                                                                          ClcNAc-Lex-5 + UDP-D-galactose

                                                                          ( GlcNAcβ1-3Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ1-4Glcβ-Cer ) (lipid link)
                                                                          category: Sphingolipids [SP]
                                                                          main_class: Neutral glycosphingolipids [SP05]
                                                                          sub_class: Galβ1-4GlcNAcβ1-3Galβ1-4Glc- (Neolacto series) [SP0505]
                                                                          formula:
                                                                          synonyms:
                                                                          kegg id:
                                                                          status:
                                                                          exact mass: 0
                                                                          lipidmaps
                                                                          localization: Golgi apparatus

                                                                          2.4.1.- Hexosyltransferases.

                                                                          (kegg)
                                                                          proteins


                                                                          map 1: Neolacto-series GSL Metabolism N1

                                                                          proteins:
                                                                          • UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 [B4GALT1] ncbi lipid_maps
                                                                          • UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 [B4GALT2] ncbi lipid_maps
                                                                          • UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 [B4GALT3] ncbi lipid_maps
                                                                          • UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 [B4GALT4] ncbi lipid_maps

                                                                          Lex-7 + UDP

                                                                          (Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ-Cer ) (lipid link)
                                                                          category: Sphingolipids [SP]
                                                                          main_class: Neutral glycosphingolipids [SP05]
                                                                          sub_class: Galβ1-4GlcNAcβ1-3Galβ1-4Glc- (Neolacto series) [SP0505]
                                                                          formula:
                                                                          synonyms:
                                                                          kegg id:
                                                                          exact mass: 0
                                                                          status:
                                                                          lipidmaps

                                                                          Lex-7 + GDP-L-fucose

                                                                          (Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ-Cer ) (lipid link)
                                                                          category: Sphingolipids [SP]
                                                                          main_class: Neutral glycosphingolipids [SP05]
                                                                          sub_class: Galβ1-4GlcNAcβ1-3Galβ1-4Glc- (Neolacto series) [SP0505]
                                                                          formula:
                                                                          synonyms:
                                                                          kegg id:
                                                                          status:
                                                                          exact mass: 0
                                                                          lipidmaps
                                                                          localization: Golgi apparatus

                                                                          2.4.1.152 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase.

                                                                          GDP-beta-L-fucose + (1->4)-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R = GDP + (1->4)-beta-D-galactosyl-(alpha-(1->3)-L-fucosyl)-N-acetyl-D- glucosaminyl-R. (kegg)
                                                                          proteins

                                                                          details
                                                                          ["Normally acts on a glycoconjugate where R (see CA line) is a glycoprotein or glycolipid.", "This enzyme fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4, unlike EC 2.4.1.65, which fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3."]


                                                                          map 1: Neolacto-series GSL Metabolism N1

                                                                          proteins:
                                                                          • fucosyltransferase 3 [FUT3] ncbi lipid_maps
                                                                          • fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) [FUT4] ncbi lipid_maps
                                                                            regulators:
                                                                            MIR199B ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                                                                            MIR26A1 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                                                                            MIR26B ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                                                                            MIR493 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                                                                          • fucosyltransferase 5 [FUT5] ncbi lipid_maps
                                                                          • fucosyltransferase 7 (alpha (1,3) fucosyltransferase) [FUT7] ncbi lipid_maps
                                                                          • fucosyltransferase 7 (alpha (1,3) fucosyltransferase) [FUT7] ncbi lipid_maps

                                                                          dimeric Lex + GDP

                                                                          (Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ1-4Glcβ-Cer) (lipid link)
                                                                          category: Sphingolipids [SP]
                                                                          main_class: Neutral glycosphingolipids [SP05]
                                                                          sub_class: Galβ1-4GlcNAcβ1-3Galβ1-4Glc- (Neolacto series) [SP0505]
                                                                          formula:
                                                                          synonyms:
                                                                          kegg id:
                                                                          exact mass: 0
                                                                          status:
                                                                          lipidmaps

                                                                          paragloboside, nLc4Cer + CMP-N-Acetylneuraminic acid

                                                                          (Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glcbeta-Cer) (lipid link)
                                                                          category: Sphingolipids [SP]
                                                                          main_class: Neutral glycosphingolipids [SP05]
                                                                          sub_class: Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc- (Neolacto series) [SP0505]
                                                                          formula:
                                                                          status:
                                                                          exact mass:
                                                                          lipidmaps
                                                                          pubchem substance url
                                                                          localization: Golgi apparatus

                                                                          2.4.99.10 Neolactotetraosylceramide alpha-2,3-sialyltransferase.

                                                                          CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D- glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N- acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-D-glucosyl- (1<->1)-ceramide. (kegg)
                                                                          proteins


                                                                          map 1: Neolacto-series GSL Metabolism N2

                                                                          proteins:
                                                                          • ST3 beta-galactoside alpha-2,3-sialyltransferase 4 [ST3GAL4] ncbi lipid_maps
                                                                            regulators:
                                                                            MIR193A ( microRNA binding ) /0 (0, 0, 0)/ rzmd
                                                                            MIR224 ( microRNA binding ) /0 (0, 0, 0)/ rzmd
                                                                          • ST3 beta-galactoside alpha-2,3-sialyltransferase 6 [ST3GAL6] ncbi lipid_maps
                                                                            regulators:
                                                                            MIR26A1 ( microRNA binding ) /1 (0, 1, 0)/ rzmd

                                                                          LM1, iso-LM1 + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                                                                          (Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glcbeta-Cer) (lipid link)
                                                                          category: Sphingolipids [SP]
                                                                          main_class: Neutral glycosphingolipids [SP05]
                                                                          sub_class: Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glc- (Lacto series) [SP0504]
                                                                          formula:
                                                                          exact mass:
                                                                          status:
                                                                          lipidmaps
                                                                          pubchem substance url

                                                                          (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + NADH + O2

                                                                          (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-[(2-{[(9Z,12Z,15Z,18Z,21Z)-tetracosa-9,12,15,18,21-pentaenoyl) (lipid link)
                                                                          category: Fatty Acyls [FA]
                                                                          main_class: Fatty esters [FA07]
                                                                          sub_class: Fatty acyl CoAs [FA0705]
                                                                          formula: C45H72N7O17P3S
                                                                          synonyms: 24:5(n-3);9Z,12Z,15Z,18Z,21Z-tetracosapentaenoyl-CoA;CoA(24:5(9Z,12Z,15Z,18Z,21Z));all-cis-9,12,15,18,21-tetracosapentaenoyl-CoA
                                                                          status:
                                                                          exact mass: 1107.39
                                                                          lipidmaps
                                                                          localization: Golgi apparatus

                                                                          1.14.19.3 Acyl-CoA 6-desaturase.

                                                                          (1) Linoleoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = gamma- linolenoyl-CoA + 2 ferricytochrome b5+ 2 H(2)O. (2) Alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = stearidonoyl-CoA + 2 ferricytochrome b5+ 2 H(2)O. (kegg)
                                                                          proteins
                                                                          O95864 FADS2_HUMAN

                                                                          details
                                                                          ["The enzyme introduces a cis double bond at carbon 6 of acyl-CoAs.", "It is a front-end desaturase, introducing the new double bond between a pre-existing double bond and the carboxyl-end of the fatty acid.", "The human enzyme has a broad substrate range; it also acts on palmitoyl-CoA, generating sapienoyl-CoA, and on (9Z,12Z,15Z,18Z,21Z)- tetracosa-9,12,15,18,21-pentaenoyl-CoA, converting it to (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexaenoyl-CoA as part of a pathway that produces docosahexaenoate.", "The enzyme contains a cytochrome b5 domain that is assumed to act in vivo as the electron donor to the active site of the desaturase."]


                                                                          map 1: n-3 Polyunsaturated fatty acid biosynthesis

                                                                          proteins:

                                                                          (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+) + H2O

                                                                          (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-[(2-{[(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexae) (lipid link)
                                                                          category: Fatty Acyls [FA]
                                                                          main_class: Fatty esters [FA07]
                                                                          sub_class: Fatty acyl CoAs [FA0705]
                                                                          formula: C45H70N7O17P3S
                                                                          synonyms: 24:6(n-3);6Z,9Z,12Z,15Z,18Z,21Z-Tetracosahexaenoyl-CoA;6Z,9Z,12Z,15Z,18Z,21Z-tetracosahexaenoyl-CoA;CoA(24:6(6Z,9Z,12Z,15Z,18Z,2
                                                                          exact mass: 1105.38
                                                                          status:
                                                                          lipidmaps

                                                                          (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + O2

                                                                          (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-[(2-{[(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexae) (lipid link)
                                                                          category: Fatty Acyls [FA]
                                                                          main_class: Fatty esters [FA07]
                                                                          sub_class: Fatty acyl CoAs [FA0705]
                                                                          formula: C45H70N7O17P3S
                                                                          synonyms: 24:6(n-3);6Z,9Z,12Z,15Z,18Z,21Z-Tetracosahexaenoyl-CoA;6Z,9Z,12Z,15Z,18Z,21Z-tetracosahexaenoyl-CoA;CoA(24:6(6Z,9Z,12Z,15Z,18Z,2
                                                                          status:
                                                                          exact mass: 1105.38
                                                                          lipidmaps
                                                                          localization: peroxisome

                                                                          1.3.3.6 Acyl-CoA oxidase.

                                                                          Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2). (kegg)
                                                                          proteins
                                                                          Q15067 ACOX1_HUMAN
                                                                          O15254 ACOX3_HUMAN

                                                                          details
                                                                          ["Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18)."]


                                                                          map 1: n-3 Polyunsaturated fatty acid biosynthesis

                                                                          proteins:
                                                                          • acyl-CoA oxidase 1, palmitoyl [ACOX1] ncbi lipid_maps
                                                                            regulators:
                                                                            MIR15B ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                                                                            MIR31 ( microRNA binding ) /0 (0, 0, 0)/ rzmd
                                                                          • acyl-CoA oxidase 2, branched chain [ACOX2] ncbi lipid_maps
                                                                          • acyl-CoA oxidase 3, pristanoyl [ACOX3] ncbi lipid_maps

                                                                          CoA(24:7(2E,6Z,9Z,12Z,15Z,18Z,21Z)) + H2O

                                                                          (1-(2E,6Z,9Z,12Z,15Z,18Z,21Z-tetracosaheptaenoyl)-CoA) (lipid link)
                                                                          category: Fatty Acyls [FA]
                                                                          main_class: Fatty esters [FA07]
                                                                          sub_class: Fatty acyl CoAs [FA0705]
                                                                          formula: C45H68N7O17P3S
                                                                          synonyms: delta2-THA-CoA
                                                                          exact mass: 1103.36
                                                                          status:
                                                                          lipidmaps
                                                                          pubchem substance url

                                                                          Lex-7 + GDP-L-fucose

                                                                          (Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ-Cer ) (lipid link)
                                                                          category: Sphingolipids [SP]
                                                                          main_class: Neutral glycosphingolipids [SP05]
                                                                          sub_class: Galβ1-4GlcNAcβ1-3Galβ1-4Glc- (Neolacto series) [SP0505]
                                                                          formula:
                                                                          synonyms:
                                                                          kegg id:
                                                                          status:
                                                                          exact mass: 0
                                                                          lipidmaps
                                                                          localization: Golgi apparatus

                                                                          2.4.1.65 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase.

                                                                          GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D- glucosaminyl-R. (kegg)
                                                                          proteins
                                                                          P21217 FUT3_HUMAN
                                                                          Q11128 FUT5_HUMAN
                                                                          P51993 FUT6_HUMAN

                                                                          details
                                                                          ["Product of the Lewis blood group gene.", "Normally acts on a glycoconjugate where R (see CA line) is a glycoprotein or glycolipid.", "Although it is a 4-fucosyltransferase, it has a persistent 3-fucosyltransferase activity toward the glucose residue in free lactose.", "Fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3, unlike EC 2.4.1.152 which fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4.", "Enzymes catalyzing the 4-alpha-fucosylation of the GlcNAc in beta-D- Gal-(1->3)-beta-GlcNAc sequences (with some activity also as 3-alpha- fucosyltransferases) are present in plants, where the function in vivo is the modification of N-glycans.", "In addition, the fucTa gene of Helicobacter strain UA948 encodes a fucosyltransferase with both 3-alpha- and 4-alpha-fucosyltransferase activities."]


                                                                          map 1: Neolacto-series GSL Metabolism N2

                                                                          proteins:

                                                                          dimeric Lex + L-fucose

                                                                          (Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ1-4Glcβ-Cer) (lipid link)
                                                                          category: Sphingolipids [SP]
                                                                          main_class: Neutral glycosphingolipids [SP05]
                                                                          sub_class: Galβ1-4GlcNAcβ1-3Galβ1-4Glc- (Neolacto series) [SP0505]
                                                                          formula:
                                                                          synonyms:
                                                                          kegg id:
                                                                          exact mass: 0
                                                                          status:
                                                                          lipidmaps

                                                                          CoA(24:7(2E,6Z,9Z,12Z,15Z,18Z,21Z)) + H2O

                                                                          (1-(2E,6Z,9Z,12Z,15Z,18Z,21Z-tetracosaheptaenoyl)-CoA) (lipid link)
                                                                          category: Fatty Acyls [FA]
                                                                          main_class: Fatty esters [FA07]
                                                                          sub_class: Fatty acyl CoAs [FA0705]
                                                                          formula: C45H68N7O17P3S
                                                                          synonyms: delta2-THA-CoA
                                                                          status:
                                                                          exact mass: 1103.36
                                                                          lipidmaps
                                                                          pubchem substance url
                                                                          localization: peroxisome

                                                                          4.2.1.17 Enoyl-CoA hydratase.

                                                                          (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O. (kegg)
                                                                          proteins
                                                                          P40939 ECHA_HUMAN
                                                                          P30084 ECHM_HUMAN
                                                                          Q08426 ECHP_HUMAN

                                                                          details
                                                                          ["Acts in the reverse direction.", "With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74)."]


                                                                          map 1: n-3 Polyunsaturated fatty acid biosynthesis

                                                                          proteins:

                                                                          (6Z,9Z,12Z,15Z,18Z,21Z)-3-hydroxytetracosahexaenoyl-CoA

                                                                          (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-[(2-{[(6Z,9Z,12Z,15Z,18Z,21Z)-3-hydroxytetracosa-6,9,12,15,18) (lipid link)
                                                                          category: Fatty Acyls [FA]
                                                                          main_class: Fatty esters [FA07]
                                                                          sub_class: Fatty acyl CoAs [FA0705]
                                                                          formula: C45H70N7O18P3S
                                                                          synonyms: (6Z,9Z,12Z,15Z,18Z,21Z)-3-hydroxytetracosa-6,9,12,15,18,21-hexaenoyl-CoA;(6Z,9Z,12Z,15Z,18Z,21Z)-3-hydroxytetracosa-6,9,12,15,18
                                                                          exact mass: 1121.37
                                                                          status:
                                                                          lipidmaps

                                                                          (6Z,9Z,12Z,15Z,18Z,21Z)-3-hydroxytetracosahexaenoyl-CoA + NAD(+)

                                                                          (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-[(2-{[(6Z,9Z,12Z,15Z,18Z,21Z)-3-hydroxytetracosa-6,9,12,15,18) (lipid link)
                                                                          category: Fatty Acyls [FA]
                                                                          main_class: Fatty esters [FA07]
                                                                          sub_class: Fatty acyl CoAs [FA0705]
                                                                          formula: C45H70N7O18P3S
                                                                          synonyms: (6Z,9Z,12Z,15Z,18Z,21Z)-3-hydroxytetracosa-6,9,12,15,18,21-hexaenoyl-CoA;(6Z,9Z,12Z,15Z,18Z,21Z)-3-hydroxytetracosa-6,9,12,15,18
                                                                          status:
                                                                          exact mass: 1121.37
                                                                          lipidmaps
                                                                          localization: Unknown

                                                                          1.1.1.35 3-hydroxyacyl-CoA dehydrogenase.

                                                                          (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. (kegg)
                                                                          proteins
                                                                          Q08426 ECHP_HUMAN
                                                                          Q99714 HCD2_HUMAN
                                                                          Q16836 HCDH_HUMAN

                                                                          details
                                                                          ["Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate.", "Some enzymes act, more slowly, with NADP(+).", "Broad specificity to acyl chain-length (cf. EC 1.1.1.211)."]


                                                                          map 1: n-3 Polyunsaturated fatty acid biosynthesis

                                                                          proteins:
                                                                          • hydroxysteroid (17-beta) dehydrogenase 4 [HSD17B4] ncbi lipid_maps
                                                                          • enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase [EHHADH] ncbi lipid_maps

                                                                          (6Z,9Z,12Z,15Z,18Z,21Z)-3-oxotetracosahexaenoyl-CoA + NADH

                                                                          (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-[(2-{[(6Z,9Z,12Z,15Z,18Z,21Z)-3-oxotetracosa-6,9,12,15,18,21-) (lipid link)
                                                                          category: Fatty Acyls [FA]
                                                                          main_class: Fatty esters [FA07]
                                                                          sub_class: Fatty acyl CoAs [FA0705]
                                                                          formula: C45H68N7O18P3S
                                                                          synonyms: (6Z,9Z,12Z,15Z,18Z,21Z)-3-Oxotetracosahexa-6,9,12,15,18,21-enoyl-CoA;(6Z,9Z,12Z,15Z,18Z,21Z)-3-oxotetracosa-6,9,12,15,18,21-hexa
                                                                          exact mass: 1119.36
                                                                          status:
                                                                          lipidmaps

                                                                          (6Z,9Z,12Z,15Z,18Z,21Z)-3-oxotetracosahexaenoyl-CoA + CoA

                                                                          (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-[(2-{[(6Z,9Z,12Z,15Z,18Z,21Z)-3-oxotetracosa-6,9,12,15,18,21-) (lipid link)
                                                                          category: Fatty Acyls [FA]
                                                                          main_class: Fatty esters [FA07]
                                                                          sub_class: Fatty acyl CoAs [FA0705]
                                                                          formula: C45H68N7O18P3S
                                                                          synonyms: (6Z,9Z,12Z,15Z,18Z,21Z)-3-Oxotetracosahexa-6,9,12,15,18,21-enoyl-CoA;(6Z,9Z,12Z,15Z,18Z,21Z)-3-oxotetracosa-6,9,12,15,18,21-hexa
                                                                          status:
                                                                          exact mass: 1119.36
                                                                          lipidmaps
                                                                          localization: peroxisome

                                                                          2.3.1.16 Acetyl-CoA C-acyltransferase.

                                                                          Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. (kegg)
                                                                          proteins
                                                                          P55084 ECHB_HUMAN
                                                                          P09110 THIK_HUMAN
                                                                          P42765 THIM_HUMAN


                                                                          map 1: n-3 Polyunsaturated fatty acid biosynthesis

                                                                          proteins:

                                                                          (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + acetyl-CoA

                                                                          (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-[(2-{[(4Z,7Z,10Z,13Z,16Z,19Z)-3-docosa-4,7,10,13,16,19-hexaen) (lipid link)
                                                                          category: Fatty Acyls [FA]
                                                                          main_class: Fatty esters [FA07]
                                                                          sub_class: Fatty acyl CoAs [FA0705]
                                                                          formula: C43H66N7O17P3S
                                                                          synonyms: (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl-CoA;(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl-coenzyme A
                                                                          exact mass: 1077.34
                                                                          status:
                                                                          lipidmaps

                                                                          PA + H2O

                                                                          (1,2-diacyl-sn-glycero-3-phosphate) (lipid link)
                                                                          category: Glycerophospholipids [GP]
                                                                          main_class: Glycerophosphates [GP10]
                                                                          sub_class: Diacylglycerophosphates [GP1001]
                                                                          formula:
                                                                          synonyms: Phosphatidic acid
                                                                          kegg id: C00416
                                                                          status:
                                                                          exact mass:
                                                                          lipidmaps
                                                                          pubchem substance url
                                                                          localization: Cytoplasm

                                                                          3.1.3.27 Phosphatidylglycerophosphatase.

                                                                          Phosphatidylglycerophosphate + H(2)O = phosphatidylglycerol + phosphate. (kegg)
                                                                          proteins
                                                                          Q8WUK0 PTPM1_HUMAN


                                                                          map 1: Triacylglycerol metabolism

                                                                          proteins:
                                                                          • phosphatidic acid phosphatase type 2A [PPAP2A] ncbi lipid_maps
                                                                          • phosphatidic acid phosphatase type 2B [PPAP2B] ncbi lipid_maps
                                                                            regulators:
                                                                            MIR184 ( microRNA binding ) /2 (0, 2, 0)/ rzmd
                                                                          • phosphatidic acid phosphatase type 2C [PPAP2C] ncbi lipid_maps

                                                                          1,2-DG + Phosphate

                                                                          (1,2-diacyl-sn-glycerol) (lipid link)
                                                                          category: Glycerolipids [GL]
                                                                          main_class: Diradylglycerols [GL02]
                                                                          sub_class: Diacylglycerols [GL0201]
                                                                          formula:
                                                                          synonyms: 1,2-diacylglycerol; 1,2-DAG
                                                                          kegg id: C00641
                                                                          exact mass:
                                                                          status:
                                                                          lipidmaps
                                                                          pubchem substance url

                                                                          CoA(24:4(9Z,12Z,15Z,18Z)) + NADH + O2

                                                                          (9Z,12Z,15Z,18Z-tetracosatetraenoyl-CoA) (lipid link)
                                                                          category: Fatty Acyls [FA]
                                                                          main_class: Fatty esters [FA07]
                                                                          sub_class: Fatty acyl CoAs [FA0705]
                                                                          formula: C45H74N7O17P3S
                                                                          status:
                                                                          exact mass: 1109.41
                                                                          lipidmaps
                                                                          pubchem substance url
                                                                          localization: Cytoplasm

                                                                          1.14.19.3 Acyl-CoA 6-desaturase.

                                                                          (1) Linoleoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = gamma- linolenoyl-CoA + 2 ferricytochrome b5+ 2 H(2)O. (2) Alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = stearidonoyl-CoA + 2 ferricytochrome b5+ 2 H(2)O. (kegg)
                                                                          proteins
                                                                          O95864 FADS2_HUMAN

                                                                          details
                                                                          ["The enzyme introduces a cis double bond at carbon 6 of acyl-CoAs.", "It is a front-end desaturase, introducing the new double bond between a pre-existing double bond and the carboxyl-end of the fatty acid.", "The human enzyme has a broad substrate range; it also acts on palmitoyl-CoA, generating sapienoyl-CoA, and on (9Z,12Z,15Z,18Z,21Z)- tetracosa-9,12,15,18,21-pentaenoyl-CoA, converting it to (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexaenoyl-CoA as part of a pathway that produces docosahexaenoate.", "The enzyme contains a cytochrome b5 domain that is assumed to act in vivo as the electron donor to the active site of the desaturase."]


                                                                          map 1: n-6 Polyunsaturated fatty acid biosynthesis

                                                                          proteins:

                                                                          (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NAD(+) + H2O

                                                                          (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-[(2-{[(6Z,9Z,12Z,15Z,18Z)-tetracosa-6,9,12,15,18-pentaenoyl]s) (lipid link)
                                                                          category: Fatty Acyls [FA]
                                                                          main_class: Fatty esters [FA07]
                                                                          sub_class: Fatty acyl CoAs [FA0705]
                                                                          formula: C45H72N7O17P3S
                                                                          synonyms: 24:5(n-6);all-cis-6,9,12,15,18-tetracosapentaenoyl-CoA;tetracosapentaenoyl-CoA
                                                                          exact mass: 1107.39
                                                                          status:
                                                                          lipidmaps

                                                                          2-Acyl-1-alkyl-sn-glycero-3-phosphate + H2O

                                                                          (2-Acyl-1-alkyl-sn-glycero-3-phosphate) (lipid link)
                                                                          category:
                                                                          main_class:
                                                                          sub_class:
                                                                          formula: C4H7O7PR2
                                                                          synonyms:
                                                                          kegg id: C05977
                                                                          status:
                                                                          exact mass: 0
                                                                          pubchem substance url
                                                                          localization: Unknown

                                                                          3.1.3.4 Phosphatidate phosphatase.

                                                                          A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate. (kegg)
                                                                          proteins
                                                                          Q14693 LPIN1_HUMAN
                                                                          Q92539 LPIN2_HUMAN
                                                                          Q9BQK8 LPIN3_HUMAN
                                                                          O14494 PLPP1_HUMAN
                                                                          O43688 PLPP2_HUMAN
                                                                          O14495 PLPP3_HUMAN
                                                                          Q5VZY2 PLPP4_HUMAN
                                                                          Q8NEB5 PLPP5_HUMAN
                                                                          Q96GM1 PLPR2_HUMAN
                                                                          Q6T4P5 PLPR3_HUMAN
                                                                          Q7Z2D5 PLPR4_HUMAN

                                                                          details
                                                                          ["This enzyme catalyzes the Mg(2+)-dependent dephosphorylation of a 1,2-diacylglycerol-3-phosphate, yielding a 1,2-diacyl-sn-glycerol (DAG), the substrate for de novo lipid synthesis via the Kennedy pathway and for the synthesis of triacylglycerol.", "In lipid signaling, the enzyme generates a pool of DAG to be used for protein kinase C activation.", "The mammalian enzymes are known as lipins."]


                                                                          map 1: ETHER lipid metabolism

                                                                          proteins:

                                                                            2-Acyl-1-alkyl-sn-glycerol + Phosphate

                                                                            (2-Acyl-1-alkyl-sn-glycerol) (lipid link)
                                                                            category:
                                                                            main_class:
                                                                            sub_class:
                                                                            formula: C4H6O4R2
                                                                            synonyms: 1-Alkyl-2-acylglycerol
                                                                            kegg id: C03201
                                                                            exact mass: 0
                                                                            status:
                                                                            pubchem substance url

                                                                            CDP-ethanolamine

                                                                            () (lipid link)
                                                                            category:
                                                                            main_class:
                                                                            sub_class:
                                                                            formula: C11H20N4O11P2
                                                                            synonyms: Cytidine diphosphate ethanolamine
                                                                            kegg id: C00570
                                                                            status:
                                                                            exact mass: 446.06
                                                                            pubchem substance url
                                                                            localization: Unknown

                                                                            2.7.8.1 Ethanolaminephosphotransferase.

                                                                            CDP-ethanolamine + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylethanolamine. (kegg)
                                                                            proteins
                                                                            Q9Y6K0 CEPT1_HUMAN
                                                                            Q9C0D9 EPT1_HUMAN


                                                                            map 1: ETHER lipid metabolism

                                                                            proteins:

                                                                              1-Alkyl-2-acylglycerophosphoethanolamine + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                                                                              (1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine) (lipid link)
                                                                              category:
                                                                              main_class:
                                                                              sub_class:
                                                                              formula: C6H12NO7PR2
                                                                              synonyms: 1-Radyl-2-acyl-sn-glycero-3-phosphoethanolamine; 1-Organyl-2-acyl-sn-glycero-3-phosphoethanolamine, O-1-Alkyl-2-acyl-sn-glycero-3-phosphoethanolamine; 2-Acyl-1-alkyl-sn-glycero-3-phosphoethanolamine
                                                                              kegg id: C04475
                                                                              exact mass: 0
                                                                              status:
                                                                              pubchem substance url

                                                                              2-Acyl-1-alkyl-sn-glycerol

                                                                              (2-Acyl-1-alkyl-sn-glycerol) (lipid link)
                                                                              category:
                                                                              main_class:
                                                                              sub_class:
                                                                              formula: C4H6O4R2
                                                                              synonyms: 1-Alkyl-2-acylglycerol
                                                                              kegg id: C03201
                                                                              status:
                                                                              exact mass: 0
                                                                              pubchem substance url
                                                                              localization: Unknown

                                                                              2.7.8.1 Ethanolaminephosphotransferase.

                                                                              CDP-ethanolamine + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylethanolamine. (kegg)
                                                                              proteins
                                                                              Q9Y6K0 CEPT1_HUMAN
                                                                              Q9C0D9 EPT1_HUMAN


                                                                              map 1: ETHER lipid metabolism

                                                                              proteins:

                                                                                1-Alkyl-2-acylglycerophosphoethanolamine + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                                                                                (1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine) (lipid link)
                                                                                category:
                                                                                main_class:
                                                                                sub_class:
                                                                                formula: C6H12NO7PR2
                                                                                synonyms: 1-Radyl-2-acyl-sn-glycero-3-phosphoethanolamine; 1-Organyl-2-acyl-sn-glycero-3-phosphoethanolamine, O-1-Alkyl-2-acyl-sn-glycero-3-phosphoethanolamine; 2-Acyl-1-alkyl-sn-glycero-3-phosphoethanolamine
                                                                                kegg id: C04475
                                                                                exact mass: 0
                                                                                status:
                                                                                pubchem substance url

                                                                                2-Acyl-1-alkyl-sn-glycerol

                                                                                (2-Acyl-1-alkyl-sn-glycerol) (lipid link)
                                                                                category:
                                                                                main_class:
                                                                                sub_class:
                                                                                formula: C4H6O4R2
                                                                                synonyms: 1-Alkyl-2-acylglycerol
                                                                                kegg id: C03201
                                                                                status:
                                                                                exact mass: 0
                                                                                pubchem substance url
                                                                                localization: Unknown

                                                                                2.4.1.45 2-hydroxyacylsphingosine 1-beta-galactosyltransferase.

                                                                                UDP-alpha-D-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D- galactosyl)-2-(2-hydroxyacyl)sphingosine. (kegg)
                                                                                proteins
                                                                                Q16880 CGT_HUMAN

                                                                                details
                                                                                ["Highly specific."]


                                                                                map 1: ETHER lipid metabolism

                                                                                proteins:

                                                                                  Galactosyl-1-alkyl-2-acylglycerol + UDP

                                                                                  (1-O-Alkyl-2-O-acyl-3-beta-galactosyl-sn-glycerol) (lipid link)
                                                                                  category:
                                                                                  main_class:
                                                                                  sub_class:
                                                                                  formula: C10H16O9R2
                                                                                  synonyms: Galactosyl-2-acyl-1-alkyl-sn-glycerol
                                                                                  kegg id: C20859
                                                                                  exact mass: 0
                                                                                  status:
                                                                                  pubchem substance url

                                                                                  UDP-alpha-D-galactose

                                                                                  (UDP-alpha-D-galactose) (lipid link)
                                                                                  category:
                                                                                  main_class:
                                                                                  sub_class:
                                                                                  formula: C15H24N2O17P2
                                                                                  synonyms: UDP-D-galactose; UDP-galactose; UDP-D-galactopyranose; UDP-alpha-D-galactopyranose
                                                                                  kegg id: C00052
                                                                                  status:
                                                                                  exact mass: 566.055
                                                                                  pubchem substance url
                                                                                  localization: Unknown

                                                                                  2.4.1.45 2-hydroxyacylsphingosine 1-beta-galactosyltransferase.

                                                                                  UDP-alpha-D-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D- galactosyl)-2-(2-hydroxyacyl)sphingosine. (kegg)
                                                                                  proteins
                                                                                  Q16880 CGT_HUMAN

                                                                                  details
                                                                                  ["Highly specific."]


                                                                                  map 1: ETHER lipid metabolism

                                                                                  proteins:

                                                                                    Galactosyl-1-alkyl-2-acylglycerol + UDP

                                                                                    (1-O-Alkyl-2-O-acyl-3-beta-galactosyl-sn-glycerol) (lipid link)
                                                                                    category:
                                                                                    main_class:
                                                                                    sub_class:
                                                                                    formula: C10H16O9R2
                                                                                    synonyms: Galactosyl-2-acyl-1-alkyl-sn-glycerol
                                                                                    kegg id: C20859
                                                                                    exact mass: 0
                                                                                    status:
                                                                                    pubchem substance url

                                                                                    Galactosyl-1-alkyl-2-acylglycerol

                                                                                    (1-O-Alkyl-2-O-acyl-3-beta-galactosyl-sn-glycerol) (lipid link)
                                                                                    category:
                                                                                    main_class:
                                                                                    sub_class:
                                                                                    formula: C10H16O9R2
                                                                                    synonyms: Galactosyl-2-acyl-1-alkyl-sn-glycerol
                                                                                    kegg id: C20859
                                                                                    status:
                                                                                    exact mass: 0
                                                                                    pubchem substance url
                                                                                    localization: Unknown

                                                                                    2.8.2.11 Galactosylceramide sulfotransferase.

                                                                                    3'-phosphoadenylyl sulfate + a galactosylceramide = adenosine3',5'-bisphosphate + a galactosylceramidesulfate. (kegg)
                                                                                    proteins
                                                                                    Q99999 G3ST1_HUMAN

                                                                                    details
                                                                                    ["Also acts on lactosylceramide and monogalactosylalkylacylglycerol."]


                                                                                    map 1: ETHER lipid metabolism

                                                                                    proteins:

                                                                                      Seminolipid

                                                                                      (1-O-Alkyl-2-O-acyl-3-beta-(3-sulfogalactosyl)-sn-glycerol) (lipid link)
                                                                                      category:
                                                                                      main_class:
                                                                                      sub_class:
                                                                                      formula: C10H16O12SR2
                                                                                      synonyms: 3-Sulfogalactosyl-1-alkyl-2-acylglycerol; 3-Sulfogalactosyl-2-acyl-1-alkyl-sn-glycerol
                                                                                      kegg id: C20825
                                                                                      exact mass: 0
                                                                                      status:
                                                                                      pubchem substance url

                                                                                      Phosphoadenosine phosphate

                                                                                      (adenosine 3,5-bismonophosphate) (lipid link)
                                                                                      category:
                                                                                      main_class:
                                                                                      sub_class:
                                                                                      formula: C10H15N5O10P2
                                                                                      synonyms: PAP; 3-Phosphoadenylate
                                                                                      kegg id: C00054
                                                                                      exact mass: 427.029
                                                                                      status:
                                                                                      pubchem substance url

                                                                                      3-Phosphoadenylyl sulfate

                                                                                      (3-phospho-5-adenylyl sulfate) (lipid link)
                                                                                      category:
                                                                                      main_class:
                                                                                      sub_class:
                                                                                      formula: C10H15N5O13P2S
                                                                                      synonyms: 3-Phosphoadenosine 5-phosphosulfate, PAPS
                                                                                      kegg id: C00053
                                                                                      status:
                                                                                      exact mass: 506.986
                                                                                      pubchem substance url
                                                                                      localization: Unknown

                                                                                      2.8.2.11 Galactosylceramide sulfotransferase.

                                                                                      3'-phosphoadenylyl sulfate + a galactosylceramide = adenosine3',5'-bisphosphate + a galactosylceramidesulfate. (kegg)
                                                                                      proteins
                                                                                      Q99999 G3ST1_HUMAN

                                                                                      details
                                                                                      ["Also acts on lactosylceramide and monogalactosylalkylacylglycerol."]


                                                                                      map 1: ETHER lipid metabolism

                                                                                      proteins:

                                                                                        Seminolipid

                                                                                        (1-O-Alkyl-2-O-acyl-3-beta-(3-sulfogalactosyl)-sn-glycerol) (lipid link)
                                                                                        category:
                                                                                        main_class:
                                                                                        sub_class:
                                                                                        formula: C10H16O12SR2
                                                                                        synonyms: 3-Sulfogalactosyl-1-alkyl-2-acylglycerol; 3-Sulfogalactosyl-2-acyl-1-alkyl-sn-glycerol
                                                                                        kegg id: C20825
                                                                                        exact mass: 0
                                                                                        status:
                                                                                        pubchem substance url

                                                                                        Phosphoadenosine phosphate

                                                                                        (adenosine 3,5-bismonophosphate) (lipid link)
                                                                                        category:
                                                                                        main_class:
                                                                                        sub_class:
                                                                                        formula: C10H15N5O10P2
                                                                                        synonyms: PAP; 3-Phosphoadenylate
                                                                                        kegg id: C00054
                                                                                        exact mass: 427.029
                                                                                        status:
                                                                                        pubchem substance url

                                                                                        1-Alkyl-2-acylglycerophosphoethanolamine + reduced acceptor + O2

                                                                                        (1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine) (lipid link)
                                                                                        category:
                                                                                        main_class:
                                                                                        sub_class:
                                                                                        formula: C6H12NO7PR2
                                                                                        synonyms: 1-Radyl-2-acyl-sn-glycero-3-phosphoethanolamine; 1-Organyl-2-acyl-sn-glycero-3-phosphoethanolamine, O-1-Alkyl-2-acyl-sn-glycero-3-phosphoethanolamine; 2-Acyl-1-alkyl-sn-glycero-3-phosphoethanolamine
                                                                                        kegg id: C04475
                                                                                        status:
                                                                                        exact mass: 0
                                                                                        pubchem substance url
                                                                                        localization: Unknown

                                                                                        1.14.99.19 Plasmanylethanolamine desaturase.

                                                                                        O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + AH(2) + O(2) = O-1- alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + A + 2 H(2)O. (kegg)
                                                                                        proteins

                                                                                        details
                                                                                        ["Either NADPH or NADH can act as AH(2).", "May involve cytochrome b5.", "Requires ATP."]


                                                                                        map 1: ETHER lipid metabolism

                                                                                        proteins:

                                                                                          Plasmenylethanolamine + acceptor + H2O

                                                                                          (1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine) (lipid link)
                                                                                          category:
                                                                                          main_class:
                                                                                          sub_class:
                                                                                          formula: C8H14NO7PR2
                                                                                          synonyms: O-1-Alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine, Phosphatidalethanolamine, Ethanolamineplasmalogen, 2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine, 1-Alkenyl-2-acylglycerophosphoethanolamine
                                                                                          kegg id:
                                                                                          exact mass: 267.051
                                                                                          status:
                                                                                          pubchem substance url

                                                                                          (6Z,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + O2

                                                                                          (3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-[(2-{[(6Z,9Z,12Z,15Z,18Z)-tetracosa-6,9,12,15,18-pentaenoyl]s) (lipid link)
                                                                                          category: Fatty Acyls [FA]
                                                                                          main_class: Fatty esters [FA07]
                                                                                          sub_class: Fatty acyl CoAs [FA0705]
                                                                                          formula: C45H72N7O17P3S
                                                                                          synonyms: 24:5(n-6);all-cis-6,9,12,15,18-tetracosapentaenoyl-CoA;tetracosapentaenoyl-CoA
                                                                                          status:
                                                                                          exact mass: 1107.39
                                                                                          lipidmaps
                                                                                          localization: Cytoplasm

                                                                                          1.3.3.6 Acyl-CoA oxidase.

                                                                                          Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2). (kegg)
                                                                                          proteins
                                                                                          Q15067 ACOX1_HUMAN
                                                                                          O15254 ACOX3_HUMAN

                                                                                          details
                                                                                          ["Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18)."]


                                                                                          map 1: n-6 Polyunsaturated fatty acid biosynthesis

                                                                                          proteins:
                                                                                          • acyl-CoA oxidase 1, palmitoyl [ACOX1] ncbi lipid_maps
                                                                                            regulators:
                                                                                            MIR15B ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                                                                                            MIR31 ( microRNA binding ) /0 (0, 0, 0)/ rzmd
                                                                                          • acyl-CoA oxidase 2, branched chain [ACOX2] ncbi lipid_maps
                                                                                          • acyl-CoA oxidase 3, pristanoyl [ACOX3] ncbi lipid_maps

                                                                                          (2E,6Z,9Z,12Z,15Z,18Z)-Tetracosahexa-2,6,9,12,15,18-enoyl-CoA + H2O

                                                                                          ( (2R)-4-({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hyd) (lipid link)
                                                                                          category:
                                                                                          main_class:
                                                                                          sub_class:
                                                                                          formula: C45H70N7O17P3S
                                                                                          synonyms:
                                                                                          kegg id: C16387
                                                                                          exact mass: 0
                                                                                          status:

                                                                                          (2E,6Z,9Z,12Z,15Z,18Z)-Tetracosahexa-2,6,9,12,15,18-enoyl-CoA + H2O

                                                                                          ( (2R)-4-({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hyd) (lipid link)
                                                                                          category:
                                                                                          main_class:
                                                                                          sub_class:
                                                                                          formula: C45H70N7O17P3S
                                                                                          synonyms:
                                                                                          kegg id: C16387
                                                                                          status:
                                                                                          exact mass: 0
                                                                                          localization: Cytoplasm

                                                                                          4.2.1.17 Enoyl-CoA hydratase.

                                                                                          (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O. (kegg)
                                                                                          proteins
                                                                                          P40939 ECHA_HUMAN
                                                                                          P30084 ECHM_HUMAN
                                                                                          Q08426 ECHP_HUMAN

                                                                                          details
                                                                                          ["Acts in the reverse direction.", "With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74)."]


                                                                                          map 1: n-6 Polyunsaturated fatty acid biosynthesis

                                                                                          proteins:
                                                                                          • hydroxysteroid (17-beta) dehydrogenase 4 [HSD17B4] ncbi lipid_maps
                                                                                          • enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase [EHHADH] ncbi lipid_maps

                                                                                          Tetracosa-6,9,12,15,18-all-cis-pentaenoyl-CoA

                                                                                          ((2R)-4-({[({[(2S,3S,4R,5S)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydr) (lipid link)
                                                                                          category:
                                                                                          main_class:
                                                                                          sub_class:
                                                                                          formula: C45H72N7O18P3S
                                                                                          synonyms:
                                                                                          kegg id:
                                                                                          exact mass: 0
                                                                                          status:

                                                                                          Tetracosa-6,9,12,15,18-all-cis-pentaenoyl-CoA + NAD(+)

                                                                                          ((2R)-4-({[({[(2S,3S,4R,5S)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydr) (lipid link)
                                                                                          category:
                                                                                          main_class:
                                                                                          sub_class:
                                                                                          formula: C45H72N7O18P3S
                                                                                          synonyms:
                                                                                          kegg id:
                                                                                          status:
                                                                                          exact mass: 0
                                                                                          localization: Cytoplasm

                                                                                          1.1.1.35 3-hydroxyacyl-CoA dehydrogenase.

                                                                                          (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. (kegg)
                                                                                          proteins
                                                                                          Q08426 ECHP_HUMAN
                                                                                          Q99714 HCD2_HUMAN
                                                                                          Q16836 HCDH_HUMAN

                                                                                          details
                                                                                          ["Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate.", "Some enzymes act, more slowly, with NADP(+).", "Broad specificity to acyl chain-length (cf. EC 1.1.1.211)."]


                                                                                          map 1: n-6 Polyunsaturated fatty acid biosynthesis

                                                                                          proteins:
                                                                                          • enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase [EHHADH] ncbi lipid_maps

                                                                                          3-oxo-all-cis-6,9,12,15,18-Tetracosapentaenoyl-CoA + NADH

                                                                                          ((2R)-4-({[({[(2S,3S,4R,5S)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydr) (lipid link)
                                                                                          category:
                                                                                          main_class:
                                                                                          sub_class:
                                                                                          formula: C45H70N7O18P3S
                                                                                          synonyms:
                                                                                          kegg id:
                                                                                          exact mass: 0
                                                                                          status:

                                                                                          Lysoplasmalogen + Acyl-CoA

                                                                                          (1-(1-Alkenyl)-sn-glycero-3-phosphoethanolamine) (lipid link)
                                                                                          category:
                                                                                          main_class:
                                                                                          sub_class:
                                                                                          formula: C7H15NO6PR
                                                                                          synonyms: 1-Alkenylglycerophosphoethanolamine
                                                                                          kegg id: C04635
                                                                                          status:
                                                                                          exact mass: 0
                                                                                          pubchem substance url
                                                                                          localization: Unknown

                                                                                          2.3.1.23 1-acylglycerophosphocholine O-acyltransferase.

                                                                                          Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl- sn-glycero-3-phosphocholine. (kegg)
                                                                                          proteins
                                                                                          Q643R3 LPCT4_HUMAN
                                                                                          Q6P1A2 MBOA5_HUMAN
                                                                                          Q8NF37 PCAT1_HUMAN
                                                                                          Q7L5N7 PCAT2_HUMAN

                                                                                          details
                                                                                          ["Acts preferentially with unsaturated acyl-CoA derivatives.", "1-acyl-sn-glycero-3-phosphoinositol can also act as acceptor."]


                                                                                          map 1: ETHER lipid metabolism

                                                                                          proteins:

                                                                                            Plasmenylethanolamine + CoA

                                                                                            (1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine) (lipid link)
                                                                                            category:
                                                                                            main_class:
                                                                                            sub_class:
                                                                                            formula: C8H14NO7PR2
                                                                                            synonyms: O-1-Alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine, Phosphatidalethanolamine, Ethanolamineplasmalogen, 2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine, 1-Alkenyl-2-acylglycerophosphoethanolamine
                                                                                            kegg id:
                                                                                            exact mass: 267.051
                                                                                            status:
                                                                                            pubchem substance url

                                                                                            Plasmenylethanolamine + H2O

                                                                                            (1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine) (lipid link)
                                                                                            category:
                                                                                            main_class:
                                                                                            sub_class:
                                                                                            formula: C8H14NO7PR2
                                                                                            synonyms: O-1-Alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine, Phosphatidalethanolamine, Ethanolamineplasmalogen, 2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine, 1-Alkenyl-2-acylglycerophosphoethanolamine
                                                                                            kegg id:
                                                                                            status:
                                                                                            exact mass: 267.051
                                                                                            pubchem substance url
                                                                                            localization: Unknown

                                                                                            3.1.1.4 Phospholipase A(2).

                                                                                            Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate. (kegg)
                                                                                            proteins
                                                                                            Q8WU67 ABHD3_HUMAN
                                                                                            P53816 HRSL3_HUMAN
                                                                                            P04054 PA21B_HUMAN
                                                                                            P47712 PA24A_HUMAN
                                                                                            P0C869 PA24B_HUMAN
                                                                                            Q9UP65 PA24C_HUMAN
                                                                                            Q86XP0 PA24D_HUMAN
                                                                                            Q3MJ16 PA24E_HUMAN
                                                                                            Q68DD2 PA24F_HUMAN
                                                                                            Q9NZ20 PA2G3_HUMAN
                                                                                            P39877 PA2G5_HUMAN
                                                                                            P14555 PA2GA_HUMAN
                                                                                            Q9UNK4 PA2GD_HUMAN
                                                                                            Q9NZK7 PA2GE_HUMAN
                                                                                            Q9BZM2 PA2GF_HUMAN
                                                                                            O15496 PA2GX_HUMAN
                                                                                            Q9BZM1 PG12A_HUMAN
                                                                                            Q6P1J6 PLB1_HUMAN
                                                                                            O60733 PLPL9_HUMAN

                                                                                            details
                                                                                            ["Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position."]


                                                                                            map 1: ETHER lipid metabolism

                                                                                            proteins:

                                                                                              Carboxylate

                                                                                              () (lipid link)
                                                                                              category:
                                                                                              main_class:
                                                                                              sub_class:
                                                                                              formula: CO2R
                                                                                              synonyms: R-COOH; Monocarboxylate; Carboxylic acid
                                                                                              kegg id: C00060
                                                                                              exact mass: 0
                                                                                              status:
                                                                                              pubchem substance url

                                                                                              Lysoplasmalogen

                                                                                              (1-(1-Alkenyl)-sn-glycero-3-phosphoethanolamine) (lipid link)
                                                                                              category:
                                                                                              main_class:
                                                                                              sub_class:
                                                                                              formula: C7H15NO6PR
                                                                                              synonyms: 1-Alkenylglycerophosphoethanolamine
                                                                                              kegg id: C04635
                                                                                              exact mass: 0
                                                                                              status:
                                                                                              pubchem substance url

                                                                                              Lysoplasmalogen + H2O

                                                                                              (1-(1-Alkenyl)-sn-glycero-3-phosphoethanolamine) (lipid link)
                                                                                              category:
                                                                                              main_class:
                                                                                              sub_class:
                                                                                              formula: C7H15NO6PR
                                                                                              synonyms: 1-Alkenylglycerophosphoethanolamine
                                                                                              kegg id: C04635
                                                                                              status:
                                                                                              exact mass: 0
                                                                                              pubchem substance url
                                                                                              localization: Unknown

                                                                                              3.1.4.38 Glycerophosphocholine cholinephosphodiesterase.

                                                                                              sn-glycero-3-phosphocholine + H(2)O = glycerol + phosphocholine. (kegg)
                                                                                              proteins
                                                                                              Q6UWR7 ENPP6_HUMAN

                                                                                              details
                                                                                              ["No activity on sn-3-glycerophosphoethanolamine."]


                                                                                              map 1: ETHER lipid metabolism

                                                                                              proteins:

                                                                                                1-(1-Alkenyl)-sn-glycerol

                                                                                                (1-(alk-1-enyl)-sn-glycerol) (lipid link)
                                                                                                category:
                                                                                                main_class:
                                                                                                sub_class:
                                                                                                formula: C5H9O3R
                                                                                                synonyms: 1-(1-Alkenyl)-sn-glycerol
                                                                                                kegg id: C15645
                                                                                                exact mass: 0
                                                                                                status:
                                                                                                pubchem substance url

                                                                                                Ethanolamine phosphate

                                                                                                (2-Aminoethyl dihydrogen phosphate) (lipid link)
                                                                                                category:
                                                                                                main_class:
                                                                                                sub_class:
                                                                                                formula: C2H8NO4P
                                                                                                synonyms: O-Phosphorylethanolamine; Phosphoethanolamine; O-Phosphoethanolamine
                                                                                                kegg id: C00346
                                                                                                exact mass: 141.019
                                                                                                status:
                                                                                                pubchem substance url

                                                                                                2-trans-9,12,15,18-all-cis-Tetracosapentaenoyl-CoA + NADPH

                                                                                                ((2R)-4-({[({[(2S,3S,4R,5S)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydr) (lipid link)
                                                                                                category:
                                                                                                main_class:
                                                                                                sub_class:
                                                                                                formula: C45H72N7O17P3S
                                                                                                synonyms: 2E,9Z,12Z,15Z,18Z-tetracosapentaenoyl-CoA
                                                                                                kegg id:
                                                                                                status:
                                                                                                exact mass: 0
                                                                                                localization: reticulum

                                                                                                1.3.1.- With NAD(+) or NADP(+) as acceptor.

                                                                                                (kegg)
                                                                                                proteins


                                                                                                map 1: n-6 Polyunsaturated fatty acid biosynthesis

                                                                                                proteins:

                                                                                                CoA(24:4(9Z,12Z,15Z,18Z)) + NADP(+)

                                                                                                (9Z,12Z,15Z,18Z-tetracosatetraenoyl-CoA) (lipid link)
                                                                                                category: Fatty Acyls [FA]
                                                                                                main_class: Fatty esters [FA07]
                                                                                                sub_class: Fatty acyl CoAs [FA0705]
                                                                                                formula: C45H74N7O17P3S
                                                                                                exact mass: 1109.41
                                                                                                status:
                                                                                                lipidmaps
                                                                                                pubchem substance url

                                                                                                Lysoplasmalogen + H2O

                                                                                                (1-(1-Alkenyl)-sn-glycero-3-phosphoethanolamine) (lipid link)
                                                                                                category:
                                                                                                main_class:
                                                                                                sub_class:
                                                                                                formula: C7H15NO6PR
                                                                                                synonyms: 1-Alkenylglycerophosphoethanolamine
                                                                                                kegg id: C04635
                                                                                                status:
                                                                                                exact mass: 0
                                                                                                pubchem substance url
                                                                                                localization: Unknown

                                                                                                3.1.4.39 Alkylglycerophosphoethanolamine phosphodiesterase.

                                                                                                1-alkyl-sn-glycero-3-phosphoethanolamine + H(2)O = 1-alkyl-sn-glycerol 3-phosphate + ethanolamine. (kegg)
                                                                                                proteins
                                                                                                Q13822 ENPP2_HUMAN

                                                                                                details
                                                                                                ["Also acts on acyl and choline analogs."]


                                                                                                map 1: ETHER lipid metabolism

                                                                                                proteins:

                                                                                                  Ethanolamine

                                                                                                  (2-Hydroxyethylamine) (lipid link)
                                                                                                  category:
                                                                                                  main_class:
                                                                                                  sub_class:
                                                                                                  formula: C2H7NO
                                                                                                  synonyms: Aminoethanol; 2-Hydroxyethylamine
                                                                                                  kegg id: c00189
                                                                                                  exact mass: 61.0528
                                                                                                  status:
                                                                                                  pubchem substance url

                                                                                                  1-(1-Alkenyl)-sn-glycero-3-phosphate

                                                                                                  (1-(alk-1-enyl)-sn-glycero-3-phosphate) (lipid link)
                                                                                                  category:
                                                                                                  main_class:
                                                                                                  sub_class:
                                                                                                  formula: C5H10O6PR
                                                                                                  synonyms:
                                                                                                  kegg id: C15646
                                                                                                  exact mass: 0
                                                                                                  status:

                                                                                                  Lysoplasmalogen + H2O

                                                                                                  (1-(1-Alkenyl)-sn-glycero-3-phosphoethanolamine) (lipid link)
                                                                                                  category:
                                                                                                  main_class:
                                                                                                  sub_class:
                                                                                                  formula: C7H15NO6PR
                                                                                                  synonyms: 1-Alkenylglycerophosphoethanolamine
                                                                                                  kegg id: C04635
                                                                                                  status:
                                                                                                  exact mass: 0
                                                                                                  pubchem substance url
                                                                                                  localization: Unknown

                                                                                                  3.3.2.5 Alkenylglycerophosphoethanolamine hydrolase.

                                                                                                  1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine + H(2)O = an aldehyde + sn-glycero-3-phosphoethanolamine. (kegg)
                                                                                                  proteins
                                                                                                  Q8N661 TM86B_HUMAN


                                                                                                  map 1: ETHER lipid metabolism

                                                                                                  proteins:

                                                                                                    sn-Glycero-3-phosphoethanolamine

                                                                                                    (sn-Glycero-3-phosphoethanolamine) (lipid link)
                                                                                                    category:
                                                                                                    main_class:
                                                                                                    sub_class:
                                                                                                    formula: C5H14NO6P
                                                                                                    synonyms: Glycerophosphoethanolamine
                                                                                                    kegg id: C01233
                                                                                                    exact mass: 215.056
                                                                                                    status:
                                                                                                    pubchem substance url

                                                                                                    Aldehyde

                                                                                                    () (lipid link)
                                                                                                    category:
                                                                                                    main_class:
                                                                                                    sub_class:
                                                                                                    formula: CHOR
                                                                                                    synonyms: RCHO
                                                                                                    kegg id: C00071
                                                                                                    exact mass: 0
                                                                                                    status:
                                                                                                    pubchem substance url

                                                                                                    1,2-DG + Acyl-CoA

                                                                                                    (1,2-diacyl-sn-glycerol) (lipid link)
                                                                                                    category: Glycerolipids [GL]
                                                                                                    main_class: Diradylglycerols [GL02]
                                                                                                    sub_class: Diacylglycerols [GL0201]
                                                                                                    formula:
                                                                                                    synonyms: 1,2-diacylglycerol; 1,2-DAG
                                                                                                    kegg id: C00641
                                                                                                    status:
                                                                                                    exact mass:
                                                                                                    lipidmaps
                                                                                                    pubchem substance url
                                                                                                    localization: Cytoplasm

                                                                                                    2.3.1.20 Diacylglycerol O-acyltransferase.

                                                                                                    Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. (kegg)
                                                                                                    proteins
                                                                                                    O75907 DGAT1_HUMAN
                                                                                                    Q96PD7 DGAT2_HUMAN
                                                                                                    Q86VF5 MOGT3_HUMAN

                                                                                                    details
                                                                                                    ["Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors."]


                                                                                                    map 1: Triacylglycerol metabolism

                                                                                                    proteins:
                                                                                                    • diacylglycerol O-acyltransferase 1 [DGAT1] ncbi lipid_maps
                                                                                                      regulators:
                                                                                                      MIR125B1 ( microRNA binding ) /1 (0, 1, 0)/ rzmd
                                                                                                      HNF4A ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd

                                                                                                    TG + CoA

                                                                                                    (triacyl-sn-glycerol) (lipid link)
                                                                                                    category: Glycerolipids [GL]
                                                                                                    main_class: Triradylglycerols [GL03]
                                                                                                    sub_class: Triacylglycerols [GL0301]
                                                                                                    formula:
                                                                                                    synonyms: Triacylglycerol; TAG
                                                                                                    kegg id: C00422
                                                                                                    exact mass:
                                                                                                    status:
                                                                                                    lipidmaps
                                                                                                    pubchem substance url

                                                                                                    1-(1-Alkenyl)-sn-glycero-3-phosphate + Acyl-CoA

                                                                                                    (1-(alk-1-enyl)-sn-glycero-3-phosphate) (lipid link)
                                                                                                    category:
                                                                                                    main_class:
                                                                                                    sub_class:
                                                                                                    formula: C5H10O6PR
                                                                                                    synonyms:
                                                                                                    kegg id: C15646
                                                                                                    status:
                                                                                                    exact mass: 0
                                                                                                    localization: Unknown

                                                                                                    2.3.1.- Transferring groups other than amino-acyl groups.

                                                                                                    (kegg)
                                                                                                    proteins


                                                                                                    map 1: ETHER lipid metabolism

                                                                                                    proteins:

                                                                                                      2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphate + CoA

                                                                                                      (1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphate(2−)) (lipid link)
                                                                                                      category:
                                                                                                      main_class:
                                                                                                      sub_class:
                                                                                                      formula: C6H9O7PR2
                                                                                                      synonyms:
                                                                                                      kegg id: C15647
                                                                                                      exact mass: 0
                                                                                                      status:
                                                                                                      pubchem substance url

                                                                                                      2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphate + H2O

                                                                                                      (1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphate(2−)) (lipid link)
                                                                                                      category:
                                                                                                      main_class:
                                                                                                      sub_class:
                                                                                                      formula: C6H9O7PR2
                                                                                                      synonyms:
                                                                                                      kegg id: C15647
                                                                                                      status:
                                                                                                      exact mass: 0
                                                                                                      pubchem substance url
                                                                                                      localization: Unknown

                                                                                                      3.1.3.- Phosphoric monoester hydrolases.

                                                                                                      (kegg)
                                                                                                      proteins


                                                                                                      map 1: ETHER lipid metabolism

                                                                                                      proteins:

                                                                                                        1-Alkenyl-2-acylglycerol + Phosphate

                                                                                                        (1-alkenyl-2-acylglycerol) (lipid link)
                                                                                                        category:
                                                                                                        main_class:
                                                                                                        sub_class:
                                                                                                        formula: C6H8O4R2
                                                                                                        synonyms:
                                                                                                        kegg id: C03454
                                                                                                        exact mass: 144.042
                                                                                                        status:
                                                                                                        pubchem substance url

                                                                                                        TG + H2O

                                                                                                        (triacyl-sn-glycerol) (lipid link)
                                                                                                        category: Glycerolipids [GL]
                                                                                                        main_class: Triradylglycerols [GL03]
                                                                                                        sub_class: Triacylglycerols [GL0301]
                                                                                                        formula:
                                                                                                        synonyms: Triacylglycerol; TAG
                                                                                                        kegg id: C00422
                                                                                                        status:
                                                                                                        exact mass:
                                                                                                        lipidmaps
                                                                                                        pubchem substance url
                                                                                                        localization: Cytoplasm

                                                                                                        3.1.1.13 Sterol esterase.

                                                                                                        A steryl ester + H(2)O = a sterol + a fatty acid. (kegg)
                                                                                                        proteins
                                                                                                        P19835 CEL_HUMAN
                                                                                                        P38571 LICH_HUMAN

                                                                                                        details
                                                                                                        ["A group of enzymes of broad specificity, acting on esters of sterols and long-chain fatty acids, that may also bring about the esterification of sterols.", "Activated by bile salts."]


                                                                                                        map 1: Triacylglycerol metabolism

                                                                                                        proteins:
                                                                                                        • lipoprotein lipase [LPL] ncbi lipid_maps
                                                                                                          regulators:
                                                                                                          ZNF202 ( transcriptional regulation ) /1 (0, 1, 0)/ rzmd
                                                                                                          NR1H3 ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                                                                                                          RXRA ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                                                                                                          SREBF1 ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                                                                                                          PPARA ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd
                                                                                                          PPARG ( transcriptional regulation ) /1 (1, 0, 0)/ rzmd

                                                                                                        Fatty acid

                                                                                                        (fatty acid) (lipid link)
                                                                                                        category: Fatty Acyls [FA]
                                                                                                        main_class: Fatty Acids and Conjugates [FA01]
                                                                                                        sub_class: Straight chain fatty acids [FA0101]
                                                                                                        formula: CHO2R
                                                                                                        synonyms:
                                                                                                        kegg id: C00162
                                                                                                        exact mass: 0
                                                                                                        status:
                                                                                                        lipidmaps
                                                                                                        pubchem substance url

                                                                                                        Plasmenylethanolamine

                                                                                                        (1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine) (lipid link)
                                                                                                        category:
                                                                                                        main_class:
                                                                                                        sub_class:
                                                                                                        formula: C8H14NO7PR2
                                                                                                        synonyms: O-1-Alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine, Phosphatidalethanolamine, Ethanolamineplasmalogen, 2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine, 1-Alkenyl-2-acylglycerophosphoethanolamine
                                                                                                        kegg id:
                                                                                                        status:
                                                                                                        exact mass: 267.051
                                                                                                        pubchem substance url
                                                                                                        localization: Unknown

                                                                                                        3.1.4.4 Phospholipase D.

                                                                                                        A phosphatidylcholine + H(2)O = choline + a phosphatidate. (kegg)
                                                                                                        proteins
                                                                                                        Q13393 PLD1_HUMAN
                                                                                                        O14939 PLD2_HUMAN
                                                                                                        Q8IV08 PLD3_HUMAN
                                                                                                        Q96BZ4 PLD4_HUMAN

                                                                                                        details
                                                                                                        ["Also acts on other phosphatidyl esters."]


                                                                                                        map 1: ETHER lipid metabolism

                                                                                                        proteins:

                                                                                                          Ethanolamine

                                                                                                          (2-Hydroxyethylamine) (lipid link)
                                                                                                          category:
                                                                                                          main_class:
                                                                                                          sub_class:
                                                                                                          formula: C2H7NO
                                                                                                          synonyms: Aminoethanol; 2-Hydroxyethylamine
                                                                                                          kegg id: c00189
                                                                                                          exact mass: 61.0528
                                                                                                          status:
                                                                                                          pubchem substance url

                                                                                                          2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphate

                                                                                                          (1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphate(2−)) (lipid link)
                                                                                                          category:
                                                                                                          main_class:
                                                                                                          sub_class:
                                                                                                          formula: C6H9O7PR2
                                                                                                          synonyms:
                                                                                                          kegg id: C15647
                                                                                                          exact mass: 0
                                                                                                          status:
                                                                                                          pubchem substance url

                                                                                                          TG + H2O

                                                                                                          (triacyl-sn-glycerol) (lipid link)
                                                                                                          category: Glycerolipids [GL]
                                                                                                          main_class: Triradylglycerols [GL03]
                                                                                                          sub_class: Triacylglycerols [GL0301]
                                                                                                          formula:
                                                                                                          synonyms: Triacylglycerol; TAG
                                                                                                          kegg id: C00422
                                                                                                          status:
                                                                                                          exact mass:
                                                                                                          lipidmaps
                                                                                                          pubchem substance url
                                                                                                          localization: Cytoplasm

                                                                                                          3.1.1.13 Sterol esterase.

                                                                                                          A steryl ester + H(2)O = a sterol + a fatty acid. (kegg)
                                                                                                          proteins
                                                                                                          P19835 CEL_HUMAN
                                                                                                          P38571 LICH_HUMAN

                                                                                                          details
                                                                                                          ["A group of enzymes of broad specificity, acting on esters of sterols and long-chain fatty acids, that may also bring about the esterification of sterols.", "Activated by bile salts."]


                                                                                                          map 1: Triacylglycerol metabolism

                                                                                                          proteins:

                                                                                                          1,2-DG

                                                                                                          (1,2-diacyl-sn-glycerol) (lipid link)
                                                                                                          category: Glycerolipids [GL]
                                                                                                          main_class: Diradylglycerols [GL02]
                                                                                                          sub_class: Diacylglycerols [GL0201]
                                                                                                          formula:
                                                                                                          synonyms: 1,2-diacylglycerol; 1,2-DAG
                                                                                                          kegg id: C00641
                                                                                                          exact mass:
                                                                                                          status:
                                                                                                          lipidmaps
                                                                                                          pubchem substance url

                                                                                                          Plasmenylethanolamine + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                                                                                                          (1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine) (lipid link)
                                                                                                          category:
                                                                                                          main_class:
                                                                                                          sub_class:
                                                                                                          formula: C8H14NO7PR2
                                                                                                          synonyms: O-1-Alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine, Phosphatidalethanolamine, Ethanolamineplasmalogen, 2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine, 1-Alkenyl-2-acylglycerophosphoethanolamine
                                                                                                          kegg id:
                                                                                                          status:
                                                                                                          exact mass: 267.051
                                                                                                          pubchem substance url
                                                                                                          localization: Unknown

                                                                                                          2.7.8.1 Ethanolaminephosphotransferase.

                                                                                                          CDP-ethanolamine + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylethanolamine. (kegg)
                                                                                                          proteins
                                                                                                          Q9Y6K0 CEPT1_HUMAN
                                                                                                          Q9C0D9 EPT1_HUMAN


                                                                                                          map 1: ETHER lipid metabolism

                                                                                                          proteins:

                                                                                                            CDP-ethanolamine

                                                                                                            () (lipid link)
                                                                                                            category:
                                                                                                            main_class:
                                                                                                            sub_class:
                                                                                                            formula: C11H20N4O11P2
                                                                                                            synonyms: Cytidine diphosphate ethanolamine
                                                                                                            kegg id: C00570
                                                                                                            exact mass: 446.06
                                                                                                            status:
                                                                                                            pubchem substance url

                                                                                                            1-Alkenyl-2-acylglycerol

                                                                                                            (1-alkenyl-2-acylglycerol) (lipid link)
                                                                                                            category:
                                                                                                            main_class:
                                                                                                            sub_class:
                                                                                                            formula: C6H8O4R2
                                                                                                            synonyms:
                                                                                                            kegg id: C03454
                                                                                                            exact mass: 144.042
                                                                                                            status:
                                                                                                            pubchem substance url

                                                                                                            CDP-choline

                                                                                                            (Cytidine 5-diphosphocholine) (lipid link)
                                                                                                            category:
                                                                                                            main_class:
                                                                                                            sub_class:
                                                                                                            formula: C14H26N4O11P2
                                                                                                            synonyms: Citicoline
                                                                                                            kegg id: C00307
                                                                                                            status:
                                                                                                            exact mass: 488.107
                                                                                                            pubchem substance url
                                                                                                            localization: Unknown

                                                                                                            2.7.8.22 1-alkenyl-2-acylglycerol choline phosphotransferase.

                                                                                                            CDP-choline + 1-alkenyl-2-acylglycerol = CMP + plasmenylcholine. (kegg)
                                                                                                            proteins


                                                                                                            map 1: ETHER lipid metabolism

                                                                                                            proteins:

                                                                                                              Plasmenylcholine + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                                                                                                              (1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine) (lipid link)
                                                                                                              category:
                                                                                                              main_class:
                                                                                                              sub_class:
                                                                                                              formula: C11H21NO7PR2
                                                                                                              synonyms: Choline plasmalogen; 1-Alkenyl-2-acylglycerophosphocholine; 2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphocholine
                                                                                                              kegg id: C00958
                                                                                                              exact mass: 718.575
                                                                                                              status:
                                                                                                              pubchem substance url

                                                                                                              1-Alkenyl-2-acylglycerol

                                                                                                              (1-alkenyl-2-acylglycerol) (lipid link)
                                                                                                              category:
                                                                                                              main_class:
                                                                                                              sub_class:
                                                                                                              formula: C6H8O4R2
                                                                                                              synonyms:
                                                                                                              kegg id: C03454
                                                                                                              status:
                                                                                                              exact mass: 144.042
                                                                                                              pubchem substance url
                                                                                                              localization: Unknown

                                                                                                              2.7.8.22 1-alkenyl-2-acylglycerol choline phosphotransferase.

                                                                                                              CDP-choline + 1-alkenyl-2-acylglycerol = CMP + plasmenylcholine. (kegg)
                                                                                                              proteins


                                                                                                              map 1: ETHER lipid metabolism

                                                                                                              proteins:

                                                                                                                Plasmenylcholine + CMP (Cytidine-5'-monophosphate; Cytidylic acid)

                                                                                                                (1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine) (lipid link)
                                                                                                                category:
                                                                                                                main_class:
                                                                                                                sub_class:
                                                                                                                formula: C11H21NO7PR2
                                                                                                                synonyms: Choline plasmalogen; 1-Alkenyl-2-acylglycerophosphocholine; 2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphocholine
                                                                                                                kegg id: C00958
                                                                                                                exact mass: 718.575
                                                                                                                status:
                                                                                                                pubchem substance url

                                                                                                                Plasmenylethanolamine + H2O

                                                                                                                (1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine) (lipid link)
                                                                                                                category:
                                                                                                                main_class:
                                                                                                                sub_class:
                                                                                                                formula: C8H14NO7PR2
                                                                                                                synonyms: O-1-Alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine, Phosphatidalethanolamine, Ethanolamineplasmalogen, 2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine, 1-Alkenyl-2-acylglycerophosphoethanolamine
                                                                                                                kegg id:
                                                                                                                status:
                                                                                                                exact mass: 267.051
                                                                                                                pubchem substance url
                                                                                                                localization: Unknown

                                                                                                                3.1.4.3 Phospholipase C.

                                                                                                                A phosphatidylcholine + H(2)O = 1,2-diacyl-sn-glycerol + phosphocholine. (kegg)
                                                                                                                proteins

                                                                                                                details
                                                                                                                ["The bacterial enzyme also acts on sphingomyelin and phosphatidylinositol.", "The enzyme from seminal plasma does not act on phosphatidylinositol."]


                                                                                                                map 1: ETHER lipid metabolism

                                                                                                                proteins:

                                                                                                                  Ethanolamine phosphate

                                                                                                                  (2-Aminoethyl dihydrogen phosphate) (lipid link)
                                                                                                                  category:
                                                                                                                  main_class:
                                                                                                                  sub_class:
                                                                                                                  formula: C2H8NO4P
                                                                                                                  synonyms: O-Phosphorylethanolamine; Phosphoethanolamine; O-Phosphoethanolamine
                                                                                                                  kegg id: C00346
                                                                                                                  exact mass: 141.019
                                                                                                                  status:
                                                                                                                  pubchem substance url

                                                                                                                  1-Alkenyl-2-acylglycerol

                                                                                                                  (1-alkenyl-2-acylglycerol) (lipid link)
                                                                                                                  category:
                                                                                                                  main_class:
                                                                                                                  sub_class:
                                                                                                                  formula: C6H8O4R2
                                                                                                                  synonyms:
                                                                                                                  kegg id: C03454
                                                                                                                  exact mass: 144.042
                                                                                                                  status:
                                                                                                                  pubchem substance url

                                                                                                                  Choline

                                                                                                                  () (lipid link)
                                                                                                                  category:
                                                                                                                  main_class:
                                                                                                                  sub_class:
                                                                                                                  formula: C5H14NO
                                                                                                                  synonyms: Bilineurine, 2-Hydroxy-N,N,N-trimethylethanaminium, Bursine
                                                                                                                  kegg id: C00114
                                                                                                                  status:
                                                                                                                  exact mass: 104.107
                                                                                                                  pubchem substance url
                                                                                                                  localization: Unknown

                                                                                                                  2.6.-.- Transferring nitrogenous groups.

                                                                                                                  (kegg)
                                                                                                                  proteins


                                                                                                                  map 1: ETHER lipid metabolism

                                                                                                                  proteins:

                                                                                                                    Ethanolamine

                                                                                                                    (2-Hydroxyethylamine) (lipid link)
                                                                                                                    category:
                                                                                                                    main_class:
                                                                                                                    sub_class:
                                                                                                                    formula: C2H7NO
                                                                                                                    synonyms: Aminoethanol; 2-Hydroxyethylamine
                                                                                                                    kegg id: c00189
                                                                                                                    exact mass: 61.0528
                                                                                                                    status:
                                                                                                                    pubchem substance url

                                                                                                                    Plasmenylcholine

                                                                                                                    (1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine) (lipid link)
                                                                                                                    category:
                                                                                                                    main_class:
                                                                                                                    sub_class:
                                                                                                                    formula: C11H21NO7PR2
                                                                                                                    synonyms: Choline plasmalogen; 1-Alkenyl-2-acylglycerophosphocholine; 2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphocholine
                                                                                                                    kegg id: C00958
                                                                                                                    exact mass: 718.575
                                                                                                                    status:
                                                                                                                    pubchem substance url

                                                                                                                    Plasmenylethanolamine

                                                                                                                    (1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine) (lipid link)
                                                                                                                    category:
                                                                                                                    main_class:
                                                                                                                    sub_class:
                                                                                                                    formula: C8H14NO7PR2
                                                                                                                    synonyms: O-1-Alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine, Phosphatidalethanolamine, Ethanolamineplasmalogen, 2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine, 1-Alkenyl-2-acylglycerophosphoethanolamine
                                                                                                                    kegg id:
                                                                                                                    status:
                                                                                                                    exact mass: 267.051
                                                                                                                    pubchem substance url
                                                                                                                    localization: Unknown

                                                                                                                    2.6.-.- Transferring nitrogenous groups.

                                                                                                                    (kegg)
                                                                                                                    proteins


                                                                                                                    map 1: ETHER lipid metabolism

                                                                                                                    proteins:

                                                                                                                      Ethanolamine

                                                                                                                      (2-Hydroxyethylamine) (lipid link)
                                                                                                                      category:
                                                                                                                      main_class:
                                                                                                                      sub_class:
                                                                                                                      formula: C2H7NO
                                                                                                                      synonyms: Aminoethanol; 2-Hydroxyethylamine
                                                                                                                      kegg id: c00189
                                                                                                                      exact mass: 61.0528
                                                                                                                      status:
                                                                                                                      pubchem substance url

                                                                                                                      Plasmenylcholine

                                                                                                                      (1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine) (lipid link)
                                                                                                                      category:
                                                                                                                      main_class:
                                                                                                                      sub_class:
                                                                                                                      formula: C11H21NO7PR2
                                                                                                                      synonyms: Choline plasmalogen; 1-Alkenyl-2-acylglycerophosphocholine; 2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphocholine
                                                                                                                      kegg id: C00958
                                                                                                                      exact mass: 718.575
                                                                                                                      status:
                                                                                                                      pubchem substance url

                                                                                                                      1-(1-Alkenyl)-sn-glycero-3-phosphocholine + Acyl-CoA

                                                                                                                      (1-O-(alk-1-enyl)-sn-glycero-3-phosphocholine) (lipid link)
                                                                                                                      category:
                                                                                                                      main_class:
                                                                                                                      sub_class:
                                                                                                                      formula: C10H22NO6PR
                                                                                                                      synonyms: 1-Alkenyl-sn-glycero-3-phosphocholine; 1-Alkenylglycerophosphocholine; 1-O-Alk-1-enyl-glycero-3-phosphocholine
                                                                                                                      kegg id: C04517
                                                                                                                      status:
                                                                                                                      exact mass: 282.111
                                                                                                                      pubchem substance url
                                                                                                                      localization: Unknown

                                                                                                                      2.3.1.25 Plasmalogen synthase.

                                                                                                                      Acyl-CoA + 1-O-(alk-1-enyl)glycero-3-phosphocholine = CoA + plasmenylcholine. (kegg)
                                                                                                                      proteins

                                                                                                                      details
                                                                                                                      ["Formerly EC 2.3.1.104."]


                                                                                                                      map 1: ETHER lipid metabolism

                                                                                                                      proteins:

                                                                                                                        Plasmenylcholine + CoA

                                                                                                                        (1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine) (lipid link)
                                                                                                                        category:
                                                                                                                        main_class:
                                                                                                                        sub_class:
                                                                                                                        formula: C11H21NO7PR2
                                                                                                                        synonyms: Choline plasmalogen; 1-Alkenyl-2-acylglycerophosphocholine; 2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphocholine
                                                                                                                        kegg id: C00958
                                                                                                                        exact mass: 718.575
                                                                                                                        status:
                                                                                                                        pubchem substance url

                                                                                                                        Plasmenylcholine + H2O

                                                                                                                        (1-O-(alk-1-enyl)-2-O-acyl-sn-glycero-3-phosphocholine) (lipid link)
                                                                                                                        category:
                                                                                                                        main_class:
                                                                                                                        sub_class:
                                                                                                                        formula: C11H21NO7PR2
                                                                                                                        synonyms: Choline plasmalogen; 1-Alkenyl-2-acylglycerophosphocholine; 2-Acyl-1-(1-alkenyl)-sn-glycero-3-phosphocholine
                                                                                                                        kegg id: C00958
                                                                                                                        status:
                                                                                                                        exact mass: 718.575
                                                                                                                        pubchem substance url
                                                                                                                        localization: Unknown

                                                                                                                        3.1.1.4 Phospholipase A(2).

                                                                                                                        Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate. (kegg)
                                                                                                                        proteins
                                                                                                                        Q8WU67 ABHD3_HUMAN
                                                                                                                        P53816 HRSL3_HUMAN
                                                                                                                        P04054 PA21B_HUMAN
                                                                                                                        P47712 PA24A_HUMAN
                                                                                                                        P0C869 PA24B_HUMAN
                                                                                                                        Q9UP65 PA24C_HUMAN
                                                                                                                        Q86XP0 PA24D_HUMAN
                                                                                                                        Q3MJ16 PA24E_HUMAN
                                                                                                                        Q68DD2 PA24F_HUMAN
                                                                                                                        Q9NZ20 PA2G3_HUMAN
                                                                                                                        P39877 PA2G5_HUMAN
                                                                                                                        P14555 PA2GA_HUMAN
                                                                                                                        Q9UNK4 PA2GD_HUMAN
                                                                                                                        Q9NZK7 PA2GE_HUMAN
                                                                                                                        Q9BZM2 PA2GF_HUMAN
                                                                                                                        O15496 PA2GX_HUMAN
                                                                                                                        Q9BZM1 PG12A_HUMAN
                                                                                                                        Q6P1J6 PLB1_HUMAN
                                                                                                                        O60733 PLPL9_HUMAN

                                                                                                                        details
                                                                                                                        ["Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position."]


                                                                                                                        map 1: ETHER lipid metabolism

                                                                                                                        proteins:

                                                                                                                          Fatty acid

                                                                                                                          (fatty acid) (lipid link)
                                                                                                                          category: Fatty Acyls [FA]
                                                                                                                          main_class: Fatty Acids and Conjugates [FA01]
                                                                                                                          sub_class: Straight chain fatty acids [FA0101]
                                                                                                                          formula: CHO2R
                                                                                                                          synonyms:
                                                                                                                          kegg id: C00162
                                                                                                                          exact mass: 0
                                                                                                                          status:
                                                                                                                          lipidmaps
                                                                                                                          pubchem substance url

                                                                                                                          1-(1-Alkenyl)-sn-glycero-3-phosphocholine

                                                                                                                          (1-O-(alk-1-enyl)-sn-glycero-3-phosphocholine) (lipid link)
                                                                                                                          category:
                                                                                                                          main_class:
                                                                                                                          sub_class:
                                                                                                                          formula: C10H22NO6PR
                                                                                                                          synonyms: 1-Alkenyl-sn-glycero-3-phosphocholine; 1-Alkenylglycerophosphocholine; 1-O-Alk-1-enyl-glycero-3-phosphocholine
                                                                                                                          kegg id: C04517
                                                                                                                          exact mass: 282.111
                                                                                                                          status:
                                                                                                                          pubchem substance url

                                                                                                                          1-(1-Alkenyl)-sn-glycero-3-phosphocholine + H2O

                                                                                                                          (1-O-(alk-1-enyl)-sn-glycero-3-phosphocholine) (lipid link)
                                                                                                                          category:
                                                                                                                          main_class:
                                                                                                                          sub_class:
                                                                                                                          formula: C10H22NO6PR
                                                                                                                          synonyms: 1-Alkenyl-sn-glycero-3-phosphocholine; 1-Alkenylglycerophosphocholine; 1-O-Alk-1-enyl-glycero-3-phosphocholine
                                                                                                                          kegg id: C04517
                                                                                                                          status:
                                                                                                                          exact mass: 282.111
                                                                                                                          pubchem substance url
                                                                                                                          localization: Unknown

                                                                                                                          3.3.2.2 Alkenylglycerophosphocholine hydrolase.

                                                                                                                          1-(1-alkenyl)-sn-glycero-3-phosphocholine + H(2)O = an aldehyde + sn-glycero-3-phosphocholine. (kegg)
                                                                                                                          proteins
                                                                                                                          Q8N661 TM86B_HUMAN


                                                                                                                          map 1: ETHER lipid metabolism

                                                                                                                          proteins:

                                                                                                                            sn-Glycero-3-phosphocholine

                                                                                                                            () (lipid link)
                                                                                                                            category:
                                                                                                                            main_class:
                                                                                                                            sub_class:
                                                                                                                            formula: C8H21NO6P
                                                                                                                            synonyms: Glycerophosphocholine
                                                                                                                            kegg id: C00670
                                                                                                                            exact mass: 258.111
                                                                                                                            status:
                                                                                                                            pubchem substance url

                                                                                                                            Aldehyde

                                                                                                                            () (lipid link)
                                                                                                                            category:
                                                                                                                            main_class:
                                                                                                                            sub_class:
                                                                                                                            formula: CHOR
                                                                                                                            synonyms: RCHO
                                                                                                                            kegg id: C00071
                                                                                                                            exact mass: 0
                                                                                                                            status:
                                                                                                                            pubchem substance url

                                                                                                                            1-Alkyl-sn-glycero-3-phosphate + NADP(+)

                                                                                                                            (1-alkyl-sn-glycerol 3-phosphate) (lipid link)
                                                                                                                            category:
                                                                                                                            main_class:
                                                                                                                            sub_class:
                                                                                                                            formula: C3H8O6PR
                                                                                                                            synonyms: 1-Alkyl-sn-glycero-3-phosphate, 1-O-Alkyl-sn-glycerol 3-phosphate
                                                                                                                            kegg id: C03968
                                                                                                                            status:
                                                                                                                            exact mass: 0
                                                                                                                            pubchem substance url
                                                                                                                            localization: Unknown

                                                                                                                            1.1.1.101 Acylglycerone-phosphate reductase.

                                                                                                                            1-palmitoylglycerol 3-phosphate + NADP(+) = palmitoylglycerone phosphate + NADPH. (kegg)
                                                                                                                            proteins

                                                                                                                            details
                                                                                                                            ["Also acts on alkylglycerone 3-phosphate and alkylglycerol 3-phosphate."]


                                                                                                                            map 1: ETHER lipid metabolism

                                                                                                                            proteins:

                                                                                                                              1-Alkyl-glycerone 3-phosphate + NADPH + H+

                                                                                                                              () (lipid link)
                                                                                                                              category:
                                                                                                                              main_class:
                                                                                                                              sub_class:
                                                                                                                              formula: C3H6O6PR
                                                                                                                              synonyms: O-Alkylglycerone phosphate; Alkyl-glycerone 3-phosphate; Dihydroxyacetone phosphate alkyl ether
                                                                                                                              kegg id: C03715
                                                                                                                              exact mass: 0
                                                                                                                              status:
                                                                                                                              pubchem substance url

                                                                                                                              Monoacylglycerol + ATP

                                                                                                                              (1-acyl-sn-glycerol) (lipid link)
                                                                                                                              category: Glycerolipids [GL]
                                                                                                                              main_class: Monoradylglycerols [GL01]
                                                                                                                              sub_class: Monoacylglycerols [GL0101]
                                                                                                                              formula: C4H7O4R
                                                                                                                              synonyms: 1-Acylglycerol, Glyceride, Monoglyceride, 1-Monoacylglycerol, MAG, 1-MAG
                                                                                                                              kegg id: C01885
                                                                                                                              status:
                                                                                                                              exact mass: 0
                                                                                                                              lipidmaps
                                                                                                                              pubchem substance url
                                                                                                                              localization: Unknown

                                                                                                                              2.7.1.93 Alkylglycerol kinase.

                                                                                                                              ATP + 1-O-alkyl-sn-glycerol = ADP + 1-O-alkyl-sn-glycerol 3-phosphate. (kegg)
                                                                                                                              proteins


                                                                                                                              map 1: ETHER lipid metabolism

                                                                                                                              proteins:

                                                                                                                                1-Alkyl-sn-glycero-3-phosphate + ADP

                                                                                                                                (1-alkyl-sn-glycerol 3-phosphate) (lipid link)
                                                                                                                                category:
                                                                                                                                main_class:
                                                                                                                                sub_class:
                                                                                                                                formula: C3H8O6PR
                                                                                                                                synonyms: 1-Alkyl-sn-glycero-3-phosphate, 1-O-Alkyl-sn-glycerol 3-phosphate
                                                                                                                                kegg id: C03968
                                                                                                                                exact mass: 0
                                                                                                                                status:
                                                                                                                                pubchem substance url

                                                                                                                                1-Alkyl-sn-glycero-3-phosphate + acetyl-CoA

                                                                                                                                (1-alkyl-sn-glycerol 3-phosphate) (lipid link)
                                                                                                                                category:
                                                                                                                                main_class:
                                                                                                                                sub_class:
                                                                                                                                formula: C3H8O6PR
                                                                                                                                synonyms: 1-Alkyl-sn-glycero-3-phosphate, 1-O-Alkyl-sn-glycerol 3-phosphate
                                                                                                                                kegg id: C03968
                                                                                                                                status:
                                                                                                                                exact mass: 0
                                                                                                                                pubchem substance url
                                                                                                                                localization: Unknown

                                                                                                                                2.3.1.105 Alkylglycerophosphate 2-O-acetyltransferase.

                                                                                                                                Acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate = CoA + 1-alkyl-2-acetyl- sn-glycero-3-phosphate. (kegg)
                                                                                                                                proteins

                                                                                                                                details
                                                                                                                                ["Involved in the biosynthesis of thrombocyte activating factor in animal tissues."]


                                                                                                                                map 1: ETHER lipid metabolism

                                                                                                                                proteins:

                                                                                                                                  2-Acetyl-1-alkyl-sn-glycero-3-phosphate + CoA

                                                                                                                                  (1-alkyl-2-acetyl-sn-glycerol 3-phosphate) (lipid link)
                                                                                                                                  category:
                                                                                                                                  main_class:
                                                                                                                                  sub_class:
                                                                                                                                  formula: C5H10O7PR
                                                                                                                                  synonyms:
                                                                                                                                  kegg id: C01264
                                                                                                                                  exact mass: 0
                                                                                                                                  status:
                                                                                                                                  pubchem substance url

                                                                                                                                  2-Acetyl-1-alkyl-sn-glycero-3-phosphate + H2O

                                                                                                                                  (1-alkyl-2-acetyl-sn-glycerol 3-phosphate) (lipid link)
                                                                                                                                  category:
                                                                                                                                  main_class:
                                                                                                                                  sub_class:
                                                                                                                                  formula: C5H10O7PR
                                                                                                                                  synonyms:
                                                                                                                                  kegg id: C01264
                                                                                                                                  status:
                                                                                                                                  exact mass: 0
                                                                                                                                  pubchem substance url
                                                                                                                                  localization: Unknown

                                                                                                                                  3.1.3.59 Alkylacetylglycerophosphatase.

                                                                                                                                  1-alkyl-2-acetyl-sn-glycero-3-phosphate + H(2)O = 1-alkyl-2-acetyl- sn-glycerol + phosphate. (kegg)
                                                                                                                                  proteins

                                                                                                                                  details
                                                                                                                                  ["Involved in the biosynthesis of thrombocyte activating factor in animal tissues."]


                                                                                                                                  map 1: ETHER lipid metabolism

                                                                                                                                  proteins:

                                                                                                                                    2-Acetyl-1-alkyl-sn-glycerol + Phosphate

                                                                                                                                    (1-alkyl-2-acetyl-sn-glycerol) (lipid link)
                                                                                                                                    category:
                                                                                                                                    main_class:
                                                                                                                                    sub_class:
                                                                                                                                    formula: C5H9O4R
                                                                                                                                    synonyms: 1-O-Alkyl-2-acetyl-sn-glycerol
                                                                                                                                    kegg id: C03820
                                                                                                                                    exact mass: 0
                                                                                                                                    status:
                                                                                                                                    pubchem substance url

                                                                                                                                    2-Acetyl-1-alkyl-sn-glycerol + Acyl-CoA

                                                                                                                                    (1-alkyl-2-acetyl-sn-glycerol) (lipid link)
                                                                                                                                    category:
                                                                                                                                    main_class:
                                                                                                                                    sub_class:
                                                                                                                                    formula: C5H9O4R
                                                                                                                                    synonyms: 1-O-Alkyl-2-acetyl-sn-glycerol
                                                                                                                                    kegg id: C03820
                                                                                                                                    status:
                                                                                                                                    exact mass: 0
                                                                                                                                    pubchem substance url
                                                                                                                                    localization: Unknown

                                                                                                                                    2.3.1.125 1-alkyl-2-acetylglycerol O-acyltransferase.

                                                                                                                                    Acyl-CoA + 1-O-alkyl-2-acetyl-sn-glycerol = CoA + 1-O-alkyl-2-acetyl-3- acyl-sn-glycerol. (kegg)
                                                                                                                                    proteins

                                                                                                                                    details
                                                                                                                                    ["A number of acyl-CoAs can act as acyl donor; maximum activity is obtained with linoleoyl-CoA.", "Not identical with EC 2.3.1.20."]


                                                                                                                                    map 1: ETHER lipid metabolism

                                                                                                                                    proteins:

                                                                                                                                      2-Acetyl-1-O-alkyl-3-acyl-sn-glycerol + CoA

                                                                                                                                      (1-alkyl-2-acetyl-3-acyl-sn-glycerol) (lipid link)
                                                                                                                                      category:
                                                                                                                                      main_class:
                                                                                                                                      sub_class:
                                                                                                                                      formula: C6H8O5R2
                                                                                                                                      synonyms: 1-O-Alkyl-2-acetyl-3-acyl-sn-glycerol
                                                                                                                                      kegg id: C04361
                                                                                                                                      exact mass: 0
                                                                                                                                      status:
                                                                                                                                      pubchem substance url

                                                                                                                                      1-Alkyl-sn-glycero-3-phosphate + Acyl-CoA

                                                                                                                                      (1-alkyl-sn-glycerol 3-phosphate) (lipid link)
                                                                                                                                      category:
                                                                                                                                      main_class:
                                                                                                                                      sub_class:
                                                                                                                                      formula: C3H8O6PR
                                                                                                                                      synonyms: 1-Alkyl-sn-glycero-3-phosphate, 1-O-Alkyl-sn-glycerol 3-phosphate
                                                                                                                                      kegg id: C03968
                                                                                                                                      status:
                                                                                                                                      exact mass: 0
                                                                                                                                      pubchem substance url
                                                                                                                                      localization: Unknown

                                                                                                                                      2.3.1.- Transferring groups other than amino-acyl groups.

                                                                                                                                      (kegg)
                                                                                                                                      proteins


                                                                                                                                      map 1: ETHER lipid metabolism

                                                                                                                                      proteins:

                                                                                                                                        2-Acyl-1-alkyl-sn-glycero-3-phosphate + CoA

                                                                                                                                        (2-Acyl-1-alkyl-sn-glycero-3-phosphate) (lipid link)
                                                                                                                                        category:
                                                                                                                                        main_class:
                                                                                                                                        sub_class:
                                                                                                                                        formula: C4H7O7PR2
                                                                                                                                        synonyms:
                                                                                                                                        kegg id: